Distribution of anti-nuclear antibodies (ANA), anti-dsdna and extractable nuclear antigens (ENA) antibodies among apparently healthy malay women and determination of ana cutofft... by Che Maraina, Che Hussin

“…Some autoantibodies play a very important role in the pathogenesis, diagnosis and prognosis of autoimmune diseases including antinuclear antibodies (ANA), antidsDNA and ENA antibodies. …”
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Differences in children and adolescents with SARS-CoV-2 infection: a cohort study in a Brazilian tertiary referral hospital by Heloisa Helena de Sousa Marques, Maria Fernanda Badue Pereira, Angélica Carreira dos Santos, Thais Toledo Fink, Camila Sanson Yoshino de Paula, Nadia Litvinov, Claudio Schvartsman, Artur Figueiredo Delgado, Maria Augusta Bento Cicaroni Gibelli, Werther Brunow de Carvalho, Vicente Odone Filho, Uenis Tannuri, Magda Carneiro-Sampaio, Sandra Grisi, Alberto José da Silva Duarte, Leila Antonangelo, Rossana Pucineli Vieira Francisco, Thelma Suely Okay, Linamara Rizzo Batisttella, Carlos Roberto Ribeiro de Carvalho, Alexandra Valéria Maria Brentani, Clovis Artur Silva, Adriana Pasmanik Eisencraft, Alfio Rossi Junior, Alice Lima Fante, Aline Pivetta Cora, Amelia Gorete A. de Costa Reis, Ana Paula Scoleze Ferrer, Anarella Penha Meirelles de Andrade, Andreia Watanabe, Angelina Maria Freire Gonçalves, Aurora Rosaria Pagliara Waetge, Camila Altenfelder Silva, Carina Ceneviva, Carolina dos Santos Lazari, Deipara Monteiro Abellan, Emilly Henrique dos Santos, Ester Cerdeira Sabino, Fabíola Roberta Marim Bianchini, Flávio Ferraz de Paes Alcantara, Gabriel Frizzo Ramos, Gabriela Nunes Leal, Isadora Souza Rodriguez, João Renato Rebello Pinho, Jorge David Avaizoglou Carneiro, Jose Albino Paz, Juliana Carvalho Ferreira, Juliana Ferreira Ferranti, Juliana de Oliveira Achili Ferreira, Juliana Valéria de Souza Framil, Katia Regina da Silva, Kelly Aparecida Kanunfre, Karina Lucio de Medeiros Bastos, Karine Vusberg Galleti, Lilian Maria Cristofani, Lisa Suzuki, Lucia Maria Arruda Campos, Maria Beatriz de Moliterno Perondi, Maria de Fatima Rodrigues Diniz, Maria Fernanda Mota Fonseca, Mariana Nutti de Almeida Cordon, Mariana Pissolato, Marina Silva Peres, Marlene Pereira Garanito, Marta Imamura, Mayra de Barros Dorna, Michele Luglio, Mussya Cisotto Rocha, Nadia Emi Aikawa, Natalia Viu Degaspare, Neusa Keico Sakita, Nicole Lee Udsen, Paula Gobi Scudeller, Paula Vieira de Vincenzi Gaiolla, Rafael da Silva Giannasi Severini, Regina Maria Rodrigues, Ricardo Katsuya Toma, Ricardo Iunis Citrangulo de Paula, Patricia Palmeira, Silvana Forsait, Sylvia Costa Lima Farhat, Tânia Miyuki Shimoda Sakano, Vera Hermina Kalika Koch, Vilson Cobello Junior

“…RESULTS: The frequencies of sore throat, anosmia, dysgeusia, headache, myalgia, nausea, lymphopenia, pre-existing chronic conditions, immunosuppressive conditions, and autoimmune diseases were significantly reduced in children and adolescents (p<0.05). …”
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Comparative effects of human-equivalent low, moderate, and high dose oral prednisone intake on autoimmunity and glucocorticoid-related toxicity in a murine model of environmental-t... by Lauren K. Heine, Lauren K. Heine, Abby D. Benninghoff, Elizabeth A. Ross, Lichchavi D. Rajasinghe, James G. Wagner, James G. Wagner, Ryan P. Lewandowski, Alexa L. Richardson, Quan-Zhen Li, John P. Buchweitz, John P. Buchweitz, John P. Buchweitz, Justin Zyskowski, Ashleigh N. Tindle, Anna E. Skedel, Nicholas J. Chargo, Laura R. McCabe, Jack R. Harkema, Jack R. Harkema, Jack R. Harkema, James J. Pestka, James J. Pestka, James J. Pestka

