Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation by Victoria Hung, Stephanie S Lam, Namrata D Udeshi, Tanya Svinkina, Gaelen Guzman, Vamsi K Mootha, Steven A Carr, Alice Y Ting

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Chromatin regulator SMARCAL1 modulates cellular lipid metabolism by Taylor Hanta Nagai, Chrissy Hartigan, Taiji Mizoguchi, Haojie Yu, Amy Deik, Kevin Bullock, Yanyan Wang, Debra Cromley, Monica Schenone, Chad A. Cowan, Daniel J. Rader, Clary B. Clish, Steven A. Carr, Yu-Xin Xu

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999 The PTPN2/N1 small molecule inhibitor ABBV-CLS-484 promotes NK cell activity driving primary tumor regression and preventing metastasis by Chirag Patel, Meng Sun, Yue Liu, Jonathan Powell, Kyle Halliwill, Jennifer M Frost, Robert T Manguso, Kathleen B Yates, Hakimeh Ebrahimi-Nik, Christina K Baumgartner, Keith M Hamel, Kira Olander, Kathleen A McGuire, Audrey J Muscato, Kelly Klinge, Joseph Klahn, Jacqueline Aguado, Payal Tiwari, Kayla J Colvin, Marcia N Paddock, Philip R Kym, Omar Avila-Monge, Alexander Schutte

CellProfiler 4: improvements in speed, utility and usability by David R. Stirling, Madison J. Swain-Bowden, Alice M. Lucas, Anne E. Carpenter, Beth A. Cimini, Allen Goodman

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Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts by Liang Ma, Zehua Chen, Da Wei Huang, Geetha Kutty, Mayumi Ishihara, Honghui Wang, Amr Abouelleil, Lisa Bishop, Emma Davey, Rebecca Deng, Xilong Deng, Lin Fan, Giovanna Fantoni, Michael Fitzgerald, Emile Gogineni, Jonathan M. Goldberg, Grace Handley, Xiaojun Hu, Charles Huber, Xiaoli Jiao, Kristine Jones, Joshua Z. Levin, Yueqin Liu, Pendexter Macdonald, Alexandre Melnikov, Castle Raley, Monica Sassi, Brad T. Sherman, Xiaohong Song, Sean Sykes, Bao Tran, Laura Walsh, Yun Xia, Jun Yang, Sarah Young, Qiandong Zeng, Xin Zheng, Robert Stephens, Chad Nusbaum, Bruce W. Birren, Parastoo Azadi, Richard A. Lempicki, Christina A. Cuomo, Joseph A. Kovacs

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Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes by Francesca Rapino, Ted Natoli, Francesco Limone, Erin O’Connor, Jack Blank, Matthew Tegtmeyer, William Chen, Erika Norabuena, Juhi Narula, Dane Hazelbaker, Gabriella Angelini, Lindy Barrett, Alison O’Neil, Ursula K. Beattie, Jessica M. Thanos, Heather de Rivera, Steven D. Sheridan, Roy H. Perlis, Steven A. McCarroll, Beth Stevens, Aravind Subramanian, Ralda Nehme, Lee L. Rubin

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Label-free cell cycle analysis for high-throughput imaging flow cytometry by Thomas Blasi, Holger Hennig, Huw D. Summers, Fabian J. Theis, Joana Cerveira, James O. Patterson, Derek Davies, Andrew Filby, Anne E. Carpenter, Paul Rees

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Mosaic mutations in blood DNA sequence are associated with solid tumor cancers by Mykyta Artomov, Manuel A. Rivas, Giulio Genovese, Mark J. Daly

“…Mark Daly and colleagues from the Broad Institute in Cambridge, Massachusetts, USA, used large genomic databases to test whether having blood cells both with and without genetic variants predicted to shorten the encoded protein—a phenomenon known as mosaic protein-truncating variants (PTVs)—was associated with developing a range of solid-tumor cancers. …”
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MAUDE: inferring expression changes in sorting-based CRISPR screens by Carl G. de Boer, John P. Ray, Nir Hacohen, Aviv Regev

