Metabolic syndrome in HIV-infected patients receiving antiretroviral therapy in Latin America by C. Alvarez, R. Salazar, J. Galindez, F. Rangel, M.L. Castañeda, G. Lopardo, C.A. Cuhna, Y. Roldan, O. Sussman, G. Gutierrez, N. Cure-Bolt, C. Seas, C. Carcamo, M. Castrillo

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Patient experience of medication administration and development of a Patient Experience and Preference Questionnaire (PEPQ) for patients with advanced or metastatic cancer by Anne Skalicky, Bryan Bennett, Judith Raimbourg, Sara Lonardi, Julia Correll, Iwona Lugowska, Matthew Dixon, Nashmel Sargalo, Mona L. Martin

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Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development by Yuko Terasawa, Sylvaine J. Cases, Jinny S. Wong, Haris Jamil, Sumana Jothi, Maret G. Traber, Lester Packer, David A. Gordon, Robert L. Hamilton, Robert V. Farese, Jr.

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Real‐world complication burden and disease management paradigms in transfusion‐related β‐thalassaemia in Greece: Results from ULYSSES, an epidemiological, multicentre, retrospectiv... by Antonis Kattamis, Ersi Voskaridou, Sophia Delicou, Evangelos Klironomos, Ioannis Lafiatis, Foteini Petropoulou, Michael D. Diamantidis, Stylianos Lafioniatis, Loukia Evliati, Eleni Kapsali, Kiki Karvounis‐Marolachakis, Despoina Timotheatou, Chrysoula Deligianni, Panagiotis Viktoratos, Alexandra Kourakli

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Increased mortality in patients with RA-associated interstitial lung disease: data from a French administrative healthcare database by Bruno Crestani, Philippe Dieude, Rene-Marc Flipo, Sebastien Ottaviani, Pierre-Antoine Juge, Lidwine Wemeau-Stervinou, Guillaume Desjeux, Joe Zhuo, Virginie Vannier-Moreau

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Treatment of De Novo Renal Transplant Recipients With Calcineurin Inhibitor–free, Belatacept Plus Everolimus–based Immunosuppression by V. Ram Peddi, MD, Bradley Marder, MD, Luis Gaite, MD, Jose Oberholzer, MD, Ryan Goldberg, MD, Thomas Pearson, MD, Harold Yang, MD, PhD, Lisa Allamassey, MSc, Martin Polinsky, MD, Richard N. Formica, MD

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Triggers of Inflammatory Heart Disease by Ninaad Lasrado, Bharathi Yalaka, Bharathi Yalaka, Jay Reddy

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Modern Antiplatelet Therapy: When Is Clopidogrel the Right Choice? by Kendrick Shunk, Punag Divanji

“…In the era of percutaneous coronary intervention with drug-eluting stents, dual anti-platelet therapy with the addition of clopidogrel (Plavix©, Bristol-Myers Squibb, New York, NY) became the mainstay of therapy. …”
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Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved by Allegaert K

“…Karel Allegaert1,2 1Intensive Care, Department of Surgery, Erasmus MC Sophia Children’s Hospital, Rotterdam, the Netherlands; 2Department of Development and Regeneration, KU Leuven, BelgiumI read, with great interest, the paper on the intraocular pressure-lowering properties of intravenous paracetamol (acetaminophen) recently published in this journal by van den Heever and Meyer.1 The authors documented a decrease from baseline in mean intraocular pressure of 15.7% in a 6-hour time interval following intravenous paracetamol (1 g Perfalgan®, Bristol-Myers Squibb, New York, NY, USA) administration. …”
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The Roles of Signaling in Cytoskeletal Changes, Random Movement, Direction-Sensing and Polarization of Eukaryotic Cells by Yougan Cheng, Bryan Felix, Hans G. Othmer

