Combined Application of Pan-AKT Inhibitor MK-2206 and BCL-2 Antagonist Venetoclax in B-Cell Precursor Acute Lymphoblastic Leukemia by Anna Richter, Elisabeth Fischer, Clemens Holz, Julia Schulze, Sandra Lange, Anett Sekora, Gudrun Knuebel, Larissa Henze, Catrin Roolf, Hugo Murua Escobar, Christian Junghanss

“…In summary, we demonstrate that the pan-AKT inhibitor MK-2206 potently blocks B-ALL cell proliferation and for the first time characterize the synergistic effect of combined MK-2206 and venetoclax treatment in B-ALL.…”
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Influence of Receptor Polymorphisms on the Response to α-Adrenergic Receptor Blockers in Pheochromocytoma Patients by Annika M. A. Berends, Mathieu S. Bolhuis, Ilja M. Nolte, Edward Buitenwerf, Thera P. Links, Henri J. L. M. Timmers, Richard A. Feelders, Elisabeth M. W. Eekhoff, Eleonora P. M. Corssmit, Peter H. Bisschop, Harm R. Haak, Ron H. N. van Schaik, Samira el Bouazzaoui, Bob Wilffert, Michiel N. Kerstens

“…Haplotypes were constructed after determining linkage disequilibrium blocks. <b>Results:</b> The <i>ADRA1B</i> SNP rs10515807 and the <i>ADRA2A</i> SNPs rs553668/rs521674 were associated with higher dosages of α-adrenergic receptor blocker (<i>p</i> < 0.05) and with a higher occurrence of side effects (rs10515807) (<i>p</i> = 0.005). …”
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Sn(IV)-Porphyrin-Based Nanostructures Featuring Pd(II)-Mediated Supramolecular Arrays and Their Photocatalytic Degradation of Acid Orange 7 Dye by Nirmal Kumar Shee, Hee-Joon Kim

“…Two robust Sn(IV)-porphyrin-based supramolecular arrays (<b>1</b> and <b>2</b>) were synthesized via the reaction of <i>trans</i>-Pd(PhCN)₂Cl₂ with two precursor building blocks (<b>SnP¹</b> and <b>SnP²</b>). …”
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Regulation of bFGF-induced effects on rat aortic smooth muscle cells by β3-adrenergic receptors by Yingzi Chang, Lei Alena Dagat, Aisha Yusuf, Yusuf Zahriya, Kotryna Staputyte, Emma Worley, Alex Holt, Natalie Canuteson, Vereena Messieha, Kasey Halila

“…Our results also revealed that suppressing phosphorylation of ERK and AKT blocked bFGF-induced cell migration and that inhibiting AKT phosphorylation reduced bFGF-mediated cell proliferation. …”
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Building Block Engineering toward Realizing High-Performance Electrochromic Materials and Glucose Biosensing Platform by Aliekber Karabag, Dilek Soyler, Yasemin Arslan Udum, Levent Toppare, Gorkem Gunbas, Saniye Soylemez

“…Herein, a series of three thieno[3,4-<i>c</i>]pyrrole-4,6-dione (TPD)-based conjugated monomers, modified with electron-rich selenophene, 3,4-ethylenedioxythiophene (EDOT), or both building blocks (<b>Se-TPD</b>, <b>EDOT-TPD</b>, and <b>EDOT-Se-TPD</b>), were synthesized using Stille cross-coupling and electrochemically polymerized, and their electrochromic properties and applications in a glucose biosensing platform were explored. …”
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Production of Load Bearing Concrete Masonry Units (blocks) From Green Concrete Containing Plastic Waste and Nano Silica Sand Powder by Mohammed Fadhil Qasim, ZENA K. ABBAS, SOHAIR Kadhem Abed

“…When increasing the curing age from 14 to 28 days, blocks (B-285and B-380) change from type B to A. The compressive strength of the types (B-400, B-300, B-200, B-380, and B-285) was (9.65, 7.11, 5.35, 6.57, and 5.86) MPa, respectively, at 14 days and (11.98, 9.33, 6.84, 8.62 and 7.64) MPa respectively at 28 days. …”
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Water repellency in eucalyptus and pine plantation forest soils and its relation to groundwater levels estimated with multi-temporal modeling by Piyaruwan H.I.G.S., Jayasinghe P.K.S.C., Leelamanie D.A.L.

