Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity by Oded Shaham, Ru Wei, Thomas J Wang, Catherine Ricciardi, Gregory D Lewis, Ramachandran S Vasan, Steven A Carr, Ravi Thadhani, Robert E Gerszten, Vamsi K Mootha

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Rational engineering of minimally immunogenic nucleases for gene therapy by Rumya Raghavan, Mirco J. Friedrich, Indigo King, Samuel Chau-Duy-Tam Vo, Daniel Strebinger, Blake Lash, Michael Kilian, Michael Platten, Rhiannon K. Macrae, Yifan Song, Lucas Nivon, Feng Zhang

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The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy by Dan A. Landau, Clare Sun, Daniel Rosebrock, Sarah E. M. Herman, Joshua Fein, Mariela Sivina, Chingiz Underbayev, Delong Liu, Julia Hoellenriegel, Sarangan Ravichandran, Mohammed Z. H. Farooqui, Wandi Zhang, Carrie Cibulskis, Asaf Zviran, Donna S. Neuberg, Dimitri Livitz, Ivana Bozic, Ignaty Leshchiner, Gad Getz, Jan A. Burger, Adrian Wiestner, Catherine J. Wu

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The impact of non-additive genetic associations on age-related complex diseases by Marta Guindo-Martínez, Ramon Amela, Silvia Bonàs-Guarch, Montserrat Puiggròs, Cecilia Salvoro, Irene Miguel-Escalada, Caitlin E. Carey, Joanne B. Cole, Sina Rüeger, Elizabeth Atkinson, Aaron Leong, Friman Sanchez, Cristian Ramon-Cortes, Jorge Ejarque, Duncan S. Palmer, Mitja Kurki, FinnGen Consortium, Krishna Aragam, Jose C. Florez, Rosa M. Badia, Josep M. Mercader, David Torrents

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Author Correction: Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases by Sanjay M. Prakadan, Christopher A. Alvarez-Breckenridge, Samuel C. Markson, Albert E. Kim, Robert H. Klein, Naema Nayyar, Andrew W. Navia, Benjamin M. Kuter, Kellie E. Kolb, Ivanna Bihun, Joana L. Mora, Mia Solana Bertalan, Brian Shaw, Michael White, Alexander Kaplan, Jackson H. Stocking, Marc H. Wadsworth, Eudocia Q. Lee, Ugonma Chukwueke, Nancy Wang, Megha Subramanian, Denisse Rotem, Daniel P. Cahill, Viktor A. Adalsteinsson, Jeffrey W. Miller, Ryan J. Sullivan, Scott L. Carter, Priscilla K. Brastianos, Alex K. Shalek

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Nivolumab to restore T-cell fitness in CAR-T refractory multiple myeloma by Johannes M. Waldschmidt, Noori Sotudeh, Sankalp Arora, Tushara Vijaykumar, Praveen Anand, Hannah Stuart, Julia Frede, Tim Campbell, Shari M. Kaiser, Xirong Zheng, Nikhil C. Munshi, Kenneth C. Anderson, Hermann Einsele, Andrew J. Yee, Birgit Knoechel, Jens G. Lohr, Noopur S. Raje

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Silhouette images enable estimation of body fat distribution and associated cardiometabolic risk by Marcus D. R. Klarqvist, Saaket Agrawal, Nathaniel Diamant, Patrick T. Ellinor, Anthony Philippakis, Kenney Ng, Puneet Batra, Amit V. Khera

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Genetic factors affecting storage and utilization of lipids during dormancy in Mycobacterium tuberculosis by Alexander Sturm, Penny Sun, Julian Avila-Pacheco, Anne E. Clatworthy, Zohar Bloom-Ackermann, Michael G. Wuo, James E. Gomez, Soomin Jin, Clary B. Clish, Laura L. Kiessling, Deborah T. Hung

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Bayesian multivariate genetic analysis improves translational insights by Sarah M. Urbut, Satoshi Koyama, Whitney Hornsby, Rohan Bhukar, Sumeet Kheterpal, Buu Truong, Margaret S. Selvaraj, Benjamin Neale, Christopher J. O’Donnell, Gina M. Peloso, Pradeep Natarajan

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Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin by Karuna Mittal, Garrett W. Cooper, Benjamin P. Lee, Yongdong Su, Katie T. Skinner, Jenny Shim, Hunter C. Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D. Kynnap, Amanda L. Christie, Xiaoping Yang, Glenn S. Cowley, Brittaney A. Leeper, Christopher L. Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M. Clinton, Manoj Bhasin, Brian D. Crompton, Yuen-Yi Tseng, Jesse S. Boehm, Keith L. Ligon, David E. Root, Andrew J. Murphy, David M. Weinstock, Prafulla C. Gokhale, Jennifer M. Spangle, Miguel N. Rivera, Elizabeth A. Mullen, Kimberly Stegmaier, Kelly C. Goldsmith, William C. Hahn, Andrew L. Hong

