Sustained Remission and Outcomes with Abatacept plus Methotrexate Following Stepwise Dose De-escalation in Patients with Early Rheumatoid Arthritis by Paul Emery, Yoshiya Tanaka, Vivian P. Bykerk, Thomas W. J. Huizinga, Gustavo Citera, Clifton O. Bingham, Subhashis Banerjee, Benjamin P. Soule, Marleen Nys, Sean E. Connolly, Karissa L. Lozenski, Joe Zhuo, Robert Wong, Kuan-Hsiang Gary Huang, Roy Fleischmann

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PB2696: QUALITATIVE INTERVIEWS TO DESCRIBE BURDEN IN PATIENTS (PT) WITH THIRD-LINE OR LATER CLL/SLL WITH PRIOR EXPOSURE TO BRUTON TYROSINE KINASE INHIBITOR (BTKI) AND/OR B-CELL LYM... by Masoom Priyadarshini, Zaneta Balantac, Simran K Tiwana, Shweta S Bapat, Sean Garrison, Mona L Martin

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BMS-986012, an Anti–Fucosyl-GM1 Monoclonal Antibody as Monotherapy or in Combination With Nivolumab in Relapsed/Refractory SCLC: Results From a First-in-Human Phase 1/2 Study by Quincy Chu, MD, Natasha B. Leighl, MD, Veerle Surmont, MD, Carla van Herpen, MD, PhD, Anne Sibille, MD, Ben Markman, MD, Stephen Clarke, MD, Rosalyn A. Juergens, MD, PhD, Mirelis Acosta Rivera, MD, Vladimir Andelkovic, MD, Charles M. Rudin, MD, PhD, Stephanie Snow, MD, Dong-Wan Kim, MD, Michael Sanatani, MD, Hongxia Lin, PhD, Kinjal Sanghavi, PhD, Sarah Tannenbaum-Dvir, MD, Paul Basciano, MD, Deanne Lathers, PhD, Katarzyna Urbanska, PhD, Georgia Kollia, PhD, Chunsheng He, PhD, Andrew DiPiero, BS, Yu Liu, MD, PhD, Neal Ready, MD, PhD

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Selective inhibition of cholesterol synthesis in liver versus extrahepatic tissues by HMG-CoA reductase inhibitors. by RA Parker, RW Clark, SY Sit, TL Lanier, RA Grosso, JJ Wright

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222-N Analysis of pathologic features and efficacy outcomes with neoadjuvant nivolumab plus platinum-doublet chemotherapy for resectable non-small cell lung cancer in CheckMate 816... by Keith M Kerr, Elizabeth Thompson, Mariano Provencio, Patrick M Forde, Jaclyn Neely, Ashley Cimino-Mathews, Ludmila Danilova, Daphne Wang, Robert A Anders, Tricia R Cottrell, Nicolas Girard, Janis Taube, Peter Illei, Junliang Cai, Joel Sunshine, Julie Stein Deutsch, Jonathan Spicer, Edward Gabrielson, Jaroslaw Jedrych, Mia Tran, Judy Bushong, Vipul Devas, David Balli, Alex S Baras

Identification of a pharmaceutical compound that partially corrects the Niemann-Pick C phenotype in cultured cells by Laura Liscum, Emily Arnio, Monique Anthony, Andrea Howley, Stephen L. Sturley, Michele Agler

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P21: SUBSEQUENT ANTI-MYELOMA THERAPY AFTER IDECABTAGENE VICLEUCEL (IDE-CEL, BB2121) TREATMENT IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA FROM THE KARMMA STUDY by P Rodríguez-Otero, J San-Miguel, LD Anderson, Jr, S Lonial, A Truppel-Hartmann, J Sanford, E Rowe, TB Campbell, N Munshi

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P1740: HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM) TREATED WITH IDECABTAGENE VICLEUCEL VS BELANTAMAB MAFODOTIN: A MATCHING-ADJUSTED... by N. Shah, D. Ayers, S. Cope, K. Karampampa, K. Towle, J. Braverman, A. Mojebi, C. Caisip, D. Dhanda

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219 Long-term clinical outcomes associated with sequential treatment of BRAF mutant advanced melanoma patients by David McDermott, Michael Atkins, Ahmad Tarhini, Apoorva Ambavane, Agnes Benedict, Cho-Han Lee, Corey Ritchings, Brian Stwalley, Meredith Regan

P1057: REAL-WORLD UTILIZATION OF FEDRATINIB FOR MYELOFIBROSIS FOLLOWING RUXOLITINIB FAILURE by C. Harrison, J. Mascarenhas, P. Abraham, J. A. Nadal, A. Balanean, A. McBride, J. K. Kish, D. Liassou, B. A. Feinberg, A. T. Gerds

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Thoracic Lymph Duct Catheterization with a Venous Shunt in the Nonhuman Primate by Jon Ehrmann, Claudia Generaux, Sharon Ostergaard, Wendy Johnson, Anne Rose, Vince Mendenhall

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Early Discontinuation of Apremilast in Patients with Psoriasis and Gastrointestinal Comorbidities: Rates and Associated Risk Factors by Lana Schmidt, Ching An Wang, Vardhaman Patel, David Davidson, Samaneh Kalirai, Ankita Panda, Lauren Seigel

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Real-world evidence for regulatory decision-making: updated guidance from around the world by Leah Burns, Nadege Le Roux, Robert Kalesnik-Orszulak, Jennifer Christian, Jennifer Dudinak, Frank Rockhold, Sean Khozin, John O’Donnell

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Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT by SJ J. Diong, Aarti Jashnani, Andrew W. Drake, Christine Bee, Felix Findeisen, Gavin Dollinger, Feng Wang, Arvind Rajpal, Pavel Strop, Peter S. Lee

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Efficacy of Abatacept and Adalimumab in Patients with Early Rheumatoid Arthritis With Multiple Poor Prognostic Factors: Post Hoc Analysis of a Randomized Controlled Clinical Trial... by Roy Fleischmann, Michael Weinblatt, Harris Ahmad, Michael A. Maldonado, Evo Alemao, June Ye, Michael Schiff

“…Trial Registration ClinicalTrials.gov NCT00929864. Funding Bristol-Myers Squibb.…”
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Characterizing and understanding the formation of cysteine conjugates and other by-products in a random, lysine-linked antibody drug conjugate by Difei Qiu, Yande Huang, Naresh Chennamsetty, Scott A. Miller, Michael Hay

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The Interplay of Permeability, Metabolism, Transporters, and Dosing in Determining the Dynamics of the Tissue/Plasma Partition Coefficient and Volume of Distribution—A Theoretical... by Lu Gaohua, Mian Zhang, Caroline Sychterz, Ming Chang, Brian James Schmidt

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Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis by Pitchumani Sivakumar, Ron Ammar, John Ryan Thompson, Yi Luo, Denis Streltsov, Mary Porteous, Carly McCoubrey, Edward Cantu, Michael F. Beers, Gabor Jarai, Jason D. Christie

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Enabling speed to clinic for monoclonal antibody programs using a pool of clones for IND-enabling toxicity studies by Parimala Bolisetty, Gabi Tremml, Sen Xu, Anurag Khetan

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Linking Tumor Growth Dynamics to Survival in Ipilimumab‐Treated Patients With Advanced Melanoma Using Mixture Tumor Growth Dynamic Modeling by Yan Feng, Xiaoning Wang, Satyendra Suryawanshi, Akintunde Bello, Amit Roy

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