TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM by Alice L. Hung, Russell Maxwell, Debebe Theodros, Zineb Belcaid, Dimitrios Mathios, Andrew S. Luksik, Eileen Kim, Adela Wu, Yuanxuan Xia, Tomas Garzon-Muvdi, Christopher Jackson, Xiaobu Ye, Betty Tyler, Mark Selby, Alan Korman, Bryan Barnhart, Su-Myeong Park, Je-In Youn, Tamrin Chowdhury, Chul-Kee Park, Henry Brem, Drew M. Pardoll, Michael Lim

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Evaluating Treatment Choice in Patients with Moderate to Severe Psoriasis in the United States: Results from a US Patient Survey by April W. Armstrong, Sayeli Jayade, Sanika Rege, Namita Joshi, Vardhaman Patel, Samaneh Kalirai, Daniel Wolin, Kimberly Boyle, Dipen Patel, Lauren Seigel

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Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety by Wei Gao, Hongxiang Hu, Lipeng Dai, Miao He, Hebao Yuan, Huixia Zhang, Jinhui Liao, Bo Wen, Yan Li, Maria Palmisano, Mohamed Dit Mady Traore, Simon Zhou, Duxin Sun

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Identification of poor prognostic joint locations in an early rheumatoid arthritis cohort at risk of rapidly progressing disease: a post-hoc analysis of the Phase III AGREE study by Patrick Durez, Rene Westhovens, Femke Baeke, Yedid Elbez, Sofie Robert, Harris A. Ahmad

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Can real-world data really replace randomised clinical trials? by Sreeram V. Ramagopalan, Alex Simpson, Cormac Sammon

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733 Integrative molecular profiling of high-grade primary prostate cancer identifies patients with a biomarker profile that favors the combination of standard of care (SOC) therapy... by David Nelson, Christos Hatzis, Jimena Trillo-Tinoco, Evisa Gjini, Ana Lako, Michaela Bowden, Andrew Browne, Ryan Powles, Tai Wang, Christine Tauras, Ruben Ferrer-Luna, Zoe Bleicher, Timothy Consedine, Chensheng Zhou, Evan Kelemen, Anne Lewin, Catherine King, Sumit Bhattacharya, Harris Bell-Temin, Ashok Dongre, Kenzie Macisaac, Fadi Towfic, Benjamin Chen

A quantum chemical interaction energy dataset for accurately modeling protein-ligand interactions by Steven A. Spronk, Zachary L. Glick, Derek P. Metcalf, C. David Sherrill, Daniel L. Cheney

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Snap-on Adaptor for Microtiter Plates to Enable Continuous-Flow Microfluidic Screening and Harvesting of Crystalline Materials by Paria Coliaie, Rajan R. Bhawnani, Rabia Ali, Manish S. Kelkar, Akshay Korde, Marianne Langston, Chengxiang Liu, Neda Nazemifard, Daniel B. Patience, Tamar Rosenbaum, Dimitri Skliar, Nandkishor K. Nere, Meenesh R. Singh

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P1042: SAFETY AND TOLERABILITY RESULTS FROM THE PHASE 3B FREEDOM TRIAL OF FEDRATINIB (FEDR), AN ORAL, SELECTIVE JAK2 INHIBITOR, IN PATIENTS WITH MYELOFIBROSIS (MF) PREVIOUSLY TREAT... by V. Gupta, A. Yacoub, S. Verstovsek, R. A. Mesa, C. N. Harrison, G. Barosi, J.-J. Kiladjian, H. J. Deeg, S. Fazal, L. Foltz, R. J. Mattison, C. B. Miller, V. Parameswaran, C. Hernandez, J. Zhang, M. Talpaz

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P1517: REAL-WORLD COMPLICATION BURDEN AND DISEASE MANAGEMENT IN TRANSFUSION-DEPENDENT ADULTS WITH ΒETA-THALASSEMIA (Β-THAL) IN GREECE: FINAL RESULTS OF THE EPIDEMIOLOGICAL CROSS-SE... by A. Kattamis, E. Voskaridou, S. Delicou, E. Klironomos, I. Lafiatis, F. Petropoulou, M. D. Diamantidis, S. Lafioniatis, L. Evliati, E. Kapsali, K. Karvounis-Marolachakis, D. Timotheatou, C. Deligianni, P. Viktoratos, A. Kourakli

