Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes by Zhou, X, Levesque, P, Chaudhary, K, Davis, M, Rodriguez, B

“…We constructed, calibrated and validated populations of human electromechanical models of failing cardiomyocytes, that were able to reproduce the prolonged action potential, reduced contractility and diastolic dysfunction as observed in human data, as well as increased propensity to proarrhythmic incidents such as early afterdepolarization and beat-to-beat alternans. Our simulation data reveal that proarrhythmic incidents tend to occur in failing myocytes with lower diastolic tension, rather than with lower contractility, due to the relative preserved SERCA and sodium calcium exchanger current. …”

Metformin may adversely affect orthostatic blood pressure recovery in patients with type 2 diabetes: substudy from the placebo-controlled Copenhagen Insulin and Metformin Therapy (... by Christian Stevns Hansen, Louise Lundby-Christiansen, Lise Tarnow, Christian Gluud, Christoffer Hedetoft, Birger Thorsteinsson, Bianca Hemmingsen, Niels Wiinberg, Simone B. Sneppen, Søren S. Lund, Thure Krarup, Sten Madsbad, Thomas Almdal, Bendix Carstensen, Marit E. Jørgensen, the CIMT study group

“…Outcomes were measures of CAN: Changes in heart rate response to deep breathing (beat-to-beat), orthostatic blood pressure (OBP) and heart rate and vibration detection threshold (VDT) as a marker DPN. …”
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Vasoconstriction Response to Mental Stress in Sickle Cell Disease: The Role of the Cardiac and Vascular Baroreflexes by Wanwara Thuptimdang, Payal Shah, Maha Khaleel, John Sunwoo, Saranya Veluswamy, Roberta M. Kato, Thomas D. Coates, Michael C. K. Khoo

“…Cardiac baroreflex sensitivity (BRSc) was estimated by applying both the “sequence” and “spectral” techniques to beat-to-beat measurements of systolic blood pressure and RRIs. …”
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Accuracy Assessment of Oura Ring Nocturnal Heart Rate and Heart Rate Variability in Comparison With Electrocardiography in Time and Frequency Domains: Comprehensive Analysis by Rui Cao, Iman Azimi, Fatemeh Sarhaddi, Hannakaisa Niela-Vilen, Anna Axelin, Pasi Liljeberg, Amir M Rahmani

“…The Pearson correlation coefficient tests (P<.001) indicated that HR, RMSSD, average of normal heart beat intervals (AVNN), and percentage of successive normal beat-to-beat intervals that differ by more than 50 ms (pNN50) had high positive correlations with the baseline values; SD of normal beat-to-beat intervals (SDNN) and high frequency (HF) had moderate positive correlations, and low frequency (LF) and LF:HF ratio had low positive correlations. …”
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Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts by Aneesh V. Karkhanis, Gopalakrishnan Venkatesan, Ryuichi Kambayashi, Jacqueline Wen Hui Leow, Marcus Qingrui Han, Hiroko Izumi-Nakaseko, Ai Goto, Jeremy Kah Sheng Pang, Boon Seng Soh, Pipin Kojodjojo, Atsushi Sugiyama, Eric Chun Yong Chan

“…Next, we show that dronedarone treatment or CYP2J2 knockdown in spontaneously beating cardiomyocytes indicative of depleted CYP2J2 activity exacerbates beat-to-beat (BTB) variability reflective of proarrhythmic phenotype. …”
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Bed-Embedded Heart and Respiration Rates Detection by Longitudinal Ballistocardiography and Pattern Recognition by Almothana Albukhari, Frederico Lima, Ulrich Mescheder

“…The major focus is placed on the beat-to-beat heart rate monitoring task, for which an unsupervised machine learning algorithm is employed, while its performance is compared to an electrocardiogram (ECG) signal that serves as a reference. …”
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Tachycardia cycle length alternans caused by alternate conduction velocity on the slow conduction zone in a postoperative scar‐related atrial tachycardia by Chen Su, Menghui Liu, Yuedong Ma, Lichun Wang

“…Abstract The underlying mechanism for stable beat‐to‐beat cycle length variability (CL alternans) in scar‐related atrial tachycardia (AT) had not been elucidated clearly. …”
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Persistent homology as a new method of the assessment of heart rate variability. by Grzegorz Graff, Beata Graff, Paweł Pilarczyk, Grzegorz Jabłoński, Dariusz Gąsecki, Krzysztof Narkiewicz

“…In particular, we show that this novel approach provides a collection of indices that might be at least as useful as the classical parameters in differentiating between series of beat-to-beat intervals (RR-intervals) in healthy subjects and patients suffering from a stroke episode.…”
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Hemodynamic impacts of entrainment of heart rate and stride rate by Mandeep S. Dhindsa, Jun Sugawara, Hirofumi Tanaka

“…Twenty-three apparently healthy subjects performed treadmill running in three different conditions, one that the step rate was matched with the heart rate (matched condition), one that the step rate was ~10 steps greater or lower than heart rate (unmatched conditions). Beat-by-beat blood pressure was measured using the finger plethysmography, and stroke volume and cardiac output were calculated using the validated Model Flow method. …”
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A Non-invasive Platform for Functional Characterization of Stem-Cell-Derived Cardiomyocytes with Applications in Cardiotoxicity Testing by Mahnaz Maddah, Julia D. Heidmann, Mohammad A. Mandegar, Chase D. Walker, Sara Bolouki, Bruce R. Conklin, Kevin E. Loewke

