A (fire)cloud-based DNA methylation data preprocessing and quality control platform by Divy Kangeyan, Andrew Dunford, Sowmya Iyer, Chip Stewart, Megan Hanna, Gad Getz, Martin J. Aryee

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Profiling the inflammatory bowel diseases using genetics, serum biomarkers, and smoking information by Ruize Liu, Dalin Li, Talin Haritunians, Yunfeng Ruan, Mark J. Daly, Hailiang Huang, Dermot P.B. McGovern

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Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI by Thomas J.F. Nieland, Jared T. Shaw, Firoz A. Jaipuri, Zoltan Maliga, Jay L. Duffner, Angela N. Koehler, Monty Krieger

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A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging by Reuven Falkovich, Eric W. Danielson, Karen Perez de Arce, Eike-C. Wamhoff, Juliana Strother, Anna P. Lapteva, Morgan Sheng, Jeffrey R. Cottrell, Mark Bathe

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Technological considerations for genome-guided diagnosis and management of cancer by Niall J. Lennon, Viktor A. Adalsteinsson, Stacey B. Gabriel

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Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase by Joshua B. Radke, Bruno Melillo, Payal Mittal, Manmohan Sharma, Amit Sharma, Yong Fu, Taher Uddin, Arthur Gonse, Eamon Comer, Stuart L. Schreiber, Anil K. Gupta, Arnab K. Chatterjee, L. David Sibley

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Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection by Armin P. Schoech, Daniel M. Jordan, Po-Ru Loh, Steven Gazal, Luke J. O’Connor, Daniel J. Balick, Pier F. Palamara, Hilary K. Finucane, Shamil R. Sunyaev, Alkes L. Price

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Disparities in brain health comorbidity management in intracerebral hemorrhage by Ernst Mayerhofer, Ernst Mayerhofer, Ernst Mayerhofer, Natalie O. Zaba, Natalie O. Zaba, Natalie O. Zaba, Livia Parodi, Livia Parodi, Livia Parodi, Livia Parodi, Alena S. Ganbold, Alena S. Ganbold, Alena S. Ganbold, Alessandro Biffi, Alessandro Biffi, Alessandro Biffi, Jonathan Rosand, Jonathan Rosand, Jonathan Rosand, Nirupama Yechoor, Nirupama Yechoor, Nirupama Yechoor, Christopher D. Anderson, Christopher D. Anderson, Christopher D. Anderson, Christopher D. Anderson

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564 Single-cell transcriptomic analysis of immune compartments following combination immunotherapy treatment in poorly immunogenic tumors by Nir Hacohen, Shuqiang Li, Darrell Irvine, Ang Cui, Kelly Moynihan, Chensu Wang, Jackson Southard

Microscaled proteogenomic methods for precision oncology by Shankha Satpathy, Eric J. Jaehnig, Karsten Krug, Beom-Jun Kim, Alexander B. Saltzman, Doug W. Chan, Kimberly R. Holloway, Meenakshi Anurag, Chen Huang, Purba Singh, Ari Gao, Noel Namai, Yongchao Dou, Bo Wen, Suhas V. Vasaikar, David Mutch, Mark A. Watson, Cynthia Ma, Foluso O. Ademuyiwa, Mothaffar F. Rimawi, Rachel Schiff, Jeremy Hoog, Samuel Jacobs, Anna Malovannaya, Terry Hyslop, Karl R. Clauser, D. R. Mani, Charles M. Perou, George Miles, Bing Zhang, Michael A. Gillette, Steven A. Carr, Matthew J. Ellis

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Proteogenomic integration reveals therapeutic targets in breast cancer xenografts by Kuan-lin Huang, Shunqiang Li, Philipp Mertins, Song Cao, Harsha P. Gunawardena, Kelly V. Ruggles, D. R. Mani, Karl R. Clauser, Maki Tanioka, Jerry Usary, Shyam M. Kavuri, Ling Xie, Christopher Yoon, Jana W Qiao, John Wrobel, Matthew A. Wyczalkowski, Petra Erdmann-Gilmore, Jacqueline E. Snider, Jeremy Hoog, Purba Singh, Beifang Niu, Zhanfang Guo, Sam Qiancheng Sun, Souzan Sanati, Emily Kawaler, Xuya Wang, Adam Scott, Kai Ye, Michael D. McLellan, Michael C. Wendl, Anna Malovannaya, Jason M. Held, Michael A. Gillette, David Fenyö, Christopher R. Kinsinger, Mehdi Mesri, Henry Rodriguez, Sherri R. Davies, Charles M. Perou, Cynthia Ma, R. Reid Townsend, Xian Chen, Steven A. Carr, Matthew J. Ellis, Li Ding

