Profile of Eric Lander <subtitle>Founding Director, Broad Institute of MIT and Harvard, Cambridge, MA</subtitle> by Kristie Nybo

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Early “reduction to practice” of the CRISPR–Cas9 invention in eukaryotic cells by Guillermo Aquino-Jarquin

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P575: The Rare Genomes Project: Improving access to genomic sequencing and identifying causes of rare disease* by Christina Austin-Tse, Stephanie DiTroia, Melanie O'Leary, Grace VanNoy, Brian Mangilog, Gulalai Shah, Eva Martinez, Jillian Serrano, Lynn Pais, Emily O'Heir, Ikeoluwa Osei-Owusu, Gabrielle Lemire, Vijay Ganesh, Sarah Stenton, Mutaz Amin, Kayla Socarras, Mugdha Singh, Stacey Hall, Katie Larsson, Moriel Singer-Berk, Daniel Marten, Michael Wilson, Hana Snow, Benjamin Blankenmeister, Jialan Ma, Ben Weisburd, Alba Sanchis-Juan, Harrison Brand, Emily Groopman, Alysia Lovgren, Clara Williamson, Marissa Hollyer, Eleina England, Eleanor Seaby, Katherine Chao, Julia Goodrich, Samantha Baxter, Daniel MacArthur, Michael Talkowski, Monica Wojcik, Anne O'Donnell-Luria, Heidi Rehm

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Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues by Jennifer G. Abelin, Erik J. Bergstrom, Keith D. Rivera, Hannah B. Taylor, Susan Klaeger, Charles Xu, Eva K. Verzani, C. Jackson White, Hilina B. Woldemichael, Maya Virshup, Meagan E. Olive, Myranda Maynard, Stephanie A. Vartany, Joseph D. Allen, Kshiti Phulphagar, M. Harry Kane, Suzanna Rachimi, D. R. Mani, Michael A. Gillette, Shankha Satpathy, Karl R. Clauser, Namrata D. Udeshi, Steven A. Carr

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Systematic profiling of conditional degron tag technologies for target validation studies by Daniel P. Bondeson, Zachary Mullin-Bernstein, Sydney Oliver, Thomas A. Skipper, Thomas C. Atack, Nolan Bick, Meilani Ching, Andrew A. Guirguis, Jason Kwon, Carly Langan, Dylan Millson, Brenton R. Paolella, Kevin Tran, Sarah J. Wie, Francisca Vazquez, Zuzana Tothova, Todd R. Golub, William R. Sellers, Alessandra Ianari

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Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state by Peter G. Miller, Murugappan Sathappa, Jamie A. Moroco, Wei Jiang, Yue Qian, Sumaiya Iqbal, Qi Guo, Andrew O. Giacomelli, Subrata Shaw, Camille Vernier, Besnik Bajrami, Xiaoping Yang, Cerise Raffier, Adam S. Sperling, Christopher J. Gibson, Josephine Kahn, Cyrus Jin, Matthew Ranaghan, Alisha Caliman, Merissa Brousseau, Eric S. Fischer, Robert Lintner, Federica Piccioni, Arthur J. Campbell, David E. Root, Colin W. Garvie, Benjamin L. Ebert

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P138: Evaluating the impact of gnomAD v4 on genetic prevalence estimates* by Samantha Baxter, Moriel Singer-Berk, Kathryn Russell, Mutaz Amin, Carmen Glaze, Riley Grant, Josephine Lee, Nick Watts, Michael Wilson, Heidi Rehm, Anne O'Donnell-Luria

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ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling by Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah Dele-Oni, Marc A. Schwartz, Rebecca J. Carlson, Aziz M. Al’Khafaji, Karsten Krug, Adam Brown, John G. Doench, Steven A. Carr, Nir Hacohen

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P559: Improved classification framework demonstrates many population predicted loss of function (pLoF) variants in genomic sequencing do not result in LoF* by Moriel Singer-Berk, Sanna Gudmundsson, Samantha Baxter, Eleanor Seaby, Eleina England, Jordan Wood, Rachel Son, Nicholas Watts, Konrad Karczewski, Steven Harrison, Daniel MacArthur, Heidi Rehm, Anne O'Donnell-Luria

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The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia by Ralda Nehme, Olli Pietiläinen, Mykyta Artomov, Matthew Tegtmeyer, Vera Valakh, Leevi Lehtonen, Christina Bell, Tarjinder Singh, Aditi Trehan, John Sherwood, Danielle Manning, Emily Peirent, Rhea Malik, Ellen J. Guss, Derek Hawes, Amanda Beccard, Anne M. Bara, Dane Z. Hazelbaker, Emanuela Zuccaro, Giulio Genovese, Alexander A. Loboda, Anna Neumann, Christina Lilliehook, Outi Kuismin, Eija Hamalainen, Mitja Kurki, Christina M. Hultman, Anna K. Kähler, Joao A. Paulo, Andrea Ganna, Jon Madison, Bruce Cohen, Donna McPhie, Rolf Adolfsson, Roy Perlis, Ricardo Dolmetsch, Samouil Farhi, Steven McCarroll, Steven Hyman, Ben Neale, Lindy E. Barrett, Wade Harper, Aarno Palotie, Mark Daly, Kevin Eggan

