Assessment of the Quality of Basic and Expanded Resuscitative Measures in a Multifield Hospital (Simulation Course) by A. N. Kuzovlev, S. N. Abdusalamov, K. A. Kuz'michev

“…The survival of patients after the sudden circulatory arrest (SCA) depends not only on immediate onset of resuscitative measures, but also on their quality.The purpose of the study. …”
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Effects of sodium arsenite in the modulation of testosterone synthesis by the hypothalamo-pituitary testicular axis and its effect on memory and learning in the rat by Ashraf, Saima

“…Sodium arsenite exposure caused complete arrest of spermatogenesis with disrupted seminiferous tubules in the testes in high dose groups (5 and 8mg/kg). …”
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Co-administration of temozolomide (TMZ) and the experimental therapeutic targeting miR-10b, profoundly affects the tumorigenic phenotype of human glioblastoma cells by Ming Chen, Ming Chen, Bryan Kim, Bryan Kim, Neil Robertson, Neil Robertson, Sujan Kumar Mondal, Sujan Kumar Mondal, Zdravka Medarova, Anna Moore, Anna Moore

“…This discovery led to the design of a sequence-dependent combination treatment, in which miR-10b inhibition and induction of apoptosis by MN-anti-miR10b was followed by a sub-therapeutic dose of TMZ, which caused cell cycle arrest and ultimately cell death. This combination was highly successful in significant enhancement of apoptosis and decrease in cell migration and invasiveness.Discussion: Considering the unexpected effects of TMZ on miR-10b expression and possible implications on its clinical application, we reasoned that comprehensive in vitro studies were warranted before embarking on studies in animals. …”
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A Mathematical Model of In Vitro Cellular Uptake of Zoledronic Acid and Isopentenyl Pyrophosphate Accumulation by Elena Lo Presti, Laura D’Orsi, Andrea De Gaetano

“…In the future, additional clinical studies are warranted to further evaluate and fine-tune dosing approaches.…”
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Anatomic and Topographic Vitreous and Vitreoretinal Interface Features in Proliferative Diabetic Vitreoretinopathy by N. M. Kislitsyna, S. V. Novikov, S. V. Kolesnik, A. I. Kolesnik, M. P. Veselkova

“…Further understanding the VMI relationship in a case of PDR is warranted in order to design better treatments, to arrest and possibly even reverse progression of PDR.  …”
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Are there “Magic Bullets” for cancer theraphy by Seow, Heng Fong

“…Thus, further work is warranted to improve treatment outcomes for cancer patients…”
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A novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastrophe by Liangning Hu, Bo Li, Gege Chen, Dongliang Song, Zhijian Xu, Lu Gao, Mengyu Xi, Jinfeng Zhou, Liping Li, Hui Zhang, Qilin Feng, Yingcong Wang, Kang Lu, Yumeng Lu, Wenxuan Bu, Houcai Wang, Xiaosong Wu, Weiliang Zhu, Jumei Shi

“…DCZ3301 induced M phase cell cycle arrest in MM mainly via inhibiting DNA repair and enhancing DNA damage. …”
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Anti-Colorectal Cancer Effects of a Novel Camptothecin Derivative PCC0208037 <i>In Vitro</i> and <i>In Vivo</i> by Min Li, Linxu Wang, Yingjie Wei, Wenyan Wang, Zongliang Liu, Aixia Zuo, Wanhui Liu, Jingwei Tian, Hongbo Wang

“…PCC0208037 suppressed colorectal cancer cell (CRC) proliferation and increased cell cycle arrest, which may be related to its effects on up-regulating DNA damage response (DDR)-related molecules and apoptosis-related proteins. …”
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Effect of propranolol and clonidine after severe traumatic brain injury: a pilot randomized clinical trial by Mina F. Nordness, Amelia W. Maiga, Laura D. Wilson, Tatsuki Koyama, Erika L. Rivera, Shayan Rakhit, Michael de Riesthal, Cari L. Motuzas, Madison R. Cook, Deepak K. Gupta, James C. Jackson, Shawniqua Williams Roberson, William J. Meurer, Roger J. Lewis, Geoffrey T. Manley, Pratik P. Pandharipande, Mayur B. Patel

“…No treatment patient experienced dysrhythmia, myocardial infarction, or cardiac arrest. The study was stopped for futility after enrolling 47 patients (26 placebo, 21 treatment), per a priori stopping rules. …”
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Deaths in Immigration and Customs Enforcement (ICE) detention: A Fiscal Year (FY) 2021–2023 update by Cara Buchanan, Sameer Ahmed, Joseph Nwadiuko, Annette M. Dekker, Amy Zeidan, Eva Bitrán, Thomas Urich, Briah Fischer, Elizabeth R.E. Burner, Parveen Parmar, Sophie Terp

“…Attentive monitoring of mortality outcomes following release from ICE custody is warranted.…”
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Targeting HDACs in Pancreatic Neuroendocrine Tumor Models by Rosa Lynn Schmitz, Julia Weissbach, Jan Kleilein, Jessica Bell, Stefan Hüttelmaier, Fabrice Viol, Till Clauditz, Patricia Grabowski, Helmut Laumen, Jonas Rosendahl, Patrick Michl, Jörg Schrader, Sebastian Krug

