Mechanisms of resistance to a PI3K inhibitor in gastrointestinal stromal tumors: an omic approach to identify novel druggable targets by Ravegnini G, Sammarini G, Moran S, Calice G, Indio V, Urbini M, Astolfi A, Zanotti F, Pantaleo MA, Hrelia P, Angelini S

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Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet by Christopher P. Hedges, Jordi Boix, Jagdish K. Jaiswal, Bhoopika Shetty, Peter R. Shepherd, Troy L. Merry

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Concomitant inhibition of PI3K/mTOR signaling pathways boosts antiproliferative effects of lanreotide in bronchopulmonary neuroendocrine tumor cells by Claus von Hessert-Vaudoncourt, Sara Lelek, Christina Geisler, Teresa Hartung, Vanessa Bröker, Franziska Briest, Liliana Mochmann, Fabian Jost-Brinkmann, Fabian Jost-Brinkmann, Dagmar Sedding, Joana Benecke, Helma Freitag, Sebastian Wolfshöfer, Hedwig Lammert, Svenja Nölting, Svenja Nölting, Michael Hummel, Jörg Schrader, Patricia Grabowski

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PIK3CA-Related Overgrowth Spectrum From Diagnosis to Targeted Therapy: A Case of CLOVES Syndrome Treated With Alpelisib by Angelica Pagliazzi, Teresa Oranges, Giovanna Traficante, Chiara Trapani, Flavio Facchini, Alessandra Martin, Alessandro Semeraro, Anna Perrone, Cesare Filippeschi, Sabrina Giglio, Sabrina Giglio

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Dual inhibition of atypical PKC signaling and PI3K/Akt signaling dysregulates c-Myc to induce apoptosis in clear cell Renal Cell Carcinoma by Khandker Mohammad Khalid, Wishrawana S. Ratnayake, Christopher A. Apostolatos, Mildred Acevedo-Duncan

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TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma by Kara M. Ruicci, Jalna Meens, Paul Plantinga, William Stecho, Nicole Pinto, John Yoo, Kevin Fung, Danielle MacNeil, Joe S. Mymryk, John W. Barrett, Christopher J. Howlett, Paul C. Boutros, Laurie Ailles, Anthony C. Nichols

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Screen for MicroRNA and Drug Interactions in Breast Cancer Cell Lines Points to miR-126 as a Modulator of CDK4/6 and PIK3CA Inhibitors by Federica Baldassari, Carlotta Zerbinati, Marco Galasso, Fabio Corrà, Linda Minotti, Chiara Agnoletto, Maurizio Previati, Carlo M. Croce, Stefano Volinia

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PI3Kα-specific inhibitor BYL-719 synergizes with cisplatin in vitro in PIK3CA-mutated ovarian cancer cells by Benoît Thibault, Adrien Thole, Romina D’Angelo, Céline Basset, Julie Guillermet-Guibert

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Effects of BYL-719 (alpelisib) on human breast cancer stem cells to overcome drug resistance in human breast cancer by Leinan Yu, Chuanbing Zang, Yuanchun Ye, Hongyu Liu, Jan Eucker, Jan Eucker

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BYL719 reverses gefitinib-resistance induced by PI3K/AKT activation in non-small cell lung cancer cells by Yaya Yu, Zhenzhen Xiao, Chenjing Lei, Changju Ma, Lina Ding, Qing Tang, Yihan He, Yadong Chen, Xuesong Chang, Yanjuan Zhu, Haibo Zhang

Subjects: “…Phosphatidylinositol 3-kinase, Gefitinib, BYL719…”
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