Effectiveness of Silver Diammine Fluoride Applications for Dental Caries Cessation in Tribal Preschool Children in India: Study Protocol for a Randomized Controlled Trial by Chandrashekar Janakiram, Venkitachalam Ramanarayanan, Induja Devan

“…The evidence is clear that the use of SDF at concentrations of 38% is effective for arresting caries in primary teeth. However, the determination of an optimal SDF application frequency for a cavitated lesion in pragmatic settings is warranted especially among high dental caries risk groups. …”
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Metronomic cyclophosphamide and metformin inhibited tumor growth and repopulated tumor-infiltrating lymphocytes in an experimental carcinoma model by Heba Mohamed Zaki, Khadiga Mohamed Ali, Mona Younis Youssef Abd Allah, Amoura Mohamed Abouelnaga, Mohamed Elsaid Abdraboh, Osama Hussein

“…The current data suggests a potential role of metformin and metronomic chemotherapy that warrants further investigation.…”
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Modulation of Immune Components on Stem Cell and Dormancy in Cancer by Xiaofan Jiang, Lu Liang, Guanglei Chen, Caigang Liu

“…Dormancy was proposed as a reversible state of cancer cells that are temporarily arrested in the cell cycle, possessing several hallmarks that facilitate their survival within a devastating niche. …”
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Mycotoxin Monitoring, Regulation and Analysis in India: A Success Story by Sujata Chatterjee, Archana Dhole, Anoop A. Krishnan, Kaushik Banerjee

“…Overall, it provides valuable insights for the Indian farming community, food supply chain stakeholders and researchers about India’s success story in arresting mycotoxins throughout the food supply chain.…”
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Anticancer imidazoacridinone C-1311 is effective in androgen-dependent and androgen-independent prostate cancer cells by Niemira, M, Borowa-Mazgaj, B, Bader, SB, Moszyńska, A, Ratajewski, M, Karaś, K, Kwaśniewski, M, Krętowski, A, Mazerska, Z, Hammond, EM, Skwarska, A

“…Irrespective of AR status, C-1311 induced DNA damage, arrested cell cycle progression, and induced apoptosis. …”

Everolimus Acts in Synergy with Vinorelbine to Suppress the Growth of Hepatocellular Carcinoma by Hung Huynh, Wai Har Ng, Khee Chee Soo

“…Our research showed that the vinorelbine arrests cells at the mitotic phase, induces apoptosis, and normalizes tumor blood vessels but upregulates survivin and activates the mTOR/p70S6K/4EBP1 pathway. …”
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Casticin Impacts Key Signaling Pathways in Colorectal Cancer Cells Leading to Cell Death with Therapeutic Implications by Michael Kowalski, Ashley Assa, Ketki Patil, Courtney Terrell, Nathan Holliday, S. Balakrishna Pai

“…Notably, a significant number of cells were arrested in the G2/M phase of the cell cycle in DLD-1 cells. …”
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Zebrafish embryonic development-interfering macrolides from Streptomyces californicus impact growth and mitochondrial function in human colorectal cancer cells by Tan, Pei Jean, Lau, Beng Fye, Krishnasamy, Getha, Ng, Mei Fong, Husin, Lili Sahira, Ruslan, Nur Faizah, Song, D.S.S., Velaithan, Vithya, Okuda, Kazuhide Shaun, Patel, Vyomesh

“…Detailed characterization of these 15 toxic hits uncovered one extract derived from Streptomyces californicus TY004-069 that arrested zebrafish embryonic development at 4–6 hpf after 24 h treatment, a phenotype indicative potentially targeting mitochondrial activity. …”

Sustained Inflation Reduces Pulmonary Blood Flow during Resuscitation with an Intact Cord by Jayasree Nair, Lauren Davidson, Sylvia Gugino, Carmon Koenigsknecht, Justin Helman, Lori Nielsen, Deepika Sankaran, Vikash Agrawal, Praveen Chandrasekharan, Munmun Rawat, Sara K. Berkelhamer, Satyan Lakshminrusimha

“…Further clinical studies evaluating the timing of cord clamping and ventilation strategy in asphyxiated infants are warranted.…”
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Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells by Magdalena Niemira, Barbara Borowa-Mazgaj, Samuel B. Bader, Adrianna Moszyńska, Marcin Ratajewski, Kaja Karaś, Mirosław Kwaśniewski, Adam Krętowski, Zofia Mazerska, Ester M. Hammond, Anna Skwarska

“…Irrespective of AR status, C-1311 induced DNA damage, arrested cell cycle progression, and induced apoptosis. …”
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Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer. by Denmeade, SR, Jakobsen, C, Janssen, S, Khan, SR, Garrett, E, Lilja, H, Christensen, S, Isaacs, J

“…CONCLUSION: Further development of PSA-activated thapsigargin prodrugs as therapy for metastatic prostate cancer is warranted.…”

Integrated network pharmacology and experimental analysis unveil multi-targeted effect of 18α- glycyrrhetinic acid against non-small cell lung cancer by Rasha Irshad, Nafis Raj, Gamal A. Gabr, Nikhat Manzoor, Mohammad Husain

“…However, further studies are warranted to elucidate the complete molecular mechanism(s) using animal models of NSCLC.…”
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Withania somnifera targets interleukin-8 and cyclooxygenase-2 in human prostate cancer progression by Anand Setty Balakrishnan, Abel Arul Nathan, Mukesh Kumar, Sudhakar Ramamoorthy, Sathish Kumar Ramia Mothilal

“…Further studies with more prostate tissue samples are warranted.…”
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Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification by Till Seime, Asim Cengiz Akbulut, Moritz Lindquist Liljeqvist, Antti Siika, Hong Jin, Greg Winski, Rick H. van Gorp, Eva Karlöf, Mariette Lengquist, Andrew J. Buckler, Malin Kronqvist, Olivia J. Waring, Jan H. N. Lindeman, Erik A. L. Biessen, Lars Maegdefessel, Anton Razuvaev, Leon J. Schurgers, Ulf Hedin, Ljubica Matic

“…The effects of PRG4 on SMC phenotype and calcification suggest its role in atherosclerotic plaque stability, warranting further investigations.…”
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Alternatives to Criminalizing Public Intoxication: Case Study of a Sobering Centre in Calgary, AB by Alina Turner

“…And what if, instead of routinely arresting those found drunk in public, we gave them a place to sober up, where they also have the opportunity to get help for other issues that may be contributing to the situation that put them there in the first place? …”
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Alternatives to Criminalizing Public Intoxication: Case Study of a Sobering Centre in Calgary, AB by Alina Turner

“…And what if, instead of routinely arresting those found drunk in public, we gave them a place to sober up, where they also have the opportunity to get help for other issues that may be contributing to the situation that put them there in the first place? …”
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The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells by Li JP, Yang YX, Liu QL, Zhou ZW, Pan ST, He ZX, Zhang X, Yang T, Pan SY, Duan W, He SM, Chen XW, Qiu JX, Zhou SF

“…Danu may represent a promising anticancer agent for breast cancer treatment. More studies are warranted to fully delineate the underlying mechanisms, efficacy, and safety of Danu in breast cancer therapy. …”
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