Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease by Connor A. Emdin, Amit V. Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam, Mary Haas, Alexander Bick, Seyedeh M. Zekavat, Akihiro Nomura, Diego Ardissino, James G. Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J. Bown, Nilesh J. Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Daniel Chasman, Paul Ridker, Joshua Denny, Lisa Bastarache, Judith H. Lichtman, Gail D’Onofrio, Jennifer Mattera, John A. Spertus, Wayne H.-H. Sheu, Kent D. Taylor, Bruce M. Psaty, Stephen S. Rich, Wendy Post, Jerome I. Rotter, Yii-Der Ida Chen, Harlan Krumholz, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan

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Neolithic and medieval virus genomes reveal complex evolution of hepatitis B by Ben Krause-Kyora, Julian Susat, Felix M Key, Denise Kühnert, Esther Bosse, Alexander Immel, Christoph Rinne, Sabin-Christin Kornell, Diego Yepes, Sören Franzenburg, Henrike O Heyne, Thomas Meier, Sandra Lösch, Harald Meller, Susanne Friederich, Nicole Nicklisch, Kurt W Alt, Stefan Schreiber, Andreas Tholey, Alexander Herbig, Almut Nebel, Johannes Krause

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A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors by Klara Klein, Klara Klein, Klara Klein, Angelique Hölzemer, Angelique Hölzemer, Angelique Hölzemer, Tim Wang, Tim Wang, Tim Wang, Tae-Eun Kim, Haley L. Dugan, Haley L. Dugan, Stephanie Jost, Stephanie Jost, Marcus Altfeld, Wilfredo F. Garcia-Beltran, Wilfredo F. Garcia-Beltran

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The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection by Kristen E. Pauken, Jernej Godec, Pamela M. Odorizzi, Keturah E. Brown, Kathleen B. Yates, Shin Foong Ngiow, Kelly P. Burke, Seth Maleri, Shannon M. Grande, Loise M. Francisco, Mohammed-Alkhatim Ali, Sabrina Imam, Gordon J. Freeman, W. Nicholas Haining, E. John Wherry, Arlene H. Sharpe

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Cohort profile: SUPER-Finland – the Finnish study for hereditary mechanisms of psychotic disorders by Jari Tiihonen, Ari Ahola-Olli, Tiina Paunio, Aarno Palotie, Mark Daly, Risto Kajanne, Erkki Isometsä, Juha Veijola, Jouko Lönnqvist, Olli Kampman, Jaana Suvisaari, Kimmo Suokas, Markku Lähteenvuo, Minna Holm, Zuzanna Misiewicz, Tuomas Jukuri, Teemu Männynsalo, Asko Wegelius, Willehard Haaki, Aija Kyttälä, Annamari Tuulio-Henriksson, Kaisla Lahdensuo, Katja Häkkinen, Jarmo Hietala, Jussi Niemi-Pynttäri, Tuula Kieseppä, Steven Hyman, Benjamin Neale

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Genomic analysis of lean individuals with NAFLD identifies monogenic disorders in a prospective cohort study by Melanie Zheng, Daniel Q. Huang, Chigoziri Konkwo, Saaket Agrawal, Amit V. Khera, Rohit Loomba, Sílvia Vilarinho, Veeral Ajmera

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Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors by Y. Esther Tak, Gaylor Boulay, Lukuo Lee, Sowmya Iyer, Nicholas T. Perry, Hayley T. Schultz, Sara P. Garcia, Liliane Broye, Joy E. Horng, Shruthi Rengarajan, Beverly Naigles, Angela Volorio, Jeffry D. Sander, Jingyi Gong, Nicolò Riggi, J. Keith Joung, Miguel N. Rivera

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Healthy Lifestyle and Clonal Hematopoiesis of Indeterminate Potential: Results From the Women's Health Initiative by Bernhard Haring, Alexander P. Reiner, Jingmin Liu, Deirdre K. Tobias, Eric Whitsel, Jeffrey S. Berger, Pinkal Desai, Sylvia Wassertheil‐Smoller, Michael J. LaMonte, Kathleen M. Hayden, Alexander G. Bick, Pradeep Natarajan, Joshua S. Weinstock, Patricia K. Nguyen, Marcia Stefanick, Michael S. Simon, Charles B. Eaton, Charles Kooperberg, JoAnn E. Manson

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Most Pathways Can Be Related to the Pathogenesis of Alzheimer’s Disease by Sarah L. Morgan, Sarah L. Morgan, Sarah L. Morgan, Pourya Naderi, Pourya Naderi, Katjuša Koler, Yered Pita-Juarez, Yered Pita-Juarez, Yered Pita-Juarez, Dmitry Prokopenko, Dmitry Prokopenko, Ioannis S. Vlachos, Ioannis S. Vlachos, Ioannis S. Vlachos, Rudolph E. Tanzi, Rudolph E. Tanzi, Lars Bertram, Lars Bertram, Winston A. Hide, Winston A. Hide

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Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance by Luana C Mathieu, Horace Cox, Angela M Early, Sachel Mok, Yassamine Lazrek, Jeanne-Celeste Paquet, Maria-Paz Ade, Naomi W Lucchi, Quacy Grant, Venkatachalam Udhayakumar, Jean SF Alexandre, Magalie Demar, Pascal Ringwald, Daniel E Neafsey, David A Fidock, Lise Musset

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Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro by Joann Diray-Arce, Asimenia Angelidou, Kristoffer Jarlov Jensen, Maria Giulia Conti, Rachel S. Kelly, Matthew A. Pettengill, Mark Liu, Simon D. van Haren, Scott D. McCulloch, Greg Michelloti, Olubukola Idoko, Tobias R. Kollmann, Beate Kampmann, Hanno Steen, Al Ozonoff, Jessica Lasky-Su, Christine S. Benn, Ofer Levy

