A single-cell atlas of the cycling murine ovary by Mary E Morris, Marie-Charlotte Meinsohn, Maeva Chauvin, Hatice D Saatcioglu, Aki Kashiwagi, Natalie A Sicher, Ngoc Nguyen, Selena Yuan, Rhian Stavely, Minsuk Hyun, Patricia K Donahoe, Bernardo L Sabatini, David Pépin

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S188: CAR-T CELLS SHAPE THE IMMUNOLOGICAL POTENTIAL OF THE TUMOR MICROENVIRONMENT by Julia Frede, Julia Poller, Kayleen Shi, Hannah Stuart, Noori Sotoudeh, Klothilda Lim, Caroline Wiggers, Johannes Waldschmidt, Valeriya Dimitrova, Anna Montanaro, Eugene Cho, Tushara Vijaykumar, Paul Richardson, Nikhil Munshi, Kenneth Anderson, Nathan Martin, Shari Kaiser, Marc-Steffen Raab, Birgit Knoechel, Jens Lohr

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Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity by Isaac M Chiu, Lee B Barrett, Erika K Williams, David E Strochlic, Seungkyu Lee, Andy D Weyer, Shan Lou, Gregory S Bryman, David P Roberson, Nader Ghasemlou, Cara Piccoli, Ezgi Ahat, Victor Wang, Enrique J Cobos, Cheryl L Stucky, Qiufu Ma, Stephen D Liberles, Clifford J Woolf

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Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility by Hatice Duygu Saatcioglu, Motohiro Kano, Heiko Horn, Lihua Zhang, Wesley Samore, Nicholas Nagykery, Marie-Charlotte Meinsohn, Minsuk Hyun, Rana Suliman, Joy Poulo, Jennifer Hsu, Caitlin Sacha, Dan Wang, Guangping Gao, Kasper Lage, Esther Oliva, Mary E Morris Sabatini, Patricia K Donahoe, David Pépin

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An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer by Ji Li, Peter S Choi, Christine L Chaffer, Katherine Labella, Justin H Hwang, Andrew O Giacomelli, Jong Wook Kim, Nina Ilic, John G Doench, Seav Huong Ly, Chao Dai, Kimberly Hagel, Andrew L Hong, Ole Gjoerup, Shom Goel, Jennifer Y Ge, David E Root, Jean J Zhao, Angela N Brooks, Robert A Weinberg, William C Hahn

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Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13 by Mei Zeng, Nicholas P Kwiatkowski, Tinghu Zhang, Behnam Nabet, Mousheng Xu, Yanke Liang, Chunshan Quan, Jinhua Wang, Mingfeng Hao, Sangeetha Palakurthi, Shan Zhou, Qing Zeng, Paul T Kirschmeier, Khyati Meghani, Alan L Leggett, Jun Qi, Geoffrey I Shapiro, Joyce F Liu, Ursula A Matulonis, Charles Y Lin, Panagiotis A Konstantinopoulos, Nathanael S Gray

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P324: CELL PLASTICITY PREDETERMINES TREATMENT RESPONSE IN T-ALL by Valeriya Dimitrova, Julia Frede, Anna Montanaro, Sayalee Potdar, Hannah Stuart, Noori Sotoudeh, Alexandria Van Scoyk, Shruti Bhatt, Anthony Letai, Jon Aster, Jens Lohr, Birgit Knoechel

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Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression by Edward Pym, Nikhil Sasidharan, Katherine L Thompson-Peer, David J Simon, Anthony Anselmo, Ruslan Sadreyev, Qi Hall, Stephen Nurrish, Joshua M Kaplan

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MELK is not necessary for the proliferation of basal-like breast cancer cells by Hai-Tsang Huang, Hyuk-Soo Seo, Tinghu Zhang, Yubao Wang, Baishan Jiang, Qing Li, Dennis L Buckley, Behnam Nabet, Justin M Roberts, Joshiawa Paulk, Shiva Dastjerdi, Georg E Winter, Hilary McLauchlan, Jennifer Moran, James E Bradner, Michael J Eck, Sirano Dhe-Paganon, Jean J Zhao, Nathanael S Gray

