CC-90001, a c-Jun N-terminal kinase (JNK) inhibitor, in patients with pulmonary fibrosis: design of a phase 2, randomised, placebo-controlled trial by Paul W Noble, Luca Richeldi, David A Lynch, Steven Greenberg, THEODORE F REISS, Zoran Popmihajlov, Donna J Sutherland, Gerald S Horan, Atalanta Ghosh

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Undertaking multi-centre randomised controlled trials in primary care: learnings and recommendations from the PULsE-AI trial researchers by Kevin G. Pollock, Carissa Dickerson, Manjit Kainth, Sarah Lawton, Michael Hurst, Daniel M. Sugrue, Chris Arden, D. Wyn Davies, Anne-Céline Martin, Belinda Sandler, Jason Gordon, Usman Farooqui, David Clifton, Christian Mallen, Jennifer Rogers, Nathan R. Hill, A. John Camm, Alexander T. Cohen

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Correction: Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma by Keiji Kurata, Anna James-Bott, Mark A. Tye, Leona Yamamoto, Mehmet K. Samur, Yu-Tzu Tai, James Dunford, Catrine Johansson, Filiz Senbabaoglu, Martin Philpott, Charlotte Palmer, Karthik Ramasamy, Sarah Gooding, Mihaela Smilova, Giorgia Gaeta, Manman Guo, John C. Christianson, N. Connor Payne, Kritika Singh, Kubra Karagoz, Matthew E. Stokes, Maria Ortiz, Patrick Hagner, Anjan Thakurta, Adam Cribbs, Ralph Mazitschek, Teru Hideshima, Kenneth C. Anderson, Udo Oppermann

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Safety outcomes in patients with rheumatoid arthritis treated with abatacept: results from a multinational surveillance study across seven European registries by Alyssa Dominique, Merete Lund Hetland, Axel Finckh, Jacques-Eric Gottenberg, Florenzo Iannone, Roberto Caporali, Tzuyung Douglas Kou, Dan Nordstrom, Maria Victoria Hernandez, Carlos Sánchez-Piedra, Fernando Sánchez-Alonso, Karel Pavelka, T. Christopher Bond, Teresa A. Simon

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Short-, Mid-, and Long-Term Efficacy of Deucravacitinib Versus Biologics and Nonbiologics for Plaque Psoriasis: A Network Meta-Analysis by April W. Armstrong, Richard B. Warren, Yichen Zhong, Joe Zhuo, Allie Cichewicz, Ananth Kadambi, Daniela Junqueira, Tracy Westley, Renata Kisa, Carolin Daamen, Matthias Augustin

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HLA-DRB1 risk alleles for RA are associated with differential clinical responsiveness to abatacept and adalimumab: data from a head-to-head, randomized, single-blind study in autoa... by William Rigby, Jane H. Buckner, S. Louis Bridges, Marleen Nys, Sheng Gao, Martin Polinsky, Neelanjana Ray, Vivian Bykerk

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Comparative risk of malignancies and infections in patients with rheumatoid arthritis initiating abatacept versus other biologics: a multi-database real-world study by Teresa A. Simon, Maarten Boers, Marc Hochberg, Nicole Baker, Mary L. Skovron, Nitesh Ray, Sanket Singhal, Samy Suissa, Andres Gomez-Caminero

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Treatment patterns and outcomes of patients with metastatic non-small cell lung cancer in five European countries: a real-world evidence survey by Hollie Bailey, Adam Lee, Laura Eccles, Yong Yuan, Helen Burlison, Cameron Forshaw, Nebibe Varol

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Estimating the cost-effectiveness of daclatasvir + sofosbuvir versus sofosbuvir + ribavirin for patients with genotype 3 hepatitis C virus by Phil McEwan, Samantha Webster, Thomas Ward, Michael Brenner, Anupama Kalsekar, Yong Yuan

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Cost-effectiveness of entecavir versus lamivudine for the suppression of viral replication in chronic hepatitis B Patients in Brazil by Anna Maria N. Costa, Gilbert L.'Italien, Marcelo Eidi Nita, Evaldo Stanislau A. Araujo

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Malignant pleural mesothelioma: treatment patterns and humanistic burden of disease in Europe by Adam Moore, Bryan Bennett, Gavin Taylor-Stokes, Laura McDonald, Melinda J. Daumont

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Engaging an HIV vaccine target through the acquisition of low B cell affinity by Larance Ronsard, Ashraf S. Yousif, Faez Amokrane Nait Mohamed, Jared Feldman, Vintus Okonkwo, Caitlin McCarthy, Julia Schnabel, Timothy Caradonna, Ralston M. Barnes, Daniel Rohrer, Nils Lonberg, Aaron Schmidt, Daniel Lingwood

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Metabolic profile and cardiovascular risk factors among Latin American HIV-infected patients receiving HAART by P Cahn, O Leite, A Rosales, R Cabello, CA Alvarez, C Seas, C Carcamo, N Cure-Bolt, Gp L'Italien, P Mantilla, L Deibis, C Zala, T Suffert

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Safety and effectiveness of apixaban in Japanese patients with nonvalvular atrial fibrillation in clinical practice: A regulatory postmarketing surveillance, the STANDARD study by Hiroshi Inoue, Michiaki Umeyama, Takako Yamada, Hiroyuki Hashimoto, Akira Komoto, Masahiro Yasaka

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Comparative effectiveness of abatacept versus TNF inhibitors in rheumatoid arthritis patients who are ACPA and shared epitope positive by Leslie R. Harrold, Keith Wittstock, Sheila Kelly, Xue Han, Joe Zhuo, Amy Schrader, Nicole Middaugh, Page C. Moore, Vadim Khaychuk

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P901: POMALIDOMIDE, BORTEZOMIB, AND DEXAMETHASONE IN LENALIDOMIDE–PRETREATED MULTIPLE MYELOMA: A SUBANALYSIS OF OPTIMISMM BY FRAILTY by A. Oriol, M. Dimopoulos, F. Schjesvold, M. Beksac, M. Yagci, A. Larocca, S. Guo, Y. Mu, K. Hong, S. Dhanasiri, P. Richardson, K. Weisel

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Unintended consequences of machine learning in medicine? [version 1; referees: 2 approved] by Laura McDonald, Sreeram V. Ramagopalan, Andrew P. Cox, Mustafa Oguz

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Quantitative Systems Pharmacology Can Reduce Attrition and Improve Productivity in Pharmaceutical Research and Development by Tarek A Leil, Richard J Bertz

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RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition by Ting Jin, Hugo Lavoie, Malha Sahmi, Maud David, Christine Hilt, Amy Hammell, Marc Therrien

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Endogenous opioids regulate moment-to-moment neuronal communication and excitability by Bryony L. Winters, Gabrielle C. Gregoriou, Sarah A. Kissiwaa, Oliver A. Wells, Danashi I. Medagoda, Sam M. Hermes, Neil T. Burford, Andrew Alt, Sue A. Aicher, Elena E. Bagley

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