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264 Correlation of virus-specific CD8+ T cells to clinical response following treatment with Pexa-Vec and Cemiplimab in patients with advanced renal cell carcinoma by Gavin Thurston, Israel Lowy, Vladimir Jankovic, Myles Dillon, Lianjie Li, Jeongsook Bang, Nicholas Gaspar, Jessica Kuhnert, Nathalie Fiaschi, Glenn Kroog, Kyoung Soo Ha, Raquel Deering

728 A phase 1/2 study of JK08, an IL-15 antibody fusion protein targeting CTLA-4, in patients with advanced solid tumors by Sylvie Rottey, Valentina Boni, Naimish Pandya, Elena Garralda, Shalabh Singhal, Vladimir Galvao, Nuria Kotecki, Maria de Miguel, Brant Delafontaine, Omar Saavedra, Amanda McEwen, Samuel L Murphy

News at Six: Hepatitis C Special by Mark Thursz, Jean-Michel Pawlotsky, Heiner Wedemeyer, Ashley Brown, Charles Gore, Alessandra Mangia, Graham Foster, Rafael Esteban

“…This Bristol Myers Squibb-sponsored symposium was chaired by Mark Thursz, who oversaw a novel news bulletin-themed symposium with sessions provided by a distinguished, international team of roving reporters; Charles Gore from the World Hepatitis Alliance, Jean-Michel Pawlotsky from France, Alessandra Mangia from Italy, Ashley Brown and Graham Foster from London, Heiner Wedemeyer from Germany, and Rafael Esteban from Spain.…”
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658 Preoperative short course radiotherapy with envafolimab, endostatin and SOX regimen in locally advanced gastric by Tao Zhang, Lei Zhao, Jin Wang, Peng Zhang, Zhenyu Lin, Kaixiong Tao, Dandan Yu, Pingdong Li, Yupin Yin

1309 Deep learning reveals predictive immune signature of response to checkpoint blockade in multiplexed spatial immunohistochemistry data by Padmanee Sharma, Seunghee Kim-Schulze, Justin David, John-William Sidhom, Sacha Gnjatic, Guray Akturk, Matthew Galsky, Saurabh Gupta, Jonathan Anker, Sudeh Izadmehr

Target toxicity design for phase I dose-finding by Wenchuan Guo, Bob Zhong

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Current status and future directions of high-throughput ADME screening in drug discovery by Wilson Z. Shou

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Ipilimumab: A novel immunomodulating therapy causing autoimmune hypophysitis: A case report and review by Juszczak, A, Gupta, A, Karavitaki, N, Middleton, MR, Grossman, AB

“…Ipilimumab (Yervoy; Medarex and Bristol-Myers Squibb) is a human MAB against cytotoxic T-lymphocyte antigen 4, which enhances co-stimulation of cytotoxic T-lymphocytes, resulting in their proliferation and an anti-tumour response. …”

nab-Paclitaxel Plus Durvalumab in Patients With Previously Treated Advanced Stage Non-small Cell Lung Cancer (ABOUND.2L+) by Daniel Morgensztern, Manuel Cobo Dols, Santiago Ponce Aix, Pieter E. Postmus, Jaafar Bennouna, Jürgen R. Fischer, Oscar Juan-Vidal, David J. Stewart, Andrea Ardizzoni, Rafia Bhore, Marianne Wolfsteiner, Martin Reck, Denis Talbot, Ramaswamy Govindan, Teng Jin Ong

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Improved survival with enasidenib versus standard of care in relapsed/refractory acute myeloid leukemia associated with IDH2 mutations using historical data and propensity score ma... by Stéphane deBotton, Joseph M. Brandwein, Andrew H. Wei, Arnaud Pigneux, Bruno Quesnel, Xavier Thomas, Ollivier Legrand, Christian Recher, Sylvain Chantepie, Mathilde Hunault‐Berger, Nicolas Boissel, Salem A. Nehme, Mark G. Frattini, Alessandra Tosolini, Roland Marion‐Gallois, Jixian J. Wang, Chris Cameron, Muhaimen Siddiqui, Brian Hutton, Gary Milkovich, Eytan M. Stein

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