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Proteomic profiling dataset of chemical perturbations in multiple biological backgrounds by Deborah O. Dele-Oni, Karen E. Christianson, Shawn B. Egri, Alvaro Sebastian Vaca Jacome, Katherine C. DeRuff, James Mullahoo, Vagisha Sharma, Desiree Davison, Tak Ko, Michael Bula, Joel Blanchard, Jennie Z. Young, Lev Litichevskiy, Xiaodong Lu, Daniel Lam, Jacob K. Asiedu, Caidin Toder, Adam Officer, Ryan Peckner, Michael J. MacCoss, Li-Huei Tsai, Steven A. Carr, Malvina Papanastasiou, Jacob D. Jaffe

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Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries by Sean A. Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G. Doench, David E. Root, James M. McFarland, Rameen Beroukhim, Jesse S. Boehm

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Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots by Saaket Agrawal, Minxian Wang, Marcus D. R. Klarqvist, Kirk Smith, Joseph Shin, Hesam Dashti, Nathaniel Diamant, Seung Hoan Choi, Sean J. Jurgens, Patrick T. Ellinor, Anthony Philippakis, Melina Claussnitzer, Kenney Ng, Miriam S. Udler, Puneet Batra, Amit V. Khera

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A highly multiplexed quantitative phosphosite assay for biology and preclinical studies by Hasmik Keshishian, E Robert McDonald, Filip Mundt, Randy Melanson, Karsten Krug, Dale A Porter, Luke Wallace, Dominique Forestier, Bokang Rabasha, Sara E Marlow, Judit Jane‐Valbuena, Ellen Todres, Harrison Specht, Margaret Lea Robinson, Pierre M Jean Beltran, Ozgun Babur, Meagan E Olive, Javad Golji, Eric Kuhn, Michael Burgess, Melanie A MacMullan, Tomas Rejtar, Karen Wang, DR Mani, Shankha Satpathy, Michael A Gillette, William R Sellers, Steven A Carr

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P114: Use of population data to empower patient organizations and improve advocacy for rare disease therapeutics by Samantha Baxter, Moriel Singer-Berk, Kathryn Russell, Emily Groopman, Nicholas Watts, Michael Wilson, Jordan Wood, Heidi Rehm, Anne O'Donnell-Luria

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O11: An atlas of 1.2M structural variants across global populations in the Genome Aggregation Database (gnomAD) by Harrison Brand, Xuefang Zhao, Jack Fu, Ryan Collins, Isaac Wong, Cal Liao, Lily Wang, Samantha Baxter, Matthew Solomonson, Philip Darnowsky, Sinéad Chapman, Christine Stevens, Caroline Cusick, Alba Sanchis-Juan, Mark Walker, Nehir Kurtas, Katherine Chao, Stacey Gabriel, Eric Banks, Anne O’Donnell-Luria, Daniel MacArthur, Heidi Rehm, Benjamin Neale, Mark Daly, Kaitlin Samocha, Konrad Karczewski, Michael Talkowski

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Author Correction: Nuclei multiplexing with barcoded antibodies for single-nucleus genomics by Jellert T. Gaublomme, Bo Li, Cristin McCabe, Abigail Knecht, Yiming Yang, Eugene Drokhlyansky, Nicholas Van Wittenberghe, Julia Waldman, Danielle Dionne, Lan Nguyen, Philip L. De Jager, Bertrand Yeung, Xinfang Zhao, Naomi Habib, Orit Rozenblatt-Rosen, Aviv Regev

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Chromatin complex dependencies reveal targeting opportunities in leukemia by Fadi J. Najm, Peter DeWeirdt, Molly M. Moore, Samantha M. Bevill, Chadi A. El Farran, Kevin A. Macias, Mudra Hegde, Amanda L. Waterbury, Brian B. Liau, Peter van Galen, John G. Doench, Bradley E. Bernstein

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Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis by Rebecca Boiarsky, Nicholas J. Haradhvala, Jean-Baptiste Alberge, Romanos Sklavenitis-Pistofidis, Tarek H. Mouhieddine, Oksana Zavidij, Ming-Chieh Shih, Danielle Firer, Mendy Miller, Habib El-Khoury, Shankara K. Anand, François Aguet, David Sontag, Irene M. Ghobrial, Gad Getz

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Development and Applications of Chimera Platforms for Tyrosine Phosphorylation by Rajaiah Pergu, Veronika M. Shoba, Santosh K. Chaudhary, Dhanushka N. P. Munkanatta Godage, Arghya Deb, Santanu Singha, Uttam Dhawa, Prashant Singh, Viktoriya Anokhina, Sameek Singh, Sachini U. Siriwardena, Amit Choudhary

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