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Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer by Kevin M Elias, Wojciech Fendler, Konrad Stawiski, Stephen J Fiascone, Allison F Vitonis, Ross S Berkowitz, Gyorgy Frendl, Panagiotis Konstantinopoulos, Christopher P Crum, Magdalena Kedzierska, Daniel W Cramer, Dipanjan Chowdhury

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Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition by Andrew L Hong, Yuen-Yi Tseng, Jeremiah A Wala, Won-Jun Kim, Bryan D Kynnap, Mihir B Doshi, Guillaume Kugener, Gabriel J Sandoval, Thomas P Howard, Ji Li, Xiaoping Yang, Michelle Tillgren, Mahmhoud Ghandi, Abeer Sayeed, Rebecca Deasy, Abigail Ward, Brian McSteen, Katherine M Labella, Paula Keskula, Adam Tracy, Cora Connor, Catherine M Clinton, Alanna J Church, Brian D Crompton, Katherine A Janeway, Barbara Van Hare, David Sandak, Ole Gjoerup, Pratiti Bandopadhayay, Paul A Clemons, Stuart L Schreiber, David E Root, Prafulla C Gokhale, Susan N Chi, Elizabeth A Mullen, Charles WM Roberts, Cigall Kadoch, Rameen Beroukhim, Keith L Ligon, Jesse S Boehm, William C Hahn

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Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence by Michael J Steinbaugh, Sri Devi Narasimhan, Stacey Robida-Stubbs, Lorenza E Moronetti Mazzeo, Jonathan M Dreyfuss, John M Hourihan, Prashant Raghavan, Theresa N Operaña, Reza Esmaillie, T Keith Blackwell

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Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models by M Catarina Silva, Fleur M Ferguson, Quan Cai, Katherine A Donovan, Ghata Nandi, Debasis Patnaik, Tinghu Zhang, Hai-Tsang Huang, Diane E Lucente, Bradford C Dickerson, Timothy J Mitchison, Eric S Fischer, Nathanael S Gray, Stephen J Haggarty

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Seipin is required for converting nascent to mature lipid droplets by Huajin Wang, Michel Becuwe, Benjamin E Housden, Chandramohan Chitraju, Ashley J Porras, Morven M Graham, Xinran N Liu, Abdou Rachid Thiam, David B Savage, Anil K Agarwal, Abhimanyu Garg, Maria-Jesus Olarte, Qingqing Lin, Florian Fröhlich, Hans Kristian Hannibal-Bach, Srigokul Upadhyayula, Norbert Perrimon, Tomas Kirchhausen, Christer S Ejsing, Tobias C Walther, Robert V Farese Jr

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MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells by Yubao Wang, Young-Mi Lee, Lukas Baitsch, Alan Huang, Yi Xiang, Haoxuan Tong, Ana Lako, Thanh Von, Christine Choi, Elgene Lim, Junxia Min, Li Li, Frank Stegmeier, Robert Schlegel, Michael J Eck, Nathanael S Gray, Timothy J Mitchison, Jean J Zhao

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Can computed tomography defined body composition measurements be used as predictors for postoperative outcomes in spinal metastases undergoing surgery? by Olivier Groot, Neal Kapoor, Colleen Buckless, peter Twining, Michiel Bongers, Joseph Schwab, Martin Torriani, Miriam Bredella

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Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells by Wenyang Li, Jennifer Y Chen, Cheng Sun, Robert P Sparks, Lorena Pantano, Raza-Ur Rahman, Sean P Moran, Joshua V Pondick, Rory Kirchner, David Wrobel, Michael Bieler, Achim Sauer, Shannan J Ho Sui, Julia F Doerner, Jörg F Rippmann, Alan C Mullen

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The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response by Sydney Lavoie, Kara L Conway, Kara G Lassen, Humberto B Jijon, Hui Pan, Eunyoung Chun, Monia Michaud, Jessica K Lang, Carey Ann Gallini Comeau, Jonathan M Dreyfuss, Jonathan N Glickman, Hera Vlamakis, Ashwin Ananthakrishnan, Aleksander Kostic, Wendy S Garrett, Ramnik J Xavier

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Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability by Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim

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Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies by Jun Xu, Ah-Ram Kim, Ross W Cheloha, Fabian A Fischer, Joshua Shing Shun Li, Yuan Feng, Emily Stoneburner, Richard Binari, Stephanie E Mohr, Jonathan Zirin, Hidde L Ploegh, Norbert Perrimon

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