“…Autoimmune diseases can be triggered by environmental toxicants such as crystalline silica dust (cSiO2). …”
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Interferon response and profiling of interferon response genes in peripheral blood of vaccine-naive COVID-19 patients by Baozhen Huang, Jinghan Huang, Nim Hang Chiang, Zigui Chen, Grace Lui, Lowell Ling, Mike Yat Wah Kwan, Joshua Sung Chih Wong, Phoebe Qiaozhen Mak, Janet Wan Hei Ling, Ivan Cheuk San Lam, Rita Wai Yin Ng, Xingyan Wang, Ruonan Gao, David Shu-Cheong Hui, Suk Ling Ma, Paul K. S. Chan, Nelson Leung Sang Tang, Nelson Leung Sang Tang, Nelson Leung Sang Tang

“…Expression of interferon-stimulated genes (ISGs) in peripheral blood (better known as interferon score) has been a well-established bioassay marker of systemic IFN responses in autoimmune diseases. Therefore, with archival samples of a cohort of COVID-19 patients collected before the availability of vaccination, we aimed to better understand this innate immune response by studying the IFN score and related ISGs expression in bulk and single cell RNAs sequencing expression datasets.MethodsIn this study, we recruited 105 patients with COVID-19 and 30 healthy controls in Hong Kong. …”
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Actualización sobre los medicamentos biocomparables en la enfermedad inflamatoria intestinal: posición y recomendación en México by A. Mayoral-Zavala, A. Esquivel-Aguilar, C.M. del Real-Calzada, Y. Gutiérrez-Grobe, J. Ramos-García, J.L. Rocha-Ramírez, M.F. Rojas-Illanes, B. Rubio-Martínez, X. Sánchez-Chávez, J.K. Yamamoto-Furusho

“…Clinical trials have shown that the infliximab biosimilar, CT-P13, and the candidates for the adalimumab biosimilars, ABP 501 and ZRC 3197, are not significantly different, with respect to efficacy and safety, from the originator drugs in patients with other autoimmune diseases. However, controversy has arisen over the use of biosimilars in inflammatory bowel disease, due to the incipient evidence not only in patients with no previous biotechnology treatment, but also in patients in remission, that could be switched to a biosimilar for non-medical reasons.The present review is the first critical analysis by different specialists in the area of gastroenterology on the use of biosimilars in inflammatory bowel disease, the evidence on interchangeability, the extrapolation of indications, efficacy, safety, immunogenicity, and the clinical impact of the Mexican health regulations. …”
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The Autoinflammatory Diseases Alliance Registry of monogenic autoinflammatory diseases by Carla Gaggiano, Antonio Vitale, Abdurrahman Tufan, Gaafar Ragab, Gaafar Ragab, Emma Aragona, Ewa Wiesik-Szewczyk, Djouher Ait-Idir, Giovanni Conti, Ludovica Iezzi, Maria Cristina Maggio, Marco Cattalini, Francesco La Torre, Giuseppe Lopalco, Elena Verrecchia, Elena Verrecchia, Amato de Paulis, Amato de Paulis, Ali Sahin, Antonella Insalaco, Petros P. Sfikakis, Achille Marino, Micol Frassi, Benson Ogunjimi, Benson Ogunjimi, Benson Ogunjimi, Benson Ogunjimi, Daniela Opris-Belinski, Paola Parronchi, Giacomo Emmi, Farhad Shahram, Francesco Ciccia, Matteo Piga, José Hernández-Rodríguez, Rosa Maria R. Pereira, Maria Alessio, Roberta Naddei, Alma Nunzia Olivieri, Emanuela Del Giudice, Paolo Sfriso, Piero Ruscitti, Francesca Li Gobbi, Hamit Kucuk, Jurgen Sota, Mohamed A. Hussein, Giuseppe Malizia, Karina Jahnz-Różyk, Rawda Sari-Hamidou, Mery Romeo, Francesca Ricci, Fabio Cardinale, Florenzo Iannone, Francesca Della Casa, Marco Francesco Natale, Katerina Laskari, Teresa Giani, Franco Franceschini, Vito Sabato, Derya Yildirim, Valeria Caggiano, Mohamed Tharwat Hegazy, Mohamed Tharwat Hegazy, Rosalba Di Marzo, Aleksandra Kucharczyk, Ghalia Khellaf, Maria Tarsia, Ibrahim A. Almaghlouth, Ibrahim A. Almaghlouth, Ahmed Hatem Laymouna, Violetta Mastrorilli, Laura Dotta, Luca Benacquista, Salvatore Grosso, Francesca Crisafulli, Veronica Parretti, Heitor F. Giordano, Ayman Abdel-Monem Ahmed Mahmoud, Rossana Nuzzolese, Marta De Musso, Cecilia Beatrice Chighizola, Cecilia Beatrice Chighizola, Stefano Gentileschi, Mirella Morrone, Ilenia Di Cola, Veronica Spedicato, Henrique A. Mayrink Giardini, Ibrahim Vasi, Alessandra Renieri, Alessandra Renieri, Alessandra Renieri, Alessandra Fabbiani, Alessandra Fabbiani, Alessandra Fabbiani, Maria Antonietta Mencarelli, Bruno Frediani, Alberto Balistreri, Gian Marco Tosi, Claudia Fabiani, Merav Lidar, Merav Lidar, Merav Lidar, Donato Rigante, Donato Rigante, Luca Cantarini

