Pre-hospital ECPR in an Australian metropolitan setting: a single-arm feasibility assessment—The CPR, pre-hospital ECPR and early reperfusion (CHEER3) study by S. A. C. Richardson, D. Anderson, A. J. C. Burrell, T. Byrne, J. Coull, A. Diehl, D. Gantner, K. Hoffman, A. Hooper, S. Hopkins, J. Ihle, P. Joyce, M. Le Guen, E. Mahony, S. McGloughlin, Z. Nehme, C. P. Nickson, P. Nixon, J. Orosz, B. Riley, J. Sheldrake, D. Stub, M. Thornton, A. Udy, V. Pellegrino, S. Bernard

“…Further prospective studies are now warranted.…”
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Synergism of AZD6738, an ATR Inhibitor, in Combination with Belotecan, a Camptothecin Analogue, in Chemotherapy-Resistant Ovarian Cancer by Jin Hur, Mithun Ghosh, Tae Heon Kim, Nahee Park, Kamal Pandey, Young Bin Cho, Sa Deok Hong, Nar Bahadur Katuwal, Minsil Kang, Hee Jung An, Yong Wha Moon

“…This consequently induced G2/M arrest in the cell cycle analysis. However, when AZD6738 was added to belotecan, pATR and pChk1 induced by belotecan alone were suppressed again. …”
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Identification and Characterization of Mortaparib^Plus—A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Ty... by Anissa Nofita Sari, Ahmed Elwakeel, Jaspreet Kaur Dhanjal, Vipul Kumar, Durai Sundar, Sunil C. Kaul, Renu Wadhwa

“…p53 has an essential role in suppressing the carcinogenesis process by inducing cell cycle arrest/apoptosis/senescence. Mortalin/GRP75 is a member of the Hsp70 protein family that binds to p53 causing its sequestration in the cell cytoplasm. …”
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Anticancer activity of grassy Hystrix brachyura bezoar and its mechanisms of action: An in vitro and in vivo based study by Khan, Al’aina Yuhainis Firus, Ahmed, Qamar Uddin, Narayanamurthy, Vigneswaran, Shakirah, Razali, Faizah, Abdullah Asuhaimi, Mohammed S. M., Saleh, Muhammad Farid, Johan, Khatib, Alfi, Azman, Seeni, Ridhwan, Abdul Wahab

“…However, more experiments with higher vertebrae models are still warranted to validate its traditional claims as an anticancer agent.…”
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Transient 2:1 Atrioventricular Block with Peri-Conduction System Pacing After Leadless Pacemaker Implantation by Salim N. Najjar, MD, Michael A. Bruno, MD, Wilson W. Lam, MD

“…Further study of techniques, limitations, and complications related to intentional right ventricular leadless conduction system pacing is warranted.…”
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Impella to Treat Acute Myocardial Infarct-Related Cardiogenic Shock by Jacob Eifer Møller, Jesper Kjaergaard, Christian Juhl Terkelsen, Christian Hassager

“…It is likely that the SCAI C patient with predominantly left ventricular failure and without prolonged cardiac arrest is the best candidate for these devices. Registry data suggest that pre-PCI Impella may be advantageous to post-PCI placement. …”
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Anesthetic management of cesarean section in a patient with Léri-Weill dyschondrosteosis – A case report by Muizz Hussain, Nikhil Nair, Matthew Foss, James Paul

“…This characteristic of LWD warrants a review of the clinical recommendations surrounding the anesthetic management of patients with LWD.…”
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Natural product ginsenoside 25-OCH3-PPD inhibits breast cancer growth and metastasis through down-regulating MDM2. by Wei Wang, Xu Zhang, Jiang-Jiang Qin, Sukesh Voruganti, Subhasree Ashok Nag, Ming-Hai Wang, Hui Wang, Ruiwen Zhang

“…Further preclinical and clinical development of this agent is warranted.…”
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Early Utilization of Mechanical Circulatory Support in Acute Myocardial Infarction Complicated by Cardiogenic Shock: The National Cardiogenic Shock Initiative by Mir B. Basir, Alejandro Lemor, Sarah Gorgis, Kirit C. Patel, Brian C. Kolski, Aditya S. Bharadwaj, Joshua W. Todd, Behnam N. Tehrani, Alexander G. Truesdell, David M. Lasorda, Thomas A. Lalonde, Amir Kaki, Theodore L. Schrieber, Nainesh C. Patel, Shaun R. Senter, Joseph L. Gelormini, Steven P. Marso, Ayaz M. Rahman, Robert E. Federici, Charles E. Wilkins, A. Thomas McRae, Ali Nsair, Christopher P. Caputo, Matheen A. Khuddus, Juan J. Chahin, Allison G. Dupont, Andrew M. Goldsweig, Michael J. Lim, Navin K. Kapur, David H. W. Wohns, Yueren Zhou, Michael J. Hacala, William W. O'Neill