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Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression by Nida Meednu, Javier Rangel-Moreno, Fan Zhang, Katherine Escalera-Rivera, Elisa Corsiero, Edoardo Prediletto, Edward DiCarlo, Susan Goodman, Laura T. Donlin, Soumya Raychauduri, Michele Bombardieri, Costantino Pitzalis, Dana E. Orange, Andrew McDavid, Jennifer H. Anolik

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Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization in vitro by Guzman Sanchez-Schmitz, Guzman Sanchez-Schmitz, Guzman Sanchez-Schmitz, Chad R. Stevens, Ian A. Bettencourt, Peter J. Flynn, Klaus Schmitz-Abe, Klaus Schmitz-Abe, Klaus Schmitz-Abe, Klaus Schmitz-Abe, Gil Metser, David Hamm, Kristoffer J. Jensen, Kristoffer J. Jensen, Kristoffer J. Jensen, Christine Benn, Christine Benn, Ofer Levy, Ofer Levy, Ofer Levy, Ofer Levy

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Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia by Barry M. Zee, Kamrine E. Poels, Cong-Hui Yao, Kimihito C. Kawabata, Gongwei Wu, Cihangir Duy, William D. Jacobus, Elizabeth Senior, Jennifer E. Endress, Ashwini Jambhekar, Scott B. Lovitch, Jiexian Ma, Abhinav Dhall, Isaac S. Harris, M. Andres Blanco, David B. Sykes, Jonathan D. Licht, David M. Weinstock, Ari Melnick, Marcia C. Haigis, Franziska Michor, Yang Shi

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Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis by Edwin Ardiansyah, Julian Avila-Pacheco, Le Thanh Hoang Nhat, Sofiati Dian, Dao Nguyen Vinh, Hoang Thanh Hai, Kevin Bullock, Bachti Alisjahbana, Mihai G Netea, Riwanti Estiasari, Trinh Thi Bich Tram, Joseph Donovan, Dorothee Heemskerk, Tran Thi Hong Chau, Nguyen Duc Bang, Ahmad Rizal Ganiem, Rovina Ruslami, Valerie ACM Koeken, Raph L Hamers, Darma Imran, Kartika Maharani, Vinod Kumar, Clary B Clish, Reinout van Crevel, Guy Thwaites, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong

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MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection by Sharon Khuzwayo, Sharon Khuzwayo, Maphe Mthembu, Maphe Mthembu, Erin W. Meermeier, Sanjay M. Prakadan, Sanjay M. Prakadan, Sanjay M. Prakadan, Samuel W. Kazer, Samuel W. Kazer, Samuel W. Kazer, Thierry Bassett, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Moosa Suleman, Moosa Suleman, Zoey Mhlane, Dirhona Ramjit, Farina Karim, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, David M. Lewinsohn, David M. Lewinsohn, David M. Lewinsohn, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Emily B. Wong, Emily B. Wong, Emily B. Wong, Emily B. Wong

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Association between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease by Laura Fernanda Ambrosio, Laura Fernanda Ambrosio, Ximena Volpini, Ximena Volpini, Juan Nahuel Quiroz, Juan Nahuel Quiroz, María Belén Brugo, María Belén Brugo, Carolina Paola Knubel, Carolina Paola Knubel, Melisa Rocío Herrera, Melisa Rocío Herrera, Laura Fozzatti, Laura Fozzatti, Julián Avila Pacheco, Clary B. Clish, Maisa C. Takenaka, Juan Beloscar, Martín Gustavo Theumer, Martín Gustavo Theumer, Francisco Javier Quintana, Francisco Javier Quintana, Ana Rosa Perez, Ana Rosa Perez, Claudia Cristina Motrán, Claudia Cristina Motrán

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Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions by Michael R. Filbin, Arnav Mehta, Alexis M. Schneider, Kyle R. Kays, Jamey R. Guess, Matteo Gentili, Bánk G. Fenyves, Nicole C. Charland, Anna L.K. Gonye, Irena Gushterova, Hargun K. Khanna, Thomas J. LaSalle, Kendall M. Lavin-Parsons, Brendan M. Lilley, Carl L. Lodenstein, Kasidet Manakongtreecheep, Justin D. Margolin, Brenna N. McKaig, Maricarmen Rojas-Lopez, Brian C. Russo, Nihaarika Sharma, Jessica Tantivit, Molly F. Thomas, Robert E. Gerszten, Graham S. Heimberg, Paul J. Hoover, David J. Lieb, Brian Lin, Debby Ngo, Karin Pelka, Miguel Reyes, Christopher S. Smillie, Avinash Waghray, Thomas E. Wood, Amanda S. Zajac, Lori L. Jennings, Ida Grundberg, Roby P. Bhattacharyya, Blair Alden Parry, Alexandra-Chloé Villani, Moshe Sade-Feldman, Nir Hacohen, Marcia B. Goldberg

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Author Correction: BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors by Xiaofeng Wang, Su Wang, Emma C. Troisi, Thomas P. Howard, Jeffrey R. Haswell, Bennett K. Wolf, William H. Hawk, Pilar Ramos, Elaine M. Oberlick, Evgeni P. Tzvetkov, Aaron Ross, Francisca Vazquez, William C. Hahn, Peter J. Park, Charles W. M. Roberts

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Spying on SARS-CoV-2 with Fluorescent Tags and Protease Reporters by Tsz-Leung To, Xiaoquan Li, Xiaokun Shu

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