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161
Pre-hospital ECPR in an Australian metropolitan setting: a single-arm feasibility assessment—The CPR, pre-hospital ECPR and early reperfusion (CHEER3) study
Published 2023-12-01“…Further prospective studies are now warranted.…”
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162
Synergism of AZD6738, an ATR Inhibitor, in Combination with Belotecan, a Camptothecin Analogue, in Chemotherapy-Resistant Ovarian Cancer
Published 2021-01-01“…This consequently induced G2/M arrest in the cell cycle analysis. However, when AZD6738 was added to belotecan, pATR and pChk1 induced by belotecan alone were suppressed again. …”
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163
Identification and Characterization of Mortaparib<sup>Plus</sup>—A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Ty...
Published 2021-02-01“…p53 has an essential role in suppressing the carcinogenesis process by inducing cell cycle arrest/apoptosis/senescence. Mortalin/GRP75 is a member of the Hsp70 protein family that binds to p53 causing its sequestration in the cell cytoplasm. …”
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164
Anticancer activity of grassy Hystrix brachyura bezoar and its mechanisms of action: An in vitro and in vivo based study
Published 2019“…However, more experiments with higher vertebrae models are still warranted to validate its traditional claims as an anticancer agent.…”
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165
Transient 2:1 Atrioventricular Block with Peri-Conduction System Pacing After Leadless Pacemaker Implantation
Published 2024-04-01“…Further study of techniques, limitations, and complications related to intentional right ventricular leadless conduction system pacing is warranted.…”
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166
Impella to Treat Acute Myocardial Infarct-Related Cardiogenic Shock
Published 2022-04-01“…It is likely that the SCAI C patient with predominantly left ventricular failure and without prolonged cardiac arrest is the best candidate for these devices. Registry data suggest that pre-PCI Impella may be advantageous to post-PCI placement. …”
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167
Anesthetic management of cesarean section in a patient with Léri-Weill dyschondrosteosis – A case report
Published 2023-01-01“…This characteristic of LWD warrants a review of the clinical recommendations surrounding the anesthetic management of patients with LWD.…”
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168
Natural product ginsenoside 25-OCH3-PPD inhibits breast cancer growth and metastasis through down-regulating MDM2.
Published 2012-01-01“…Further preclinical and clinical development of this agent is warranted.…”
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169
Early Utilization of Mechanical Circulatory Support in Acute Myocardial Infarction Complicated by Cardiogenic Shock: The National Cardiogenic Shock Initiative
Published 2023-12-01“…Average age was 64±12 years, 24% were female, 17% had a witnessed out‐of‐hospital cardiac arrest, 27% had in‐hospital cardiac arrest, and 9% were under active cardiopulmonary resuscitation during MCS implantation. …”
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170
From exit to voice: reflections on exile through the accounts of Turkey’s intelligentsia
Published 2022“…The findings are based on 25 interviews conducted in 2021 with former academics, activists, artists, journalists and politicians who migrated to a variety of locations as a result of pending trials or arrest warrants against them, dehumanization discourse that pro-regime politicians directed toward them, as well as lack of freedom of speech and assembly.…”
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171
Nicotine overrides DNA damage-induced G1/S restriction in lung cells.
Published 2011-04-01“…In this study, we investigated the events occurred during G(1) arrest induced by γ-radiation or BP in nicotine-treated murine or human lung epithelial cells. …”
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172
Senescence induces proteolytically-active PAPP-A secretion and association with extracellular vesicles in human pre-adipocytes
Published 2023-02-01“…Senescence is a cellular response to various stressors characterized by irreversible cell cycle arrest, resistance to apoptosis and expression of a senescence-associated secretory phenotype (SASP). …”
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173
Innovative Purification Method of Ovatodiolide from <i>Anisomeles indica</i> to Induce Apoptosis in Human Gastric Cancer Cells
Published 2022-01-01“…Specific protein expression data warrant further research to further confirm the proposed Ova-induced apoptotic pathway in AGS cells.…”
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174
The Impact of p53 Dysfunction in ATR Inhibitor Cytotoxicity and Chemo- and Radiosensitisation
Published 2018-08-01“…Ataxia telangiectasia mutated and Rad3 related kinase (ATR) signals replication stress and DNA damage to S and G2 arrest and promotes DNA repair. Mutations in p53, critical for G1 checkpoint control, are common in cancer and predicted to confer vulnerability to ATR inhibitors. …”
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175
Initial Experience of the Levodopa–Entacapone–Carbidopa Intestinal Gel in Clinical Practice
Published 2021-03-01“…Patients are generally happy with the size and usability of the pump, but some technical improvements of the software are warranted, as well as larger, prospective studies.…”
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176
COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research
Published 2023-04-01“…Since its mechanism is currently a gray area, we included a separate section on basic science research studies that are warranted in the future to comprehend its underlying pathogenic mechanisms. …”
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177
25-Hydroxycholecalciferol Inhibits Cell Growth and Induces Apoptosis in SiHa Cervical Cells via Autocrine Vitamin D Metabolism
Published 2023-03-01“…These data identify promising therapeutic potential of 25(OH)D3 in cervical cancer, which warrants further clinical translational investigations.…”
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178
Autopsy findings of acute erythroid leukemia
Published 2023-05-01“… Acute erythroid leukemia (AEL) is an exceedingly uncommon but distinct hematological malignancy that shows neoplastic proliferation of erythroid precursors with maturation arrest and no significant myeloblasts. We describe an autopsy case of this rare entity in a 62-year-old man with co-morbidities. …”
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179
Respiratory support strategies in the management of severe, longstanding bronchopulmonary dysplasia
Published 2022-11-01“…Failure of conventional, lung-protective strategies (e.g., high rate/low tidal-volume and/or high frequency ventilation) warrants consideration of ventilatory strategies individualized to the disease physiology. …”
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180
Fatty acid oxidation is an adaptive survival pathway induced in prostate tumors by HSP90 inhibition
Published 2020“…This combination warrants further preclinical and clinical investigation as a novel strategy to overcome resistance to HSP90 inhibition. …”
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