Synergistic interactions with PI3K inhibition that induce apoptosis by Yaara Zwang, Oliver Jonas, Casandra Chen, Mikael L Rinne, John G Doench, Federica Piccioni, Li Tan, Hai-Tsang Huang, Jinhua Wang, Young Jin Ham, Joyce O'Connell, Patrick Bhola, Mihir Doshi, Matthew Whitman, Michael Cima, Anthony Letai, David E Root, Robert S Langer, Nathanael Gray, William C Hahn

Get full text

LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma by Sho Sato, Michael Gillette, Pamela R. de Santiago, Eric Kuhn, Michael Burgess, Kristen Doucette, Yi Feng, Carlos Mendez-Dorantes, Paul J. Ippoliti, Sara Hobday, Marilyn A. Mitchell, Kai Doberstein, Stefan M. Gysler, Michelle S. Hirsch, Lauren Schwartz, Michael J. Birrer, Steven J. Skates, Kathleen H. Burns, Steven A. Carr, Ronny Drapkin

Get full text

Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell by Eran Mick, Denis V Titov, Owen S Skinner, Rohit Sharma, Alexis A Jourdain, Vamsi K Mootha

Get full text

Vascular smooth muscle cell phenotype switching in carotid atherosclerosis by Elizabeth L. Chou, MD, Christian L. Lino Cardenas, PharmD, MSc, PhD, Mark Chaffin, MS, Alessandro D. Arduini, PhD, Dejan Juric, MD, James R. Stone, MD, PhD, Glenn M. LaMuraglia, MD, Matthew J. Eagleton, MD, Mark F. Conrad, MD, Eric M. Isselbacher, MD, Patrick T. Ellinor, MD, PhD, Mark E. Lindsay, MD, PhD

Get full text

A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses by Sean M. Gross, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Ian C. McLean, Daniel S. Derrick, Caitlin E. Mills, Kartik Subramanian, Alexandra B. London, Denis Torre, John Erol Evangelista, Daniel J. B. Clarke, Zhuorui Xie, Cemal Erdem, Nicholas Lyons, Ted Natoli, Sarah Pessa, Xiaodong Lu, James Mullahoo, Jonathan Li, Miriam Adam, Brook Wassie, Moqing Liu, David F. Kilburn, Tiera A. Liby, Elmar Bucher, Crystal Sanchez-Aguila, Kenneth Daily, Larsson Omberg, Yunguan Wang, Connor Jacobson, Clarence Yapp, Mirra Chung, Dusica Vidovic, Yiling Lu, Stephan Schurer, Albert Lee, Ajay Pillai, Aravind Subramanian, Malvina Papanastasiou, Ernest Fraenkel, Heidi S. Feiler, Gordon B. Mills, Jake D. Jaffe, Avi Ma’ayan, Marc R. Birtwistle, Peter K. Sorger, James E. Korkola, Joe W. Gray, Laura M. Heiser

Get full text

Comparative Genomics of Vancomycin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content> Strains and Their Positions within the Clade Most Com... by Veronica N. Kos, Christopher A. Desjardins, Allison Griggs, Gustavo Cerqueira, Andries Van Tonder, Matthew T. G. Holden, Paul Godfrey, Kelli L. Palmer, Kip Bodi, Emmanuel F. Mongodin, Jennifer Wortman, Michael Feldgarden, Trevor Lawley, Steven R. Gill, Brian J. Haas, Bruce Birren, Michael S. Gilmore

Get full text

Fly model sheds light on brain disease by Martin H Berryer, Sara G Kosmaczewski, Lindy E Barrett

Get full text

EMBRACING DIGITAL AND COMPUTATIONAL PATHOLOGY DURING RESIDENCY TRAINING: PERSPECTIVES FROM TWO FORMER ANATOMIC PATHOLOGY RESIDENTS by Tiffany Y. Chen, Drew F.K. Williamson, Faisal Mahmood

Get full text

Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets by Carla Márquez-Luna, Steven Gazal, Po-Ru Loh, Samuel S. Kim, Nicholas Furlotte, Adam Auton, 23andMe Research Team, Alkes L. Price

Get full text

Diversity, multifaceted evolution, and facultative saprotrophism in the European Batrachochytrium salamandrivorans epidemic by Moira Kelly, Frank Pasmans, Jose F. Muñoz, Terrance P. Shea, Salvador Carranza, Christina A. Cuomo, An Martel

