Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response. by Stephen Wood, Vijayakumar Jayaraman, Erica J Huelsmann, Brian Bonish, Derick Burgad, Gayathri Sivaramakrishnan, Shanshan Qin, Luisa A DiPietro, Andrew Zloza, Chunxiang Zhang, Sasha H Shafikhani

“…The delay in the macrophage response in diabetic wounds results from reduced Chemokine (C-C motif) ligand 2 (CCL2) expression. Importantly, one-time treatment with chemoattractant CCL2 significantly stimulated healing in diabetic wounds by restoring the macrophage response. …”
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Correction: Tag SNP Polymorphism of CCL2 and Its Role in Clinical Tuberculosis in Han Chinese Pediatric Population

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Exploration of the mechanism of Taohong Siwu Decoction for the treatment of ischemic stroke based on CCL2/CCR2 axis by Jingjing Li, Jingjing Li, Lijuan Zhang, Lijuan Zhang, Sujun Xue, Sujun Xue, Chao Yu, Chao Yu, Yumeng Li, Yumeng Li, Shuangping Li, Shuangping Li, Qingping Ye, Qingping Ye, Xianchun Duan, Xianchun Duan, Daiyin Peng, Daiyin Peng

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A systematic review and meta-analysis of blood level of MCP-1/CCL-2 in severe and uncomplicated malaria by Manas Kotepui, Pattamaporn Kwankaew, Aongart Mahittikorn, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Apichai Wattanapisit, Polrat Wilairatana

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Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies. by Cordelia Ziraldo, Yoram Vodovotz, Rami A Namas, Khalid Almahmoud, Victor Tapias, Qi Mi, Derek Barclay, Bahiyyah S Jefferson, Guoqiang Chen, Timothy R Billiar, Ruben Zamora

“…Statistical analyses, hierarchical and k-means clustering, Principal Component Analysis, and Dynamic Network Analysis suggested MCP-1/CCL2 and IL-1α as central coordinators of hepatocyte-mediated inflammation in C57BL/6 mouse hepatocytes. …”
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Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma by Zihang Ling, Wei Li, Jiaqi Hu, Yuanyuan Li, Miao Deng, Siyuan Zhang, Xianyue Ren, Tong Wu, Juan Xia, Bin Cheng, Xiaoan Tao

“…Herein, we showed that C-C motif chemokine ligand 2 (CCL2)- C-C motif chemokine receptor 4 (CCR4) signaling, but not the CCL2- C-C motif chemokine receptor 2 (CCR2) axis, induces the formation of the vav guanine nucleotide exchange factor 2 (Vav2)- Rac family small GTPase 1 (Rac1) complex to activate the phosphorylation of myosin light chain (MLC), which is involved in the regulation of cell motility and cancer metastasis. …”
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Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus by Katki Khurshed, Arisi Gabriel M, Foresti Maira L, Montañez Andres, Sanchez Russell M, Shapiro Lee A

“…In this work CCR2 and CCL2 expression were examined following status epilepticus (SE) induced by pilocarpine injection.…”
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Peripheral CCL2 induces inflammatory pain via regulation of Ih currents in small diameter DRG neurons by Lamei Li, Lamei Li, Yuanying Liu, Yuanying Liu, Wenchao Hu, Jing Yang, Suibin Ma, Zhicheng Tian, Zixuan Cao, Kunqing Pan, Ming Jiang, Xia Liu, Shengxi Wu, Ceng Luo, Rou-Gang Xie

Subjects: “…the C-C motif chemokine ligand 2 (CCL2)…”
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Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. by Mei Chen, John V Forrester, Heping Xu

“…In this study, we examined this hypothesis in mice deficient in chemokine CCL2 or its cognate receptor CCR2. CCL2- or CCR2-deficient mice developed retinal degenerative changes with age, characterized as retinal pigment epithelial (RPE) cell and photoreceptor cell death. …”
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CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice. by Xuguang Chen, Yunyue Wang, David Nelson, Sara Tian, Erin Mulvey, Bhumi Patel, Ilaria Conti, Juan Jaen, Barrett J Rollins

“…Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear. …”
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Elevated <it>ex vivo </it>monocyte chemotactic protein-1 (CCL2) in pulmonary as compared with extra-pulmonary tuberculosis by Khan M Aslam, Jamil Bushra, Zaidi Irfan, Hasan Zahra, Kanji Akbar, Hussain Rabia