“…Each land was separated into three blocks (B1, B2, B3) based on the slope. Water repellency was measured with water drop penetration time (WDPT) and contact angle. …”
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A Longitudinal Prospective Study: The Effect of Annual Seasonal Transition and Coaching Influence on Aerobic Capacity and Body Composition in Division I Female Soccer Players by Troy M. Purdom, Kyle S. Levers, Chase S. McPherson, Jacob Giles, Lindsey Brown

“…Eleven division 1 female soccer players were tested after five predesignated time blocks (B1–B5): post-season 2016 (B1), nine-week transition (B2), spring season (B3), pre-season (B4), and post-season 2017 (B5). …”
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CLINICAL PROTOCOL FOR THE PREPARATION AND ELECTRON MICROSCOPIC ANALYSIS OF THE OBTAINED PRODUCTS OF AUTOLOGOUS MESOCONCENTRATE – PLASMA RICH IN GROWTH FACTORS (PRGF) by Anatolii P. Oshurko, Ihor Yu. Oliinyk, Tetiana M. Kerimova, Elina S. Pompii

“…Based on our own clinical experience of using the Endoret-PRGF technique (Human Technology, BTI, Spain) to collect, prepare, and form autocellular transplant products rationally, we used the method of morphological study of objects using a stream of electrons that passed through thin films under high voltage, allowing us to study the structure of these objects at the macromolecular and subcellular levels – transmission electron microscopy, which contributed to the study of the density (number of occurrences in 10 μm2 ), diameter (Ø) of the formed fibrin fibers in the PRGF – F1 and F2 fractions of mesoconcentrate products, namely, isolating membranes (M) and obturating blocks (B). An equally important step in PRGF technology is to follow the step-by-step instructions for preparing and using autocellular transplants. …”
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RESULTS OF AN OBSERVATIONAL PROSPECTIVE STUDY OF THE EFFICACY AND SAFETY OF BELIMUMAB (BENLYSTA®) IN SYSTEMIC LUPUS ERYTHEMATOSUS IN REAL CLINICAL PRACTICE by E. A. Aseeva, S. K. Soloviev, A. A. Mesnyankina, T. M. Reshetnyak, N. E. Lopatina, S. I. Glukhova, E. L. Nasonov

“…To evaluate the efficacy of belimumab (BLM), a biological agent, that blocks B-lymphocyte-stimulating factor registered for the treatment of active SLE, is an important task of the practice of rheumatology.Objective: to evaluate the efficacy and safety of BLM in patients with high and moderate SLE activity.Subjects and methods. …”
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The effects of trampling to the abundance and diversity of litter ants in stability of Altered Forest Ecosystem (Safe) Kalabakan, Sabah by Hasrin Rossleykho

“…Winkler extraction method was used to collect litter samples from six blocks namely blocks B, C, D, LFE, Old Growth 2 (OG2), and Oil Palm 3 (OP3). …”
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The effects of trampling to the abundance and diversity of litter ants in Stability of Altered Forest Ecosystem (SAFE) Kalabakan, Sabah by Hasrin Rossleykho

“…Winkler extraction method was used to collect litter samples from six blocks namely blocks B, C, D, LFE, Old Growth 2 (OG2), and Oil Palm 3 (OP3). …”
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Percepção de bloqueio/facilitação de comunicação: um experimento Percepción de bloqueo/facilitación de la comunicación: un experimento Perception of the blocking/facilitating commu... by Lucianne Dalla Bemardina, Maria Márcia Bachion, Emília Campos de Carvalho, Luís de Souza

“…Treatment consisted of interviews with different proportions of categories of facilitating (F) and blocking (B) communication: Group A - 55% F category and 45% B category; Group B - 75% B category and 25% F category, There was no statistical difference between groups in terms of any of the proposed evaluation items. …”
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