Trends in characteristics and outcomes among US adults hospitalised with COVID-19 throughout 2020: an observational cohort study by Jie Zhang, Peter Yu, Ying Bao, Cathy W Critchlow, Corina Bennett, Fang He, Julia Zhu, Zhongyuan Wei, Qian Xia, Jenny Jiang, Olulade Ayodele, Brian D Bradbury, Corinne Brooks, Carolyn A Brown, Alvan Cheng, Giovanna Devercelli, Kathleen Gondek, Ajit A Londhe, Junjie Ma, Michele Jonsson-Funk, Hillary A Keenan, Kaili Ren, Lynn Sanders, Linyun Zhou, John H Page, J Michael Sprafka, Megan Braunlin, Prista Charuworn, Karminder Gill, Jeffrey Petersen, Katherine B Carlson, Shun-Chiao Chang, Kimberly A Roehl, Luyang Wang

Get full text

Long-term use of dasatinib in patients with metastatic castration-resistant prostate cancer after receiving the combination of dasatinib and docetaxel by Araujo JC, Trudel GC, Paliwal P

“…John C Araujo,1 Geralyn C Trudel,2 Prashni Paliwal3 1Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Bristol-Myers Squibb, Montreal, Quebec, Canada; 3Bristol-Myers Squibb, Wallingford, CT, USA Abstract: Dasatinib is a potent oral tyrosine kinase inhibitor which targets several kinases, including the SRC family kinases. …”
Get full text

PB2017: CLINICAL OUTCOMES BY SF3B1 MUTATION STATUS IN PATIENTS WITH LOWER-RISK MYELODYSPLASTIC SYNDROMES RETREATED WITH ERYTHROPOIESIS-STIMULATING AGENTS by Guillermo Garcia-Manero, Rayna K. Matsuno, Ali Mcbride, Adeola Y Makinde, Thomas D. Brown, Danny Idryo, Ronda Broome, Autumn Herriman, Kristiana Wilkinson, Sheetal Walters, Andrew Schrag, Hina Mohammed, Monika A. Izano, Sudipto Mukherjee

Get full text

P700: TREATMENT-FREE REMISSION (TFR) AFTER DASATINIB IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA IN CHRONIC PHASE (CML-CP) AND DEEP MOLECULAR RESPONSE (DMR): FINAL 5-YEAR RESULTS OF... by N. P. Shah, V. García-Gutiérrez, A. Jiménez-Velasco, S. Saussele, D. Rea, F.-X. Mahon, M. Y. Levy, M. T. Gómez-Casares, M. J. Mauro, O. Sy, P. Martin-Regueira, J. H. Lipton

Get full text

Lubricants in Pharmaceutical Solid Dosage Forms by Jinjiang Li, Yongmei Wu

Get full text

Matching-Adjusted Indirect Comparison of the Long-Term Efficacy of Deucravacitinib Versus Adalimumab for Moderate to Severe Plaque Psoriasis by April W. Armstrong, Sang Hee Park, Vardhaman Patel, Malcolm Hogan, Wei-Jhih Wang, David Davidson, Viktor Chirikov

Get full text

Randomised, siteless study to compare systematic atrial fibrillation screening using enrichment by a risk prediction model with standard care in a Swedish population aged ≥ 65 year... by Peter Magnusson, Johan Engdahl, Emma Sandgren, Angelo Modica, Farzaneh Etminani, Johan Holm, Karin Moberg, Thomas Davidsson, Linda Stalpe, Sara Kiflemariam, Ninia Younan, Purvee Parikh, Manish Wadhwa, Anna Sundin

Get full text

Real-World Recurrence Rates and Economic Burden in Patients with Resected Early-Stage Melanoma by Sekwon Jang, Tayla Poretta, Tarun Bhagnani, Qing Harshaw, Matthew Burke, Sumati Rao

Get full text

Effects of tumor grade and dexamethasone on myeloid cells in patients with glioma by Kara W Moyes, Amira Davis, Virginia Hoglund, Kristen Haberthur, Nicole AP Lieberman, Shannon A Kreuser, Gail H. Deutsch, Stephanie Franco, Darren Locke, Michael O Carleton, Debra G Gilbertson, Randi Simmons, Conrad Winter, John Silber, Luis F Gonzalez-Cuyar, Richard G Ellenbogen, Courtney A. Crane

Get full text

Differential effects of dosing regimen on the safety and efficacy of dasatinib: retrospective exposure–response analysis of a Phase III study by Wang X, Roy A, Hochhaus A, Kantarjian HM, Chen TT, Shah NP

“…Xiaoning Wang,1 Amit Roy,2 Andreas Hochhaus,3 Hagop M Kantarjian,4 Tai-Tsang Chen,5 Neil P Shah6 1Discovery Medicine and Clinical Pharmacology, Bristol-Myers Squibb, Lawrenceville, NJ, USA; 2Clinical Pharmacology and Pharmacometrics, Research and Development, Bristol-Myers Squibb, Lawrenceville, NJ, USA; 3Hematology/Oncology, Jena University Hospital, Jena, Germany; 4Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 5Department of Global Biometric Sciences, Bristol-Myers Squibb, Wallingford, CT, USA; 6Hematology/Oncology, University of California, San Francisco School of Medicine, San Francisco, CA, USA Purpose: Dasatinib is a prototypic short half-life BCR-ABL1 tyrosine kinase inhibitor. …”
Get full text