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CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies by Justin H Hwang, Rand Arafeh, Ji-Heui Seo, Sylvan C Baca, Megan Ludwig, Taylor E Arnoff, Lydia Sawyer, Camden Richter, Sydney Tape, Hannah E Bergom, Sean McSweeney, Jonathan P Rennhack, Sarah A Klingenberg, Alexander TM Cheung, Jason Kwon, Jonathan So, Steven Kregel, Eliezer M Van Allen, Justin M Drake, Matthew L Freedman, William C Hahn

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Greater genetic diversity is needed in human pluripotent stem cell models by Sulagna Ghosh, Ralda Nehme, Lindy E. Barrett

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Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects by Allison A. Regier, Yossi Farjoun, David E. Larson, Olga Krasheninina, Hyun Min Kang, Daniel P. Howrigan, Bo-Juen Chen, Manisha Kher, Eric Banks, Darren C. Ames, Adam C. English, Heng Li, Jinchuan Xing, Yeting Zhang, Tara Matise, Goncalo R. Abecasis, Will Salerno, Michael C. Zody, Benjamin M. Neale, Ira M. Hall

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Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass by Shaan Khurshid, Julieta Lazarte, James P. Pirruccello, Lu-Chen Weng, Seung Hoan Choi, Amelia W. Hall, Xin Wang, Samuel F. Friedman, Victor Nauffal, Kiran J. Biddinger, Krishna G. Aragam, Puneet Batra, Jennifer E. Ho, Anthony A. Philippakis, Patrick T. Ellinor, Steven A. Lubitz

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The case for altruism in institutional diagnostic testing by Ivan Specht, Kian Sani, Yolanda Botti-Lodovico, Michael Hughes, Kristin Heumann, Amy Bronson, John Marshall, Emily Baron, Eric Parrie, Olivia Glennon, Ben Fry, Andrés Colubri, Pardis C. Sabeti

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A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling by Chi-Hong Wu, Vedakumar Tatavarty, Pierre M Jean Beltran, Andrea A Guerrero, Hasmik Keshishian, Karsten Krug, Melanie A MacMullan, Li Li, Steven A Carr, Jeffrey R Cottrell, Gina G Turrigiano

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Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery by Kevin Chun-Ho Ngan, Samuel M Hoenig, Hui Si Kwok, Nicholas Z Lue, Pallavi M Gosavi, David A Tanner, Emma M Garcia, Ceejay Lee, Brian B Liau

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Dissecting mammalian spermatogenesis using spatial transcriptomics by Haiqi Chen, Evan Murray, Anubhav Sinha, Anisha Laumas, Jilong Li, Daniel Lesman, Xichen Nie, Jim Hotaling, Jingtao Guo, Bradley R. Cairns, Evan Z. Macosko, C. Yan Cheng, Fei Chen

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Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation by Zhengjian Zhang, Zarko Boskovic, Mahmud M Hussain, Wenxin Hu, Carla Inouye, Han-Je Kim, A Katherine Abole, Mary K Doud, Timothy A Lewis, Angela N Koehler, Stuart L Schreiber, Robert Tjian

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Algorithms for the identification of prevalent diabetes in the All of Us Research Program validated using polygenic scores by Lukasz Szczerbinski, Ravi Mandla, Philip Schroeder, Bianca C. Porneala, Josephine H. Li, Jose C. Florez, Josep M. Mercader, Miriam S. Udler, Alisa K. Manning

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Prediction performance and fairness heterogeneity in cardiovascular risk models by Uri Kartoun, Shaan Khurshid, Bum Chul Kwon, Aniruddh P. Patel, Puneet Batra, Anthony Philippakis, Amit V. Khera, Patrick T. Ellinor, Steven A. Lubitz, Kenney Ng

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