Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions by Dheeraj S. Roy, Young-Gyun Park, Minyoung E. Kim, Ying Zhang, Sachie K. Ogawa, Nicholas DiNapoli, Xinyi Gu, Jae H. Cho, Heejin Choi, Lee Kamentsky, Jared Martin, Olivia Mosto, Tomomi Aida, Kwanghun Chung, Susumu Tonegawa

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Vulnerability of The Male Reproductive System to SARS-CoV-2 Invasion: Potential Role for The Endoplasmic Reticulum Chaperone Grp78/HSPA5/BiP by Niloofar Sadeghi, Marziyeh Tavalaee, Abdolhossein Shahverdi, Pallav Sengupta, Kristian Leisegang, Ramadan Saleh, Ashok Agarwal, Mohammad Hossein Nasr Esfahani

“…SARS-CoVs use the endoplasmic reticulum (ER) as a site for viral protein synthesis and processing, as well as glucose-regulated protein 78 (Grp78) is a key ER chaperone involved in protein folding by preventing newly synthesized proteins from aggregation.Therefore, we analyzed Grp78 expression in various human organs, particularly male reproductive organs, using BroadInstitute Cancer Cell Line Encyclopedia (CCLE), the Genotype-Tissue Expression (GTEx), and Human Protein Atlas onlinedatasets. …”
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IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1 by Ning Dai, Fei Ji, Jason Wright, Liliana Minichiello, Ruslan Sadreyev, Joseph Avruch

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High-Dimensional Bayesian Network Inference From Systems Genetics Data Using Genetic Node Ordering by Lingfei Wang, Lingfei Wang, Lingfei Wang, Pieter Audenaert, Pieter Audenaert, Tom Michoel, Tom Michoel

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LoFTK: a framework for fully automated calculation of predicted Loss-of-Function variants and genes by Abdulrahman Alasiri, Konrad J. Karczewski, Brian Cole, Bao-Li Loza, Jason H. Moore, Sander W. van der Laan, Folkert W. Asselbergs, Brendan J. Keating, Jessica van Setten

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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma by Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E., Young, Richard A.

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High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis by Schwartz, Schraga, Mumbach, Maxwell R., Jovanovic, Marko, Mertins, Philipp, Shishkin, Alexander, Tabach, Yuval, Mikkelsen, Tarjei S., Satija, Rahul, Ruvkun, Gary, Carr, Steven A., Regev, Aviv, Agarwala, Sudeep, Lander, Eric Steven, Fink, Gerald R.

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Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis by Hiraki, Masatsugu, Hwang, So-Young, Cao, Shugeng, Ramadhar, Timothy R., Byun, Sanguine, Yoon, Kyoung Wan, Lee, Jung Hyun, Chu, Kiki, Gurkar, Aditi U., Kolev, Vihren, Zhang, Jianming, Namba, Takushi, Murphy, Maureen E., Newman, David J., Clardy, Jon, Lee, Samuel W., Mandinova, Anna

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Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor by Christensen, Camilla L., Carretero, Julian, Al-Shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian D., Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani E., Gray, Nathanael S., Wong, Kwok-Kin, Kwiatkowski, Nick, Abraham, Brian Joseph, Young, Richard A.

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Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation by Udeshi, Namrata D, Svinkina, Tanya, Hung, Victoria, Lam, Stephanie Shih-Min, Guzman, Gaelen Donnelly, Mootha, Vamsi, Carr, Steven A, Ting, Alice Y

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Two dynamic regimes in the human gut microbiome by Gibbons, Sean Michael, Kearney, Sean M, Smillie, Chris S, Alm, Eric J

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Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms by Xiao, Sheng, Yosef, Nir, Yang, Jianfei, Wang, Yonghui, Zhou, Ling, Zhu, Chen, Wu, Chuan, Baloglu, Erkan, Schmidt, Darby, Ramesh, Radha, Lobera, Mercedes, Sundrud, Mark S., Tsai, Pei-Yun, Xiang, Zhijun, Wang, Jinsong, Xu, Yan, Lin, Xichen, Kretschmer, Karsten, Rahl, Peter B., Zhong, Zhong, Hafler, David A., Ghosh, Shomir, Marson, Alexander, Kuchroo, Vijay K., Regev, Aviv, Young, Richard A.

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Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification by Logan, David J, Shan, Jing, Bhatia, Sangeeta N, Van Dyk, Anne Carpenter

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Improved vectors and genome-wide libraries for CRISPR screening by Sanjana, Neville E, Shalem, Ophir, Zhang, Feng

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Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions by Ernst, Jason, Melnikov, Alexandre, Zhang, Xiaolan, Wang, Li, Rogov, Peter L, Mikkelsen, Tarjei, Kellis, Manolis

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IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress by Lerner, Alana G., Upton, John-Paul, Praveen, P.V.K., Ghosh, Rajarshi, Nakagawa, Yoshimi, Igbaria, Aeid, Shen, Sarah, Nguyen, Vinh, Backes, Bradley J., Heintz, Nathaniel, Greengard, Paul, Hui, Simon, Tang, Qizhi, Trusina, Ala, Oakes, Scott A., Papa, Feroz R., Heiman, Myriam

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An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling by Yosef, Nir, Qiao, Jana, Raychowdhury, Raktima, Maritzen, Tanja, Haucke, Volker, Satoh, Takashi, Akira, Shizuo, Mertins, Philipp, Przybylski, Dariusz, Eisenhaure, Thomas, Carr, Steven A, Regev, Aviv, Hacohen, Nir, Chevrier, Nicolas, Clauser, Karl R.

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Transcriptional regulatory dynamics drive coordinated metabolic and neural response to social challenge in mice by Saul, Michael C., Seward, Christopher H., Troy, Joseph M., Zhang, Huimin, Sloofman, Laura G., Lu, Xiaochen, Weisner, Patricia A., Caetano-Anolles, Derek, Sun, Hao, Zhao, Sihai Dave, Sinha, Saurabh, Stubbs, Lisa, Chandrasekaran, Sriram

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Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay by Park, Daniel S., Liu, Brandon, Winnicki, Sarah, Reilly, Steven K., Andersen, Kristian G., Tewhey, Ryan, Kotliar, Dylan A., Andersen, Kristian, Mikkelsen, Tarjei, Lander, Eric Steven, Schaffner, Stephen F, Sabeti, Pardis

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Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq by Venteicher, Andrew S., Tirosh, Itay, Hebert, Christine, Yizhak, Keren, Neftel, Cyril, Filbin, Mariella G., Hovestadt, Volker, Escalante, Leah E., Shaw, McKenzie L., Rodman, Christopher, Gillespie, Shawn M., Luo, Christina C., Ravichandran, Hiranmayi, Mylvaganam, Ravindra, Mount, Christopher, Onozato, Maristela L., Nahed, Brian V., Wakimoto, Hiroaki, Curry, William T., Iafrate, A. John, Rivera, Miguel N., Frosch, Matthew P., Brastianos, Priscilla K., Patel, Anoop P., Monje, Michelle, Cahill, Daniel P., Rozenblatt-Rosen, Orit, Louis, David N., Suvà, Mario L., Dionne, Danielle, Golub, Todd, Getz, Gad Asher, Regev, Aviv, Bernstein, Bradley E.

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