Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations by Tian Ge, Marguerite R. Irvin, Amit Patki, Vinodh Srinivasasainagendra, Yen-Feng Lin, Hemant K. Tiwari, Nicole D. Armstrong, Barbara Benoit, Chia-Yen Chen, Karmel W. Choi, James J. Cimino, Brittney H. Davis, Ozan Dikilitas, Bethany Etheridge, Yen-Chen Anne Feng, Vivian Gainer, Hailiang Huang, Gail P. Jarvik, Christopher Kachulis, Eimear E. Kenny, Atlas Khan, Krzysztof Kiryluk, Leah Kottyan, Iftikhar J. Kullo, Christoph Lange, Niall Lennon, Aaron Leong, Edyta Malolepsza, Ayme D. Miles, Shawn Murphy, Bahram Namjou, Renuka Narayan, Mark J. O’Connor, Jennifer A. Pacheco, Emma Perez, Laura J. Rasmussen-Torvik, Elisabeth A. Rosenthal, Daniel Schaid, Maria Stamou, Miriam S. Udler, Wei-Qi Wei, Scott T. Weiss, Maggie C. Y. Ng, Jordan W. Smoller, Matthew S. Lebo, James B. Meigs, Nita A. Limdi, Elizabeth W. Karlson

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Physiology as a Lingua Franca for Clinical Machine Learning by Gopal P. Sarma, Erik Reinertsen, Aaron Aguirre, Chris Anderson, Puneet Batra, Seung-Hoan Choi, Paolo Di Achille, Nathaniel Diamant, Patrick Ellinor, Connor Emdin, Akl C. Fahed, Samuel Friedman, Lia Harrington, Jennifer E. Ho, Amit V. Khera, Shaan Khurshid, Marcus Klarqvist, Steve Lubitz, Anthony Philippakis, James Pirruccello, Christopher Reeder, Collin Stultz, Brandon Westover

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Mapping the landscape of genetic dependencies in chordoma by Tanaz Sharifnia, Mathias J. Wawer, Amy Goodale, Yenarae Lee, Mariya Kazachkova, Joshua M. Dempster, Sandrine Muller, Joan Levy, Daniel M. Freed, Josh Sommer, Jérémie Kalfon, Francisca Vazquez, William C. Hahn, David E. Root, Paul A. Clemons, Stuart L. Schreiber

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Gene networks that compensate for crosstalk with crosstalk by Isaak E. Müller, Jacob R. Rubens, Tomi Jun, Daniel Graham, Ramnik Xavier, Timothy K. Lu

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High-throughput Identification of Phage-derived Imaging Agents by Kimberly A. Kelly, Paul A. Clemons, Amy M. Yu, Ralph Weissleder

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Targeting fidelity of adenine and cytosine base editors in mouse embryos by Hye Kyung Lee, Michaela Willi, Shannon M. Miller, Sojung Kim, Chengyu Liu, David R. Liu, Lothar Hennighausen

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P673: Batch ClinVar submission support in ClinGen’s Variant Curation Interface (VCI) by Matthew Wright, Christine Preston, Karen Dalton, Gloria Cheung, Mark Mandell, Bryan Wulf, Lawrence Babb, Marina DiStefano, Steven Harrison, Clarissa Klein, Rachel Shapira, Ingrid Keseler, Deborah Ritter, Neethu Shah, Kevin Riehle, Aleksandar Milosavljevic, Sharon Plon, Teri Klein

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Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair by N. J. Haradhvala, J. Kim, Y. E. Maruvka, P. Polak, D. Rosebrock, D. Livitz, J. M. Hess, I. Leshchiner, A. Kamburov, K. W. Mouw, M. S. Lawrence, G. Getz

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O29: Low rate of hereditary ovarian cancer screening in individuals meeting National Comprehensive Cancer Network guidelines by Jacklyn Omorodion, Emma Perez, Robert Green, Pradeep Natarajan, Nina Gold

