Editorial: Chromosome structural variants: Epidemiology, identification and contribution to human diseases by Zirui Dong, Zirui Dong, Zirui Dong, Zirui Dong, Dezso David, Claudia Gonzaga-Jauregui, Cynthia C. Morton, Cynthia C. Morton, Cynthia C. Morton, Cynthia C. Morton, Cynthia C. Morton, Cinthya J. Zepeda-Mendoza

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Single-cell transcriptomics of a dynamic cell behavior in murine airways by Sheldon JJ Kwok, Daniel T Montoro, Adam L Haber, Seok-Hyun Yun, Vladimir Vinarsky

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Combined protein and nucleic acid staining in tissues with PANINI by Addison Deisher, Yao Yu Yeo, Sizun Jiang

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Phages in the Gut Ecosystem by Michele Zuppi, Heather L. Hendrickson, Justin M. O’Sullivan, Justin M. O’Sullivan, Justin M. O’Sullivan, Tommi Vatanen, Tommi Vatanen

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Genetic mapping and exome sequencing identify variants associated with five novel diseases. by Erik G Puffenberger, Robert N Jinks, Carrie Sougnez, Kristian Cibulskis, Rebecca A Willert, Nathan P Achilly, Ryan P Cassidy, Christopher J Fiorentini, Kory F Heiken, Johnny J Lawrence, Molly H Mahoney, Christopher J Miller, Devika T Nair, Kristin A Politi, Kimberly N Worcester, Roni A Setton, Rosa Dipiazza, Eric A Sherman, James T Eastman, Christopher Francklyn, Susan Robey-Bond, Nicholas L Rider, Stacey Gabriel, D Holmes Morton, Kevin A Strauss

“…Seven such conditions were selected for exome sequencing at the Broad Institute; all had been previously mapped at the CSC using low density SNP microarrays coupled with autozygosity and linkage analyses. …”
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Biomimetic and bioinspired nano‐platforms for cancer vaccine development by Chenchao Feng, Peng Tan, Guangjun Nie, Motao Zhu

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Evaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping by Chang Meiping, Smith Sarah, Thorpe Andrew, Barratt Michael J, Karim Farzana

“…We used the Connectivity Map approach to identify pharmacologic agents in the Broad Institute Build02 database that had gene expression signatures that were inversely related ('negatively connected') with our CFA signature. …”
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Contextual Effects of Neighborhoods and Schools on Adolescent and Young Adult Marijuana Use in the United States by Carly E Milliren, Tracy K Richmond, Clare R Evans, Erin C Dunn, Renee M Johnson

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Reconstruction of complex single-cell trajectories using CellRouter by Edroaldo Lummertz da Rocha, R. Grant Rowe, Vanessa Lundin, Mohan Malleshaiah, Deepak Kumar Jha, Carlos R. Rambo, Hu Li, Trista E. North, James J. Collins, George Q. Daley

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655 Dissecting pancreatic cancer tumor-immune microenvironment crosstalk using spatial transcriptomics by David Ting, David Ryan, Amaya Pankaj, Linda Nieman, Katherine Xu, Arnav Mehta, Michael J Raabe, Julie L Koenig, Bidish Patel, Evan R Lang, Joshua Kocher, Alec Kimmelman, William Hwang, Martin Aryee, Theodore Hong, Aparna R Parikh

Novel Therapeutic Targets and Immune Dysfunction in Malignant Pleural Mesothelioma by Moshe Lapidot, Srinivas Vinod Saladi, Srinivas Vinod Saladi, Ravi Salgia, Martin Sattler, Martin Sattler

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Effects of Pseudorabies Virus Infection on the Tracheobronchial Lymph Node Transcriptome by Laura C. Miller, Darrell O. Bayles, Eraldo L. Zanella, Kelly M. Lager

“…Hive plots were created to visualize the differential expression within the swine transcriptome defined by the Broad Institute's GSEA reference datasets between infected and uninfected animals, allowing us to directly compare different conditions.…”
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1255 Single cell dissection of human checkpoint inhibitor hepatitis reveals insights into liver immune tolerance by Nir Hacohen, Ryan Sullivan, Molly Thomas, John McGuire, Dejan Juric, Leyre Zubiri, Kerry Reynolds, Genevieve M Boland, Alexandra-Chloe Villani, Mazen Nasrallah, Neal Smith, Kasidet Manakongtreecheep, Jessica Tantivit, Alice Tirard, Swetha Ramesh, Tos Chan, Marc Sherman, Georg Lauer, Shreyash Sonthalia

Re-examining physician-scientist training through the prism of the discovery-invention cycle [version 1; peer review: 2 approved] by Gopal P. Sarma, Allan Levey, Victor Faundez

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Molecular sled sequences are common in mammalian proteins by Xiong, Kan, Blainey, Paul C.

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Cellular and synaptic network defects in autism by Peca, Joao, Feng, Guoping

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Erratum to: Host lifestyle affects human microbiota on daily timescales by Friedman, Jonathan, Perrotta, Allison, David, Lawrence A., Materna, Arne C., Baptista, Maria I. C., Blackburn, Matthew C., Erdman, Susan E, Alm, Eric J, Perrotta, Allison

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A New Take on John Maynard Smith's Concept of Protein Space for Understanding Molecular Evolution by Ogbunugafor, C. Brandon, Hartl, Daniel

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Upholding a role for EMT in pancreatic cancer metastasis by Aiello, Nicole M., Brabletz, Thomas, Kang, Yibin, Nieto, Maria, Weinberg, Robert A, Stanger, Ben Z.

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Negative Selection by Spiral Inertial Microfluidics Improves Viral Recovery and Sequencing from Blood by Choi, Kyungyong, Ryu, Hyunryul, Siddle, Katherine J., Piantadosi, Anne, Freimark, Lisa, Park, Daniel J., Sabeti, Pardis, Han, Jongyoon

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