Extended safety and tolerability of subcutaneous CAP256V2LS and VRC07-523LS in HIV-negative women: study protocol for the randomised, placebo-controlled double-blinded, phase 2 CAPRISA 012C trial by Nigel Garrett, Farzana Osman, Sharana Mahomed, Edmund Capparelli, Nonhlanhla Yende Zuma, Derseree Archary, Penny Moore, Natasha Samsunder, Lynn Morris, Salim Abdool Karim, Catherine Hankins, Carolyn Williamson, Bruno Pozzetto, Kevin Carlton, Richard A Koup, Quarraisha Abdool Karim, Leila Mansoor, Tanuja Narayansamy Gengiah, Ishana Harkoo, Precious Radebe, Izukanji T Sikazwe, Disebo Potloane, Nqobile Myeni, Nicole Doria Rose, Lucio Gama, Sandeep Narpala, Leonid Serebryannyy

“…The completed CAPRISA 012A and 012B phase 1 trials provided critical data for the CAPRISA 012C trial, which is divided into parts A and B. …”
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Assessing the safety and pharmacokinetics of the anti-HIV monoclonal antibody CAP256V2LS alone and in combination with VRC07-523LS and PGT121 in South African women: study protocol for the first-in-human CAPRISA 012B phase I clinical trial by Nigel Garrett, Sharana Mahomed, Edmund Capparelli, Cheryl Baxter, Tanuja Gengiah, Derseree Archary, Penny Moore, Natasha Samsunder, Dan H Barouch, John Mascola, Julie Ledgerwood, Lynn Morris, Salim Abdool Karim, Catherine Hankins, Quarraisha A Karim, Nonhlanhla Y Zuma, Carolyn Williamson, Patricia E Fast, Bruno Pozzetto, Kevin Carlton, Nicole Doria-Rose

“…This bNAb was subsequently structurally engineered and the clinical variant is now referred to as CAP256V2LS.Methods and analysis CAPRISA 012B is the second of three trials in the CAPRISA 012 bNAb trial programme. …”
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Stres Kerja Anggota Satlantas Polrestabes Semarang ditinjau dari Kepribadian Multikultural dan Hubungan Interpersonal dengan Rekan Kerja by Desy Caprisa Herlinda Anggraeni, Y. Bagus Wismanto, Daniel Purwoko Budi Susetyo

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NK cell phenotypic profile during active TB in people living with HIV-evolution during TB treatment and implications for bacterial clearance and disease severity by Thando Glory Maseko, Santhuri Rambaran, Slindile Ngubane, Lara Lewis, Sinaye Ngcapu, Razia Hassan-Moosa, Derseree Archary, Rubeshan Perumal, Nesri Padayatchi, Kogieleum Naidoo, Aida Sivro

“…Here, we utilized peripheral blood specimens from the Improving Retreatment Success CAPRISA 011 study to characterize NK cell phenotypes during active TB in individuals with or without HIV co-infection. …”
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Field evaluations of four SARS-CoV-2 rapid antigen tests during SARS-CoV-2 Delta variant wave in South Africa by Natasha Samsunder, Gila Lustig, Slindile Ngubane, Thando Glory Maseko, Santhuri Rambaran, Sinaye Ngcapu, Stanley Nzuzo Magini, Lara Lewis, Cherie Cawood, Ayesha B. M. Kharsany, Quarraisha Abdool Karim, Salim Abdool Karim, Kogieleum Naidoo, Aida Sivro

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Higher plasma interleukin − 6 levels are associated with lung cavitation in drug-resistant tuberculosis by Thando Glory Maseko, Slindile Ngubane, Marothi Letsoalo, Santhuri Rambaran, Derseree Archary, Natasha Samsunder, Rubeshan Perumal, Surie Chinappa, Nesri Padayatchi, Kogieleum Naidoo, Aida Sivro

“…Methods Plasma samples were obtained from 128 participants from the CAPRISA 020 Individualized M(X)drug-resistant TB Treatment Strategy Study (InDEX) prior to treatment initiation. …”
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Metronidazole Treatment Failure and Persistent BV Lead to Increased Frequencies of Activated T- and Dendritic-Cell Subsets by Wenkosi Perez Qulu, Gugulethu Mzobe, Andile Mtshali, Marothi Peter Letsoalo, Farzana Osman, James Emmanuel San, Asavela Olona Kama, Nigel Garrett, Adrian Mindel, Anne Rompalo, Lenine J. P. Liebenberg, Derseree Archary, Aida Sivro, Sinaye Ngcapu

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Blood monocyte and dendritic cell profiles among people living with HIV with Mycobacterium tuberculosis co-infection by Santhuri Rambaran, Thando Glory Maseko, Lara Lewis, Razia Hassan-Moosa, Derseree Archary, Sinaye Ngcapu, Nigel Garrett, Lyle R. McKinnon, Nesri Padayatchi, Kogieleum Naidoo, Aida Sivro

