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181
Anticancer Activity of Measles–Mumps–Rubella MMR Vaccine Viruses against Glioblastoma
Published 2023-08-01“…Accordingly, the MMR vaccine warrants further study as a potential new tool for GBM therapy and relapse prevention. …”
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182
Could the BGN Gene Be Pathogenic with Spontaneous Coronary Artery Dissection (SCAD) and Fibromuscular Dysplasia (FMD)?
Published 2022-10-01“…Further research looking at this association is warranted.…”
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183
Neferine Targets the Oncogenic Characteristics of Androgen-Dependent Prostate Cancer Cells via Inducing Reactive Oxygen Species
Published 2023-09-01“…Further investigations are warranted to assess its efficacy and safety in preclinical and clinical settings.…”
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184
Anticancer Mechanism of Flavonoids on High-Grade Adult-Type Diffuse Gliomas
Published 2023-02-01“…Despite the positive pre-clinical results, further investigations in clinical studies are warranted to substantiate the efficacy and safety of the use of flavonoids on high-grade adult-type diffuse glioma patients.…”
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185
External validation of the modified HOPPE score to predict low risk pulmonary embolism suitable for early discharge
Published 2020-06-01“…Prospective validation is warranted.…”
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186
Synthesis and Biological Evaluation of Harmirins, Novel Harmine–Coumarin Hybrids as Potential Anticancer Agents
Published 2021-10-01“…In conclusion, harmirin <b>12b</b> is a novel harmine and coumarin hybrid with significant antiproliferative activity and warrants further evaluation as a potential anticancer agent.…”
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187
Bioactivity-guided fractionation of Helicteres angustifolia L. extract and its molecular evidence for tumor suppression
Published 2023-06-01“…We propose that EF40 may serve as a potential natural anti-NSCLC drug that warrants further mechanistic and clinical attention.…”
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188
Is severe hypocalcemia immediately life threatening?
Published 2018-10-01“…Objective: Severe hypocalcemia (Ca <1.9 mmol/L) is often considered an emergency because of a potential risk of cardiac arrest or seizures. However, there is little evidence to support this. …”
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189
WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage
Published 2019-11-01“…In addition, we demonstrate that both G2/M cell cycle arrest and DNA damage induction put a similar stress on DLBCL cells, thereby enhancing anti-apoptotic dependency. …”
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190
Menthol: An underestimated anticancer agent
Published 2023-03-01“…Owing to the excellent anticancer activity menthol has demonstrated, further research is warranted for developing it as a novel anticancer agent. …”
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191
Microbiome and Human Aging: Probiotic and Prebiotic Potentials in Longevity, Skin Health and Cellular Senescence
Published 2021-12-01“…With age, cells become senescent in response to stress wherein they undergo irreversible growth arrest while maintaining high metabolic activity. …”
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192
Combination Treatment Targeting mTOR and MAPK Pathways Has Synergistic Activity in Multiple Myeloma
Published 2023-04-01“…Thus, new therapeutic approaches are warranted. The phosphatidylinositol-3-kinase (PI3K) pathway plays a key role in many critical cellular processes, including cell proliferation and survival. …”
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193
Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature
Published 2019-08-01“…Further investigations are warranted to confirm the clinical anti-neoplastic activity of MBZ and its safety in combination with other drugs in a clinical setting.…”
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194
Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR
Published 2023-01-01“…These findings strongly suggest that compound <b>8b</b> serves as a dual inhibitor of c-Met and TrxR, warranting further exploitation for cancer therapy.…”
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195
The Potential Effects of Curcumin on Pulmonary Fibroblasts of Idiopathic Pulmonary Fibrosis (IPF)—Approaching with Next-Generation Sequencing and Bioinformatics
Published 2020-11-01“…Therefore, curcumin might decrease the level of hsa-miR-6724-5p, leading to increased <i>KLF10</i> expression, resulting in cell cycle arrest in curcumin-treated IPF fibroblasts. In conclusion, our findings might support the potential role of curcumin in the treatment of IPF, but further in-depth study is warranted to confirm our findings.…”
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196
The Translational Landscape Revealed the Sequential Treatment Containing ATRA plus PI3K/AKT Inhibitors as an Efficient Strategy for AML Therapy
Published 2022-10-01“…Future clinical studies are warranted to further support the clinical application of the sequential strategy for the effective treatment of AML.…”
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197
Combined Aspiration and Stent Retriever Thrombectomy for Distal Carotid Artery Occlusion Using Balloon Guide versus Non-Balloon Guide Catheter
Published 2024-03-01“…Further prospective studies with a larger number of patients and better methodology are warranted.…”
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198
Characterization of dentatin isolated from Clausena excavate and its potential use for treatment of human breast and prostate cancers
Published 2012“…The DTN treatment significantly arrested MCF-7 cells at G0/G1 phase (p < 0.05). The ROS was significantly found to be elevated. …”
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199
The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo
Published 2023-09-01“…It was accompanied by G0/G1 cell cycle arrest and cell death of pancreatic cancer cells. …”
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200
Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer
Published 2022-08-01“…Our results also imply that the effect of antitumor drugs on TAMs may affect its therapeutic efficacy, and the combined application with TAMs modifiers should be warranted to achieve great clinical success.…”
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