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Recommendations for clinical interpretation of variants found in non-coding regions of the genome by Jamie M. Ellingford, Joo Wook Ahn, Richard D. Bagnall, Diana Baralle, Stephanie Barton, Chris Campbell, Kate Downes, Sian Ellard, Celia Duff-Farrier, David R. FitzPatrick, John M. Greally, Jodie Ingles, Neesha Krishnan, Jenny Lord, Hilary C. Martin, William G. Newman, Anne O’Donnell-Luria, Simon C. Ramsden, Heidi L. Rehm, Ebony Richardson, Moriel Singer-Berk, Jenny C. Taylor, Maggie Williams, Jordan C. Wood, Caroline F. Wright, Steven M. Harrison, Nicola Whiffin

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Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors by Oxana Rotar, Maria Boyarinova, Ekaterina Moguchaya, Kristina Tolkunova, Nikita Kolosov, Nikita Kolosov, Nikita Kolosov, Valeriia Rezapova, Valeriia Rezapova, Valeriia Rezapova, Olga Freylikhman, Dmitrii Usoltsev, Dmitrii Usoltsev, Dmitrii Usoltsev, Olesya Melnik, Alexey Sergushichev, Vladislav Solntsev, Anna Kostareva, Elena Dubinina, Elena Dubinina, Trudy Voortman, Trudy Voortman, Christine Stevens, Mark J. Daly, Mark J. Daly, Mark J. Daly, Alexandra Konradi, Alexandra Konradi, Evgeny Shlyakhto, Mykyta Artomov, Mykyta Artomov, Mykyta Artomov, Mykyta Artomov, Mykyta Artomov

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Evaluation of the Access Bio CareStart rapid SARS-CoV-2 antigen test in asymptomatic individuals tested at a community mass-testing program in Western Massachusetts by Sara Suliman, Wilfredo R. Matias, Isabel R. Fulcher, Francisco J. Molano, Shannon Collins, Elizabeth Uceta, Jack Zhu, Ryan M. Paxton, Sean F. Gonsalves, Maegan V. Harden, Marissa Fisher, Jim Meldrim, Stacey Gabriel, Molly F. Franke, Deborah T. Hung, Sandra C. Smole, Lawrence C. Madoff, Louise C. Ivers

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Dynamic Colonization of Microbes and Their Functions after Fecal Microbiota Transplantation for Inflammatory Bowel Disease by Nathaniel D. Chu, Jessica W. Crothers, Le T. T. Nguyen, Sean M. Kearney, Mark B. Smith, Zain Kassam, Cheryl Collins, Ramnik Xavier, Peter L. Moses, Eric J. Alm

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The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer by Minakshi Gandhi, Matthias Groß, Jessica M. Holler, Si’Ana A. Coggins, Nitin Patil, Joerg H. Leupold, Mathias Munschauer, Monica Schenone, Christina R. Hartigan, Heike Allgayer, Baek Kim, Sven Diederichs

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Editing GWAS: experimental approaches to dissect and exploit disease-associated genetic variation by Shuquan Rao, Yao Yao, Daniel E. Bauer

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Best practices on the differential expression analysis of multi-species RNA-seq by Matthew Chung, Vincent M. Bruno, David A. Rasko, Christina A. Cuomo, José F. Muñoz, Jonathan Livny, Amol C. Shetty, Anup Mahurkar, Julie C. Dunning Hotopp

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PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA by Tovah A. Day, Jacob V. Layer, J. Patrick Cleary, Srijoy Guha, Kristen E. Stevenson, Trevor Tivey, Sunhee Kim, Anna C. Schinzel, Francesca Izzo, John Doench, David E. Root, William C. Hahn, Brendan D. Price, David M. Weinstock

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RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition by Lishan Fang, Dane Ford-Roshon, Max Russo, Casey O’Brien, Xiaozhe Xiong, Carino Gurjao, Maximilien Grandclaudon, Srivatsan Raghavan, Steven M. Corsello, Steven A. Carr, Namrata D. Udeshi, James Berstler, Ewa Sicinska, Kimmie Ng, Marios Giannakis

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