Ataxia-telangiectasia mutated plays an important role in cerebellar integrity and functionality by Yulia Mitiagin, Ari Barzilai

“…Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for maintaining cellular homeostasis and that it has both nuclear and cytoplasmic functions. …”
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The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging by Reiko Suzuki, Xiujuan Tan, Katarzyna J. Szymanska, Nada Kubikova, Columba Avila Perez, Dagan Wells, Kutluk H. Oktay

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The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging by Suzuki, R, Tan, X, Szymanska, KJ, Kubikova, N, Perez, CA, Wells, D, Oktay, KH

The role of the ataxia telangiectasia mutated gene in lung cancer: recent advances in research by Yanling Xu, Peng Gao, Xuejiao Lv, Lin Zhang, Jie Zhang

“…Early detection and treatment are crucial for improvements in both prognosis and quality of life of lung cancer patients. The ataxia telangiectasia mutated (ATM) gene is a cancer-susceptibility gene that encodes a key apical kinase in the DNA damage response pathway. …”
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Association of Ataxia Telangiectasia Mutated (ATM) Gene Mutation/Deletion with Rhabdomyosarcoma – retraction by Feramisco James R, Newbury Robert O, Puri Pier, Bhakta Kunjan S, Zhang Peilin, Wang Jean Y

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Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction by Lixin Jia, Wenmei Zhang, Youcai Ma, Boya Chen, Yan Liu, Chunmei Piao, Yuan Wang, Min Yang, Tingting Liu, Junmeng Zhang, Taotao Li, Shaoping Nie, Jie Du

“…Methods and ResultsSenescence‐related genes (ie, p21, p53, and ataxia telangiectasia mutated [ATM]) were shown to be elevated after myocardial infarction (MI) in both mouse and human hearts. …”
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MEK inhibitors block growth of lung tumors with mutations in Ataxia Telangiectasia Mutated by Smida, M, Fece de la Cruz, F, Kerzendorfer, C, Muir, B, Konopka, T, Nijman, S

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants by Angelo Agathanggelou, Victoria J. Weston, Tracey Perry, Nicholas J. Davies, Anna Skowronska, Daniel T. Payne, John S. Fossey, Ceri E. Oldreive, Wenbin Wei, Guy Pratt, Helen Parry, David Oscier, Steve J. Coles, Paul S. Hole, Richard L. Darley, Michael McMahon, John D. Hayes, Paul Moss, Grant S. Stewart, A. Malcolm R. Taylor, Tatjana Stankovic

“…Hence, p53-independent strategies are required to target Ataxia Telangiectasia Mutated-deficient chronic lymphocytic leukemia. …”
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Evaluation of ataxia–telangiectasia mutated IVS10 mutation in breast cancer along with clinicopathological parameters by Sana Ahuja, Himani Aneja, Amit Kumar Yadav, Sunil Ranga, Chintamani, Jaishree Paul

Subjects: “…ataxia–telangiectasia mutated allele ivs10-6t>g…”
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Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease by Jennifer Q. J. Zhang, Sayanthooran Saravanabavan, Gopala K. Rangan

“…The DNA damage response (DDR) pathway is upregulated in autosomal dominant polycystic kidney disease (ADPKD) but its functional role is not known. The ataxia-telangiectasia mutated (ATM) and AT and Rad3-related (ATR) protein kinases are key proximal transducers of the DDR. …”
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Severe reaction to radiotherapy provoked by hypomorphic germline mutations in ATM (ataxia–telangiectasia mutated gene) by Reza Asadollahi, Christian Britschgi, Pascal Joset, Beatrice Oneda, Detlev Schindler, Urs R. Meier, Anita Rauch

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Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis by Jennifer Beauvarlet, Jean-Louis Mergny, Mojgan Djavaheri-Mergny

“…We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. …”
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Ataxia-telangiectasia mutated (ATM) gene mutation in a patient with primary cutaneous marginal zone lymphoma by Melissa M. Sarver, BS, Kimberly F. Breglio, MD, DPhil, Elise A. Olsen, MD