Get full text

Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo by Julian C. W. Willis, Pedro Silva-Pinheiro, Lily Widdup, Michal Minczuk, David R. Liu

Get full text

PATHOLOGY RESIDENT EXPERIENCE USING A LOW-COST 3D PRINTED MICROSCOPE FOR PORTABLE DIGITAL PATHOLOGY by Drew F.K. Williamson, Tiffany Y. Chen, Faisal Mahmood

Get full text

Comparative optimization of combinatorial CRISPR screens by Ruitong Li, Olaf Klingbeil, Davide Monducci, Michael J. Young, Diego J. Rodriguez, Zaid Bayyat, Joshua M. Dempster, Devishi Kesar, Xiaoping Yang, Mahdi Zamanighomi, Christopher R. Vakoc, Takahiro Ito, William R. Sellers

Get full text

1408 Non-canonical peptide sources broaden the landscape of targetable antigens in pancreatic cancer by Philip D Greenberg, Eva K Verzani, Jennifer G Abelin, Alex M Jaeger, Tyler Jacks, Andrew J Aguirre, Susan Klaeger, Zackery A Ely, Zachary J Kulstad, Sudarsana Addepalli, Karl Clauser, Kevin S Kapner, Connor J Hennessey, Miles Agus, Jennifer Su, Steven Carr, William Freed-Pastor

Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium by Sanja Vickovic, Denis Schapiro, Konstantin Carlberg, Britta Lötstedt, Ludvig Larsson, Franziska Hildebrandt, Marina Korotkova, Aase H. Hensvold, Anca I. Catrina, Peter K. Sorger, Vivianne Malmström, Aviv Regev, Patrik L. Ståhl

Get full text

Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals by Nicola Whiffin, Konrad J. Karczewski, Xiaolei Zhang, Sonia Chothani, Miriam J. Smith, D. Gareth Evans, Angharad M. Roberts, Nicholas M. Quaife, Sebastian Schafer, Owen Rackham, Jessica Alföldi, Anne H. O’Donnell-Luria, Laurent C. Francioli, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Stuart A. Cook, Paul J. R. Barton, Daniel G. MacArthur, James S. Ware

Get full text

Corrigendum: Genetic heritability as a tool to evaluate the precision of 24-hour recall dietary questionnaire variables in UK Biobank by Joanne B. Cole, Joanne B. Cole, Joanne B. Cole, Joanne B. Cole, Joanne B. Cole, Kenneth E. Westerman, Kenneth E. Westerman, Kenneth E. Westerman, Alisa K. Manning, Alisa K. Manning, Alisa K. Manning, Jose C. Florez, Jose C. Florez, Jose C. Florez, Joel N. Hirschhorn, Joel N. Hirschhorn, Joel N. Hirschhorn

Get full text

Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals by Nicola Whiffin, Konrad J. Karczewski, Xiaolei Zhang, Sonia Chothani, Miriam J. Smith, D. Gareth Evans, Angharad M. Roberts, Nicholas M. Quaife, Sebastian Schafer, Owen Rackham, Jessica Alföldi, Anne H. O’Donnell-Luria, Laurent C. Francioli, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Stuart A. Cook, Paul J. R. Barton, Daniel G. MacArthur, James S. Ware

Get full text

Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons by Brian J. Wainger, Evangelos Kiskinis, Cassidy Mellin, Ole Wiskow, Steve S.W. Han, Jackson Sandoe, Numa P. Perez, Luis A. Williams, Seungkyu Lee, Gabriella Boulting, James D. Berry, Robert H. Brown Jr., Merit E. Cudkowicz, Bruce P. Bean, Kevin Eggan, Clifford J. Woolf

Get full text

Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans by Lucydalila Cedillo, Fasih M Ahsan, Sainan Li, Nicole L Stuhr, Yifei Zhou, Yuyao Zhang, Adebanjo Adedoja, Luke M Murphy, Armen Yerevanian, Sinclair Emans, Khoi Dao, Zhaozhi Li, Nicholas D Peterson, Jeramie Watrous, Mohit Jain, Sudeshna Das, Read Pukkila-Worley, Sean P Curran, Alexander A Soukas

Get full text