Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process by Caitlin Morris, Ashli Polanco, Andrew Yongky, Jianlin Xu, Zhuangrong Huang, Jia Zhao, Kevin S. McFarland, Seoyoung Park, Bethanne Warrack, Michael Reily, Michael C. Borys, Zhengjian Li, Seongkyu Yoon

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P697: DISTINCT SPLICING ALTERATIONS ASSOCIATED WITH CLINICAL RESPONSE TO LUSPATERCEPT IN PATIENTS WITH LOWER‑RISK MYELODYSPLASTIC SYNDROMES FROM THE MEDALIST STUDY by Srinivas Aluri, Aarif Ahsan, Sheida Hayati, Manuel Ugidos, Punit Shah, Kate Lizotte, Samarpana Chakraborty, Kith Pradhan, Srabani Sahu, Shahina Maqbool, Aditi Shastri, Ashok Dongre, Uwe Platzbecker, Anita Gandhi, Rajasekhar Nvs Suragani, Sadanand Vodala, Amit Verma

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Effects of rifampin on the pharmacokinetics and pharmacodynamics of milvexian, a potent, selective, oral small molecule factor XIa inhibitor by Vidya Perera, Zhaoqing Wang, Susan Lubin, Lisa J. Christopher, Wei Chen, Sophia Xu, Dietmar Seiffert, Mary DeSouza, Bindu Murthy

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On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies by Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Peifeng Tang, Laurel Hoffman, June Kuang, Peiran Liu, Chao Huang, Cheng Du, Li Tao, Letha Chemmalil, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li, Shijie Liu

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Comprehensive immunophenotyping of solid tumor-infiltrating immune cells reveals the expression characteristics of LAG-3 and its ligands by Bradley Garman, Can Jiang, Sherif Daouti, Sanah Kumar, Priyanka Mehta, Miye K. Jacques, Laurence Menard, Nataly Manjarrez-Orduno, Sonia Dolfi, Piali Mukherjee, Piali Mukherjee, Sharmila Chamling Rai, Ana Lako, Jennifer D. Koenitzer, Justin M. David

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P1696: ECONOMIC BURDEN IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) FOR PATIENTS WITH ≥2 PRIOR LINES OF THERAPY INCLUDING A BRUTON TYROSINE KINASE INHIBITOR (BTKI) AND/OR B-CELL LYMPHOMA... by Masoom Priyadarshini, Gaurav Deshpande, Simran K Tiwana, T. Kim Le, Sean Garrison, Farrukh Awan

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S213: BMS-986158, A POTENT BET INHIBITOR, AS MONOTHERAPY AND IN COMBINATION WITH RUXOLITINIB OR FEDRATINIB IN INTERMEDIATE- OR HIGH-RISK MYELOFIBROSIS (MF): RESULTS FROM A PHASE 1/... by Rosa Ayala, Nieves Lopez, Adi Shacham Abulafia, Maan Alwan, Costas K. Yannakou, Indu Raman, Vincent Ribrag, Chun Yew Fong, Yulia Volchek, Massimiliano Bonifacio, Alessandra Tucci, Jean-Jacques Kiladjian, Jésus Marïa Hernandez Rivas, Blanca Xicoy, Haifa Kathrin Al-Ali, Jean-Christope Ianotto, Si Tuen Lee-Hoeflich, Sharmilla Das, Bin Wu, Palanikumar Ravindran, Qian Zhao, Guan Wang, Oriana Esposito, Yu Liu, Zariana Nikolova, Christopher Tehlirian, Shodeinde Coker, David Lavie

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Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses by Peifeng Tang, Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Laurel Hoffman, Cheng Du, Yuanli Song, Li Tao, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li, Shijie Liu

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A perspective on the current use of the phase distribution model for predicting milk‐to‐plasma drug concentration ratio by Mian Zhang, Caroline Sychterz, Ming Chang, Lu Huang, Brian J. Schmidt, Lu Gaohua