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A cell type-aware framework for nominating non-coding variants in Mendelian regulatory disorders by Arthur S. Lee, Lauren J. Ayers, Michael Kosicki, Wai-Man Chan, Lydia N. Fozo, Brandon M. Pratt, Thomas E. Collins, Boxun Zhao, Matthew F. Rose, Alba Sanchis-Juan, Jack M. Fu, Isaac Wong, Xuefang Zhao, Alan P. Tenney, Cassia Lee, Kristen M. Laricchia, Brenda J. Barry, Victoria R. Bradford, Julie A. Jurgens, Eleina M. England, Monkol Lek, Daniel G. MacArthur, Eunjung Alice Lee, Michael E. Talkowski, Harrison Brand, Len A. Pennacchio, Elizabeth C. Engle

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The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein by Charles Zou, Hojong Yoon, Paul M.C. Park, J.J. Patten, Jesse Pellman, Jeannie Carreiro, Jonathan M. Tsai, Yen-Der Li, Shourya S. Roy Burman, Katherine A. Donovan, Jessica Gasser, Adam S. Sperling, Radosław P. Nowak, Eric S. Fischer, Robert A. Davey, Benjamin L. Ebert, Mikołaj Słabicki

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Deep learning to estimate cardiac magnetic resonance–derived left ventricular mass by Shaan Khurshid, MD, Samuel Freesun Friedman, PhD, James P. Pirruccello, MD, Paolo Di Achille, PhD, Nathaniel Diamant, BS, Christopher D. Anderson, MD, MMSc, Patrick T. Ellinor, MD, PhD, Puneet Batra, PhD, Jennifer E. Ho, MD, Anthony A. Philippakis, MD, PhD, Steven A. Lubitz, MD, MPH

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Automated single-cell proteomics providing sufficient proteome depth to study complex biology beyond cell type classifications by Claudia Ctortecka, Natalie M. Clark, Brian W. Boyle, Anjali Seth, D. R. Mani, Namrata D. Udeshi, Steven A. Carr

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Genome-wide tracking of dCas9-methyltransferase footprints by Christina Galonska, Jocelyn Charlton, Alexandra L. Mattei, Julie Donaghey, Kendell Clement, Hongcang Gu, Arman W. Mohammad, Elena K. Stamenova, Davide Cacchiarelli, Sven Klages, Bernd Timmermann, Tobias Cantz, Hans R. Schöler, Andreas Gnirke, Michael J. Ziller, Alexander Meissner

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Detection of low-density Plasmodium falciparum infections using amplicon deep sequencing by Angela M. Early, Rachel F. Daniels, Timothy M. Farrell, Jonna Grimsby, Sarah K. Volkman, Dyann F. Wirth, Bronwyn L. MacInnis, Daniel E. Neafsey

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Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity by Matan Sorek, Walaa Oweis, Malka Nissim-Rafinia, Moria Maman, Shahar Simon, Cynthia C. Hession, Xian Adiconis, Sean K. Simmons, Neville E. Sanjana, Xi Shi, Congyi Lu, Jen Q. Pan, Xiaohong Xu, Mahmoud A. Pouladi, Lisa M. Ellerby, Feng Zhang, Joshua Z. Levin, Eran Meshorer

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Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases by Sanjay M. Prakadan, Christopher A. Alvarez-Breckenridge, Samuel C. Markson, Albert E. Kim, Robert H. Klein, Naema Nayyar, Andrew W. Navia, Benjamin M. Kuter, Kellie E. Kolb, Ivanna Bihun, Joana L. Mora, Mia Solana Bertalan, Brian Shaw, Michael White, Alexander Kaplan, Jackson H. Stocking, Marc H. Wadsworth, Eudocia Q. Lee, Ugonma Chukwueke, Nancy Wang, Megha Subramanian, Denisse Rotem, Daniel P. Cahill, Viktor A. Adalsteinsson, Jeffrey W. Miller, Ryan J. Sullivan, Scott L. Carter, Priscilla K. Brastianos, Alex K. Shalek

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Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing by Juan Lorenzo B. Pablo, Savannah L. Cornett, Lei A. Wang, Sooyeon Jo, Tobias Brünger, Nikita Budnik, Mudra Hegde, Jean-Marc DeKeyser, Christopher H. Thompson, John G. Doench, Dennis Lal, Alfred L. George, Jr., Jen Q. Pan

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Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes by Mark Bustoros, Shankara Anand, Romanos Sklavenitis-Pistofidis, Robert Redd, Eileen M. Boyle, Benny Zhitomirsky, Andrew J. Dunford, Yu-Tzu Tai, Selina J. Chavda, Cody Boehner, Carl Jannes Neuse, Mahshid Rahmat, Ankit Dutta, Tineke Casneuf, Raluca Verona, Efstathis Kastritis, Lorenzo Trippa, Chip Stewart, Brian A. Walker, Faith E. Davies, Meletios-Athanasios Dimopoulos, P. Leif Bergsagel, Kwee Yong, Gareth J. Morgan, François Aguet, Gad Getz, Irene M. Ghobrial

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