Correlates of protection and determinants of SARS-CoV-2 breakthrough infections 1 year after third dose vaccination by Carla Martín Pérez, Ruth Aguilar, Alfons Jiménez, Gemma Salmerón, Mar Canyelles, Rocío Rubio, Marta Vidal, Inocencia Cuamba, Diana Barrios, Natalia Díaz, Rebeca Santano, Pau Serra, Pere Santamaria, Luis Izquierdo, Antoni Trilla, Anna Vilella, Sonia Barroso, Marta Tortajada, Alberto L. García-Basteiro, Gemma Moncunill, Carlota Dobaño

“…Methods We evaluated antibody responses to SARS-CoV-2 spike (S) and nucleocapsid (N) antigens from Wuhan and variants of concern by Luminex and their role in preventing breakthrough infections 1 year after a third dose of mRNA vaccination, in a cohort of health care workers followed since the pandemic onset in Spain (N = 393). …”
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Immunotherapy in hematologic malignancies: past, present, and future by Annie Im, Steven Z. Pavletic

“…Prior to its designation as the Science Breakthrough of the Year in 2013, cancer immunotherapy was active in the treatment of hematologic malignancies. …”
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Novel cancer antigens for personalized immunotherapies: latest evidence and clinical potential by Gregory T. Wurz, Chiao-Jung Kao, Michael W. DeGregorio

“…The clinical success of monoclonal antibody immune checkpoint modulators such as ipilimumab, which targets cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), and the recently approved agents nivolumab and pembrolizumab, which target programmed cell death receptor 1 (PD-1), has stimulated renewed enthusiasm for anticancer immunotherapy, which was heralded by Science as ‘Breakthrough of the Year’ in 2013. As the potential of cancer immunotherapy has been recognized since the 1890s when William Coley showed that bacterial products could be beneficial in cancer patients, leveraging the immune system in the treatment of cancer is certainly not a new concept; however, earlier attempts to develop effective therapeutic vaccines and antibodies against solid tumors, for example, melanoma, frequently met with failure due in part to self-tolerance and the development of an immunosuppressive tumor microenvironment. …”
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Rational design for controlled release of Dicer-substrate siRNA harbored in phi29 pRNA-based nanoparticles by Daniel W. Binzel, Songchuan Guo, Hongran Yin, Tae Jin Lee, Shujun Liu, Dan Shu, Peixuan Guo

“…Small interfering RNA (siRNA) for silencing genes and treating disease has been a dream since ranking as a top Breakthrough of the Year in 2002 by Science. With the recent FDA approval of four siRNA-based drugs, the potential of RNA therapeutics to become the third milestone in pharmaceutical drug development has become a reality. …”
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Current Status for Anaplastic Lymphoma Kinase in Non-small Cell Lung Cancer by Peng SONG, Li ZHANG, Congcong SHANG

“…ALK gene inhibitors have made great breakthrough in recent years, significantly extending the survival period of patients with ALK(+) advanced NSCLC. …”
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Is Artificial Intelligence Better Than Human Clinicians in Predicting Patient Outcomes? by Lee, Joon

“…In contrast with medical imaging diagnostics powered by artificial intelligence (AI), in which deep learning has led to breakthroughs in recent years, patient outcome prediction poses an inherently challenging problem because it focuses on events that have not yet occurred. …”
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Polymerization-Enhanced Photophysical Performances of AIEgens for Chemo/Bio-Sensing and Therapy by Shanshan Huang, Guogang Shan, Chao Qin, Shunjie Liu

“…AIE polymers have been extensively researched in the fields of OLEDs, sensing, and cancer treatment since its first report in 2003, which have achieved numerous breakthroughs during the years. In comparison with small molecules, it can simultaneously combine the unique advantages of AIE materials and the polymer itself, to further enhance their corresponding photophysical performances. …”
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Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics by Robert Gironés Petit, Amanda Cano, Alba Ortiz, Marta Espina, Josefina Prat, Montserrat Muñoz, Patrícia Severino, Eliana B. Souto, Maria L. García, Montserrat Pujol, Elena Sánchez-López

“…Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. …”
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Targeting the CD27-CD70 Pathway to Improve Outcomes in Both Checkpoint Immunotherapy and Allogeneic Hematopoietic Cell Transplantation by Forat Lutfi, Long Wu, Sarah Sunshine, Xuefang Cao, Xuefang Cao