Real-world treatment patterns and survival outcomes for advanced non-small cell lung cancer in the pre-immunotherapy era in Portugal: a retrospective analysis from the I-O Optimise... by Marta Soares, Luís Antunes, Patrícia Redondo, Marina Borges, Ruben Hermans, Dony Patel, Fiona Grimson, Robin Munro, Carlos Chaib, Laure Lacoin, Melinda Daumont, John R. Penrod, John C. O’Donnell, Maria José Bento, Francisco Rocha Gonçalves

Get full text

Management of adverse events in patients with acute myeloid leukemia in remission receiving oral azacitidine: experience from the phase 3 randomized QUAZAR AML-001 trial by Farhad Ravandi, Gail J. Roboz, Andrew H. Wei, Hartmut Döhner, Christopher Pocock, Dominik Selleslag, Pau Montesinos, Hamid Sayar, Maurizio Musso, Angela Figuera-Alvarez, Hana Safah, William Tse, Sang Kyun Sohn, Devendra Hiwase, Timothy Chevassut, Francesca Pierdomenico, Ignazia La Torre, Barry Skikne, Rochelle Bailey, Jianhua Zhong, C. L. Beach, Herve Dombret

Get full text

Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles by Sarah Alice Long, Virginia S. Muir, Britta E. Jones, Valerie Z. Wall, Alyssa Ylescupidez, Anne M. Hocking, Stephan Pribitzer, Jerill Thorpe, Bryce Fuchs, Alice E. Wiedeman, Megan Tatum, Katharina Lambert, Hannes Uchtenhagen, Cate Speake, Bernard Ng, Bernard Ng, Bernard Ng, Alexander T. Heubeck, Troy R. Torgerson, Adam K. Savage, Michael A. Maldonado, Neelanjana Ray, Vadim Khaychuk, Jinqi Liu, Peter S. Linsley, Jane H. Buckner

Get full text

B Cell Mobilization, Dissemination, Fine Tuning of Local Antigen Specificity and Isotype Selection in Asthma by Line Ohm-Laursen, Line Ohm-Laursen, Hailong Meng, Kenneth B. Hoehn, Nima Nouri, Nima Nouri, Yue Jiang, Chris Clouser, Timothy G. Johnstone, Ron Hause, Balraj S. Sandhar, Balraj S. Sandhar, Nadine E. G. Upton, Nadine E. G. Upton, Elfy B. Chevretton, Raj Lakhani, Chris J. Corrigan, Chris J. Corrigan, Steven H. Kleinstein, Steven H. Kleinstein, Steven H. Kleinstein, Hannah J. Gould, Hannah J. Gould

Get full text

Community - Secure the future: seven steps to involve the community in HIV/AIDS treatment support programmes by Richard Sebastian Wanless

Get full text

The Emerging Discipline of Quantitative Systems Pharmacology by Tarek A Leil, Sergey eErmakov

Get full text

Generation of a clonal induced pluripotent stem cell (iPSC) line expressing the mutant MECP2 allele from a Rett Syndrome patient fibroblast line by Lisa Hunihan, Jeffrey Brown, Angela Cacace, Alda Fernandes, Andrea Weston

Get full text

Retrospective analysis of drug utilization, health care resource use, and costs associated with IFN therapy for adjuvant treatment of malignant melanoma by Zhang Y, Le TK, Shaw JW, Kotapati S

“…≥Ying Zhang,1 Trong Kim Le,1 James W Shaw,2 Srividya Kotapati31Center for Observational Research and Data Sciences, Worldwide Health Economics and Outcomes Research, Bristol-Myers Squibb Research and Development, Hopewell, NJ, USA; 2Worldwide Health Economics and Outcomes Research, Bristol-Myers Squibb Research and Development, Princeton, NJ, USA; 3Worldwide Health Economics and Outcomes Research, Bristol-Myers Squibb Research and Development, Wallingford Center, CT, USABackground: This study examines real-world drug utilization patterns, health care resource use, and costs among patients receiving adjuvant treatment with IFN versus patients receiving no treatment ("observation") for malignant melanoma following surgery.Methods: A retrospective cohort study was conducted using administrative claims from Truven Health Analytics (MarketScan®) to identify all adjuvant melanoma patients (aged ≥18 years) diagnosed between June 2007 and June 2011 who had a lymph node dissection (ie, index surgery) and were treated with IFN or subsequently observed. …”
Get full text

Real-world study of the impact of recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) on quality of life and productivity in Europe by Prianka Singh, Bryan Bennett, Tom Bailey, Gavin Taylor-Stokes, Ivana Rajkovic, Marta Contente, Sharon Curtis, Chris Curtis

Get full text

Major Bleeding Complications and Persistence With Oral Anticoagulation in Non‐Valvular Atrial Fibrillation: Contemporary Findings in Real‐Life Danish Patients by Morten Lamberts, Laila Staerk, Jonas Bjerring Olesen, Emil Loldrup Fosbøl, Morten Lock Hansen, Louise Harboe, Cinira Lefevre, David Evans, Gunnar Hilmar Gislason

Get full text