The genomics of heart failure: design and rationale of the HERMES consortium by R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans‐Peter Brunner‐La Rocca, David J. Carey, Mark D. Chaffin, Daniel I. Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H. Chung, William Chutkow, John G.F. Cleland, James P. Cook, Simon deDenus, Abbas Dehghan, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Dörr, Samuel C. Dudley, Gunnar Engström, Tõnu Esko, Ghazaleh Fatemifar, Stephan B. Felix, Chris Finan, Ian Ford, Francoise Fougerousse, René Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daníel F. Guðbjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M. Haggerty, Pim van derHarst, Åsa K. Hedman, Anna Helgadottir, Hans Hillege, Craig L. Hyde, Jaison Jacob, J. Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay‐Tee Khaw, Marcus E. Kleber, Lars Køber, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B. Margulies, Nicholas A. Marston, Winfried März, John J.V. McMurray, Olle Melander, Giorgio Melloni, Ify R. Mordi, Michael P. Morley, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Christopher Newton‐Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L. O'Donoghue, Anjali T. Owens, Colin N.A. Palmer, Guillaume Paré, Markus Perola, Louis‐Philippe Lemieux Perreault, Eliana Portilla‐Fernandez, Bruce M. Psaty, Kenneth M. Rice, Paul M. Ridker, Simon P.R. Romaine, Carolina Roselli, Jerome I. Rotter, Christian T. Ruff, Marc S. Sabatine, Perttu Salo, Veikko Salomaa, Jessica vanSetten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Kari Stefansson, Steen Stender, David J. Stott, Garðar Sveinbjörnsson, Mari‐Liis Tammesoo, Jean‐Claude Tardif, Kent D. Taylor, Maris Teder‐Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp‐Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G. Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M. Visscher, Uwe Völker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Peter E. Weeke, Raul Weiss, Harvey D. White, Kerri L. Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M. Yerges‐Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Regeneron Genetics Center, Jemma B. Wilk, Hilma Holm, Naveed Sattar, Steven A. Lubitz, David E. Lanfear, Svati Shah, Michael E. Dunn, Quinn S. Wells, Folkert W. Asselbergs, Aroon D. Hingorani, Marie‐Pierre Dubé, Nilesh J. Samani, Chim C. Lang, Thomas P. Cappola, Patrick T. Ellinor, Ramachandran S. Vasan, J. Gustav Smith

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317 B7-H3-targeted CAR T cell with an inducible caspase 9 suicide gene effectively eradicates uveal melanoma liver metastases by Yi Sun, Cristina R Ferrone, Rizwan Haq, Soldano Ferrone, Genevieve M Boland, Sandra Ryeom, Russell W Jenkins, Giulia Cattaneo, Marco Ventin, Shahrzad Arya, Jingyu Jia, Luke Maggs, Xinhui Wang, Bruce R Ksander

Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world by Jean-Pierre Levraud, John F. Rawls, Anne E. Clatworthy

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Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma by Jessica Tome-Garcia, Parsa Erfani, German Nudelman, Alexander M. Tsankov, Igor Katsyv, Rut Tejero, Bin Zhang, Martin Walsh, Roland H. Friedel, Elena Zaslavsky, Nadejda M. Tsankova

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New Approaches to Target T-ALL. by Giovanni eRoti, Giovanni eRoti, Giovanni eRoti, Kimberly eStegmaier, Kimberly eStegmaier, Kimberly eStegmaier

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Robust differentiation of human enteroendocrine cells from intestinal stem cells by Daniel Zeve, Eric Stas, Joshua de Sousa Casal, Prabhath Mannam, Wanshu Qi, Xiaolei Yin, Sarah Dubois, Manasvi S. Shah, Erin P. Syverson, Sophie Hafner, Jeffrey M. Karp, Diana L. Carlone, Jose Ordovas-Montanes, David T. Breault

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Decoding the genetics of rare disease: an interview with Monkol Lek by Monkol Lek

