Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening by Peter C. DeWeirdt, Abby V. McGee, Fengyi Zheng, Ifunanya Nwolah, Mudra Hegde, John G. Doench

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Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging by Martin L. Tomov, Alison O’Neil, Hamdah S. Abbasi, Beth A. Cimini, Anne E. Carpenter, Lee L. Rubin, Mark Bathe

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P523: The NeuroDev Study: Genetic characterization of neurodevelopmental disorders in African populations by Emily O'Heir, Patricia Kipkemoi, Heesu Ally Kim, Bjorn Christ, Emma Eastman, Celia van der Merwe, Alice Galvin, Jake Allen, Victoria de Menil, Alysia Lovgren, Christina Austin-Tse, Amina Abubakar, Charles Newton, Kirsten Donald, Anne O'Donnell-Luria, Elise Robinson

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Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons by Olli Pietiläinen, Aditi Trehan, Daniel Meyer, Jana Mitchell, Matthew Tegtmeyer, Vera Valakh, Hilena Gebre, Theresa Chen, Emilia Vartiainen, Samouil L. Farhi, Kevin Eggan, Steven A. McCarroll, Ralda Nehme

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Advancing neuropsychiatric genetics training and collaboration in Africa by Celia van der Merwe, Emmanuel K Mwesiga, Nathaniel W McGregor, Abebe Ejigu, Abigiya Wondimagegnehu Tilahun, Allan Kalungi, Benedict Akimana, Benyam Worku Dubale, Felicita Omari, Jackline Mmochi, Lerato Majara, Linnet Ongeri, Melkam Alemayehu, Nastassja Koen, Shareefa Dalvie, Symon M Kariuki, Michelle Hoogenhout

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CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer by Justin H. Hwang, Ji-Heui Seo, Michael L. Beshiri, Stephanie Wankowicz, David Liu, Alexander Cheung, Ji Li, Xintao Qiu, Andrew L. Hong, Ginevra Botta, Lior Golumb, Camden Richter, Jonathan So, Gabriel J. Sandoval, Andrew O. Giacomelli, Seav Huong Ly, Celine Han, Chao Dai, Hubert Pakula, Anjali Sheahan, Federica Piccioni, Ole Gjoerup, Massimo Loda, Adam G. Sowalsky, Leigh Ellis, Henry Long, David E. Root, Kathleen Kelly, Eliezer M. Van Allen, Matthew L. Freedman, Atish D. Choudhury, William C. Hahn

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Generating experimentally unrelated target molecule-binding highly functionalized nucleic-acid polymers using machine learning by Jonathan C. Chen, Jonathan P. Chen, Max W. Shen, Michael Wornow, Minwoo Bae, Wei-Hsi Yeh, Alvin Hsu, David R. Liu

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Author Correction: Disulfide-compatible phage-assisted continuous evolution in the periplasmic space by Mary S. Morrison, Tina Wang, Aditya Raguram, Colin Hemez, David R. Liu

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Orthogonal translation enables heterologous ribosome engineering in E. coli by Natalie S. Kolber, Ranan Fattal, Sinisa Bratulic, Gavriela D. Carver, Ahmed H. Badran

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BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks by Winston X. Yan, Reza Mirzazadeh, Silvano Garnerone, David Scott, Martin W. Schneider, Tomasz Kallas, Joaquin Custodio, Erik Wernersson, Yinqing Li, Linyi Gao, Yana Federova, Bernd Zetsche, Feng Zhang, Magda Bienko, Nicola Crosetto

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Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder by Hyun Ji Noh, Ruqi Tang, Jason Flannick, Colm O’Dushlaine, Ross Swofford, Daniel Howrigan, Diane P. Genereux, Jeremy Johnson, Gerard van Grootheest, Edna Grünblatt, Erik Andersson, Diana R. Djurfeldt, Paresh D. Patel, Michele Koltookian, Christina M. Hultman, Michele T. Pato, Carlos N. Pato, Steven A. Rasmussen, Michael A. Jenike, Gregory L. Hanna, S. Evelyn Stewart, James A. Knowles, Stephan Ruhrmann, Hans-Jörgen Grabe, Michael Wagner, Christian Rück, Carol A. Mathews, Susanne Walitza, Daniëlle C. Cath, Guoping Feng, Elinor K. Karlsson, Kerstin Lindblad-Toh

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High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly by Martin H Berryer, Gizem Rizki, Anna Nathanson, Jenny A Klein, Darina Trendafilova, Sara G Susco, Daisy Lam, Angelica Messana, Kristina M Holton, Kyle W Karhohs, Beth A Cimini, Kathleen Pfaff, Anne E Carpenter, Lee L Rubin, Lindy E Barrett

