A mechanistic kinetic description of lactate dehydrogenase elucidating cancer diagnosis and inhibitor evaluation by Peifeng Tang, Jianlin Xu, Christopher L. Oliveira, Zheng Jian Li, Shijie Liu

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Four-year clinical update and treatment switching-adjusted outcomes with first-line nivolumab plus ipilimumab with chemotherapy for metastatic non-small cell lung cancer in the Che... by Enriqueta Felip, David P. Carbone, Martin Reck, Luis Paz-Ares, Yong Yuan, Nan Hu, Niels Reinmuth, Xiaoqing Zhang, Thomas John, Ying Cheng, Shun Lu, Manuel Cobo, Michael Schenker, Tudor-Eliade Ciuleanu, Stéphanie Bordenave, Oscar Juan-Vidal, Juliana Menezes, Eduardo Richardet, Hideaki Mizutani, Bogdan Zurawski, Aurelia Alexandru, Javed Mahmood, Tuli De, Irene Santi, John R. Penrod, Adam Lee

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Temporal Responses of a Low-Energy Meal Replacement Plan or Exercise Training on Cardiovascular Function and Fibro-Inflammatory Markers in People with Type 2 Diabetes—A Secondary A... by Joanna M. Bilak, Gaurav S. Gulsin, Vasiliki Bountziouka, Kelly S. Parke, Emma Redman, Joseph Henson, Lei Zhao, Phillipe Costet, Mary Ellen Cvijic, Juan Maya, Ching-Pin Chang, Melanie J. Davies, Thomas Yates, Gerry P. McCann, Emer M. Brady

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Evolution of treatment patterns and survival outcomes in patients with advanced non-small cell lung cancer treated at Frankfurt University Hospital in 2012–2018 by Andrea Wolf, Jan A. Stratmann, Shabnam Shaid, Nicolas Niklas, Alan Calleja, Harveen Ubhi, Robin Munro, Daniela Waldenberger, Robert Carroll, Melinda J. Daumont, John R. Penrod, Laure Lacoin, Gernot Rohde

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Patient-reported Effects of Fedratinib, an Oral, Selective Inhibitor of Janus Kinase 2, on Myelofibrosis-related Symptoms and Health-related Quality of Life in the Randomized, Plac... by Ruben A. Mesa, Nicolaas Schaap, Alessandro M. Vannucchi, Jean-Jacques Kiladjian, Francesco Passamonti, Sonja Zweegman, Moshe Talpaz, Srdan Verstovsek, Shelonitda Rose, Pranav Abraham, Jennifer Lord-Bessen, Derek Tang, Shien Guo, Xiaomei Ye, Claire N. Harrison

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Psychometric evaluation of the NTDT-PRO questionnaire for assessing symptoms in patients with non-transfusion-dependent beta-thalassaemia by Ali T Taher, Maria Domenica Cappellini, Khaled M Musallam, Vip Viprakasit, Antonis Kattamis, Jennifer Lord-Bessen, Aylin Yucel, Shien Guo, Christopher Pelligra, Alan L Shields, Jeevan K Shetty, Dimana Miteva, Luciana Moro Bueno

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Pan-cancer analysis of the effect of biopsy site on tumor mutational burden observations by Simon Papillon-Cavanagh, Julia F. Hopkins, Shakti H. Ramkissoon, Lee A. Albacker, Alice M. Walsh

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A review of data sharing statements in observational studies published in the BMJ: A cross-sectional study [version 2; referees: 2 approved] by Laura McDonald, Anna Schultze, Alex Simpson, Sophie Graham, Radek Wasiak, Sreeram V. Ramagopalan

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External Quality Assessment 2.0: The Importance of a Standardized Implementation of TILs for Daily and Trial Practices by Inne Nauwelaers, Nele Laudus, Dieter Peeters, Balazs Acs, Carsten Denkert, Stefan Michiels, Hugo Horlings, Kalliopi P. Siziopikou, Scott Ely, Dimitrios Zardavas, Roberts Mustimbo, John Bartlett, Giuseppe Floris, Johan Hartman, Carolien H. M. van Deurzen, Dorien Ceusters, Els Dequeker, Roberto Salgado

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Software-aided detection and structural characterization of cyclic peptide metabolites in biological matrix by high-resolution mass spectrometry by Ming Yao, Tingting Cai, Eva Duchoslav, Li Ma, Xu Guo, Mingshe Zhu

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Suboptimal Clinical and Quality of Life Outcomes in Patients with Psoriasis Undertreated with Oral Therapies: International Physician and Patient Survey by Sydney Thai, Sophie Barlow, James Lucas, James Piercy, Yichen Zhong, Joe Zhuo, Jashin J. Wu