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Negative costimulatory molecule B7-H4 mediates protective effect of mesenchymal stem cells on experimental autoimmune encephalomyelitis by Xiao-Pei Ji, Yan-Zheng Gu, Hao Li, Zhou Yin, Nagam Varshithreddy, Ling-Tao Tang, Nan Li, Ying Zhang, Ming-Yuan Wang, Qin Shi, Si-Wei You, Xi-Ying Luan, Wan-Li Dong, Qi Fang, Xue-Guang Zhang, Qun Xue

“…These findings may provide a new avenue and target molecule in MSC-based therapy for autoimmune diseases in the central nervous system, such as multiple sclerosis and neuromyelitis optica spectrum disorder.…”
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miR-146a in Myasthenia Gravis Thymus Bridges Innate Immunity With Autoimmunity and Is Linked to Therapeutic Effects of Corticosteroids by Federica Bortone, Letizia Scandiffio, Stefania Marcuzzo, Silvia Bonanno, Rita Frangiamore, Teresio Motta, Carlo Antozzi, Renato Mantegazza, Paola Cavalcante, Pia Bernasconi

“…Considerable evidence indicate that uncontrolled TLR activation and chronic inflammation significantly contribute to hyperplastic changes and germinal center (GC) formation in the MG thymus, ultimately leading to autoantibody production and autoimmunity. miR-146a is a key modulator of innate immunity, whose dysregulation has been associated with autoimmune diseases. It acts as inhibitor of TLR pathways, mainly by targeting the nuclear factor kappa B (NF-κB) signaling transducers, interleukin 1 receptor associated kinase 1 (IRAK1) and tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6); miR-146a is also able to target c-REL, inducible T-cell costimulator (ICOS), and Fas cell surface death receptor (FAS), known to regulate B-cell function and GC response. …”
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SURGERY FOR PRIMARY DIFFUSE LARGE B-CELL-LYMPHOMA OF THE CENTRAL NERVOUS SYSTEM - A CASE REPORT by JOR Cassiano, ACP Silva, CM Freitas, NN Kloster, SLBG Oliveira, MM Garcia, LN Chaer, VLP Figueiredo

“…They are often associated with EBV or HIV infection and also affect transplant patients or those with autoimmune diseases, as in the reported case. They usually do not present B symptoms as manifestations, but rather neurological symptoms such as speech and/or motor disorders, mental confusion, seizures, and change on consciousness level. …”
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MOLECULAR GENETIC TESTING OF ACCP-POSITIVE PATIENTS WITH RHEUMATOID ARTHRITIS AND HIGH INFLAMMATORY DISEASE ACTIVITY (A REMARCA STUDY) by I. A. Guseva, E. L. Luchikhina, N. V. Demidova, A. S. Avdeeva, N. E. Soroka, D. D. Abramov, M. V. Cherkasova, E. Yu. Samarkina, D. E. Karateev, E. L. Nasonov

“…A molecular genetic study enrolled 146 aCCP-positive patients from the REMARCA program and a control group of 314 healthy blood donors without autoimmune diseases and their presence in the history, who were matched with the study group for gender and sex. …”
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Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer’s disease mouse model: a role for ER-mitochondria interaction by Laura Tapella, Giulia Dematteis, Marianna Moro, Beatrice Pistolato, Elisa Tonelli, Virginia Vita Vanella, Daniele Giustina, Aleida La Forgia, Elena Restelli, Elettra Barberis, Tito Cali, Marisa Brini, Salvatore Villani, Erika Del Grosso, Mariagrazia Grilli, Marcello Manfredi, Marco Corazzari, Ambra A. Grolla, Armando A. Genazzani, Dmitry Lim

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[Artículo traducido] Baja dosis de rituximab para penfigoide ampolloso. Protocolo y experiencia de un único centro by C. Suárez-Carantoña, J. Jiménez-Cauhé, A. González-García, M. Fernández-Guarino, M. Asunción Ballester

“…Abstract: Background: Low-dose rituximab is a protocol used in several autoimmune diseases, that has also shown to be effective and safe in pemphigus vulgaris. …”
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Features of renal dysfunction in children with systemic lupus erythematosus and juvenile idiopathic arthritis by L.F. Bogmat, V.V. Nikonova, N.S. Shevchenko, I.M. Bessonova

