Health sector corruption in the times of COVID-19 pandemic in Bangladesh: Newspapers as mirrors of society by Mahruba Khanam, Noshin Sayiara Shuchi, Raihana S. Kamal, Syed Masud Ahmed

“…Among the measures taken to contain corruption during COVID-19 included filing cases, issuing arrest warrants and asking for submission of wealth statement and source of income of the accused persons. …”
Get full text

Cytotoxicity and Multi-Enzyme Inhibition of <i>Nepenthes miranda</i> Stem Extract on H838 Human Non-Small Cell Lung Cancer Cells and RPA32, Elastase, Tyrosinase, and Hyaluronidase... by Ching-Yi Lee, Yu-Cheng Chen, Yen-Hua Huang, Yi Lien, Cheng-Yang Huang

“…Flow cytometry analysis suggested that the stem extract might suppress H838 cell proliferation by inducing G2 cell cycle arrest, thereby inhibiting carcinoma cell proliferation. …”
Get full text

Association Between Critical Events in the PICU and Outcomes in Neighboring Patients by Ahmed Arshad, MD, Catherine Blandon, MS, Kyle Carey, MPH, Philip Verhoef, MD, PhD, Priti Jani, MD, MPH, Samuel Volchenboum, MD, PhD, Matthew Churpek, MD, MPH, PhD, Anoop Mayampurath, PhD

“…Further studies targeted toward exploring the mechanism behind this effect as well as identification of other nonpatient factors that adversely affect outcomes in children are warranted.…”
Get full text

Beliefs, attitudes and experiences of virtual overdose monitoring services from the perspectives of people who use substances in Canada: a qualitative study by Tyler Marshall, Dylan Viste, Stephanie Jones, Julia Kim, Amanda Lee, Farah Jafri, Oona Krieg, S. Monty Ghosh

“…PWUS generally felt optimistic about the potential of VOMS as a suitable harm reduction intervention, but several potential barriers around accessing VOMS were identified that may limit uptake. Future research is warranted.…”
Get full text

The Role of Selective Flavonoids on Triple-Negative Breast Cancer: An Update by Pooja Chinnikrishnan, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Naiyer Shahzad, Prathibha Sivaprakasam, Ashok Kumar Pandurangan

“…Flavonoids are known to have enormous health benefits, such as anticancer, antiviral, anti-inflammatory, and antiallergic properties. They are known to arrest the cell cycle of the tumor cells and induces apoptosis by modulating Bcl-2, Bax, and Caspase activity. …”
Get full text

Caspase activation counteracts interferon signaling after G2 checkpoint abrogation by ATR inhibition in irradiated human cancer cells by Adrian Eek Mariampillai, Sissel Hauge, Inger Øynebråten, Gro Elise Rødland, Alexandre Corthay, Alexandre Corthay, Randi G. Syljuåsen

“…Caspase activation thus warrants further consideration as a possible predictive marker for lack of IFN signaling.…”
Get full text

Identification of a new member of Mortaparib class of inhibitors that target mortalin and PARP1 by Hazna Noor Meidinna, Seyad Shefrin, Anissa Nofita Sari, Huayue Zhang, Jaspreet Kaur Dhanjal, Sunil C. Kaul, Durai Sundar, Renu Wadhwa

“…Abrogation of mortalin-p53 interaction and reactivation of p53 has been shown to trigger growth arrest/apoptosis in cancer cells and hence, suggested to be useful in cancer therapy. …”
Get full text

Design, synthesis, and activity evaluation of 2-iminobenzimidazoles as c-Myc inhibitors for treating multiple myeloma by Shihao Li, Yinchuan Wang, Jiacheng Yin, Kaihang Li, Linlin Liu, Jian Gao

“…Taken together, our findings suggest that further investigations are warranted for potential therapeutic applications of 5b and 5d for c-Myc-related diseases.…”
Get full text

Chemical Characterization of Taif Rose (<i>Rosa damascena</i> Mill var. <i>trigentipetala</i>) Waste Methanolic Extract and Its Hepatoprotective and Antioxidant Effects against Cad... by Reham Z. Hamza, Hatim M. Al-Yasi, Esmat F. Ali, Mustafa A. Fawzy, Tharwat G. Abdelkader, Tarek M. Galal

“…Additional in vitro and in vivo studies are warranted.…”
Get full text

Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor‐positive breast cancer via regulation of the mTOR pathway by Hui‐Ping Hsu, Pei‐Yi Chu, Tsung‐Ming Chang, Kuo‐Wei Huang, Wen‐Chun Hung, Shih Sheng Jiang, Hui‐You Lin, Hui‐Jen Tsai

“…Decreased cell proliferation and G0/G1 arrest were induced in ER+ breast cancer cell lines by knockdown of PCK2. …”
Get full text