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Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer by Weber, A, Drobnitzky, N, Devery, A, Bokobza, S, Adams, R, Maughan, T, Ryan, A

“…Mutations in the Ataxia-telangiectasia mutated (ATM) gene are frequently found in human cancers, including non-small cell lung cancer (NSCLC). …”

Reduced expression of phosphorylated ataxia-telangiectasia mutated gene is related to poor prognosis and gemcitabine chemoresistance in pancreatic cancer by Jingyu Xun, Hideo Ohtsuka, Katsuya Hirose, Daisuke Douchi, Shun Nakayama, Masaharu Ishida, Takayuki Miura, Kyohei Ariake, Masamichi Mizuma, Kei Nakagawa, Takanori Morikawa, Toru Furukawa, Michiaki Unno

“…Abstract Background Loss of expression of the gene ataxia-telangiectasia mutated (ATM), occurring in patients with multiple primary malignancies, including pancreatic cancer, is associated with poor prognosis. …”
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Phenformin and ataxia‐telangiectasia mutated inhibitors synergistically co‐suppress liver cancer cell growth by damaging mitochondria by Tianyu Wu, Sichun Zhou, Mei Qin, Jing Tang, Xinjian Yan, Lingli Huang, Meiyuan Huang, Jun Deng, Di Xiao, Xin Hu, Jingtao Wu, Xiaoping Yang, Gaofeng Li

“…Inhibitors of ataxia–telangiectasia mutated (ATM), such as KU‐55933 (Ku), represent a promising class of novel anticancer drugs. …”
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Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis. by Cerrone R Foster, Laura L Daniel, Christopher R Daniels, Suman Dalal, Mahipal Singh, Krishna Singh

“…Ataxia telangiectasia mutated kinase (ATM) is a cell cycle checkpoint protein activated in response to DNA damage. …”
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THE ATAXIA-TELANGIECTASIA MUTATED (ATM) GENE PLAYS A PIVOTAL ROLE IN THE REPAIR OF DNA IN CASES OF MYELODYSPLASTIC NEOPLASM by JVC Goes, LR Sampaio, RTG Oliveira, DP Borges, RDB Dias, CLA Araujo, PRC Passos, HLR Junior, SMM Magalhães, RF Pinheiro

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Deficiency of ataxia‐telangiectasia mutated kinase attenuates Western‐type diet‐induced cardiac dysfunction in female mice by Mary C. Wingard, Suman Dalal, Paige L. Shook, Paulina Ramirez, Muhammad U. Raza, Patrick Johnson, Barbara A. Connelly, Douglas P. Thewke, Mahipal Singh, Krishna Singh

“…Previously, we have shown that WD consumption in male ATM (ataxia‐telangiectasia mutated kinase) deficient mice associates with accelerated body weight (BW) gain, cardiac systolic dysfunction with increased preload, and exacerbation of hypertrophy, apoptosis, and inflammation. …”
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Impaired arterial dilation and increased NOX2 generated oxidative stress in subjects with ataxia-telangiectasia mutated (ATM) kinase by Lorenzo Loffredo, Annarosa Soresina, Bianca Laura Cinicola, Martina Capponi, Francesca Salvatori, Simona Bartimoccia, Vittorio Picchio, Maurizio Forte, Caterina Caputi, Roberto Poscia, Vincenzo Leuzzi, Alberto Spalice, Pasquale Pignatelli, Raffaele Badolato, Marzia Duse, Francesco Violi, Roberto Carnevale, Anna Maria Zicari, Ilaria Maria Palumbo, Arianna Magna, Alessia Fallarino, Arianna Pannunzio, Enrico Maggio, Chiara Bagnato, Vittoria Cammisotto, Valentina Castellani

“…Background: Subjects with mutations in the Ataxia-Telangiectasia mutated (ATM) gene encoding for ATM kinase have a greater predisposition to develop atherosclerosis, but the mechanism behind this phenomenon is not yet understood. …”
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