Silymarin prevents acetaminophen-induced hepatotoxicity via up-regulation of the glutathione conjugation capacity in mice by Young Chul Kim, Jong Deok Na, Do Young Kwon, Jae Hak Park

“…Silymarin treatment did not induce proteins or activities of Cyp2e1, Cyp1a2, and Cyp3a11, the major cytochrome P450 subtypes responsible for the metabolic activation of APAP to a reactive metabolite, N-acetyl-p-benzoquinoneimine. …”
Get full text

Pharmacogenomic profile of a central European urban random population-Czech population by Riccardo Proietti, Geraldo A. Maranho Neto, Sarka Kunzova, Oriana Lo Re, Ari Ahola-Olli, Juho Heliste, Juan Pablo Gonzalez-Rivas, Manlio Vinciguerra

“…Blood DNA was extracted and 59 single nucleotide polymorphisms within 13 genes (BCHE, CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A5, F2, F5, IFNL3, SLCO1B1, TPMT, UGT1A1, VKORC1), associated to different drug metabolizing rates, were characterized by genotyping using a genome wide commercial array. …”
Get full text

Enantiospecific effects of ketoconazole on aryl hydrocarbon receptor. by Aneta Novotna, Martina Korhonova, Iveta Bartonkova, Anatoly A Soshilov, Michael S Denison, Katerina Bogdanova, Milan Kolar, Petr Bednar, Zdenek Dvorak

“…In primary human hepatocytes, both enantiomers preferentially induced CYP1A2 over CYP1A1 mRNA and protein, and the potency of (+)-KET was slightly higher as compared to (-)-KET. …”
Get full text

Critical appraisal and update on the clinical utility of agomelatine, a melatonergic agonist, for the treatment of major depressive disease in adults by Robert H Howland

“…Agomelatine is contraindicated in patients with impaired liver function and in patients taking drugs that potently inhibit CYP-1A2 metabolic enzymes. Because elevated liver enzymes are common, and there is a rare risk of more serious liver reactions, routine laboratory monitoring of liver function is recommended periodically throughout treatment. …”
Get full text

A Biomedical Investigation of the Hepatoprotective Effect of Radix salviae miltiorrhizae and Network Pharmacology-Based Prediction of the Active Compounds and Molecular Targets by Ming Hong, Sha Li, Ning Wang, Hor-Yue Tan, Fan Cheung, Yibin Feng

“…The action mechanism may relate with regulating the intracellular molecular targets such as PPARα, CYP1A2, and MMP2 for regulation of lipid metabolism, antioxidant and anti-fibrogenesis by these potential active ingredients. …”
Get full text

In vitro study of chlorine dioxide on porcine intestinal epithelial cell gene markers by Orsolya Palócz, Zoltán Noszticzius, Kristóf Kály‐Kullai, Emma Bradley, György Csikó

“…We determined the alterations in mRNA levels of inflammatory mediators, such as IL6, CXCL8/IL8, TNF, HSPA6 (Hsp70), CAT and PTGS2 (COX2); furthermore, the expression of three cytochrome genes (CYP1A1, CYP1A2, CYP3A29) were analysed by quantitative PCR method. …”
Get full text

Involvement of hepatic lipid droplets and their associated proteins in the detoxification of aflatoxin B1 in aflatoxin-resistance BALB/C mouse by Nour Hammoudeh, Chadi Soukkarieh, Denis J. Murphy, Abdulsamie Hanano

“…Finally, transcript levels of CYP1A2, CYP1B1, GSTA3 and EH1 genes were elevated in livers of high-dose mice. …”
Get full text

A modeling approach to evaluate the balance between bioactivation and detoxification of MeIQx in human hepatocytes by Victorien Delannée, Sophie Langouët, Nathalie Théret, Anne Siegel

“…Results Our results demonstrate that (1) the detoxification pathway predominates, (2) the ratio between detoxification and bioactivation pathways is not linear and shows a maximum at 10 µM of MeIQx in hepatocyte cell models, and (3) CYP1A2 is a key enzyme in the system that regulates the balance between bioactivation and detoxification. …”
Get full text

Multidirectional vector pathways of vitamin D metabolism as modifiers of its interaction with drugs by O.M. Nikolova, O.A. Yakovleva

“…In the metabolism of medicines, the following six are involved: CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, which provide biotransformation of drugs through oxidation. …”
Get full text

Model Cell Lines and Tissues of Different HGSOC Subtypes Differ in Local Estrogen Biosynthesis by Renata Pavlič, Marija Gjorgoska, Tea Lanišnik Rižner

“…In addition, higher <i>HSD17B14</i> and <i>CYP1A2</i> expressions were observed in highly chemoresistant COV362 cells and platinum-resistant tissues compared to those in HIO-80 cells and platinum-sensitive tissues. …”
Get full text

