Anticancer Activity of Measles–Mumps–Rubella MMR Vaccine Viruses against Glioblastoma by Zumama Khalid, Simona Coco, Nadir Ullah, Alessandra Pulliero, Katia Cortese, Serena Varesano, Andrea Orsi, Alberto Izzotti

“…Accordingly, the MMR vaccine warrants further study as a potential new tool for GBM therapy and relapse prevention. …”
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Could the BGN Gene Be Pathogenic with Spontaneous Coronary Artery Dissection (SCAD) and Fibromuscular Dysplasia (FMD)? by Lexie Kolton, Charlie Robin, Jianfeng Xu, Jun Wei, Rupa Patil, Jason Robin

“…Further research looking at this association is warranted.…”
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Neferine Targets the Oncogenic Characteristics of Androgen-Dependent Prostate Cancer Cells via Inducing Reactive Oxygen Species by Subramanyam Dasari, Nishtha Pathak, Amy Thomas, Shreeja Bitla, Raj Kumar, Gnanasekar Munirathinam

“…Further investigations are warranted to assess its efficacy and safety in preclinical and clinical settings.…”
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Anticancer Mechanism of Flavonoids on High-Grade Adult-Type Diffuse Gliomas by Shu Chyi Wong, Muhamad Noor Alfarizal Kamarudin, Rakesh Naidu

“…Despite the positive pre-clinical results, further investigations in clinical studies are warranted to substantiate the efficacy and safety of the use of flavonoids on high-grade adult-type diffuse glioma patients.…”
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External validation of the modified HOPPE score to predict low risk pulmonary embolism suitable for early discharge by Kajal Patel, Sharon Klim, Peter Ritchie, Ieuan Johns, Anne-Maree Kelly

“…Prospective validation is warranted.…”
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Synthesis and Biological Evaluation of Harmirins, Novel Harmine–Coumarin Hybrids as Potential Anticancer Agents by Kristina Pavić, Maja Beus, Goran Poje, Lidija Uzelac, Marijeta Kralj, Zrinka Rajić

“…In conclusion, harmirin <b>12b</b> is a novel harmine and coumarin hybrid with significant antiproliferative activity and warrants further evaluation as a potential anticancer agent.…”
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Bioactivity-guided fractionation of Helicteres angustifolia L. extract and its molecular evidence for tumor suppression by Kejuan Li, Kejuan Li, Shuang Sun, Long Xiao, Zhenya Zhang

“…We propose that EF40 may serve as a potential natural anti-NSCLC drug that warrants further mechanistic and clinical attention.…”
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Is severe hypocalcemia immediately life threatening? by Maxime Duval, Kalyane Bach-Ngohou, Damien Masson, Camille Guimard, Philippe Le Conte, David Trewick

“…Objective: Severe hypocalcemia (Ca <1.9 mmol/L) is often considered an emergency because of a potential risk of cardiac arrest or seizures. However, there is little evidence to support this. …”
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WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage by Mathilde Rikje Willemijn de Jong, Myra Langendonk, Bart Reitsma, Pien Herbers, Marcel Nijland, Gerwin Huls, Anke van den Berg, Emanuele Ammatuna, Lydia Visser, Tom van Meerten

“…In addition, we demonstrate that both G2/M cell cycle arrest and DNA damage induction put a similar stress on DLBCL cells, thereby enhancing anti-apoptotic dependency. …”
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Menthol: An underestimated anticancer agent by Yijia Zhao, Huafeng Pan, Wei Liu, E. Liu, Yaobin Pang, Hongjin Gao, Qingying He, Wenhao Liao, Yejing Yao, Jinhao Zeng, Jinhao Zeng, Jing Guo

“…Owing to the excellent anticancer activity menthol has demonstrated, further research is warranted for developing it as a novel anticancer agent. …”
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Microbiome and Human Aging: Probiotic and Prebiotic Potentials in Longevity, Skin Health and Cellular Senescence by Jacqueline Lena Boyajian, Merry Ghebretatios, Sabrina Schaly, Paromita Islam, Satya Prakash

