Pharmacogenetics of Praziquantel Metabolism: Evaluating the Cytochrome P450 Genes of Zimbabwean Patients During a Schistosomiasis Treatment by Grace Zdesenko, Grace Zdesenko, Takafira Mduluza, Takafira Mduluza, Francisca Mutapi, Francisca Mutapi

“…Genomic DNA from blood samples of 114 case-control Zimbabweans infected with schistosomes were sequenced using the CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 genes as targets. …”
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Analysis of Xenobiotics Biotransformation and DNA Repair Genes as Factors of Aetiology, Pathogenesis and Criteria of Progression in Children with Congenital Spine Deformities by Sergei E Khalchitsky, Marina V Sogoyan, Sergei V Vissarionov, Alexei G Baindurashvili, Dmitry N Kokushin, Alexandra N Filippova

“…Results: The polymorphisms of the genes CYP1A2, GSTM1, GSTT1, GSTP1, NAT2, XRCC1, XRCC3 and their frequency distribution among patients with CSD and control group were investigated. …”
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An expanded analysis of pharmacogenetics determinants of efavirenz response that includes 3'-UTR single nucleotide polymorphisms among Black South African HIV/AIDS patients by Marelize eSwart, Jonathan eEvans, Michelle eSkelton, sandra ecastel, Lubbe eWeisner, Peter John Smith, Collet eDandara

“…The drug metabolising enzyme (DME), CYP2B6, is primarily responsible for EFV metabolism with minor contributions by CYP2A6, CYP3A4, CYP3A5, UGT2B7 and CYP1A2. Genes coding for DMEs have been shown to be regulated by microRNAs through targeting the 3'-untranslated region. …”
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Limited Sampling Modeling for Estimation of Phenotypic Metrics for CYP Enzymes and the ABCB1 Transporter Using a Cocktail Approach by Eduardo Barbosa Coelho, Diego Alberto Ciscato Cusinato, João Paulo Ximenez, Vera Lucia Lanchote, Claudio José Struchiner, Guilherme Suarez-Kurtz, Guilherme Suarez-Kurtz

“…In conclusion, the LSS models provided accurate prediction of phenotypic indices for CYP1A2, CYP2C19, CYP2D6, CYP3A, and ABCB1, when using subtherapeutic doses of selective probes for these enzymes and transporter.…”
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POLIMORFISMOS GENÉTICOS E NÍVEIS DE FERRITINA EM PACIENTES COM ANEMIA FALCIFORME EM USO DE DEFERASIROX by ACV Almeida, C Dinardo, MC Ozahata, B Custer, EC Sabino, S Kelly

“…Os polimorfismo UGT1A1 rs887829 TT (homozigoto mutado) e CYP1A2 rs762551 CC (homozigoto referência) foram descritos na literatura como preditores de menores níveis de ferritina em pacientes com uso de deferasirox. …”
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Dexketoprofen Pharmacokinetics is not Significantly Altered by Genetic Polymorphism by Gina Mejía-Abril, Gina Mejía-Abril, Pablo Zubiaur, Pablo Zubiaur, Marcos Navares-Gómez, Gonzalo Villapalos-García, Manuel Román, Manuel Román, Dolores Ochoa, Dolores Ochoa, Francisco Abad-Santos, Francisco Abad-Santos, Francisco Abad-Santos

“…Women showed lower AUC adjusted by dose/weight (AUC/DW) and higher Vd/F and Cl/F than men (p < 0.05 in univariate and multivariate analysis). CYP1A2*1B allele, CYP2B6 IM/PM and CYP2D6 IM/PM phenotypes were related to drug accumulation (AUC/DW or Cmax/DW) compared to the CYP1A2*1 allele, CYP2B6 NM/RM and CYP2D6 NM/UM phenotypes (p < 0.05 in the univariate analysis). …”
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Plasma metabolomics and network pharmacology analyses combined identify the action of Xiongzhi Dilong decoction in migraine treatment by Meisi Liu, Qing Wang, Zihan Lu, Liwei Wang, Shibo Zhao, Selinda Shi, Yonglie Zhao