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Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma by Keiji Kurata, Anna-James Bott, Mark A. Tye, Leona Yamamoto, Mehmet K. Samur, Yu-Tzu Tai, James Dunford, Catrine Johansson, Filiz Senbabaoglu, Martin Philpott, Charlotte Palmer, Karthik Ramasamy, Sarah Gooding, Mihaela Smilova, Giorgia Gaeta, Manman Guo, John C. Christianson, N. Connor Payne, Kritika Singh, Kubra Karagoz, Matthew E. Stokes, Maria Ortiz, Patrick Hagner, Anjan Thakurta, Adam Cribbs, Ralph Mazitschek, Teru Hideshima, Kenneth C. Anderson, Udo Oppermann

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Global pharmaceutical firms in Singapore : the organization of R&D activities. by Prabjote Kaur., Teo, Wai Keong., Zhuang, Xiang Hong.

“…Case study on the organization of R&D activities of 3 global pharmaceutical firms in Singapore namely, Bristol-Myers Squibb, GlaxoSmithKline and Eli Lilly.…”
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Staged endovascular and surgical treatment of a hemorrhagic colorectal venous malformation by Naiem Nassiri, MD, RPVI, Dustin T. Crystal, BS, Vyacheslav Gendel, MD, Francesco Pontoriero, DO, Amy N. Tilara, MD, Susan Murphy, MD, Yi-Horng Lee, MD

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Shallow shotgun sequencing reduces technical variation in microbiome analysis by Alex J. La Reau, Noah B. Strom, Ellen Filvaroff, Konstantinos Mavrommatis, Tonya L. Ward, Dan Knights

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Changing the drug development and therapeutic paradigm with biologic drug combinations and bispecifics: How to choose between these two approaches? by Songmao Zheng, Rodney Prell, Jennifer Sheng, Yow‐Ming Wang, Lora Hamuro

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Correction to: Safety and efficacy of nivolumab in combination with sunitinib or pazopanib in advanced or metastatic renal cell carcinoma: the CheckMate 016 study by Asim Amin, Elizabeth R. Plimack, Marc S. Ernstoff, Lionel D. Lewis, Todd M. Bauer, David F. McDermott, Michael Carducci, Christian Kollmannsberger, Brian I. Rini, Daniel Y. C. Heng, Jennifer Knox, Martin H. Voss, Jennifer Spratlin, Elmer Berghorn, Lingfeng Yang, Hans J. Hammers

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Aiming for a standardized protocol for preparing a process green synthesis report and for ranking multiple synthesis plans to a common target product by Andraos John

“…Illustrative examples of process green synthesis reports are given for the following pharmaceuticals: 5-HT2B and 5-HT7 receptors antagonist (Astellas Pharma), brivanib (Bristol-Myers Squibb), and orexin receptor agonist (Merck). …”
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Real-world treatment sequencing and survival in previously treated advanced renal cell carcinoma patients receiving nivolumab monotherapy: a UK retrospective cohort study by T. Waddell, K. Fife, R. Griffiths, A. Sharma, P. Dhokia, L. Groves, M. Hurst, C. Tsang, D. Sugrue, S. McKenna, J. Houghton, R. Carroll

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The genetic architecture of NAFLD among inbred strains of mice by Simon T Hui, Brian W Parks, Elin Org, Frode Norheim, Nam Che, Calvin Pan, Lawrence W Castellani, Sarada Charugundla, Darwin L Dirks, Nikolaos Psychogios, Isaac Neuhaus, Robert E Gerszten, Todd Kirchgessner, Peter S Gargalovic, Aldons J Lusis

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Real-world predictors of 12–month intravenous abatacept retention in patients with rheumatoid arthritis in the ACTION observational study by Xavier Mariette, Alain Cantagrel, Rieke Alten, Manuela Le Bars, Yedid Elbez, Hanns-Martin Lorenz, Mauro Galeazzi, Hubert G Nüßlein, Melanie Chartier, Christiane Rauch

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