“…PB dose dependently induced cell cycle arrest and apoptosis in neuroendocrine cells in human and murine species. …”
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Early ACEI/ARB use and in-hospital outcomes of acute myocardial infarction patients with systolic blood pressure <100 mmHg and undergoing percutaneous coronary intervention: Findin... by Xuedong Zhao, Guanqi Zhao, Mengge Zhou, Ge Wang, Changsheng Ma, Sidney C. Smith, Gregg C. Fonarow, Louise Morgan, Bin Que, Hui Ai, Jing Liu, Dong Zhao, Shaoping Nie

“…Additional studies of the early use of ACEIs/ARBs in AMI patients with relatively low blood pressure are warranted.…”
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The Role of Chest Compressions on Ventilation during Advanced Cardiopulmonary Resuscitation by Izaskun Azcarate, Jose Antonio Urigüen, Mikel Leturiondo, Camilo Leonardo Sandoval, Koldo Redondo, José Julio Gutiérrez, James Knox Russell, Pia Wallmüller, Fritz Sterz, Mohamud Ramzan Daya, Sofía Ruiz de Gauna

“…Further research is warranted to assess the impact of these findings on ventilation quality during CPR.…”
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Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer by Dipranjan Laha, Robert R.C. Grant, Prachi Mishra, Myriem Boufraqech, Min Shen, Ya-Qin Zhang, Matthew D. Hall, Martha Quezado, Michelly Sampaio De Melo, Jaydira Del Rivero, Martha Zeiger, Naris Nilubol

“…A phase Ib/II clinical trial in patients with advanced ACC is therefore warranted.…”
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AXL Inhibition Represents a Novel Therapeutic Approach in BCR-ABL Negative Myeloproliferative Neoplasms by Antonia Beitzen-Heineke, Nikolaus Berenbrok, Jonas Waizenegger, Sarina Paesler, Victoria Gensch, Florian Udonta, Maria Elena Vargas Delgado, Janik Engelmann, Friederike Hoffmann, Philippe Schafhausen, Gunhild von Amsberg, Kristoffer Riecken, Niklas Beumer, Charles D. Imbusch, James Lorens, Thomas Fischer, Klaus Pantel, Carsten Bokemeyer, Isabel Ben-Batalla, Sonja Loges

“…We found that AXL is abundantly activated in MPN cells and that its ligand growth arrest-specific gene 6 is upregulated in MPN patients. …”
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Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dep... by Jin Shuhan, Li Bo, Zhang Bibo, Gao Xuejie, Jia Xinyan, Xu Li, Chang Shuaikang, Hu Ke, Wang Guanli, Xu Zhijian, Zhang Ting, Song Dongliang, Yang Guang, Wu Xiaosong, Zhu Huabin, Huang Cheng, Lu Yumeng, Shi Jumei, Zhu Weiliang, Chen Gege

“…Overall, our findings imply that DHCE may become a potential therapeutic option that warrants clinical evaluation for BTZ-R MM.…”
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Preclinical Evaluation of a Novel Small Molecule Inhibitor of LIM Kinases (LIMK) CEL_Amide in Philadelphia-Chromosome Positive (<i>BCR::ABL+</i>) Acute Lymphoblastic Leukemia (ALL) by Jeannig Berrou, Mélanie Dupont, Hanane Djamai, Emilie Adicéam, Véronique Parietti, Anna Kaci, Emmanuelle Clappier, Jean-Michel Cayuela, André Baruchel, Fabrice Paublant, Renaud Prudent, Jacques Ghysdael, Claude Gardin, Hervé Dombret, Thorsten Braun

“…Altogether, the LIMKi CEL_Amide yields activity in Ph+ ALL models when combined with <i>BCR::ABL</i>-targeting TKIs, showing promising synergy that warrants further investigation.…”
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Multiorgan recovery in a cadaver body using mild hypothermic ECMO treatment in a murine model by Nodir Madrahimov, Vitalii Mutsenko, Ruslan Natanov, Dejan Radaković, André Klapproth, Mohamed Hassan, Mathias Rosenfeldt, Florian Kleefeldt, Ivan Aleksic, Süleyman Ergün, Christoph Otto, Rainer G. Leyh, Constanze Bening

“…Therefore, as a preliminary strategy to fulfill this task, experimental protocols using feasible animal models are highly warranted. The primary aim of the study was to develop a model of ECMO-based cadaver organ recovery in mice. …”
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Efficacy of Selinexor in Relapsed/Refractory Multiple Myeloma (RRMM) Patients with del17p and Other High-Risk Abnormalities (A Retrospective Single-Center Study) by Hamid Ehsan, Myra Robinson, Peter M. Voorhees, Kristen Cassetta, Shanice Borden, Shebli Atrash, Manisha Bhutani, Cindy Varga, Mauricio Pineda-Roman, Reed Friend, Barry A. Paul

“…Further investigation into this population is warranted, including in earlier lines of therapy, in hopes of seeing a more durable response.…”
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Navitoclax Enhances the Therapeutic Effects of PLK1 Targeting on Lung Cancer Cells in 2D and 3D Culture Systems by Bárbara Pinto, Pedro Novais, Ana C. Henriques, Juliana Carvalho-Tavares, Patrícia M. A. Silva, Hassan Bousbaa

“…The efficacy of antimitotics is limited by slippage, whereby treated cells arrested in mitosis exit mitosis without cell division and, eventually, escape apoptosis, constituting a serious resistance mechanism to antimitotics. …”
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