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Image analysis reveals molecularly distinct patterns of TILs in NSCLC associated with treatment outcome by Ruiwen Ding, Prateek Prasanna, Germán Corredor, Cristian Barrera, Philipp Zens, Cheng Lu, Priya Velu, Patrick Leo, Niha Beig, Haojia Li, Paula Toro, Sabina Berezowska, Vipul Baxi, David Balli, Merzu Belete, David L. Rimm, Vamsidhar Velcheti, Kurt Schalper, Anant Madabhushi

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Organizational Impact of Immunotherapies in Advanced Cancers in France by Valentine Grumberg, Christos Chouaïd, Anne-Françoise Gaudin, Christophe Le Tourneau, Aurélien Marabelle, Isabelle Bongiovanni-Delarozière, François-Emery Cotté, Isabelle Borget

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3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering by Atabak Ghanizadeh Tabriz, Quentin Gonot-Munck, Arnaud Baudoux, Vivek Garg, Richard Farnish, Orestis L. Katsamenis, Ho-Wah Hui, Nathan Boersen, Sandra Roberts, John Jones, Dennis Douroumis

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Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus by Whaley JM, Tirmenstein M, Reilly TP, Poucher SM, Saye J, Parikh S, List JF

“…Jean M Whaley,1 Mark Tirmenstein,2 Timothy P Reilly,2 Simon M Poucher,3 JoAnne Saye,4 Shamik Parikh,5 James F List61Bristol-Myers Squibb, Metabolic Disease Discovery Biology, Research and Development, Princeton, NJ, USA; 2Bristol-Myers Squibb, Drug Safety Evaluation, Research and Development, New Brunswick and Princeton, NJ, USA; 3AstraZeneca, Cardiovascular and Gastrointestinal Innovative Medicines Science Unit, Alderley Park, Macclesfield, Cheshire, UK; 4AstraZeneca, Global Safety Assessment, Research and Development, Wilmington, DE, USA; 5AstraZeneca, Cardiovascular, Clinical Development, Wilmington, DE, USA; 6Bristol-Myers Squibb, Global Clinical Development, Research and Development, Princeton, NJ, USAAbstract: Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a novel class of glucuretic, antihyperglycemic drugs that target the process of renal glucose reabsorption and induce glucuresis independently of insulin secretion or action. …”
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Treatment and disease management patterns for bacillus Calmette-Guérin unresponsive nonmuscle invasive bladder cancer in North America, Europe and Asia: A real-world data analysis by Edward I. Broughton, Danielle S. Chun, Kyna M. Gooden, Katie L. Mycock, Ivana Rajkovic, Gavin Taylor-Stokes

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Engineering an Antibody V Gene-Selective Vaccine by Larance Ronsard, Ashraf S. Yousif, Julianne Peabody, Vintus Okonkwo, Pascal Devant, Alemu Tekewe Mogus, Ralston M. Barnes, Daniel Rohrer, Nils Lonberg, David Peabody, Bryce Chackerian, Daniel Lingwood

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Switching to Another Oral Anticoagulant and Drug Discontinuation Among Elderly Patients With Nonvalvular Atrial Fibrillation Treated With Different Direct Oral Anticoagulants by Christine L. Baker JD, MPH, Amol D. Dhamane BPharm, MS, Jigar Rajpura PhD, Jack Mardekian PhD, Oluwaseyi Dina MPH, Cristina Russ MD, PhD, Lisa Rosenblatt MD, MPH, Melissa Lingohr-Smith PhD, Jay Lin PhD, MBA

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Selective Histone Deacetylase Inhibitor ACY-241 (Citarinostat) Plus Nivolumab in Advanced Non-Small Cell Lung Cancer: Results From a Phase Ib Study by Mark M. Awad, Yvan Le Bruchec, Brian Lu, Jason Ye, JulieAnn Miller, Patrick H. Lizotte, Megan E. Cavanaugh, Amanda J. Rode, Calin Dan Dumitru, Alexander Spira

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Fedratinib Improves Myelofibrosis-related Symptoms and Health-related Quality of Life in Patients with Myelofibrosis Previously Treated with Ruxolitinib: Patient-reported Outcomes... by Claire N. Harrison, Nicolaas Schaap, Alessandro M. Vannucchi, Jean-Jacques Kiladjian, Eric Jourdan, Richard T. Silver, Harry C. Schouten, Francesco Passamonti, Sonja Zweegman, Moshe Talpaz, Srdan Verstovsek, Derek Tang, Pranav Abraham, Jennifer Lord-Bessen, Shelonitda Rose, Shien Guo, Weiqin Liao, Ruben A. Mesa

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