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Development of a Platform for Near-Infrared Photoredox Catalysis by Benjamin D. Ravetz, Nicholas E. S. Tay, Candice L. Joe, Melda Sezen-Edmonds, Michael A. Schmidt, Yichen Tan, Jacob M. Janey, Martin D. Eastgate, Tomislav Rovis

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P825: SOLUBLE FACTORS CORRELATED WITH CYTOKINE RELEASE SYNDROME (CRS) WITH IV VS SUBCUTANEOUS (SC) ALNUCTAMAB (ALNUC; BMS-986349; CC-93269) IN PATIENTS WITH RELAPSED/REFRACTORY MUL... by Isaac Boss, Ethan Thompson, Allison Gaudy, Thi Minh Diem Vu, Colin Godwin, Michael Burgess, Sandy W. Wong, Luciano Costa

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Immunomodulation by durvalumab and pomalidomide in patients with relapsed/refractory multiple myeloma by Mary H. Young, Greg Pietz, Elizabeth Whalen, Wilbert Copeland, Ethan Thompson, Brian A. Fox, Kathryn J. Newhall

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PB2535: TRIAL IN PROGRESS: A PHASE 2, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LUSPATERCEPT TO TREAT ANEMIA IN ADULTS... by Vip Viprakasit, Yongrong Lai, Gian Luca Forni, Meng-Yao Lu, Liudi Yang, Wenhui Shi, Loyse Felber Medlin, Frederik Lersch, Jeevan K. Shetty, Luciana Moro Bueno, Richard Wei, Antonis Kattamis

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Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics by Zhiqiang Chen, Yueming Qian, Yuanli Song, Xuankuo Xu, Li Tao, Nesredin Mussa, Sanchayita Ghose, Zheng Jian Li

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Activation-inducible CAR expression enables precise control over engineered CAR T cell function by Simon P. Fraessle, Claudia Tschulik, Manuel Effenberger, Vlad Cletiu, Maria Gerget, Kilian Schober, Dirk H. Busch, Lothar Germeroth, Christian Stemberger, Mateusz P. Poltorak

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An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay by Jing Yang, Claudio Mapelli, Zhaoqing Wang, Chi Shing Sum, Ji Hua, R. Michael Lawrence, Yan Ni, Dietmar A. Seiffert

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Cost-Effective and Scalable Synthesis of 4-Bromo-1,2-dimethyl-1<i>H</i>-imidazole: A Key Building Block for Bioactive Molecules by Muthalagu Vetrichelvan, Veeranjaneyulu Lanke, Bellam Chandu, Arvind Mathur, Anuradha Gupta

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Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study by Jianlin Xu, Xuankuo Xu, Chao Huang, James Angelo, Christopher L. Oliveira, Mengmeng Xu, Xia Xu, Deniz Temel, Julia Ding, Sanchayita Ghose, Michael C. Borys, Zheng Jian Li

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P499: THE PHASE 1B OMNIVERSE TRIAL OF ORAL AZACITIDINE IN COMBINATION WITH VENETOCLAX FOR TREATMENT OF RELAPSED/REFRACTORY OR NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA (TRIAL IN PROGR... by A. H. Wei, H. E. Carraway, L. Taningco, E. Laille, J. Gong, T. Prebet, D. Lopes de Menezes, F. Ravandi

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P693: LUSPATERCEPT RESTORES EFFECTIVE ERYTHROPOIESIS AND PROVIDES SUPERIOR AND SUSTAINED CLINICAL BENEFIT VS EPOETIN ALFA: BIOMARKER ANALYSIS FROM THE PHASE 3 COMMANDS STUDY by Uwe Platzbecker, Sheida Hayati, Aarif Ahsan, Amit Verma, Srinivas Aluri, Shelonitda Rose, Anita Gandhi, Rajasekhar Nvs Suragani, Sadanand Vodala

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