Cross-Packaging and Capsid Mosaic Formation in Multiplexed AAV Libraries by Pauline F. Schmit, Simon Pacouret, Eric Zinn, Elizabeth Telford, Fotini Nicolaou, Frédéric Broucque, Eva Andres-Mateos, Ru Xiao, Magalie Penaud-Budloo, Mohammed Bouzelha, Nicolas Jaulin, Oumeya Adjali, Eduard Ayuso, Luk H. Vandenberghe

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Genetic and methylation variation in the CYP2B6 gene is related to circulating p,p′-dde levels in a population-based sample by Lars Lind, Esther Ng, Erik Ingelsson, Cecilia Lindgren, Samira Salihovic, Bert van Bavel, Anubha Mahajan, Erik Lampa, Andrew P. Morris, P. Monica Lind

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Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis by Shruthi Thada, Gabor L. Horvath, Mario M. Müller, Nickel Dittrich, Melanie L. Conrad, Saubashya Sur, Abid Hussain, Karin Pelka, Suman Latha Gaddam, Eicke Latz, Hortense Slevogt, Ralf R. Schumann, Sanne Burkert

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National prevalence and trends in food labeling awareness, comprehension, usage, and COVID-19 pandemic-related factors in South Korea, 2014–2022 by Yujin Choi, Hyeon Jin Kim, Jaeyu Park, Seung Won Lee, Masoud Rahmati, Ai Koyanagi, Lee Smith, Min Seo Kim, Guillermo F. López Sánchez, Elena Dragioti, Jinseok Lee, Sang Youl Rhee, Sunyoung Kim, Hyunjung Lim, Dong Keon Yon

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Contributions of PTSD polygenic risk and environmental stress to suicidality in preadolescents by Nikolaos P. Daskalakis, Laura M. Schultz, Elina Visoki, Tyler M. Moore, Stirling T. Argabright, Nathaniel G. Harnett, Grace E. DiDomenico, Varun Warrier, Laura Almasy, Ran Barzilay

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Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia by Zachary C. Rosenthal, Daniel M. Fass, N. Connor Payne, Angela She, Debasis Patnaik, Krista M. Hennig, Rachel Tesla, Gordon C. Werthmann, Charlotte Guhl, Surya A. Reis, Xiaoyu Wang, Yueting Chen, Michael Placzek, Noelle S. Williams, Jacob Hooker, Joachim Herz, Ralph Mazitschek, Stephen J. Haggarty

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Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes by Robert Krencik, Kyounghee Seo, Jessy V. van Asperen, Nupur Basu, Caroline Cvetkovic, Saba Barlas, Robert Chen, Connor Ludwig, Chao Wang, Michael E. Ward, Li Gan, Philip J. Horner, David H. Rowitch, Erik M. Ullian

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Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses by Iman Tavassoly, Yuan Hu, Shan Zhao, Chiara Mariottini, Aislyn Boran, Yibang Chen, Lisa Li, Rosa E. Tolentino, Gomathi Jayaraman, Joseph Goldfarb, James Gallo, Ravi Iyengar

“…We tested allopurinol, an FDA‐approved drug that inhibits XDH, on human non‐small‐cell lung cancer (NSCLC) cell lines obtained from the Broad Institute Cancer Cell Line Encyclopedia and identified sensitive and resistant cell lines. …”
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Sanger Validation of High-Throughput Sequencing in Genetic Diagnosis: Still the Best Practice? by Rosina De Cario, Ada Kura, Samuele Suraci, Alberto Magi, Andrea Volta, Rossella Marcucci, Rossella Marcucci, Anna Maria Gori, Anna Maria Gori, Guglielmina Pepe, Guglielmina Pepe, Betti Giusti, Betti Giusti, Elena Sticchi, Elena Sticchi

“…Variants called following guidelines suggested by the Broad Institute and identified according to MAF <0.01 and allele balance >0.2 were Sanger validated. …”
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Comparative transcriptional analysis of satellite glial cell injury response [version 1; peer review: 2 approved] by Lin Lin, Franziska Denk, Lone Tjener Pallesen, Alana Miranda Pinheiro, Francesca Izzi, Christian Bjerggaard Vaegter, Paolo Cesare, Sara Elgaard Jager, Sara Villa-Hernandez