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Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing by Aixin Zhang, Lei Jin, Shenqin Yao, Makoto Matsuyama, Cindy TJ van Velthoven, Heather Anne Sullivan, Na Sun, Manolis Kellis, Bosiljka Tasic, Ian Wickersham, Xiaoyin Chen

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Jamestown Canyon virus in Massachusetts: clinical case series and vector screening by Cormac M. Kinsella, Molly L. Paras, Sandra Smole, Samar Mehta, Vijay Ganesh, Lin H. Chen, Daniel P. McQuillen, Ruta Shah, Justin Chan, Matthew Osborne, Scott Hennigan, Frederic Halpern-Smith, Catherine M. Brown, Pardis Sabeti, Anne Piantadosi

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Targets and genomic constraints of ectopic Dnmt3b expression by Yingying Zhang, Jocelyn Charlton, Rahul Karnik, Isabel Beerman, Zachary D Smith, Hongcang Gu, Patrick Boyle, Xiaoli Mi, Kendell Clement, Ramona Pop, Andreas Gnirke, Derrick J Rossi, Alexander Meissner

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A pooled electronic consultation program to improve access to genetics specialists by Emma K. Folkerts, Renée C. Pelletier, Daniel C. Chung, Susan A. Goldstein, Douglas S. Micalizzi, Kristen M. Shannon, David A. Sweetser, Eugene K. Wong, Heidi L. Rehm, Leland E. Hull

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Sex Differences in Temporal Trends of Cardiovascular Health in Young US Adults by So Mi Jemma Cho, Sara Haidermota, Michael C. Honigberg, Pradeep Natarajan

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Author Correction: Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics by Mathias Wilhelm, Daniel P. Zolg, Michael Graber, Siegfried Gessulat, Tobias Schmidt, Karsten Schnatbaum, Celina Schwencke-Westphal, Philipp Seifert, Niklas de Andrade Krätzig, Johannes Zerweck, Tobias Knaute, Eva Bräunlein, Patroklos Samaras, Ludwig Lautenbacher, Susan Klaeger, Holger Wenschuh, Roland Rad, Bernard Delanghe, Andreas Huhmer, Steven A. Carr, Karl R. Clauser, Angela M. Krackhardt, Ulf Reimer, Bernhard Kuster

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Multiple Myeloma With Amplification of Chr1q: Therapeutic Opportunity and Challenges by Romanos Sklavenitis-Pistofidis, Romanos Sklavenitis-Pistofidis, Romanos Sklavenitis-Pistofidis, Romanos Sklavenitis-Pistofidis, Gad Getz, Gad Getz, Gad Getz, Irene Ghobrial, Irene Ghobrial, Irene Ghobrial, Maria Papaioannou, Maria Papaioannou

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Integrated multi-omics analyses reveal homology-directed repair pathway as a unique dependency in near-haploid leukemia by Yunpeng Liu-Lupo, James Dongjoo Ham, Swarna K. A. Jeewajee, Lan Nguyen, Toni Delorey, Azucena Ramos, David M. Weinstock, Aviv Regev, Michael T. Hemann

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Benchmarking AlphaFold‐enabled molecular docking predictions for antibiotic discovery by Felix Wong, Aarti Krishnan, Erica J Zheng, Hannes Stärk, Abigail L Manson, Ashlee M Earl, Tommi Jaakkola, James J Collins

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Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets by Michael H. Guo, Prashanth Sama, Brenna A. LaBarre, Hrishikesh Lokhande, John Balibalos, Ci Chu, Xiaomi Du, Pouya Kheradpour, Charles C. Kim, Taylor Oniskey, Thomas Snyder, Damien Z. Soghoian, Howard L. Weiner, Tanuja Chitnis, Nikolaos A. Patsopoulos

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Lipoprotein(a) and Coronary Artery Disease Risk Without a Family History of Heart Disease by Phoebe Finneran, Akhil Pampana, Sumeet A. Khetarpal, Mark Trinder, Aniruddh P. Patel, Kaavya Paruchuri, Krishna Aragam, Gina M. Peloso, Pradeep Natarajan

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