“…The platform, called Pulse, generates automated measurements of beating frequency, beat duration, amplitude, and beat-to-beat variation based on motion analysis of phase-contrast images captured at a fast frame rate. …”
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Bidirectional Ventricular Tachycardia: Challenges and Solutions by Almarzuqi A, Kimber S, Quadros K, Senaratne J

“…Ahmed Almarzuqi,1 Shane Kimber,1 Kenneth Quadros,1 Janek Senaratne1,2 1Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada; 2Department of Critical Care Medicine, University of Alberta, Edmonton, CanadaCorrespondence: Janek Senaratne, Tel +1 (780) 463-2184, Fax +1 (780) 450-8359, Email janeks@ualberta.caAbstract: Bidirectional ventricular tachycardia (BiVT) is a rare form of ventricular tachycardia that manifests on surface electrocardiogram by dual QRS morphologies alternating on a beat-to-beat basis. It was first reported in the 1920s as a complication of digoxin, and since then, it has been reported in other conditions including fulminant myocarditis, sarcoidosis, catecholaminergic polymorphic ventricular tachycardia, and Andersen-Tawil syndrome. …”
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Heart rate complexity during the temporary systems dedifferentiation by A.V. Bakhchina, Y.I. Alexandrov

“…We hypothesized that temporary system dedifferentiation (reversible decreasing the number of highly differentiated systems subserving behavior) is accompanied by reduction of heart rate complexity. Beat-to-beat intervals were recorded during stress (Experiment 1) and alcohol administration (Experiment 2). …”
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Spectral analysis of heart rate variability in bronchial asthma. by Garrard, C, Seidler, A, McKibben, A, McAlpine, L, Gordon, D

“…Spectral density of the beat-to-beat heart rate was measured within the low frequency band 0.04 to 0.10 Hz (low frequency power) modulated by sympathetic and parasympathetic activity, and within a 0.12 Hz band width at the respiratory frequency mode (respiratory frequency power) modulated by parasympathetic activity. …”

Fimasartan for independent reduction of blood pressure variability in mild-to-moderate hypertension by Shin MS, Kang DR, Kim C, Cho EJ, Sung KC, Kang SM, Kim DS, Joo SJ, Lee SH, Hwang KK, Park JB

“…BP variability included beat-to-beat variability (clinical) and day-to-day variability (home).Results: Fimasartan reduced BP after 3 months of treatment. …”
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Distal Pulse Measurement Provides Statistical, but not Dynamical, Features of the Central Pulse by Choi, Marya Olegovna, Merkulova, Kseniya Olegovna, Postnov, Dmitry Engelevich

“…Using a high-precision measurement technique, we show that on the way from the heart to distally located measurement points, the value of each individual beat-to-beat time may change. It can happen since each subsequent pulse wave propagates through the vessels with a speed different from the previous one, faster or slower. …”
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The capacities of automated oscillometric blood pressure measuring devices in patients with atrial fibrillation by A N Rogoza, Sh B Goriyeva

“…Beat-to-beat variability of blood pressure (BP) hampers its exact measurements in patients with arrhythmias, which can give rise to diagnostic inaccuracies and accordingly wrong treatment. …”
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Rhythm and groove as cognitive mechanisms of dance intervention in Parkinson's disease. by Anna Krotinger, Psyche Loui

“…We assessed prior music and dance experience, beat perception (Beat Alignment Test), sensorimotor coupling (tapping to high- and low-groove songs), and disease severity (Unified Parkinson's Disease Rating Scale in PD individuals) before and after four months of weekly dance classes. …”
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Cardiovascular dysautonomia in Achalasia Patients: Blood pressure and heart rate variability alterations. by Ana Leonor Rivera, Bruno Estañol, Julio J Macias-Gallardo, Guillermo Delgado-Garcia, Ruben Fossion, Alejandro Frank, Gonzalo M Torres-Villalobos

“…Therefore simultaneous non-invasive records of the heart inter-beat intervals (IBI) and beat-to-beat systolic blood pressure (SBP) of 14 patients (9 female, 5 male) with achalasia were compared with the records of 34 rigorously screened healthy control subjects (17 female, 17 male) in three different conditions: supine, standing up, and controlled breathing at 0.1 Hz, using a variety of measures in the time and spectral domains. …”
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QUANTIFICATION OF RESPIRATORY SINUS ARRHYTHMIA WITH HIGH-FRAMERATE ELECTRICAL IMPEDANCE TOMOGRAPHY by Christoph Hoog Antink, Steffen Leonhardt

“…It is demonstrated that beat-to-beat intervals can be extracted with a median absolute error below 20 ms. …”
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Pulse arrival time: Measurement and clinical applications by Chaitali A Deshmukh, Ghanshyam D Jindal, Uttam R Bagal, Gajanan D Nagare

“…All along there have been efforts to monitor beat-to-beat blood pressure with the help of these time intervals and other pulse parameters. …”
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