Supplementing Claims Data with Electronic Medical Records to Improve Estimation and Classification of Rheumatoid Arthritis Disease Activity: A Machine Learning Approach by Candace H. Feldman, Kazuki Yoshida, Chang Xu, Michelle L. Frits, Nancy A. Shadick, Michael E. Weinblatt, Sean E. Connolly, Evo Alemao, Daniel H. Solomon

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Hospitalisation costs of metastatic melanoma in France; the MELISSA study (MELanoma In hoSpital coSts Assessment) by Jérôme Fernandes, Bruno Bregman, Patrick Combemale, Camille Amaz, Lucie de Léotoing, Alexandre Vainchtock, Anne-Françoise Gaudin

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Relative value assessment: characterizing the benefit of oncology therapies through diverse survival metrics from a US perspective by Macaulay R, Ahuja A, Ademisoye E, Juarez-Garcia A, Shaw JW

“…Richard Macaulay,1 Amit Ahuja,2 Ebenezer Ademisoye,1 Ariadna Juarez-Garcia,3 James W Shaw4 1PAREXEL Access Consulting, London, UK; 2PAREXEL Access Consulting, Union Territory of Chandigarh, India; 3Bristol-Myers Squibb, Mexico City, Mexico; 4Bristol-Myers Squibb, Princeton, NJ, USA Objectives: The introduction of innovative, high-cost oncology treatments, coupled with mounting budgetary pressures, necessitates value trade-offs across cancer types. …”
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Evaluation of antisense oligonucleotide therapy targeting Hsd17b13 in a fibrosis mice model by Yanling Ma, Hong Cai, Julia Smith, Ching-Hsuen Chu, Stephen E. Mercer, Stephanie Boehm, Ivar Mcdonald, Bradley Zinker, Dong Cheng

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Comparative Evaluation of the Powder and Tableting Properties of Regular and Direct Compression Hypromellose from Different Vendors by Nihad Mawla, Maen Alshafiee, John Gamble, Mike Tobyn, Lande Liu, Karl Walton, Barbara R. Conway, Peter Timmins, Kofi Asare-Addo

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Systematic literature review of treatment patterns for venous thromboembolism patients during transitions from inpatient to post-discharge settings by Trocio J, Rosen VM, Gupta A, Dina O, Vo L, Hlavacek P, Rosenblatt L

“…Jeffrey Trocio,1 Virginia M Rosen,2 Anu Gupta,3 Oluwaseyi Dina,1 Lien Vo,4 Patrick Hlavacek,1 Lisa Rosenblatt5 1US Health Economics and Outcomes Research Pfizer Inc., New York, NY, USA; 2Health Economics and Outcomes Research, Optum Inc., Eden Prairie, MN, USA; 3US Medical Affairs, Pfizer Inc., New York, NY, USA; 4US Health Economics and Outcomes Research, Bristol-Myers Squibb, Lawrenceville, NJ, USA; 5US Medical Affairs, Bristol-Myers Squibb, Lawrenceville, NJ, USA Introduction: Direct oral anticoagulants (DOACs) have emerged as viable alternatives to traditional treatments such as vitamin K antagonists (VKAs) for venous thromboembolism (VTE). …”
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Adjuvant nivolumab for stage III/IV melanoma: evaluation of safety outcomes and association with recurrence-free survival by James Larkin, Jeffrey Weber, Victoria Atkinson, Michael Millward, Ivan Marquez-Rodas, Luis de la Cruz-Merino, Helen Gogas, Paolo A Ascierto, Anna Maria Di Giacomo, Veerle de Pril, Vanna Chiarion-Sileni, Stephane Dalle, Leslie Fecher, Ana Arance, Jean-Jacques Grob, Nikhil I Khushalani, Michele Del Vecchio, Mario Mandala, C Lance Cowey, Michael Schenker, Petr Arenberger, Maurice Lobo

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Cross-company evaluation of the human lymphocyte activation assay by Mark Collinge, Patricia Schneider, Dingzhou Li, Stanley Parish, Carolyne Dumont, Wendy Freebern, Joseph Ghanime, Fanny Guimont-Derochers, Anja Langenkamp, Jose Lebron, Nianyu Li, Celine Marban, Lisa Plitnick, Jennifer Wheeler

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Structured expert elicitation to inform long-term survival extrapolations using alternative parametric distributions: a case study of CAR T therapy for relapsed/ refractory multipl... by Dieter Ayers, Shannon Cope, Kevin Towle, Ali Mojebi, Thomas Marshall, Devender Dhanda

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The NMDA receptor co-agonists, d-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex by Darrick T. Balu, Alo C. Basu, John P. Corradi, Angela M. Cacace, Joseph T. Coyle

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Improved efficacy/safety profile of factor XIa inhibitor BMS‐724296 versus factor Xa inhibitor apixaban and thrombin inhibitor dabigatran in cynomolgus monkeys by Pancras C. Wong, Mimi L. Quan

