XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells by Tao Zou, Meng Zhou, Akansha Gupta, Patrick Zhuang, Alyssa R. Fishbein, Hope Y. Wei, Diego Capcha-Rodriguez, Zhouwei Zhang, Andrew D. Cherniack, Matthew Meyerson

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Multiple knockout mouse models reveal lincRNAs are required for life and brain development by Martin Sauvageau, Loyal A Goff, Simona Lodato, Boyan Bonev, Abigail F Groff, Chiara Gerhardinger, Diana B Sanchez-Gomez, Ezgi Hacisuleyman, Eric Li, Matthew Spence, Stephen C Liapis, William Mallard, Michael Morse, Mavis R Swerdel, Michael F D’Ecclessis, Jennifer C Moore, Venus Lai, Guochun Gong, George D Yancopoulos, David Frendewey, Manolis Kellis, Ronald P Hart, David M Valenzuela, Paola Arlotta, John L Rinn

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Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes by Jennifer L. Halford, Valerie N. Morrill, Seung Hoan Choi, Sean J. Jurgens, Giorgio Melloni, Nicholas A. Marston, Lu-Chen Weng, Victor Nauffal, Amelia W. Hall, Sophia Gunn, Christina A. Austin-Tse, James P. Pirruccello, Shaan Khurshid, Heidi L. Rehm, Emelia J. Benjamin, Eric Boerwinkle, Jennifer A. Brody, Adolfo Correa, Brandon K. Fornwalt, Namrata Gupta, Christopher M. Haggerty, Stephanie Harris, Susan R. Heckbert, Charles C. Hong, Charles Kooperberg, Henry J. Lin, Ruth J. F. Loos, Braxton D. Mitchell, Alanna C. Morrison, Wendy Post, Bruce M. Psaty, Susan Redline, Kenneth M. Rice, Stephen S. Rich, Jerome I. Rotter, Peter F. Schnatz, Elsayed Z. Soliman, Nona Sotoodehnia, Eugene K. Wong, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Marc S. Sabatine, Christian T. Ruff, Kathryn L. Lunetta, Patrick T. Ellinor, Steven A. Lubitz

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Population structure discovery in meta-analyzed microbial communities and inflammatory bowel disease using MMUPHin by Siyuan Ma, Dmitry Shungin, Himel Mallick, Melanie Schirmer, Long H. Nguyen, Raivo Kolde, Eric Franzosa, Hera Vlamakis, Ramnik Xavier, Curtis Huttenhower

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A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies by Xun Chen, Matteo Gentili, Nir Hacohen, Aviv Regev

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CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis by Vivien A. C. Schoonenberg, Mitchel A. Cole, Qiuming Yao, Claudio Macias-Treviño, Falak Sher, Patrick G. Schupp, Matthew C. Canver, Takahiro Maeda, Luca Pinello, Daniel E. Bauer

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221 CRISPR screen identifies loss of IFNγR signaling and downstream adhesion as a resistance mechanism to CAR T-cell cytotoxicity in solid but not liquid tumors by Marcela Maus, Rebecca Larson, Irene Scarfò, Max Jan, Stefanie Bailey, Amanda Bouffard, Michael Kann, Nicholas Haradhvala, Kai Stewart, Mark Leick, Trisha Berger, Julia Joung, Tamara Ouspenskaia, Travis Law, Aviv Regev, Gad Getz

AI-BASED PATHOLOGY PREDICTS ORIGINS FOR CANCERS OF UNKNOWN PRIMARY by Ming Y. Lu, Tiffany Y. Chen, Drew F.K. Williamson, Melissa Zhao, Maha Shady, Jana Lipkova, Faisal Mahmood

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In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration by Elliot H. Choi, Susie Suh, Andrzej T. Foik, Henri Leinonen, Gregory A. Newby, Xin D. Gao, Samagya Banskota, Thanh Hoang, Samuel W. Du, Zhiqian Dong, Aditya Raguram, Sajeev Kohli, Seth Blackshaw, David C. Lyon, David R. Liu, Krzysztof Palczewski

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Emergence of Epidemic Multidrug-Resistant <named-content content-type="genus-species">Enterococcus faecium</named-content> from Animal and Commensal Strains by François Lebreton, Willem van Schaik, Abigail Manson McGuire, Paul Godfrey, Allison Griggs, Varun Mazumdar, Jukka Corander, Lu Cheng, Sakina Saif, Sarah Young, Qiandong Zeng, Jennifer Wortman, Bruce Birren, Rob J. L. Willems, Ashlee M. Earl, Michael S. Gilmore

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Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood by Art Schuermans, Tetsushi Nakao, Yunfeng Ruan, Satoshi Koyama, Zhi Yu, Md Mesbah Uddin, Sara Haidermota, Whitney Hornsby, Adam J. Lewandowski, Alexander G. Bick, Abhishek Niroula, Siddhartha Jaiswal, Benjamin L. Ebert, Pradeep Natarajan, Michael C. Honigberg

