Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression by Qiang Chen, Jiuyang Jiao, Youyuan Wang, Zhihui Mai, Jing Ren, Sijie He, Xiaolan Li, Zheng Chen

“…Abstract Background Arecoline is an alkaloid natural product found in the areca nut that can induce oral submucous fibrosis and subsequent development of cancer. …”
Get full text

A Critical Interpretive Synthesis of the Role of Arecoline in Oral Carcinogenesis: Is the Local Cholinergic Axis a Missing Link in Disease Pathophysiology? by Hakan Gocol, Jin Han Zeng, Sara Chang, Buo Yu Koh, Hoang Nguyen, Nicola Cirillo

“…Arecoline is the primary active carcinogen found in areca nut and has been implicated in the pathogenesis of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF). …”
Get full text

Areca Yellow Leaf Disease Severity Monitoring Using UAV-Based Multispectral and Thermal Infrared Imagery by Dong Xu, Yuwei Lu, Heng Liang, Zhen Lu, Lejun Yu, Qian Liu

“…The areca nut is the primary economic source for some farmers in southeast Asia. …”
Get full text

β-catenin expression in areca quid chewing-associated oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells by Shiuan-Shinn Lee, Chung-Hung Tsai, Lo-Lin Tsai, Ming-Chih Chou, Ming-Yung Chou, Yu-Chao Chang

“…The oral epithelial cell line GNM cells were challenged with arecoline, a major areca nut alkaloid, by using Western blot analysis. …”
Get full text

Pathological investigations and correlation research of microfibrillar-associated protein 4 and tropoelastin in oral submucous fibrosis by Binjie Liu, Wenqun Gou, Hui Feng

“…All OSF cases had chewed areca nut, with 51.67% smoking tobacco. Conclusions Our study elucidates that the accumulation of MFAP4 and TE proteins may play a vital role in the occurrence and development of OSF and may be promising candidate moleculars for prevention, diagnosis, and treatment strategies for OSF in the future.…”
Get full text

JENIS DAN BOBOT SAMPAH LAUT (MARINE DEBRIS) PANTAI PANJANG KOTA BENGKULU by Yar Johan, Person Pesona Renta, Dewi Purnama, Ali Muqsit, Pinsi Hariman

“…The results showed that there were 13 types of waste classified as organic waste in Pantai Beach, namely wood, paper, coconut, leaves, roots, cardboard, bamboo, durian, areca nut, ketapang, fibers, corn and mangrove. While inorganic waste types were found 21 kinds of marine debris, namely plastic, glass bottles, foam, cloth, shoes, pipettes, sandals, bottle caps, ropes, broken glass, plastic toys, carpets, pens, dolls, steorofomes, rubber, cork, brakes and tooth brush. …”
Get full text

Cytotoxic Effects of Indonesian Betel Quid Components on Oral Keratinocytes and Fibroblasts by Elizabeth Fitriana Sari, Ali I. Mohammed, Antonio Celentano, Michael John McCullough, Nicola Cirillo

“…In order to investigate whether individual components of BQ mixtures have distinct physio-pathological effects on oral mucosal cells, we examined the impact of areca nut (AN), <i>Piper betle</i> leaf (Leaf), <i>Piper betle</i> stem inflorescence (SI), areca husk (Husk) and the complete BQ mixture on the growth of oral keratinocytes (OKF-6) and primary oral fibroblasts (MMF-1). …”
Get full text

Factors affecting commencement and cessation of betel quid chewing behaviour in Malaysian adults by Handa Yujiro, Gupta Prakash C, Axell Tony, Ikeda Noriaki, Talib Norain A, Yang Yi-Hsin, Razak Ishak A, Ghani Wan MN, Abdullah Norlida, Zain Rosnah B

“…Cessation was also more likely to be seen among those who chewed less than 5 quids per day (p < 0.05) and less likely to be seen among those who included areca nut and tobacco in their quid (p < 0.0001).</p> <p>Conclusion</p> <p>Factors that influence the development and cessation of this behaviour are gender, age, ethnicity, and also history of smoking habit while frequency and type of quid chewed are important factors for cessation of this habit.…”
Get full text

Transforming growth factor beta receptor 2 single-nucleotide polymorphism association with oral cancer and In silico identification of small drug-like molecules as inhibitors to tr... by Shaleen Multani, Hetal Damani Shah, Dhananjaya Saranath

“…The major risk factors include tobacco, areca nut, alcohol, and human papillomavirus 16/18; however, only 5%–10% of the high-risk individuals develop oral cancer, indicating the role of genomic variants in susceptibility to oral cancer. …”
Get full text

Cellular diameter in desquamated cells of smokeless tobacco users by Sonia Jaiswal, Pradeep Kumar Sharma, Tahsin Munsif

“…Materials and Methods: In a case controlled study, 240 participants were divided into four groups according to their habit of consumption of tobacco leaves, tobacco with areca nut, participants with oral lesions, and participants without any such habit. …”
Get full text

