An in vitro study of stereoselectivity of cytochrome p450 enzymes in the metabolism of 3,4-methylenedioxymethamphetamine by Asim, Wan Raihana Wan Aasim @ Wan

“…The inhibition experiments indicated CYP2D6, CYP1A2, CYP2C19 and CYP2B6 are responsible for HHMA formation. …”
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A CASE REPORT OF AN ULTRA-RAPID METABOLIZER ON DEPOT FORMULATIONS OF RISPERIDONE AND HALOPERIDOL AND REFLECTIONS ON METABOLIC PATHWAYS by Horst Koch, Heike Zellmer, Eva-Gabriele Steinbach

“…Polycyclic aromatic hydrocarbons (PAH) in tobacco are potent inducers of Cytochrome P450 (CYP) 1A2, which metabolizes a plenty of drugs including antipsychotics such as olanzapine or clozapine. …”
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Synthesis and preliminary hepatotoxicity evaluation of new caffeine-8-(2-thio)-propanoic hydrazid-hydrazone derivatives by Javor Mitkov, Magdalena Kondeva-Burdina, Alexander Zlatkov

“…The prediction for indicated that the evaluated compounds would most probably act as CYP1A2 substrates. The performed in vitro studies didn’t reveal statistically significant hepatotoxicity of the tested compounds, probably due to the pro-oxidant effects expressed on sub-cellular (isolated rat liver microsomes) level. …”
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Metabolomics combined with network pharmacology exploration reveals the modulatory properties of Astragali Radix extract in the treatment of liver fibrosis by Dan Wang, Ruisheng Li, Shizhang Wei, Sijia Gao, Zhuo Xu, Honghong Liu, Ruilin Wang, Haotian Li, Huadan Cai, Jian Wang, Yanling Zhao

“…Validation of the key targets by network pharmacology analysis of potential metabolic markers showed that AR significantly down-regulated the expression of CYP1B1 and up-regulated the expression of CYP1A2 and PCYT1A. Conclusion Metabolomics combined with network pharmacology was used for the first time to clarify that the treatment of AR on liver fibrosis, which is related to the regulation of arachidonic acid metabolism and ether lipid metabolism by modulating the expression of CYP1A2, CYP1B1 and PCYT1A. …”
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Interest of Fluvoxamine as an Add-On to Clozapine in Children With Severe Psychiatric Disorder According to CYP Polymorphisms: Experience From a Case Series by Camille Berel, Ulysse Mossé, Julien Wils, Julien Wils, Lauriane Cousin, Laurent Imbert, Priscille Gerardin, Priscille Gerardin, Boris Chaumette, Boris Chaumette, Boris Chaumette, Fabien Lamoureux, Fabien Lamoureux, Vladimir Ferrafiat, Vladimir Ferrafiat

“…This drug is a potent enzymatic inhibitor of CYP1A2 and, to a lesser extent, of CYP3A4 and CYP2D6. …”
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The Effectiveness of Dietary Byproduct Antioxidants on Induced CYP Genes Expression and Histological Alteration in Piglets Liver and Kidney Fed with Aflatoxin B1 and Ochratoxin A by Roua Gabriela Popescu, Cristina Bulgaru, Arabela Untea, Mihaela Vlassa, Miuta Filip, Anca Hermenean, Daniela Marin, Ionelia Țăranu, Sergiu Emil Georgescu, Anca Dinischiotu

“…Among the CYP450 family, <i>CYP1A2</i> was the gene with the highest downregulation. …”
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Effect of Hemodialysis on Hepatic Cytochrome P450 Functional Expression by Josée Michaud, Thomas D. Nolin, Judith Naud, Mélina Dani, Jean-Philippe Lafrance, Francois A. Leblond, Jonathan Himmelfarb, Vincent Pichette

“…The aim of this study was to evaluate the effect of conventional hemodialysis on the functional expression of CYP1A, 2C, and 3A. We also investigated the role of nuclear factor-κB (NF-κB) in CYP regulation during uremia. …”
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Case report: Avoiding intolerance to antipsychotics through a personalized treatment approach based on pharmacogenetics by Liam Korošec Hudnik, Tanja Blagus, Sara Redenšek Trampuž, Vita Dolžan, Jurij Bon, Jurij Bon, Milica Pjevac

“…Most psychotropic drugs are metabolized by genetically variable CYP2D6, CYP1A2, CYP3A4, and CYP2C19 enzymes. To demonstrate the utility of pharmacogenetic testing for tailoring antipsychotic treatment, in this paper, we present the case of a patient in whom a pharmacogenetic approach remarkably altered an otherwise intolerant or ineffective conventional TAU with antipsychotics.MethodsIn this case report, we present a 60-year-old patient with psychotic symptoms who suffered from severe extrapyramidal symptoms and a malignant neuroleptic syndrome during treatment with risperidone, fluphenazine, aripiprazole, brexpiprazole, and olanzapine. …”
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Synthesis, in silico prediction of sites of metabolism and in-vitro hepatotoxicity evaluationofnew seriesN’-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides by Javor Mitkov, Magdalena Kondeva-Burdina, Maya Georgieva, Alexander Zlatkov