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Cohort design and natural language processing to reduce bias in electronic health records research by Shaan Khurshid, Christopher Reeder, Lia X. Harrington, Pulkit Singh, Gopal Sarma, Samuel F. Friedman, Paolo Di Achille, Nathaniel Diamant, Jonathan W. Cunningham, Ashby C. Turner, Emily S. Lau, Julian S. Haimovich, Mostafa A. Al-Alusi, Xin Wang, Marcus D. R. Klarqvist, Jeffrey M. Ashburner, Christian Diedrich, Mercedeh Ghadessi, Johanna Mielke, Hanna M. Eilken, Alice McElhinney, Andrea Derix, Steven J. Atlas, Patrick T. Ellinor, Anthony A. Philippakis, Christopher D. Anderson, Jennifer E. Ho, Puneet Batra, Steven A. Lubitz

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Chromosomal phase improves aneuploidy detection in non-invasive prenatal testing at low fetal DNA fractions by Giulio Genovese, Curtis J. Mello, Po-Ru Loh, Robert E. Handsaker, Seva Kashin, Christopher W. Whelan, Lucy A. Bayer-Zwirello, Steven A. McCarroll

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Systematic morphological profiling of human gene and allele function via Cell Painting by Mohammad Hossein Rohban, Shantanu Singh, Xiaoyun Wu, Julia B Berthet, Mark-Anthony Bray, Yashaswi Shrestha, Xaralabos Varelas, Jesse S Boehm, Anne E Carpenter

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REDUCING INTER-OBSERVER VARIABILITY IN ENDOMYOCARDIAL BIOPSY ASSESSMENT by Jana Lipkova, Tiffany Y. Chen, Ming Y. Lu, Richard J. Chen, Maha Shady, Mane Williams, Jingwen Wang, Zahra Noor, Richard N. Mitchell, Faisal Mahmood

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MULTIMODAL AI-BASED ASSESSMENT OF RENAL ALLOGRAFT BIOPSIES by Sharifa Sahai, Richard J. Chen, Jana Lipkova, Kuan Chen, Tiffany Y. Chen, Drew Williamson, Judy J. Wang, Astrid Weins, Faisal Mahmood

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Integrated genetic and pharmacologic interrogation of rare cancers by Andrew L. Hong, Yuen-Yi Tseng, Glenn S. Cowley, Oliver Jonas, Jaime H. Cheah, Bryan D. Kynnap, Mihir B. Doshi, Coyin Oh, Stephanie C. Meyer, Alanna J. Church, Shubhroz Gill, Craig M. Bielski, Paula Keskula, Alma Imamovic, Sara Howell, Gregory V. Kryukov, Paul A. Clemons, Aviad Tsherniak, Francisca Vazquez, Brian D. Crompton, Alykhan F. Shamji, Carlos Rodriguez-Galindo, Katherine A. Janeway, Charles W. M. Roberts, Kimberly Stegmaier, Paul van Hummelen, Michael J. Cima, Robert S. Langer, Levi A. Garraway, Stuart L. Schreiber, David E. Root, William C. Hahn, Jesse S. Boehm

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Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection by Bo Li, Sara M. Clohisey, Bing Shao Chia, Bo Wang, Ang Cui, Thomas Eisenhaure, Lawrence D. Schweitzer, Paul Hoover, Nicholas J. Parkinson, Aharon Nachshon, Nikki Smith, Tim Regan, David Farr, Michael U. Gutmann, Syed Irfan Bukhari, Andrew Law, Maya Sangesland, Irit Gat-Viks, Paul Digard, Shobha Vasudevan, Daniel Lingwood, David H. Dockrell, John G. Doench, J. Kenneth Baillie, Nir Hacohen

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Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome by Eileen P Hamilton, Aurélie Kapusta, Piroska E Huvos, Shelby L Bidwell, Nikhat Zafar, Haibao Tang, Michalis Hadjithomas, Vivek Krishnakumar, Jonathan H Badger, Elisabet V Caler, Carsten Russ, Qiandong Zeng, Lin Fan, Joshua Z Levin, Terrance Shea, Sarah K Young, Ryan Hegarty, Riza Daza, Sharvari Gujja, Jennifer R Wortman, Bruce W Birren, Chad Nusbaum, Jainy Thomas, Clayton M Carey, Ellen J Pritham, Cédric Feschotte, Tomoko Noto, Kazufumi Mochizuki, Romeo Papazyan, Sean D Taverna, Paul H Dear, Donna M Cassidy-Hanley, Jie Xiong, Wei Miao, Eduardo Orias, Robert S Coyne

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AI-BASED FAST AND SCALABLE IMAGE SEARCH FOR RARE DISEASE DIAGNOSIS by Chengkuan Chen, Ming Y. Lu, Drew F.K. Williamson, Tiffany Y. Chen, Andrew J. Schaumberg, Faisal Mahmood

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