Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery by Kevin Chun-Ho Ngan, Samuel M Hoenig, Hui Si Kwok, Nicholas Z Lue, Pallavi M Gosavi, David A Tanner, Emma M Garcia, Ceejay Lee, Brian B Liau

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Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation by Zhengjian Zhang, Zarko Boskovic, Mahmud M Hussain, Wenxin Hu, Carla Inouye, Han-Je Kim, A Katherine Abole, Mary K Doud, Timothy A Lewis, Angela N Koehler, Stuart L Schreiber, Robert Tjian

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Prediction performance and fairness heterogeneity in cardiovascular risk models by Uri Kartoun, Shaan Khurshid, Bum Chul Kwon, Aniruddh P. Patel, Puneet Batra, Anthony Philippakis, Amit V. Khera, Patrick T. Ellinor, Steven A. Lubitz, Kenney Ng

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Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations by Joanne B. Cole, Jose C. Florez, Joel N. Hirschhorn

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Target-driven machine learning-enabled virtual screening (TAME-VS) platform for early-stage hit identification by Yuemin Bian, Jason J. Kwon, Jason J. Kwon, Jason J. Kwon, Cong Liu, Enrico Margiotta, Mrinal Shekhar, Alexandra E. Gould

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Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance by Gustavo C. Cerqueira, Ian H. Cheeseman, Steve F. Schaffner, Shalini Nair, Marina McDew-White, Aung Pyae Phyo, Elizabeth A. Ashley, Alexandre Melnikov, Peter Rogov, Bruce W. Birren, François Nosten, Timothy J. C. Anderson, Daniel E. Neafsey

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Protocol for bulk RNA sequencing of enriched human neutrophils from whole blood and estimation of sample purity by Anna L.K. Gonye, Thomas J. LaSalle, Samuel S. Freeman, Miguel Reyes, Nir Hacohen, Alexandra-Chloé Villani, Moshe Sade-Feldman

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Functional annotation of rare structural variation in the human brain by Lide Han, Xuefang Zhao, Mary Lauren Benton, Thaneer Perumal, Ryan L. Collins, Gabriel E. Hoffman, Jessica S. Johnson, Laura Sloofman, Harold Z. Wang, Matthew R. Stone, CommonMind Consortium, Kristen J. Brennand, Harrison Brand, Solveig K. Sieberts, Stefano Marenco, Mette A. Peters, Barbara K. Lipska, Panos Roussos, John A. Capra, Michael Talkowski, Douglas M. Ruderfer

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The female protective effect against autism spectrum disorder by Emilie M. Wigdor, Daniel J. Weiner, Jakob Grove, Jack M. Fu, Wesley K. Thompson, Caitlin E. Carey, Nikolas Baya, Celia van der Merwe, Raymond K. Walters, F. Kyle Satterstrom, Duncan S. Palmer, Anders Rosengren, Jonas Bybjerg-Grauholm, David M. Hougaard, Preben Bo Mortensen, Mark J. Daly, Michael E. Talkowski, Stephan J. Sanders, Somer L. Bishop, Anders D. Børglum, Elise B. Robinson

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O39: Comprehensive, high-resolution, and non-invasive prenatal screening of coding variation* by Michael Duyzend, Harrison Brand, Christopher Whelan, John Lemanski, Monica Salani, Stephanie Hao, Isaac Wong, Elise Valkanas, Caroline Cusick, Lori Dobson, Courtney Studwell, Kathleen Gianforcaro, Stephanie Guseh, Benjamin Currall, Kathryn Gray, Michael Talkowski

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N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model by Stefano Suzzi, Tommaso Croese, Adi Ravid, Or Gold, Abbe R. Clark, Sedi Medina, Daniel Kitsberg, Miriam Adam, Katherine A. Vernon, Eva Kohnert, Inbar Shapira, Sergey Malitsky, Maxim Itkin, Alexander Brandis, Tevie Mehlman, Tomer M. Salame, Sarah P. Colaiuta, Liora Cahalon, Michal Slyper, Anna Greka, Naomi Habib, Michal Schwartz

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Spatiotemporally-resolved mapping of RNA binding proteins via functional proximity labeling reveals a mitochondrial mRNA anchor promoting stress recovery by Wei Qin, Samuel A. Myers, Dominique K. Carey, Steven A. Carr, Alice Y. Ting

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Development of hRad51–Cas9 nickase fusions that mediate HDR without double-stranded breaks by Holly A. Rees, Wei-Hsi Yeh, David R. Liu