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1403-A PTPN2/N1 inhibitor ABBV-CLS-484 unleashes potent anti-tumor immunity by Wei Qiu, Qi Sun, Yi Yang, Chirag Patel, Meng Sun, Yue Liu, Kyle Halliwill, Sarah Kim, Rebecca Mathew, Jennifer M Frost, Jennifer A Roth, Domenick Kennedy, Robert T Manguso, Kathleen B Yates, Hakimeh Ebrahimi-Nik, Christina K Baumgartner, Arvin Iracheta-Vellve, Keith M Hamel, Kira Olander, Thomas GR Davis, Kathleen A McGuire, Geoff T Halvorsen, Omar I Avila, Ashwin V Kammula, Audrey J Muscato, Prasanthi Geda, Kelly Klinge, Zhaoming Xiong, Ryan Duggan, Liang Mu, Mitchell D Yeary, James C Patti, Tyler M Balon, Carey Backus, Angeline Chen, Kenton Longenecker, Joseph Klahn, Cara Hrusch, Navasona Krishnan, Charles W Hutchins, Jacqueline Aguado, Marinka Bulic, Payal Tiwari, Kayla J Colvin, Cun Lan Chuong, Ian C Kohnle, Matthew G Rees, Andrew Boghossian, Melissa Ronan, Meng-Ju Wu, Debattama R Sen, Gabriel K Griffin, Nabeel El-Bardeesy, Patricia Trusk, Joshua H Decker, Stacey Fossey, Marcia N Paddock, Elliot P Farney, Clay Beauregard, Philip R Kym

High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways by Jamie L. Marshall, Teia Noel, Qingbo S. Wang, Haiqi Chen, Evan Murray, Ayshwarya Subramanian, Katherine A. Vernon, Silvana Bazua-Valenti, Katie Liguori, Keith Keller, Robert R. Stickels, Breanna McBean, Rowan M. Heneghan, Astrid Weins, Evan Z. Macosko, Fei Chen, Anna Greka

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399 Class I HLA-independent lysis of cancer cells by tumor-infiltrating CD8 T cells by Nir Hacohen, Robert T Manguso, Russell W Jenkins, Moshe Sade-Feldman, Hongyan Xie, Aiping Jiang, Jonathan Perera

P713: Estimating the prevalence of de novo monogenic disorders from gnomAD database by Mutaz Amin, Samantha Baxter, Kaitlin Samocha, Anne O'Donnell-Luria

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Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes by Vedagopuram Sreekanth, Qingxuan Zhou, Praveen Kokkonda, Heysol C. Bermudez-Cabrera, Donghyun Lim, Benjamin K. Law, Benjamin R. Holmes, Santosh K. Chaudhary, Rajaiah Pergu, Brittany S. Leger, James A. Walker, David K. Gifford, Richard I. Sherwood, Amit Choudhary

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PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation by Prasidda Khadka, Zachary J. Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M. Carvalho, Juliann Shih, Shu Zhang, Noah F. Greenwald, Travis Zack, Ofer Shapira, Kristine Pelton, Rachel Hartley, Heather Bear, Yohanna Georgis, Spandana Jarmale, Randy Melanson, Kevin Bonanno, Kathleen Schoolcraft, Peter G. Miller, Alexandra L. Condurat, Elizabeth M. Gonzalez, Kenin Qian, Eric Morin, Jaldeep Langhnoja, Leslie E. Lupien, Veronica Rendo, Jeromy Digiacomo, Dayle Wang, Kevin Zhou, Rushil Kumbhani, Maria E. Guerra Garcia, Claire E. Sinai, Sarah Becker, Rachel Schneider, Jayne Vogelzang, Karsten Krug, Amy Goodale, Tanaz Abid, Zohra Kalani, Federica Piccioni, Rameen Beroukhim, Nicole S. Persky, David E. Root, Angel M. Carcaboso, Benjamin L. Ebert, Christine Fuller, Ozgun Babur, Mark W. Kieran, Chris Jones, Hasmik Keshishian, Keith L. Ligon, Steven A. Carr, Timothy N. Phoenix, Pratiti Bandopadhayay

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Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies by Mashaal Sohail, Robert M Maier, Andrea Ganna, Alex Bloemendal, Alicia R Martin, Michael C Turchin, Charleston WK Chiang, Joel Hirschhorn, Mark J Daly, Nick Patterson, Benjamin Neale, Iain Mathieson, David Reich, Shamil R Sunyaev

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A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease by Dane Z. Hazelbaker, Amanda Beccard, Anne M. Bara, Nicole Dabkowski, Angelica Messana, Patrizia Mazzucato, Daisy Lam, Danielle Manning, Kevin Eggan, Lindy E. Barrett

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