“…Average age was 64±12 years, 24% were female, 17% had a witnessed out‐of‐hospital cardiac arrest, 27% had in‐hospital cardiac arrest, and 9% were under active cardiopulmonary resuscitation during MCS implantation. …”
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From exit to voice: reflections on exile through the accounts of Turkey’s intelligentsia by Baser, Bahar, Öztürk, Ahmet Erdi

“…The findings are based on 25 interviews conducted in 2021 with former academics, activists, artists, journalists and politicians who migrated to a variety of locations as a result of pending trials or arrest warrants against them, dehumanization discourse that pro-regime politicians directed toward them, as well as lack of freedom of speech and assembly.…”
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Nicotine overrides DNA damage-induced G1/S restriction in lung cells. by Takashi Nishioka, Daisuke Yamamoto, Tongbo Zhu, Jinjin Guo, Sung-Hoon Kim, Chang Yan Chen

“…In this study, we investigated the events occurred during G(1) arrest induced by γ-radiation or BP in nicotine-treated murine or human lung epithelial cells. …”
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Senescence induces proteolytically-active PAPP-A secretion and association with extracellular vesicles in human pre-adipocytes by Cheryl A. Conover, Laurie K. Bale

“…Senescence is a cellular response to various stressors characterized by irreversible cell cycle arrest, resistance to apoptosis and expression of a senescence-associated secretory phenotype (SASP). …”
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Innovative Purification Method of Ovatodiolide from <i>Anisomeles indica</i> to Induce Apoptosis in Human Gastric Cancer Cells by Hsiu-Man Lien, Shiau-Huei Huang, Chi-Huang Chang, Chao-Lu Huang, Chia-Chang Chen, Charng-Cherng Chyau

“…Specific protein expression data warrant further research to further confirm the proposed Ova-induced apoptotic pathway in AGS cells.…”
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The Impact of p53 Dysfunction in ATR Inhibitor Cytotoxicity and Chemo- and Radiosensitisation by Fiona K. Middleton, John R. Pollard, Nicola J. Curtin

“…Ataxia telangiectasia mutated and Rad3 related kinase (ATR) signals replication stress and DNA damage to S and G2 arrest and promotes DNA repair. Mutations in p53, critical for G1 checkpoint control, are common in cancer and predicted to confer vulnerability to ATR inhibitors. …”
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Initial Experience of the Levodopa–Entacapone–Carbidopa Intestinal Gel in Clinical Practice by Mezin Öthman, Erik Widman, Ingela Nygren, Dag Nyholm

“…Patients are generally happy with the size and usability of the pump, but some technical improvements of the software are warranted, as well as larger, prospective studies.…”
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COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research by Sri Harsha Kanuri, Prapthi Jayesh Sirrkay, Ayse Sena Ulucay

“…Since its mechanism is currently a gray area, we included a separate section on basic science research studies that are warranted in the future to comprehend its underlying pathogenic mechanisms. …”
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25-Hydroxycholecalciferol Inhibits Cell Growth and Induces Apoptosis in SiHa Cervical Cells via Autocrine Vitamin D Metabolism by Rivak Punchoo, Greta Dreyer, Tahir S. Pillay

“…These data identify promising therapeutic potential of 25(OH)D3 in cervical cancer, which warrants further clinical translational investigations.…”
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Autopsy findings of acute erythroid leukemia by Mayur Parkhi, Nabhajit Mallik, Deepesh Lad, Man Updesh Singh Sachdeva, Amanjit Bal, Pankaj Malhotra, Suvradeep Mitra

“… Acute erythroid leukemia (AEL) is an exceedingly uncommon but distinct hematological malignancy that shows neoplastic proliferation of erythroid precursors with maturation arrest and no significant myeloblasts. We describe an autopsy case of this rare entity in a 62-year-old man with co-morbidities. …”
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Respiratory support strategies in the management of severe, longstanding bronchopulmonary dysplasia by J. Wells Logan, Sfurti Nath, Sanket D. Shah, Padma S. Nandula, Mark L. Hudak

“…Failure of conventional, lung-protective strategies (e.g., high rate/low tidal-volume and/or high frequency ventilation) warrants consideration of ventilatory strategies individualized to the disease physiology. …”
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Fatty acid oxidation is an adaptive survival pathway induced in prostate tumors by HSP90 inhibition by Nassar, ZD, Mah, CY, Centenera, MM, Irani, S, Sadowski, MC, Scott, JS, Nguyen, EV, Nagarajan, SR, Moldovan M, Lynn, DJ, Daly, RJ, Hoy, AJ, Butler, LM

“…This combination warrants further preclinical and clinical investigation as a novel strategy to overcome resistance to HSP90 inhibition. …”