“…Our results are available via the Broad Institute Single Cell Portal, so that readers can explore and search for genes of interest.…”
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Mitochondrial Genome Sequences of the Emerging Fungal Pathogen Candida auris by Elizabeth Misas, Elizabeth Misas, Nancy A. Chow, Oscar M. Gómez, Oscar M. Gómez, Oscar M. Gómez, José F. Muñoz, Juan G. McEwen, Juan G. McEwen, Anastasia P. Litvintseva, Oliver K. Clay, Oliver K. Clay

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Mechanics of morphogenesis in neural development: In vivo, in vitro, and in silico by Joseph Sutlive, Hamed Seyyedhosseinzadeh, Zheng Ao, Haning Xiu, Sangita Choudhury, Kun Gou, Feng Guo, Zi Chen

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Insulin-sensitizing effects of vitamin D repletion mediated by adipocyte vitamin D receptor: Studies in humans and mice by Eric Lontchi-Yimagou, Sona Kang, Akankasha Goyal, Kehao Zhang, Jee Y. You, Michelle Carey, Swati Jain, Shobhit Bhansali, Sylvia Kehlenbrink, Peng Guo, Evan D. Rosen, Preeti Kishore, Meredith Hawkins

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Origin in <named-content content-type="genus-species">Acinetobacter guillouiae</named-content> and Dissemination of the Aminoglycoside-Modifying Enzyme Aph(3′)-VI by Eun-Jeong Yoon, Sylvie Goussard, Marie Touchon, Lenka Krizova, Gustavo Cerqueira, Cheryl Murphy, Thierry Lambert, Catherine Grillot-Courvalin, Alexandr Nemec, Patrice Courvalin

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Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development by Evie Stergiakouli, George Davey Smith, Joanna Martin, David H. Skuse, Wolfgang Viechtbauer, Susan M. Ring, Angelica Ronald, David E. Evans, Simon E. Fisher, Anita Thapar, Beate St Pourcain

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Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information by Huseyin Gedik, Tan Hoang Nguyen, Roseann E. Peterson, Roseann E. Peterson, Christos Chatzinakos, Christos Chatzinakos, Vladimir I. Vladimirov, Brien P. Riley, Silviu-Alin Bacanu

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Identifying Therapies to Combat Epithelial Mesenchymal Plasticity-Associated Chemoresistance to Conventional Breast Cancer Therapies Using An shRNA Library Screen by Sugandha Bhatia, Tony Blick, Cletus Pinto, Mark Waltham, James Monkman, Ekaterina Ivanova, Pamela M. Pollock, Shivashankar H. Nagaraj, Adrian P. Wiegmans, Izhak Haviv, Kaylene J. Simpson, Erik W. Thompson

“…We first identified candidate genes with depleted shRNA, implying that their silencing could promote a response. Using the Broad Institute’s Connectivity Map (CMap), we identified partner inhibitors targeting the identified gene families that may induce cell death in combination with doxorubicin, and tested them with all three drug treatments. …”
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Palaeogenomes of Eurasian straight-tusked elephants challenge the current view of elephant evolution by Matthias Meyer, Eleftheria Palkopoulou, Sina Baleka, Mathias Stiller, Kirsty E H Penkman, Kurt W Alt, Yasuko Ishida, Dietrich Mania, Swapan Mallick, Tom Meijer, Harald Meller, Sarah Nagel, Birgit Nickel, Sven Ostritz, Nadin Rohland, Karol Schauer, Tim Schüler, Alfred L Roca, David Reich, Beth Shapiro, Michael Hofreiter

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Sleep and circadian biomarkers of postoperative delirium (SLEEP-POD): protocol for a prospective and observational cohort study by Peng Li, Richa Saxena, Lei Gao, Hao Deng, Oluwaseun Akeju, Ariel Mueller, Kun Hu, Zhongcong Xie, Elizabeth Sugg, Elizabeth Gleeson, Sarah N Baker, Chenlu Gao, Shiqian Shen, Esteban Franco-Garcia, Erik S Musiek

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Increased circulating regulatory T cells and decreased follicular T helper cells are associated with colorectal carcinogenesis by Qiao Meng, Qiao Meng, Yang Zhao, Miao Xu, Pingzhang Wang, Jun Li, Rongli Cui, Weiwei Fu, Weiwei Fu, Shigang Ding, Shigang Ding

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