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241
Effectiveness of Silver Diammine Fluoride Applications for Dental Caries Cessation in Tribal Preschool Children in India: Study Protocol for a Randomized Controlled Trial
Published 2021-05-01“…The evidence is clear that the use of SDF at concentrations of 38% is effective for arresting caries in primary teeth. However, the determination of an optimal SDF application frequency for a cavitated lesion in pragmatic settings is warranted especially among high dental caries risk groups. …”
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242
Metronomic cyclophosphamide and metformin inhibited tumor growth and repopulated tumor-infiltrating lymphocytes in an experimental carcinoma model
Published 2024-01-01“…The current data suggests a potential role of metformin and metronomic chemotherapy that warrants further investigation.…”
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243
Modulation of Immune Components on Stem Cell and Dormancy in Cancer
Published 2021-10-01“…Dormancy was proposed as a reversible state of cancer cells that are temporarily arrested in the cell cycle, possessing several hallmarks that facilitate their survival within a devastating niche. …”
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244
Mycotoxin Monitoring, Regulation and Analysis in India: A Success Story
Published 2023-02-01“…Overall, it provides valuable insights for the Indian farming community, food supply chain stakeholders and researchers about India’s success story in arresting mycotoxins throughout the food supply chain.…”
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245
Anticancer imidazoacridinone C-1311 is effective in androgen-dependent and androgen-independent prostate cancer cells
Published 2020“…Irrespective of AR status, C-1311 induced DNA damage, arrested cell cycle progression, and induced apoptosis. …”
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246
Everolimus Acts in Synergy with Vinorelbine to Suppress the Growth of Hepatocellular Carcinoma
Published 2023-12-01“…Our research showed that the vinorelbine arrests cells at the mitotic phase, induces apoptosis, and normalizes tumor blood vessels but upregulates survivin and activates the mTOR/p70S6K/4EBP1 pathway. …”
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247
Casticin Impacts Key Signaling Pathways in Colorectal Cancer Cells Leading to Cell Death with Therapeutic Implications
Published 2022-05-01“…Notably, a significant number of cells were arrested in the G2/M phase of the cell cycle in DLD-1 cells. …”
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248
Zebrafish embryonic development-interfering macrolides from Streptomyces californicus impact growth and mitochondrial function in human colorectal cancer cells
Published 2018“…Detailed characterization of these 15 toxic hits uncovered one extract derived from Streptomyces californicus TY004-069 that arrested zebrafish embryonic development at 4–6 hpf after 24 h treatment, a phenotype indicative potentially targeting mitochondrial activity. …”
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249
Sustained Inflation Reduces Pulmonary Blood Flow during Resuscitation with an Intact Cord
Published 2021-04-01“…Further clinical studies evaluating the timing of cord clamping and ventilation strategy in asphyxiated infants are warranted.…”
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250
Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
Published 2020-08-01“…Irrespective of AR status, C-1311 induced DNA damage, arrested cell cycle progression, and induced apoptosis. …”
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251
Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer.
Published 2003“…CONCLUSION: Further development of PSA-activated thapsigargin prodrugs as therapy for metastatic prostate cancer is warranted.…”
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252
Integrated network pharmacology and experimental analysis unveil multi-targeted effect of 18α- glycyrrhetinic acid against non-small cell lung cancer
Published 2022-10-01“…However, further studies are warranted to elucidate the complete molecular mechanism(s) using animal models of NSCLC.…”
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253
Withania somnifera targets interleukin-8 and cyclooxygenase-2 in human prostate cancer progression
Published 2017-06-01“…Further studies with more prostate tissue samples are warranted.…”
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254
Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification
Published 2021-05-01“…The effects of PRG4 on SMC phenotype and calcification suggest its role in atherosclerotic plaque stability, warranting further investigations.…”
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255
Alternatives to Criminalizing Public Intoxication: Case Study of a Sobering Centre in Calgary, AB
Published 2015-06-01“…And what if, instead of routinely arresting those found drunk in public, we gave them a place to sober up, where they also have the opportunity to get help for other issues that may be contributing to the situation that put them there in the first place? …”
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256
Alternatives to Criminalizing Public Intoxication: Case Study of a Sobering Centre in Calgary, AB
Published 2015-06-01“…And what if, instead of routinely arresting those found drunk in public, we gave them a place to sober up, where they also have the opportunity to get help for other issues that may be contributing to the situation that put them there in the first place? …”
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257
The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells
Published 2015-02-01“…Danu may represent a promising anticancer agent for breast cancer treatment. More studies are warranted to fully delineate the underlying mechanisms, efficacy, and safety of Danu in breast cancer therapy. …”
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