Ultrastructure Characteristics and Sexual Dimorphism of Antennal Sensilla in <i>Tirathaba rufivena</i> (Lepidoptera: Pyralidae) by Jixing Guo, Zimeng Du, Guangchao Cui, Zheng Wang, Junfang Wang, Xiang Zhou

“…<i>Tirathaba rufivena</i> Walker, a major insect pest of <i>Areca catechu</i> L., has severely threatened areca nut cultivation in Hainan, China. To improve our understanding of the communication mechanism in host plant seeking and mate-finding for <i>T. rufivena</i>, we described and further characterized the external morphology and internal sensilla structures using scanning electron microscopy and transmission electron microscopy in this study. …”
Get full text

Serum Iron and Haemoglobin Estimation in Oral Submucous Fibrosis and Iron Deficiency Anaemia: A Diagnostic Approach by Divya Bhardwaj, Ajit D Dinkar, Sujata K Satoskar, Sapna Raut Desai

“…The iron deficiency anaemia group was not found to be suffering from OSMF in the absence of areca-nut or tobacco chewing habits, but OSMF patients with chewing habits were found to be suffering from iron deficiency anaemia. …”
Get full text

Testing the efficacy of a school-based tobacco and supari cessation intervention in Mumbai, India by Himanshu Gupte, Gauri Mandal, Tshering Bhutia, Leni Chaudhuri, Nilesh Chatterjee

“…Background Tobacco and supari (areca nut or betel nut) use has been reported with a high prevalence among students in secondary schools in Mumbai, India. …”
Get full text

Factors affecting commencement and cessation of betel quid chewing behaviour in Malaysian adults. by Ghani, W.M., Razak, I.A., Yang, Y.H., Talib, N.A., Ikeda, N., Axell, T., Gupta, P.C., Handa, Y., Abdullah, N., Zain, R.B.

“…Cessation was also more likely to be seen among those who chewed less than 5 quids per day (p < 0.05) and less likely to be seen among those who included areca nut and tobacco in their quid (p < 0.0001). …”

BUDAYA SIRIH PINANG DAN PELUANG PELESTARIANNYA DI SUMBA BARAT, INDONESIA by Arief Dwinanto, Rini S. Soemarwoto, Miranda Risang Ayu Palar

“…Sirih pinang refers to the material (betel nut, areca nut, lime) and its practice of chewing it. Sumbanese, plant and use sirih pinang in their daily lives, and use it in ritual practices and ceremonial events. …”
Get full text

Src Family Kinases Mediate Betel Quid-Induced Oral Cancer Cell Motility and Could Be a Biomarker for Early Invasion in Oral Squamous Cell Carcinoma by Jeff Yi-Fu Chen, Chih-Chang Hung, Kai-Lieh Huang, Yi-Ting Chen, Shyun-Yeu Liu, Wei-Fan Chiang, Hau-Ren Chen, Ching-Yu Yen, Yu-Jen Wu, Jenq-Yuh Ko, Yuh-Shan Jou

“…Furthermore, we identified that areca nut, a major component of BQ, is the key factor accounting for BQ-induced cell migration and invasion through SFKs-mediated signaling pathways. …”
Get full text

Tobacco use behaviour among minors in India by Amrita Gupta

“…The most commonly used tobacco produt among males was gutkha (tobacco, lime and areca nut mixture), followed by kahini (tobacco lime mixture), betel quid with tobacco, cigarette and bidi . …”
Get full text

Effect of Habits and Nutritional Status on Clinical Grading and Histopathological Staging in Patients with Oral Sub Mucous Fibrosis by Abhayjeet Singh, Rama Brahmam Lanke, Rakhith Shetty, Syed Akifuddin, Manish Sahu, Navneet Singh, Gagandeep Kaur, Garish Goyal

“…Conclusion: The duration and frequency of areca nut product use effects on the incidence and severity of OSMF and the patient becomes unable to eat due to burning, ulcers and inability to open mouth which affect the health of the individual. …”
Get full text

Arecoline-Induced Hepatotoxicity in Rats: Screening of Abnormal Metabolic Markers and Potential Mechanisms by Jing Sun, Kai Zhang, Yihui Yin, Yunpeng Qi, Siyuan Li, Haonan Sun, Min Luo, Yixuan Sun, Zhiying Yu, Jie Yang, Jingjing Wu, Lijuan Chen, Wenjuan Xu, Ling Dong

“…Arecoline is a pyridine alkaloid derived from areca nut in the Arecaceae family. It has extensive medicinal activity, such as analgesic, anti-inflammatory, and anti-allergic. …”
Get full text

Effectiveness of health promotion intervention on the knowledge and selected practices related with oral cancer among a group of vulnerable youth in Sri Lanka by Manori Dhanapriyanka, Kanthi RDFC, Prasanna Jayasekara

“…Awareness of oral cancer and oral potentially malignant disorders, tobacco chewing practice (betel quid chewing and commercially prepared tobacco and areca nut packet (CPTAP) chewing) and self-mouth examination practice were assessed at the beginning and after 6 months in both groups using an interviewer administered questionnaire. …”
Get full text