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221
Assessment of the Quality of Basic and Expanded Resuscitative Measures in a Multifield Hospital (Simulation Course)
Published 2017-01-01“…The survival of patients after the sudden circulatory arrest (SCA) depends not only on immediate onset of resuscitative measures, but also on their quality.The purpose of the study. …”
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222
Effects of sodium arsenite in the modulation of testosterone synthesis by the hypothalamo-pituitary testicular axis and its effect on memory and learning in the rat
Published 2018“…Sodium arsenite exposure caused complete arrest of spermatogenesis with disrupted seminiferous tubules in the testes in high dose groups (5 and 8mg/kg). …”
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Thesis -
223
Co-administration of temozolomide (TMZ) and the experimental therapeutic targeting miR-10b, profoundly affects the tumorigenic phenotype of human glioblastoma cells
Published 2023-06-01“…This discovery led to the design of a sequence-dependent combination treatment, in which miR-10b inhibition and induction of apoptosis by MN-anti-miR10b was followed by a sub-therapeutic dose of TMZ, which caused cell cycle arrest and ultimately cell death. This combination was highly successful in significant enhancement of apoptosis and decrease in cell migration and invasiveness.Discussion: Considering the unexpected effects of TMZ on miR-10b expression and possible implications on its clinical application, we reasoned that comprehensive in vitro studies were warranted before embarking on studies in animals. …”
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224
A Mathematical Model of In Vitro Cellular Uptake of Zoledronic Acid and Isopentenyl Pyrophosphate Accumulation
Published 2022-06-01“…In the future, additional clinical studies are warranted to further evaluate and fine-tune dosing approaches.…”
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225
Anatomic and Topographic Vitreous and Vitreoretinal Interface Features in Proliferative Diabetic Vitreoretinopathy
Published 2020-06-01“…Further understanding the VMI relationship in a case of PDR is warranted in order to design better treatments, to arrest and possibly even reverse progression of PDR. …”
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226
Are there “Magic Bullets” for cancer theraphy
Published 2011“…Thus, further work is warranted to improve treatment outcomes for cancer patients…”
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Inaugural Lecture -
227
A novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastrophe
Published 2020-06-01“…DCZ3301 induced M phase cell cycle arrest in MM mainly via inhibiting DNA repair and enhancing DNA damage. …”
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228
Anti-Colorectal Cancer Effects of a Novel Camptothecin Derivative PCC0208037 <i>In Vitro</i> and <i>In Vivo</i>
Published 2022-12-01“…PCC0208037 suppressed colorectal cancer cell (CRC) proliferation and increased cell cycle arrest, which may be related to its effects on up-regulating DNA damage response (DDR)-related molecules and apoptosis-related proteins. …”
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229
Effect of propranolol and clonidine after severe traumatic brain injury: a pilot randomized clinical trial
Published 2023-06-01“…No treatment patient experienced dysrhythmia, myocardial infarction, or cardiac arrest. The study was stopped for futility after enrolling 47 patients (26 placebo, 21 treatment), per a priori stopping rules. …”
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230
Deaths in Immigration and Customs Enforcement (ICE) detention: A Fiscal Year (FY) 2021–2023 update
Published 2024-02-01“…Attentive monitoring of mortality outcomes following release from ICE custody is warranted.…”
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231
Targeting HDACs in Pancreatic Neuroendocrine Tumor Models
Published 2021-06-01“…PB dose dependently induced cell cycle arrest and apoptosis in neuroendocrine cells in human and murine species. …”
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232
Early ACEI/ARB use and in-hospital outcomes of acute myocardial infarction patients with systolic blood pressure <100 mmHg and undergoing percutaneous coronary intervention: Findin...
Published 2022-09-01“…Additional studies of the early use of ACEIs/ARBs in AMI patients with relatively low blood pressure are warranted.…”
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233
The Role of Chest Compressions on Ventilation during Advanced Cardiopulmonary Resuscitation
Published 2023-11-01“…Further research is warranted to assess the impact of these findings on ventilation quality during CPR.…”
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234
Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer
Published 2022-09-01“…A phase Ib/II clinical trial in patients with advanced ACC is therefore warranted.…”
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235
AXL Inhibition Represents a Novel Therapeutic Approach in BCR-ABL Negative Myeloproliferative Neoplasms
Published 2021-09-01“…We found that AXL is abundantly activated in MPN cells and that its ligand growth arrest-specific gene 6 is upregulated in MPN patients. …”
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236
Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dep...
Published 2023-11-01“…Overall, our findings imply that DHCE may become a potential therapeutic option that warrants clinical evaluation for BTZ-R MM.…”
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237
Preclinical Evaluation of a Novel Small Molecule Inhibitor of LIM Kinases (LIMK) CEL_Amide in Philadelphia-Chromosome Positive (<i>BCR::ABL+</i>) Acute Lymphoblastic Leukemia (ALL)
Published 2022-11-01“…Altogether, the LIMKi CEL_Amide yields activity in Ph+ ALL models when combined with <i>BCR::ABL</i>-targeting TKIs, showing promising synergy that warrants further investigation.…”
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238
Multiorgan recovery in a cadaver body using mild hypothermic ECMO treatment in a murine model
Published 2023-08-01“…Therefore, as a preliminary strategy to fulfill this task, experimental protocols using feasible animal models are highly warranted. The primary aim of the study was to develop a model of ECMO-based cadaver organ recovery in mice. …”
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239
Efficacy of Selinexor in Relapsed/Refractory Multiple Myeloma (RRMM) Patients with del17p and Other High-Risk Abnormalities (A Retrospective Single-Center Study)
Published 2024-03-01“…Further investigation into this population is warranted, including in earlier lines of therapy, in hopes of seeing a more durable response.…”
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240
Navitoclax Enhances the Therapeutic Effects of PLK1 Targeting on Lung Cancer Cells in 2D and 3D Culture Systems
Published 2022-06-01“…The efficacy of antimitotics is limited by slippage, whereby treated cells arrested in mitosis exit mitosis without cell division and, eventually, escape apoptosis, constituting a serious resistance mechanism to antimitotics. …”
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Article