“…The predictions show thatthe main metabolic changes will be primarily related to oxidation of the sulfur atom in the side chain, carried out under the action of CYP2C19, as well as O-demethylation of compounds containing methoxy groups.The N-demethylation of the xanthine fragment was determined to be regulated by CYP1A2, CYP2C9, CYP2D6 and CYP3A4. Theperformed in vitro studies confirmed for two of the tested compounds to be low hepatotoxic, due to the presented prooxidant effects at subcellular level (isolated rat liver microsomes). …”
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Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes. by Miao Hao, Yuqing Zhao, Peizhan Chen, He Huang, Hong Liu, Hualiang Jiang, Ruiwen Zhang, Hui Wang

“…Herein, we first evaluated the inhibitory effects of fifteen ginsenosides and sapogenins on human CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 enzymes by using commercially available fluorescent probes. …”
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Electrochemical Detection of Anti-Breast-Cancer Agents in Human Serum by Cytochrome P450-Coated Carbon Nanotubes by Camilla Baj-Rossi, Sandro Carrara, Giovanni De Micheli

“…Multi-walled carbon nanotubes were functionalized with three different cytochrome P450 isoforms (CYP1A2, CYP2B6, and CYP3A4). A model used to effectively describe the cytochrome P450 deposition onto carbon nanotubes was confirmed by Monte Carlo simulations. …”
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Metabolism of six CYP probe substrates in fetal hepatocytes by Abdul Naveed Shaik, Sandeep Kumar Vishwakarma, Aleem A Khan

“…The results obtained show the expression of various CYPs (CYP1A2, CYP2C19, CYP2C9, CYP2D6, and CYP3A4) in human foetus and their involvement in metabolism of CYP probe substrates.…”
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Pharmacogenomics of MDD as a Developing Field: Challenges and Opportunities by B. Baune

“…While some trials suggest that candidates such as CYP2D6, CYP2C19, CYP1A2, SLC6A4 and HTR2A polymorphisms may improve the prediction of response/remission, these results should be interpreted cautiously and required confirmation in larger samples. …”
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Preliminary Studies on Genetic Profiling of Coffee and Caffeine Consumption by Roseane M. Santos

“…The DNA samples were the same from a previous pilot study where 15 healthy volunteers donated two blood samples collected before and after drinking a standard cup of coffee and had caffeine plasma levels and CYP 1A2 genotype (rs762551) determined. The cross-examination of the data showed that six of the sixteen SNPs exhibited a negative allelic effect direction and nine of them showed a positive effect direction of which three of them had results confirmed by a recent GWAS. …”
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Identification of Gut Microbiome Metabolites via Network Pharmacology Analysis in Treating Alcoholic Liver Disease by Ki-Kwang Oh, Ye-Rin Choi, Haripriya Gupta, Raja Ganesan, Satya Priya Sharma, Sung-Min Won, Jin-Ju Jeong, Su-Been Lee, Min-Gi Cha, Goo-Hyun Kwon, Dong-Joon Kim, Ki-Tae Suk

“…We identified the uppermost six key targets (TLR4, RELA, IL6, PPARG, COX-2, and CYP1A2) against AFLD. The PPI network analysis revealed that TLR4, RELA, IL6, PPARG, and COX-2 had equivalent degrees of value (4); however, CYP1A2 had no associations with the other targets. …”
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Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular... by Qiu JX, Zhou ZW, He ZX, Zhang X, Zhou SF, Zhu S

“…Docking studies showed that ginger components interacted with a panel of amino acids in the active sites of CYP1A2, 2C9, 2C19, 2D6, and 3A4 mainly through hydrogen bond formation, to a lesser extent, via &pi;&ndash;&pi; stacking. …”
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A real‐life pilot study of the clinical application of pharmacogenomics testing on saliva in epilepsy by Antonella Riva, Roberta Roberti, Gianluca D'Onofrio, Maria Stella Vari, Elisabetta Amadori, Valentina De Giorgis, Caterina Cerminara, Nicola Specchio, Nicola Pietrafusa, Mario Tombini, Giovanni Assenza, Silvia Cappanera, Carla Marini, Paolo Rasmini, Pierangelo Veggiotti, Federico Zara, Emilio Russo, Pasquale Striano

“…Genetic variants on five genes (i.e., CYP1A2, CYP2C9, CYP2C19, EPHX1, and ABCB1) involved in common ASMs metabolism were selected. …”
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Influence of cigarette smoking habit on clozapine-to-norclozapine ratio in male patients by Roberto Lozano, Carina Bona

“…Conclusion: This study has shown a significant decrease in CLZ and norCLZ plasma levels, and an increase in the CLZ-to-norCLZ ratio, in smokers as compared to nonsmokers, due to an increase in the clearance of CLZ and norCLZ by smoking induction of CYP 1A2 and glucuronidation by uridyl glucuronyl transferase enzymes (UGT), mainly UGT 1A4, respectively, as the most probable cause.…”
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Effects of Kaempferia galanga L. and ethyl-p-methoxycinnamate (EPMC) by Wanna Sirisangtragul, Bungorn Sripanidkulchai

“…None of the treatments did affect CYP1A2 andCYP3A4 activity when compared to the control group. …”
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Determinación simultánea del fenotipo para las enzimas citocromo p450 1a2, 2d6, n-acetiltranferasa y xantina oxidasa en una población colombiana by Jesualdo Fuentes, Fanny Cuesta González, Damaris Díaz

“…El objetivo de este trabajo es determinar en una población de colombianos sanos, la actividad de las enzimas CYP1A2, NAT-2 y XO, de manera simultánea, empleando cafeína como fármaco prueba, así como a la enzima CYP2D6 en individuos de la misma población.…”
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