“…Using flow cytometry, we characterized the frequencies and phenotypic differences in monocytes and dendritic cell populations using peripheral blood mononuclear cells from individuals with recurrent, active pulmonary tuberculosis with and without coexisting HIV infection (CAPRISA 011, Clinicaltrials.gov, NCT02114684, 29/01/2014) and compared them to samples from HIV positive individuals and healthy controls. …”
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Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance by Senamile Lale Ngema, Navisha Dookie, Rubeshan Perumal, Louansha Nandlal, Nikita Naicker, Marothi Peter Letsoalo, Max O'Donnell, Azraa Khan, Nesri Padayatchi, Kogieleum Naidoo

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Adaptive evaluation of mHealth and conventional adherence support interventions to optimize outcomes with new treatment regimens for drug-resistant tuberculosis and HIV in South Af... by Jesse Ross, Rubeshan Perumal, Allison Wolf, Mbali Zulu, Kevin Guzman, Boitumelo Seepamore, Karl Reis, Hlengiwe Nyilana, Senzo Hlathi, Radhamoney Narasimmulu, Ying Kuen K. Cheung, K. Rivet Amico, Gerald Friedland, Amrita Daftary, Jennifer R. Zelnick, Kogieleum Naidoo, Max R. O’Donnell

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Clinical impact of plasma concentrations of first-line antituberculosis drugs by R Perumal, K Naidoo, A Naidoo, N Padayatchi

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Biological mechanisms underpinning the development of long COVID by Rubeshan Perumal, Letitia Shunmugam, Kogieleum Naidoo, Dave Wilkins, Alfredo Garzino-Demo, Christian Brechot, Anders Vahlne, Janko Nikolich

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Application of Next Generation Sequencing for Diagnosis and Clinical Management of Drug-Resistant Tuberculosis: Updates on Recent Developments in the Field by Navisha Dookie, Azraa Khan, Nesri Padayatchi, Nesri Padayatchi, Kogieleum Naidoo, Kogieleum Naidoo

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Long COVID: a review and proposed visualization of the complexity of long COVID by Rubeshan Perumal, Rubeshan Perumal, Rubeshan Perumal, Letitia Shunmugam, Kogieleum Naidoo, Salim S. Abdool Karim, Dave Wilkins, Dave Wilkins, Alfredo Garzino-Demo, Alfredo Garzino-Demo, Christian Brechot, Sairam Parthasarathy, Anders Vahlne, Anders Vahlne, Janko Ž. Nikolich, Janko Ž. Nikolich, Janko Ž. Nikolich

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A third-line antiretroviral therapy register to track patient clinical and virological outcomes by K Naidoo, J Ramruthan, M Reddy, R Lancaster

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Detection of differentially culturable tubercle bacteria in sputum from drug-resistant tuberculosis patients by Bhavna G. Gordhan, Astika Sewcharran, Marothi Letsoalo, Thilgavathy Chinappa, Nonhlanhla Yende-Zuma, Nonhlanhla Yende-Zuma, Nesri Padayatchi, Nesri Padayatchi, Kogieleum Naidoo, Kogieleum Naidoo, Bavesh D. Kana

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Role of Immunity and Vaginal Microbiome in Clearance and Persistence of Human Papillomavirus Infection by Lungelo Ntuli, Lungelo Ntuli, Andile Mtshali, Gugulethu Mzobe, Lenine JP Liebenberg, Lenine JP Liebenberg, Sinaye Ngcapu, Sinaye Ngcapu

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Corrigendum: An in vitro study to elucidate the effects of Product Nkabinde on immune response in peripheral blood mononuclear cells of healthy donors by Boitumelo Setlhare, Marothi Letsoalo, Siphathimandla Authority Nkabinde, Magugu Nkabinde, Gugulethu Mzobe, Gugulethu Mzobe, Andile Mtshali, Andile Mtshali, Sobia Parveen, Sobia Parveen, Samukelisiwe Ngcobo, Samukelisiwe Ngcobo, Luke Invernizzi, Vinesh Maharaj, Mlungisi Ngcobo, Nceba Gqaleni, Nceba Gqaleni, Nceba Gqaleni

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Rapid Diagnosis of Drug-Resistant Tuberculosis–Opportunities and Challenges by Kogieleum Naidoo, Rubeshan Perumal, Senamile L. Ngema, Letitia Shunmugam, Anou M. Somboro

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Rapid Molecular Assays for the Diagnosis of Drug-Resistant Tuberculosis by Nandlal L, Perumal R, Naidoo K

“…Louansha Nandlal,* Rubeshan Perumal,* Kogieleum Naidoo* Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, University of KwaZulu-Natal Nelson R Mandela School of Medicine, Durban, South Africa*These authors contributed equally to this workCorrespondence: Rubeshan Perumal, Centre for the AIDS Programme of Research in South Africa (CAPRISA), South African Medical Research Council (SAMRC)-CAPRISA-TB-HIV Pathogenesis and Treatment Research Unit, University of KwaZulu-Natal Nelson R Mandela School of Medicine, Durban, South Africa, Email Rubeshan.Perumal@caprisa.orgAbstract: The recognition that drug-resistant tuberculosis (DR-TB) poses a major threat to global tuberculosis (TB) control efforts has catalysed the development of new and urgently needed TB diagnostics. …”
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