Short Culture of Bovine Hepatocytes Biopsied from Dairy Cows as a Model for Toxicological Studies—CYP 1A1 Activity Response to Zearalenone Treatment by Justyna Barć, Jadwiga Flaga, Anna Kozubek, Zygmunt Maciej Kowalski

“…The expression of hepatocyte marker genes (<i>G6PC</i>, <i>ALB</i>, <i>CYP1A2</i>) was measured and found to be highest at 6 h post-isolation, with a subsequent decrease over time. …”
Get full text

Effect of guggulsterone, a sterol identified in Commiphora gileadensis (Becham), on the dengue virus enzymes: Pharmacokinetics, molecular docking and molecular dynamics simulations... by Jawaher Abdualbaqi Abdulhakim

“…The tested compound may inhibit CYP2C19 and CYP2C9 and cannot inhibit CYP1A2, CYP2D6, and CYP3A4. Guggulsterone was shown to have no hepatotoxicity, cytotoxicity, or mutagenicity effect. …”
Get full text

The reproductive inhibitory effects of levonorgestrel, quinestrol, and EP-1 in Brandt’s vole (Lasiopodomys brandtii) by Luye Shi, Xiujuan Li, Zhihong Ji, Zishi Wang, Yuhua Shi, Xiangyu Tian, Zhenlong Wang

“…However, quinestrol caused a greater degree of toxicity, as determined by visible liver damage and reduced expression of the detoxifying molecule CYP1A2. Of the remaining two fertility control agents, EP-1 was superior to levonorgestrel in inhibiting the secretion of follicle-stimulating hormone and causing reproductive inhibition. …”
Get full text

Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer by Zhang Shuangshuang, Zhang Yongjing, Chen Kun, Jin Mingjuan, Fan Chunhong, Liu Bing

“…Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC).…”
Get full text

Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities by Okey Allan B, Chen Hanbo, Boutros Paul C, Moffat Ivy D, Pohjanvirta Raimo

“…However, well-known AHR-regulated and dioxin-inducible genes such as <it>CYP1A1</it>, <it>CYP1A2</it>, and <it>CYP1B1 </it>remained fully responsive to TCDD in all strains/lines. …”
Get full text

Effects of Diabetes Mellitus Induced by Alloxan on the Pharmacokinetics of Metformin in Rats: Restoration of Pharmacokinetic Parameters to the Control State by Insulin Treatment by Myung G. Lee, Young H Choi, Inchul Lee

“…The increase in hepatic CYP1A2, 2B1, and 2E1, and decrease in hepatic CYP2C11 in DMIA rats was returned to the controls by insulin treatment. …”
Get full text

Dose-dependent exposure to indoxyl sulfate alters AHR signaling, sirtuins gene expression, oxidative DNA damage, and bone mineral status in rats by Malgorzata Karbowska, Krystyna Pawlak, Beata Sieklucka, Tomasz Domaniewski, Urszula Lebkowska, Radoslaw Zawadzki, Dariusz Pawlak

“…The exposure to 100 IS increased AhR repressor (AhRR)-CYP1A2 gene expression, which was associated with SIRT-1, SIRT-3 and SIRT-7 expression. …”
Get full text

Pharmacogenetics of Osteoporosis: A Pathway Analysis of the Genetic Influence on the Effects of Antiresorptive Drugs by Álvaro del Real, Carmen Valero, José M. Olmos, Jose L. Hernández, José A. Riancho

“…Several SNPs located in genes FDPS and FNTA were associated with the bisphosphonate-induced changes in hip bone mineral density (BMD), whereas polymorphisms of the PDSS1, CYP19A1, CYP1A1, and CYP1A2 genes were associated with SERM-induced changes in spine BMD. …”
Get full text

Synthesis, Characterization, and Pharmacokinetic Studies of Thiazolidine-2,4-Dione Derivatives by Bushra Ansari, Haroon Khan, Muhammad Saeed Jan, Khalaf F. Alsharif, Khalid J. Alzahrani, Umer Rashid, Abdul Saboor Pirzada

“…Drug metabolism of TZDs derivatives showed that C3 was identified as an inhibitor of CYP2C9 and C5 as an inhibitor of CYP1A2 and CYP2C19. Drug likeness properties indicate that C1 has only one violation of the Ghose rule while C3 has violations in the Ghose and Egan rules. …”
Get full text

The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics by Nadda Muhamad, Kesara Na‐Bangchang

“…Reaction phenotyping using human recombinant CYPs (rCYPs) and selective chemical inhibitors of CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 was performed, and enzyme kinetics and metabolic stability were investigated using human liver microsome (HLM). …”
Get full text