“…With age, cells become senescent in response to stress wherein they undergo irreversible growth arrest while maintaining high metabolic activity. …”
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Combination Treatment Targeting mTOR and MAPK Pathways Has Synergistic Activity in Multiple Myeloma by Kaiyan Sun, Ling Jin, Jana Karolová, Jan Vorwerk, Stephan Hailfinger, Bertram Opalka, Myroslav Zapukhlyak, Georg Lenz, Cyrus Khandanpour

“…Thus, new therapeutic approaches are warranted. The phosphatidylinositol-3-kinase (PI3K) pathway plays a key role in many critical cellular processes, including cell proliferation and survival. …”
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Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature by Andrea Emanuele Guerini, Luca Triggiani, Marta Maddalo, Marco Lorenzo Bonù, Francesco Frassine, Anna Baiguini, Alessandro Alghisi, Davide Tomasini, Paolo Borghetti, Nadia Pasinetti, Roberto Bresciani, Stefano Maria Magrini, Michela Buglione

“…Further investigations are warranted to confirm the clinical anti-neoplastic activity of MBZ and its safety in combination with other drugs in a clinical setting.…”
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Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR by Jinhui Hu, Li Chen, Zhonghui Lu, Han Yao, Yunfei Hu, Luanqi Feng, Yanqing Pang, Jia-Qiang Wu, Zhiling Yu, Wen-Hua Chen

“…These findings strongly suggest that compound <b>8b</b> serves as a dual inhibitor of c-Met and TrxR, warranting further exploitation for cancer therapy.…”
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The Potential Effects of Curcumin on Pulmonary Fibroblasts of Idiopathic Pulmonary Fibrosis (IPF)—Approaching with Next-Generation Sequencing and Bioinformatics by Wei-An Chang, Chia-Min Chen, Chau-Chyun Sheu, Ssu-Hui Liao, Ya-Ling Hsu, Ming-Ju Tsai, Po-Lin Kuo

“…Therefore, curcumin might decrease the level of hsa-miR-6724-5p, leading to increased <i>KLF10</i> expression, resulting in cell cycle arrest in curcumin-treated IPF fibroblasts. In conclusion, our findings might support the potential role of curcumin in the treatment of IPF, but further in-depth study is warranted to confirm our findings.…”
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The Translational Landscape Revealed the Sequential Treatment Containing ATRA plus PI3K/AKT Inhibitors as an Efficient Strategy for AML Therapy by Ke Wang, Ziyao Ou, Ge Deng, Shufang Li, Jingjing Su, Yayun Xu, Renpeng Zhou, Wei Hu, Feihu Chen

“…Future clinical studies are warranted to further support the clinical application of the sequential strategy for the effective treatment of AML.…”
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Combined Aspiration and Stent Retriever Thrombectomy for Distal Carotid Artery Occlusion Using Balloon Guide versus Non-Balloon Guide Catheter by Ender Uysal, Bade von Bodelschwingh, Omer Naci Tabakci, Celal Ilker Basarir, Serpil Bulut

“…Further prospective studies with a larger number of patients and better methodology are warranted.…”
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Characterization of dentatin isolated from Clausena excavate and its potential use for treatment of human breast and prostate cancers by Ishag, Ismail Adam Arbab

“…The DTN treatment significantly arrested MCF-7 cells at G0/G1 phase (p < 0.05). The ROS was significantly found to be elevated. …”
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The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo by Mariola Gimła, Agnieszka Pyrczak-Felczykowska, Marcelina Malinowska, Aleksandra Hać, Magdalena Narajczyk, Irena Bylińska, Tristan A. Reekie, Anna Herman-Antosiewicz

“…It was accompanied by G0/G1 cell cycle arrest and cell death of pancreatic cancer cells. …”
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Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer by Ya-fang Wang, Lei Yu, Zong-long Hu, Yan-fen Fang, Yan-yan Shen, Min-fang Song, Yi Chen

“…Our results also imply that the effect of antitumor drugs on TAMs may affect its therapeutic efficacy, and the combined application with TAMs modifiers should be warranted to achieve great clinical success.…”
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