“…Tumor necrosis factor (TNF)-α is essential for granuloma formation and is a potent activator of monocyte chemotactic protein (MCP-1, CCL2). CCL2 is essential for recruitment of monocytes and T cells and has been shown to play a role in protection against tuberculosis. …”
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Corrigendum to “PIPKIγ Regulates CCL2 Expression in Colorectal Cancer by Activating AKT-STAT3 Signaling” by JunLi Xue, XiaoXiao Ge, Wei Zhao, Liqiong Xue, Congqi Dai, Fengjuan Lin, Wei Peng

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CCL2, CCL8, CXCL12 chemokines in resectable non-small cell lung cancer (NSCLC) by Marie Drosslerova, Martina Sterclova, Alice Taskova, Vladislav Hytych, Eva Richterova, Magdalena Bruzova, Miloslav Spunda, Martin Komarc, Martina Koziar Vasakova

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CCR2/CCL2-mediated inflammation protects photoreceptor cells from amyloid-β-induced apoptosis by Julien Bruban, Agathe Maoui, Naïma Chalour, Na An, Laurent Jonet, Charles Feumi, Jacques Tréton, Florian Sennlaub, Francine Behar-Cohen, Frédéric Mascarelli, Virginie Dinet

“…Our study pinpoints the roles of Aβ and of CCL2/CCR2 axis-dependent inflammation in photoreceptor apoptosis.…”
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Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (orCCL2) in the Regulation of Metabolism by Anna Rull, Jordi Camps, Carlos Alonso-Villaverde, Jorge Joven

“…Main topics cover the relationship between MCP-1/CCL2, insulin resistance, inflammation, obesity, and related metabolic disturbances.…”
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A nerve injury–specific long noncoding RNA promotes neuropathic pain by increasing Ccl2 expression by Shibin Du, Shaogen Wu, Xiaozhou Feng, Bing Wang, Shangzhou Xia, Lingli Liang, Li Zhang, Gokulapriya Govindarajalu, Alexander Bunk, Feni Kadakia, Qingxiang Mao, Xinying Guo, Hui Zhao, Tolga Berkman, Tong Liu, Hong Li, Jordan Stillman, Alex Bekker, Steve Davidson, Yuan-Xiang Tao

“…Mimicking NIS-lncRNA upregulation elevated CCL2 expression, increased CCL2-mediated excitability in DRG neurons, and produced neuropathic pain symptoms. …”
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Blood–brain barrier disruption in CCL2 transgenic mice during pertussis toxin-induced brain inflammation by Schellenberg Angela E, Buist Richard, Del Bigio Marc R, Toft-Hansen Henrik, Khorooshi Reza, Owens Trevor, Peeling James

“…<p>Abstract</p> <p>Background</p> <p>The chemokine CCL2 has an important role in the recruitment of inflammatory cells into the central nervous system (CNS). …”
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Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire by Assi Kiran, Patterson Scott, Dedhar Shoukat, Owen David, Levings Megan, Salh Baljinder

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The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. by Luhmann, U, Robbie, S, Munro, P, Barker, SE, Duran, Y, Luong, V, Fitzke, F, Bainbridge, J, Ali, R, Maclaren, R

“…PURPOSE: Drusen, which are defined clinically as yellowish white spots in the outer retina, are cardinal features of age-related macular degeneration (AMD). Ccl2-knockout (Ccl2(-/-)) mice have been reported to develop drusen and phenotypic features similar to AMD, including an increased susceptibility to choroidal neovascularization (CNV). …”

Recombinant VP1, an Akt inhibitor, suppresses progression of hepatocellular carcinoma by inducing apoptosis and modulation of CCL2 production. by Tai-An Chen, Jui-Ling Wang, Shao-Wen Hung, Chiao-Li Chu, Yung-Chih Cheng, Shu-Mei Liang

“…Treatment with 0.025 µM rVP1, which did not affect the viability of normal hepatocytes, suppressed cell migration and invasion via attenuating CCL2 production. The production of CCL2 was modulated by Akt-dependent NF-κB activation that was decreased after rVP1 treatment. …”
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