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First-line nivolumab plus ipilimumab for metastatic non-small cell lung cancer, including patients with ECOG performance status 2 and other special populations: CheckMate 817 by Enriqueta Felip, Helena Linardou, Fabrice Barlesi, Michele Maio, Luis Paz-Ares, Jonathan W Goldman, Karim Vermaelen, Osvaldo Arén Frontera, Erika Rijavec, Kevin Jao, Clarisse Audigier-valette, Han Chang, David R Spigel, Neal E Ready, Tudor-Eliade Ciuleanu, María Rosario García Campelo, Stéphanie Bordenave, Laszlo Urban, Jean-Sébastien Aucoin, Cristina Zannori, Alessandra Curioni Fontecedro, Amparo Sánchez-Gastaldo, Oscar Juan-Vidal, Elena Poddubskaya, Samreen Ahmed, Sunney Li, Joseph Fiore, Angelic Acevedo

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Recommendations from a Dialogue on Evolving National Cancer Institute-Designated Comprehensive Cancer Center Community Outreach and Engagement Requirements: A Path Forward

“…To help address inequities in cancer treatment, care, support and research, the National Cancer Institute (NCI) instituted the community outreach and engagement (COE) mandate for NCI-designated comprehensive cancer centers (CCCs). The Bristol Myers Squibb Foundation designed a convening and listening session on COE with NCI leaders and staff gathering representatives from CCCs and the broader cancer community. …”
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IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs by Hao Zhou, Katarzyna Bulek, Xiao Li, Tomasz Herjan, Minjia Yu, Wen Qian, Han Wang, Gao Zhou, Xing Chen, Hui Yang, Lingzi Hong, Junjie Zhao, Luke Qin, Koichi Fukuda, Annette Flotho, Ji Gao, Ashok Dongre, Julie A Carman, Zizhen Kang, Bing Su, Timothy S Kern, Jonathan D Smith, Thomas A Hamilton, Frauke Melchior, Paul L Fox, Xiaoxia Li

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Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma by Chung-Wei Lee, Thomas Powles, Sabina Signoretti, David F McDermott, Sumanta K Pal, Toni K Choueiri, Brian I Rini, Saby George, Robert J Motzer, Frede Donskov, Scott S Tykodi, Nizar M Tannir, Saurabh Gupta, Ruiyun Jiang

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Phase Ib study of avadomide (CC‐122) in combination with rituximab in patients with relapsed/refractory diffuse large B‐cell lymphoma and follicular lymphoma by Loretta J. Nastoupil, John Kuruvilla, Julio C. Chavez, Fontanet Bijou, Thomas E. Witzig, Armando Santoro, Ian W. Flinn, Carola Boccomini, Vaishalee P. Kenkre, Paolo Corradini, Iris Isufi, David J. Andorsky, Leonard M. Klein, Daniel R. Greenwald, Randeep Sangha, Frank Shen, Patrick Hagner, Yan Li, Juergen Dobmeyer, Nian Gong, Shailaja Uttamsingh, Michael Pourdehnad, Vincent Ribrag

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PATIENTS WITH RELAPSED/REFRACTORY MARGINAL ZONE LYMPHOMA IN THE MAGNIFY PHASE 3B INTERIM ANALYSIS OF INDUCTION R2 FOLLOWED BY MAINTENANCE by M Coleman, DJ Andorsky, A Yacoub, JM Melear, SR Fanning, KS Kolibaba, F Lansigan, C Reynolds, G Nowakowski, M Gharibo, E Ahn, J Li, MJ Rummel, JP Sharman

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Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning by Raul Castellanos-Moreira, Diego Benavent, Alejandra López Robles, Ernesto Trallero-Araguás, Lucía Silva-Fernández, Juliana Restrepo, Jose A Román Ivorra, Maria Lopez Lasanta, Laura Cebrián, Leticia Lojo, Belén López-Muñíz, Julia Fernández-Melon, Belén Núñez, Raúl Veiga Cabello, Pilar Ahijado, Isabel De la Morena Barrio, Nerea Costas Torrijo, Belén Safont, Enrique Ornilla, Arantxa Campo, Jose L Andreu, Elvira Díez, Elena Bollo, David Vilanova, Sara Luján Valdés

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Ketamine: stimulating antidepressant treatment? by Malhi, G, Byrow, Y, Cassidy, F, Cipriani, A, Demyttenaere, K, Frye, M, Gitlin, M, Kennedy, S, Ketter, T, Lam, R, McShane, R, Mitchell, A, Ostacher, M, Rizvi, S, Thase, M, Tohen, M

“…Advisory/Consultant: Alkermes, Allergan, AstraZeneca, Bristol-Myers Squibb Company, Cerecor inc., Eli Lilly & Co., Forest Laboratories, Gerson Lehrman Group, Fabre-Kramer Pharmaceuticals, Inc., GlaxoSmithKline, Guidepoint Global, H. …”

The journey to AAPS 2020: a reflection from strategic planning to PharmSci 360 by Joseph W. Polli, Christopher R. McCurdy, Dale Eric Wurster, Binodh S. DeSilva, Annette Bak, Reina Bendayan, Bernd Meibohm, Allen C. Templeton, William Weiser, for the AAPS Leadership

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