“…Background. In systemic autoimmune diseases of the connective tissue, kidney damage in some cases is a syndrome of the disease, and in others, it is a consequence of the underlying process. …”
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Immunological markers for predicting the response to immunotherapy in non-small cell lung cancer by A. A. Musaelyan, S. V. Lapin, M. A. Urtenova, S. V. Odintsova, I. V. Chistyakov, A. M. Ulitin, N. T. Ismanbaev, A. L. Akopov, S. V. Orlov

“…All patients from 2 groups did not have autoimmune diseases before starting treatment. The determination of autoantibodies, β-2-microglobulin, neopterin, interleukin 6, interleukin 18 and the allelic variant of HLA-DRB1 in patients in the Group 1 was carried out 2 months after the start of therapy, and in the Group 2 – before the start of the next chemotherapy cycle.Results. …”
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Long-term impact of pre-incision antibiotics on children born by caesarean section: a longitudinal study based on UK electronic health records by Dana Šumilo, Krishnarajah Nirantharakumar, Brian H Willis, Gavin M Rudge, James Martin, Krishna Gokhale, Rasiah Thayakaran, Nicola J Adderley, Joht Singh Chandan, Kelvin Okoth, Isobel M Harris, Ruth Hewston, Magdalena Skrybant, Jonathan J Deeks, Peter Brocklehurst

“…Additional secondary outcomes, including other allergy-related conditions, autoimmune diseases, infections, other immune system-related diseases and neurodevelopmental conditions, were also assessed. …”
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The Performance of Pulmonary Function Tests in Predicting Systemic Sclerosis—Interstitial Lung Disease in the European Scleroderma Trial and Research Database by Gemma Lepri, Cosimo Bruni, Lorenzo Tofani, Alberto Moggi-Pignone, Martina Orlandi, Sara Tomassetti, Michael Hughes, Francesco Del Galdo, Rosaria Irace, Oliver Distler, Valeria Riccieri, Yannick Allanore, Ana Maria Gheorghiu, Elise Siegert, Jeska De Vries-Bouwstra, Eric Hachulla, Mohammed Tikly, Nemanja Damjanov, Francois Spertini, Luc Mouthon, Anna-Maria Hoffmann-Vold, Armando Gabrielli, Serena Guiducci, Marco Matucci-Cerinic, Daniel Furst, Silvia Bellando-Randone, EUSTAR Collaborators

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Complementary Therapies and Their Association with Problems in Therapeutic Adherence to Conventional Synthetic DMARDs in Rheumatoid Arthritis: A Cross-Sectional Study by Aline Priscilla Santiago-Garcia, Jorge Ivan Gamez-Nava, Felipe Alexis Avalos-Salgado, Sergio Cerpa-Cruz, Edna Lizeth Amaya-Cabrera, Sergio Gutierrez-Ureña, Cesar Arturo Nava-Valdivia, Sergio Gonzalez-Vazquez, Diana Esperanza Arevalo-Simental, Jose Jorge Gomez-Camarena, Juan Manuel Ponce-Guarneros, Norma Alejandra Rodriguez-Jimenez, Ana Miriam Saldaña-Cruz, Ernesto German Cardona-Muñoz, Laura Gonzalez-Lopez

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Polyphenols and Their Impact on the Prevention of Neurodegenerative Diseases and Development by Izabela Grabska-Kobyłecka, Piotr Szpakowski, Aleksandra Król, Dominika Książek-Winiarek, Andrzej Kobyłecki, Andrzej Głąbiński, Dariusz Nowak

“…Polyphenols act on the brain endothelial cells and improve the BBB’s integrity and reduce inflammation, thus protecting the brain from additional injury during stroke or autoimmune diseases. Polyphenolic compounds are capable of lowering blood pressure and improving cerebral blood flow. …”
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Regulation of CD47 expression on CD14+ monocytes by interferon-α in PBC patients by Xi Su, Xi Su, Wenwen Jin, Wenwen Jin, Lizhi Liu, Zifei Zhu, Zifei Zhu, Cunyan Li, Cunyan Li

“…CD47/signal-regulatory protein alpha (SIRPα) is closely related to developing autoimmune diseases by promoting inflammatory response. …”
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Low-Dose Rituximab for Bullous Pemphigoid. Protocol and Single-Center Experience by C. Suárez-Carantoña, J. Jiménez-Cauhé, A. González-García, M. Fernández-Guarino, M. Asunción Ballester

“…Background: Low-dose rituximab is a protocol used in several autoimmune diseases, that has also shown to be effective and safe in pemphigus vulgaris. …”
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