Low-Temperature Multiple Micro-Dispensing on Microneedles for Accurate Transcutaneous Smallpox Vaccination by Sang-Gu Yim, Yun-Ho Hwang, Seonyeong An, Keum-Yong Seong, Seo-Yeon Kim, Semin Kim, Hyeseon Lee, Kang-Oh Lee, Mi-Young Kim, Dokeun Kim, You-Jin Kim, Seung-Yun Yang

“…According to WHO guidelines, the smallpox vaccine is administrated by scarification into the epidermis using a bifurcated needle moistened with a vaccine solution. However, this invasive vaccination method involving multiple skin punctures requires a special technique to inoculate, as well as a cold chain for storage and distribution of vaccine solutions containing a live virus. …”
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