“…Six key targets were identified and used for molecular validation: MAOA, MAOB, CYP1A1, CYP1A2, CYP1B1, and ADH1C. Compared with the model group, XZDLD significantly decreased the expression of MAOA, MAOB, and CYP1B1 proteins (P = .024, P = .004, P = .039, respectively) and elevated the expression of CYP1A1, CYP1A2, and ADH1C (P = .033, P = .045, P = .027, respectively). …”
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Polymorphisms of Drug-Metabolizing Enzymes and Transporters Contribute to the Individual Variations of Erlotinib Steady State Trough Concentration, Treatment Outcomes, and Adverse... by Dehua Liao, Dehua Liao, Zhigang Liu, Yongchang Zhang, Ni Liu, Dunwu Yao, Lizhi Cao, Yun Chen, Yilan Fu, Nong Yang, Daxiong Xiang

“…SNPs in CYP1A1 appeared to influence the steady state trough concentration of erlotinib. Correlation between CYP1A2 polymorphisms and severity of skin rash was observed, together with the correlation between the development of diarrhea and SNPs in ABCB1 and CYP3A5.…”
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The effects of polyethylene microplastics on the growth, reproduction, metabolic enzymes, and metabolomics of earthworms Eisenia fetida by Xiaoxia Yang, Xuemei Zhang, Xiao Shu, Jiuping Gong, Junying Yang, Biquan Li, Junjie Lin, Yong Chai, Jianfei Liu

“…The individual growth, reproduction, and metabolic enzyme activities, including phase I enzymes (cytochrome P450 [CYP] 1A2, 2B6, 2C9, and 3A4), and phase II metabolic enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione sulfotransferase (GST)), and metabolomics were measured. …”
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Impact of Panax ginseng and Ginkgo biloba extracts on expression level of transcriptional factors and xenobiotic-metabolizing cytochrome P450 enzymes by Bogacz Anna, Karasiewicz Monika, Dziekan Karolina, Procyk Danuta, Górska-Paukszta Małgorzata, Kowalska Aleksandra, Mikołajczak Przemysław Ł., Ożarowski Marcin, Czerny Bogusław

“…Dodatkowo, obserwowaliśmy wzrost ekspresji CYP1A1 (homolog ludzkiego enzymu CYP1A1) i CYP1A2 (homolog ludzkiego enzymu CYP1A2) po 10 dniach stosowania P. ginseng. …”
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Inhibitory Effect of Selaginellins from Selaginella tamariscina (Beauv.) Spring against Cytochrome P450 and Uridine 5′-Diphosphoglucuronosyltransferase Isoforms on Human Liver Micr... by Jae-Kyung Heo, Phi-Hung Nguyen, Won Cheol Kim, Nguyen Minh Phuc, Kwang-Hyeon Liu

“…These two selaginellins had low inhibitory potential against CYP1A2, CYP2A6, CYP2E1, and UGT1A6 (IC50 > 25 μM). …”
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Gene Expression and Protein Abundance of Hepatic Drug Metabolizing Enzymes in Liver Pathology by Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Sylwia Szelag-Pieniek, Mariola Post, Łukasz Skalski, Mateusz Kurzawski, Stefan Oswald

“…Alcoholic liver disease and primary biliary cholangitis were involved in the most prominent changes in the protein abundances, with downregulation of 6 (CYP1A2, CYP2C8, CYP2D6, CYP2E1, CYP3A4, UGT2B7) and 5 (CYP1A1, CYP2B6, CYP2C8, CYP2E1, CYP3A4) significantly downregulated enzymes, respectively. …”
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Inhibition of Human Liver Cytochrome P450 by Star Fruit Juice by Jiang-Wei Zhang, Yong Liu, Jie Cheng, Wei Li, Hong Ma, Hong-Tao Liu, Jie Sun, Li-Ming Wang, Yu-Qi He, Yun Wang, Zheng-Tao Wang, Ling Yang