“…Daniel MacArthur's lab at Massachusetts General Hospital and the Broad Institute. During his postdoc, he led several large-scale studies aimed at distinguishing pathogenic from benign variants, including the Exome Aggregation Consortium (ExAC) project ( Lek et al., 2016). …”
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Control of Synapse Structure and Function by Actin and Its Regulators by Juliana E. Gentile, Melissa G. Carrizales, Anthony J. Koleske

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Integrating readout of somatic mutations in individual cells with single-cell transcriptional profiling by Shichen Liu, Maximilian Nguyen, Sahand Hormoz

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Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS by Xiaojian Shi, Bryn Reinstadler, Hardik Shah, Tsz-Leung To, Katie Byrne, Luanna Summer, Sarah E. Calvo, Olga Goldberger, John G. Doench, Vamsi K. Mootha, Hongying Shen

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O04: Developing a framework for sequence variant interpretation for multiple X-linked inborn errors of metabolism: The ClinGen IEM Working Group Experience by Emily Groopman, Amanda Thomas-Wilson, Shruthi Mohan, Jennifer Goldstein, Meredith Weaver, Raquel Fernandez, Heidi Wallis, Ljuba Caldovic, Nicholas Ah Mew, Irene De Biase, Ann Moser, Sharon Suchy, Tatiana Yuzyuk, Sarah Young, Saadet Mercimek-Andrews, Nancy Braverman, Rong Mao

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Truncating SOX9 Alterations Are Heterozygous Null Alleles in Genome-Stable Colorectal Cancer by G.N. Duronio, X. Liang, P. Hebbar, M. Islam, S. Spisak, N.S. Sethi

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Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation by Éadaoin Harney, Hila May, Dina Shalem, Nadin Rohland, Swapan Mallick, Iosif Lazaridis, Rachel Sarig, Kristin Stewardson, Susanne Nordenfelt, Nick Patterson, Israel Hershkovitz, David Reich

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Correction to: African evolutionary history inferred from whole genome sequence data of 44 indigenous African populations by Shaohua Fan, Derek E. Kelly, Marcia H. Beltrame, Matthew E. B. Hansen, Swapan Mallick, Alessia Ranciaro, Jibril Hirbo, Simon Thompson, William Beggs, Thomas Nyambo, Sabah A. Omar, Dawit Wolde Meskel, Gurja Belay, Alain Froment, Nick Patterson, David Reich, Sarah A. Tishkoff

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CAR-Based Approaches to Cutaneous T-Cell Lymphoma by Irene Scarfò, Irene Scarfò, Matthew J. Frigault, Matthew J. Frigault, Marcela V. Maus, Marcela V. Maus, Marcela V. Maus

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EmptyDrops: distinguishing cells from empty droplets in droplet-based single-cell RNA sequencing data by Aaron T. L. Lun, Samantha Riesenfeld, Tallulah Andrews, The Phuong Dao, Tomas Gomes, participants in the 1st Human Cell Atlas Jamboree, John C. Marioni

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The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons by Andrew Lutas, Carolina Lahmann, Magali Soumillon, Gary Yellen

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Clonal Hematopoiesis Defined by Somatic Mutations Infrequently Co-occurs With Mosaic Loss of the Y Chromosome in a Population-based Cohort by Priscilla Kamphuis, Isabelle A. van Zeventer, Aniek O. de Graaf, Giulio Genovese, Jonas B. Salzbrunn, Avinash G. Dinmohamed, Bert A. van der Reijden, Jan Jacob Schuringa, Joop H. Jansen, Gerwin Huls

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Innate immune activation: Parallels in alcohol use disorder and Alzheimer’s disease by Adriana Ramos, Radhika S. Joshi, Gyongyi Szabo, Gyongyi Szabo

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Tumor-Specific T Cell Activation in Malignant Brain Tumors by Malte Mohme, Marian Christoph Neidert, Marian Christoph Neidert, Marian Christoph Neidert

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