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Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes by Julia K. Goodrich, Moriel Singer-Berk, Rachel Son, Abigail Sveden, Jordan Wood, Eleina England, Joanne B. Cole, Ben Weisburd, Nick Watts, Lizz Caulkins, Peter Dornbos, Ryan Koesterer, Zachary Zappala, Haichen Zhang, Kristin A. Maloney, Andy Dahl, Carlos A. Aguilar-Salinas, Gil Atzmon, Francisco Barajas-Olmos, Nir Barzilai, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Donald W. Bowden, Federico Centeno-Cruz, John C. Chambers, Nathalie Chami, Edmund Chan, Juliana Chan, Ching-Yu Cheng, Yoon Shin Cho, Cecilia Contreras-Cubas, Emilio Córdova, Adolfo Correa, Ralph A. DeFronzo, Ravindranath Duggirala, Josée Dupuis, Ma Eugenia Garay-Sevilla, Humberto García-Ortiz, Christian Gieger, Benjamin Glaser, Clicerio González-Villalpando, Ma Elena Gonzalez, Niels Grarup, Leif Groop, Myron Gross, Christopher Haiman, Sohee Han, Craig L. Hanis, Torben Hansen, Nancy L. Heard-Costa, Brian E. Henderson, Juan Manuel Malacara Hernandez, Mi Yeong Hwang, Sergio Islas-Andrade, Marit E. Jørgensen, Hyun Min Kang, Bong-Jo Kim, Young Jin Kim, Heikki A. Koistinen, Jaspal Singh Kooner, Johanna Kuusisto, Soo-Heon Kwak, Markku Laakso, Leslie Lange, Jong-Young Lee, Juyoung Lee, Donna M. Lehman, Allan Linneberg, Jianjun Liu, Ruth J. F. Loos, Valeriya Lyssenko, Ronald C. W. Ma, Angélica Martínez-Hernández, James B. Meigs, Thomas Meitinger, Elvia Mendoza-Caamal, Karen L. Mohlke, Andrew D. Morris, Alanna C. Morrison, Maggie C. Y. Ng, Peter M. Nilsson, Christopher J. O’Donnell, Lorena Orozco, Colin N. A. Palmer, Kyong Soo Park, Wendy S. Post, Oluf Pedersen, Michael Preuss, Bruce M. Psaty, Alexander P. Reiner, Cristina Revilla-Monsalve, Stephen S. Rich, Jerome I. Rotter, Danish Saleheen, Claudia Schurmann, Xueling Sim, Rob Sladek, Kerrin S. Small, Wing Yee So, Timothy D. Spector, Konstantin Strauch, Tim M. Strom, E. Shyong Tai, Claudia H. T. Tam, Yik Ying Teo, Farook Thameem, Brian Tomlinson, Russell P. Tracy, Tiinamaija Tuomi, Jaakko Tuomilehto, Teresa Tusié-Luna, Rob M. van Dam, Ramachandran S. Vasan, James G. Wilson, Daniel R. Witte, Tien-Yin Wong, AMP-T2D-GENES Consortia, Noël P. Burtt, Noah Zaitlen, Mark I. McCarthy, Michael Boehnke, Toni I. Pollin, Jason Flannick, Josep M. Mercader, Anne O’Donnell-Luria, Samantha Baxter, Jose C. Florez, Daniel G. MacArthur, Miriam S. Udler

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Low and differential polygenic score generalizability among African populations due largely to genetic diversity by Lerato Majara, Allan Kalungi, Nastassja Koen, Kristin Tsuo, Ying Wang, Rahul Gupta, Lethukuthula L. Nkambule, Heather Zar, Dan J. Stein, Eugene Kinyanda, Elizabeth G. Atkinson, Alicia R. Martin

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Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections by Timothy J. Straub, Wen-Chi Chou, Abigail L. Manson, Henry L. Schreiber, Bruce J. Walker, Christopher A. Desjardins, Sinéad B. Chapman, Kerrie L. Kaspar, Orsalem J. Kahsai, Elizabeth Traylor, Karen W. Dodson, Meredith A. J. Hullar, Scott J. Hultgren, Christina Khoo, Ashlee M. Earl

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Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines by Manmohan Sharma, Nipun Malhotra, Manickam Yogavel, Karl Harlos, Bruno Melillo, Eamon Comer, Arthur Gonse, Suhel Parvez, Branko Mitasev, Francis G. Fang, Stuart L. Schreiber, Amit Sharma

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Integrated cross-study datasets of genetic dependencies in cancer by Clare Pacini, Joshua M. Dempster, Isabella Boyle, Emanuel Gonçalves, Hanna Najgebauer, Emre Karakoc, Dieudonne van der Meer, Andrew Barthorpe, Howard Lightfoot, Patricia Jaaks, James M. McFarland, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio

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Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis by Arantxa Cebrian-Silla, Marcos Assis Nascimento, Stephanie A Redmond, Benjamin Mansky, David Wu, Kirsten Obernier, Ricardo Romero Rodriguez, Susana Gonzalez-Granero, Jose Manuel García-Verdugo, Daniel A Lim, Arturo Álvarez-Buylla

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The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells by Bernard Khor, John D Gagnon, Gautam Goel, Marly I Roche, Kara L Conway, Khoa Tran, Leslie N Aldrich, Thomas B Sundberg, Alison M Paterson, Scott Mordecai, David Dombkowski, Melanie Schirmer, Pauline H Tan, Atul K Bhan, Rahul Roychoudhuri, Nicholas P Restifo, John J O'Shea, Benjamin D Medoff, Alykhan F Shamji, Stuart L Schreiber, Arlene H Sharpe, Stanley Y Shaw, Ramnik J Xavier

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