“…The inhibitory effects of star fruit juice (0.5 to 5%, v/v) against the activities of seven CYP isoforms including CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4 and CPR were examined in human liver microsomes. …”
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Investigation on Intestinal Proteins and Drug Metabolizing Enzymes in Simulated Microgravity Rats by a Proteomics Method by Huayan Liu, Jingjing Guo, Yujuan Li, Yushi Zhang, Jiaping Wang, Jianyi Gao, Yulin Deng, Yongzhi Li

“…Compared with control rats, the expression of CYP1A2, CYP2D1, CYP3A2, and ADH1 in the simulated microgravity (SMG) group of rats were dramatically decreased by 33.16%, 21.93%, 48.49%, and 22.83%, respectively. …”
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Hydrolysable tannin-based diet rich in gallotannins has a minimal impact on pig performance but significantly reduces salivary and bulbourethral gland size by G. Bee, P. Silacci, S. Ampuero-Kragten, M. Čandek-Potokar, A.L. Wealleans, J. Litten-Brown, J.-P. Salminen, I. Mueller-Harvey

“…Growth performance, carcass characteristics, boar taint compounds in the adipose tissue and cytochrome P450 (CYP) isoenzymes CYP2E1, CYP1A2 and CYP2A19 gene expression in the liver was assessed. …”
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Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-Glycoprotein Activity Using the Geneva Cocktail Approach by Hengameh Ghasim, Mohammadreza Rouini, Saeed Safari, Farnoosh Larti, Mohammadreza Khoshayand, Kheirollah Gholami, Navid Neyshaburinezhad, Yvonne Gloor, Youssef Daali, Yalda H. Ardakani

“…In addition, there was a trend toward increased activity for CYP1A2, CYP2B6, CYP2C9, and CYP2C19 in obese patients compared to the control group, without reaching statistical insignificance (<i>p</i>-value ≥ 0.05). …”
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Calotropis gigantea stem bark extract activates HepG2 cell apoptosis through ROS and its effect on cytochrome P450 by Pennapha Suknoppakit, Apirath Wangteeraprasert, Orakot Simanurak, Julintorn Somran, Supawadee Parhira, Dumrongsak Pekthong, Piyarat Srisawang

“…All four fractions of the extract were shown to be poor inhibitors of CYP1A2 and CYP2E1 (IC50 > 1000 μg/mL) and moderate inhibitors of CYP3A4 (IC50 = 56.54–296.9 μg/mL). …”
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The dose-dependent effect of caffeine supplementation on performance, reaction time and postural stability in CrossFit – a randomized placebo-controlled crossover trial by Natalia Główka, Jakub Malik, Tomasz Podgórski, Rafał Stemplewski, Janusz Maciaszek, Julia Ciążyńska, Emilia E. Zawieja, Agata Chmurzynska, Paulina M. Nowaczyk, Krzysztof Durkalec-Michalski

“…There was no effect of CYP1A2 or ADORA2A SNPs on performance.Conclusions The dose-dependent effect of CAF supplementation appears to be limited to statistically nonsignificant but clinically considered changes on specific performance, RTime, PStab, RPE or HR. …”
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Pharmacological characterization of geraniol in sheep and its potential use in the control of gastrointestinal nematodes by María Victoria Miró, Livio Martins Costa-Júnior, Luis Ignacio Alvarez, Carlos Lanusse, Guillermo Virkel, Adrián Lifschitz

“…In sheep liver microsomes, the presence of 2 mM GNL reduced the CYP1A1, CYP1A2 and FMO pathways by 77.9, 90.8 and 84.5%, respectively, with respect to control (P < 0.05). …”
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Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR by Ya-bin Duan, Ya-bin Duan, Jun-bo Zhu, Jun-bo Zhu, Jian-xin Yang, Gui-qin Liu, Xue Bai, Ning Qu, Xue-jun Wang, Xiang-yang Li

“…Taken together, our results suggest that hypoxia inhibits CYP1A2, CYP2C9, CYP2E1, CYP3A4, and UGT1A1 expression via the PXR and CAR regulatory pathway.…”
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