Multifaceted Effects of Kinase Inhibitors on Pancreatic Cancer Cells Reveals Pivotal Entities with Therapeutic Implications by Yoo Na Kim, Ketki Patil, Jeonghwa Ma, Griffin A. Dufek, S. Balakrishna Pai

“…Therefore, future studies with the two kinases as monotherapy/combination therapy are warranted.…”
Get full text

Vasopressin versus epinephrine during neonatal cardiopulmonary resuscitation of asphyxiated post-transitional piglets by Megan O'Reilly, Tze-Fun Lee, Po-Yin Cheung, Georg M. Schmölzer

“…Conclusions: Vasopressin improved post-resuscitation survival and hemodynamics, and might be an alternative cardio-resuscitative medication during neonatal CPR, but further studies are warranted.…”
Get full text

GA-OH enhances the cytotoxicity of photon and proton radiation in HPV+ HNSCC cells by Lennox Chitsike, Antonella Bertucci, Marcelo Vazquez, Marcelo Vazquez, Steve Lee, Juli J. Unternaehrer, Penelope J. Duerksen-Hughes

“…Future research is warranted to further characterize the interaction of GA-OH derivatives and other E6-specific inhibitors with radiation, as well as its potential to improve the safety and effectiveness of radiation treatment for patients with oropharyngeal cancer.…”
Get full text

Propranolol blocks osteosarcoma cell cycle progression, inhibits angiogenesis and slows xenograft growth in combination with cisplatin-based chemotherapy by Luisina M. Solernó, Natasha T. Sobol, María F. Gottardo, Carla S. Capobianco, Maximiliano R. Ferrero, Liliana Vásquez, Daniel F. Alonso, Juan Garona

“…Further translational studies of propranolol repurposing in osteosarcoma are warranted.…”
Get full text

Amniotic fluid embolism: an Australian-New Zealand population-based study. by McDonnell, N, Knight, M, Peek, M, Ellwood, D, Homer, C, McLintock, C, Vaughan, G, Pollock, W, Li, Z, Javid, N, Sullivan, E

“…A potential link between AFE and assisted reproductive technology warrants further investigation.…”

miR-137-mediated loss of KDM5B expression leads to suppression of the malignant phenotype of bladder cancer cells by Kodiappan, Radha, Lai, Jiun Yee, Chan, Soon Choy, Rosli, Rozita, Nordin, Norshariza, Hussin, Huzlinda, Abd. Ghani, Fauzah, Yunus, Rosna, Abdul Razack, Azad Hassan, Ong, Teng Aik, Veerakumarasivam, Abhimanyu

“…We demonstrated that the overexpression of miR-137 significantly attenuated KDM5B expression, induced G1 cell-cycle arrest, suppressed cell growth and blocked invasion and migration of BC cells. …”
Get full text

LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis by Zuwei Yang, Jiexue Pan, Chengliang Zhou, Chuanjin Yu, Zhiyang Zhou, Guolian Ding, Xinmei Liu, Jianzhong Sheng, Li Jin, Hefeng Huang

“…Additional investigations such as large-scale clinical studies and functional assays are warranted to validate and expand upon these findings.…”
Get full text

Metformin Enhancement of Therapeutic Effects of 5-Fluorouracil and Oxaliplatin in Colon Cancer Cells and Nude Mice by Kwan-Ling Yip, Tsen-Ni Tsai, I-Ping Yang, Zhi-Feng Miao, Yen-Cheng Chen, Ching-Chun Li, Wei-Chih Su, Tsung-Kun Chang, Ching-Wen Huang, Hsiang-Lin Tsai, Yung-Sung Yeh, Jaw-Yuan Wang

“…However, further clinical trials are warranted to validate the clinical implications of the findings.…”
Get full text

p21 as a Predictor and Prognostic Indicator of Clinical Outcome in Rectal Cancer Patients by Li Ching Ooi, Vincent Ho, Jing Zhou Zhu, Stephanie Lim, Liping Chung, Askar Abubakar, Tristan Rutland, Wei Chua, Weng Ng, Mark Lee, Matthew Morgan, Scott MacKenzie, Cheok Soon Lee

“…The cell cycle plays a key and complex role in the development of human cancers. p21 is a potent cyclin-dependent kinase inhibitor (CDKI) involved in the promotion of cell cycle arrest and the regulation of cellular senescence. …”
Get full text

Nelfinavir Induces Cytotoxicity towards High-Grade Serous Ovarian Cancer Cells, Involving Induction of the Unfolded Protein Response, Modulation of Protein Synthesis, DNA Damage, L... by Mahbuba R. Subeha, Alicia A. Goyeneche, Prisca Bustamante, Michael A. Lisio, Julia V. Burnier, Carlos M. Telleria

“…Traditional treatment consists of platinum-based therapy; however, rapid development of platinum resistance contributes to lower life expectancy, warranting newer therapies to supplement the current platinum-based protocol. …”
Get full text