“…Immune checkpoint inhibitor therapies and allogeneic hematopoietic cell transplant (alloHCT) represent two distinct modalities that offer a chance for long-term cure in a diverse array of malignancies and have experienced many breakthroughs in recent years. Herein, we review the CD27-CD70 co-stimulatory pathway and its therapeutic potential in 1) combination with checkpoint inhibitor and other immune therapies and 2) its potential ability to serve as a novel approach in graft-versus-host disease (GVHD) prevention. …”
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A minimalist approach to stereoselective glycosylation with unprotected donors by Hoang, Kim Le Mai, He, Jing-xi, Báti, Gábor, Chan-Park, Mary B., Liu, Xue-Wei

“…Owing to the specific stereo-configuration at each anomeric linkage and diversity in branching, significant breakthroughs in recent years have focused on either stereoselective glycosylation methods or facile assembly of glycan chains. …”
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Advances in the Influence of EGFR Mutation on the PD-L1 Expression in Non-small Cell Lung Cancer by Xiaoyu ZHI, Weiwei LI, Shaowei WANG, Jinliang WANG

“…Researches on the inhibitors of programmed death-1 (PD-1) and programmed death-1 ligand (PD-L1) enjoy considerable breakthroughs in recent years, which has brought relative changes in the therapeutic model of non-small cell lung cancer (NSCLC) at an unexpected speed. …”
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Genetics of Severe Cutaneous Adverse Reactions by Shang-Chen Yang, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Mao-Ying Lin, Zhi-Yang Zhang, Xiao-Yan Jia, Ming Huang, Ya-Fen Zou, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung

“…Advances in identification of multiple genetic alleles associated with specific drugs related SCARS in different populations is an important breakthrough in recent years for prevention of SCARs. This article summarized the findings on genetic factors related to SJS/TEN, especially for HLA.…”
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3D ultrastructure of the nuclear pore complex by Bilokapic, Silvija, Schwartz, Thomas

“…Here we summarize the current state of these structural efforts, describe the breakthroughs of recent years, point out the existing disputes in the field, and give an outlook of what we should expect to happen in the near future.…”
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Pembrolizumab in cervical cancer: latest evidence and clinical usefulness by Edith Borcoman, Christophe Le Tourneau

“…Immunotherapy has represented a breakthrough in recent years in oncology, with antitumor activity reported with immune-checkpoint inhibitors in a variety of tumor types. …”
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Macroscopic negative differential thermal resistance in the overlapping graphene homojunction structure by Rui Wu, He Tian, Zhengqiang Zhu, Yanming Liu, Chao-Yang Xing, Gang Zhang, Tian-Ling Ren

“…Summary: As one of the most potential ways to manipulate heat, thermal functional devices have achieved several breakthroughs in recent years, but are still limited to theoretical simulations. …”
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Metal and Metal Oxide Nanoparticle as a Novel Antibiotic Carrier for the Direct Delivery of Antibiotics by Harshada Kotrange, Agnieszka Najda, Aarti Bains, Robert Gruszecki, Prince Chawla, Mansuri M. Tosif

“…Leading to its modern and profitable uses, emerging nanotechnology is a significant field of research that is considered as the most important scientific breakthrough in recent years. Metal nanoparticles as nanocarriers are currently attracting a lot of interest from scientists, because of their wide range of applications and higher compatibility with bioactive components. …”
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SURVEY OF HYBRID EDFA/RAMAN IN C AND L BANDS by JUAN DAVID BONILLA

“…Optical amplifiers have had a breakthrough in recent years. Initially, amplification of optical signals was performed passing the optical signal to the electrical domain, then the amplified signal back again to the optical domain. …”
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Bottom-up Instance Segmentation using Deep Higher-Order CRFs by Arnab, A, Torr, PHS

“…Traditional Scene Understanding problems such as Object Detection and Semantic Segmentation have made breakthroughs in recent years due to the adoption of deep learning. …”

Resultados de la cirugía de mínimo acceso sobre la válvula aórtica en nuestro centro by Nora García, Aníbal Bermúdez, M. Ángeles Martín, Carmen Carmona, Cristina Jaén, Tomás Daroca

“…Abstract: Minimal access cardiac surgery has been a breakthrough in recent years. Numerousprevious published reports have suggested the results are favorable when compared with conventional surgery and, in some aspects, better. …”
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Les élections de 2018 au Québec : un « moment populiste » ? by Jean Bernatchez

“…The 2018 elections in Quebec marked a breakthrough. After fifty years of alternating power between the centre-right Parti Libéral and the centre-left Parti Québécois, the Coalition Avenir Québec, a right-wing party founded in 2011, is called upon to form a majority government. …”
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