Inhibitory Effect of Antituberculosis Drugs on Human Cytochrome P450-Mediated Activities by Yuki Nishimura, Norimitsu Kurata, Eriko Sakurai, Hajime Yasuhara

“…In contrast, in addition to the reported inhibitory effect of isoniazid on CYP1A2, CYP2A6, CYP2C19, and CYP3A activities, our results newly showed its effect on CYP2C9 and CYP2E1 activities. …”
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Gut microbiome affects the metabolism of metronidazole in mice through regulation of hepatic cytochromes P450 expression. by Nina Zemanová, Kateřina Lněničková, Markéta Vavrečková, Eva Anzenbacherová, Pavel Anzenbacher, Iveta Zapletalová, Petra Hermanová, Tomáš Hudcovic, Hana Kozáková, Lenka Jourová

“…Administration of metronidazole itself influenced significantly mRNA expression of Cyp1a2, Cyp2b10, Cyp2c38 and Cyp2d22. Finally, GF mice have shown lower level of enzyme activity of CYP2A and CYP3A than their SPF counterparts. …”
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Menadione Suppresses Benzo(α)pyrene-Induced Activation of Cytochromes P450 1A: Insights into a Possible Molecular Mechanism. by Yulia A Sidorova, Maria L Perepechaeva, Elena N Pivovarova, Arkady L Markel, Vyacheslav V Lyakhovich, Alevtina Y Grishanova

“…Here we show that menadione (a water-soluble analog of vitamin K3) inhibits BP-induced expression and enzymatic activity of both CYP1A1 and CYP1A2 in vivo (in the rat liver) and BP-induced activity of CYP1A1 in vitro. …”
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Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes. by Martina Korhonova, Aneta Doricakova, Zdenek Dvorak

“…The expression of CYP1A1 and CYP1A2 in human hepatocytes was not influenced by tested statins. …”
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Melatonin Interaction Resulting in Severe Sedation by Brian C Foster, Kosta Cvijovic, Heather S Boon, Teresa W Tam, Rui Liu, Mano Murty, Duc Vu, Walter Jaeger, Ross T Tsuyuki, Joanne Barnes, Sunita Vohra

“…In vitro analysis involving several melatonin products showed product-dependent inhibition of CYP1A2, CYP2C19 and CYP3A7. Conclusion: The adverse event was likely due to a primary pharmacokinetic interaction between melatonin and citalopram; although mechanistically, interactions affecting cytochrome P450-mediated metabolism may have occurred with all of these health products. …”
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Direct conversion of porcine primary fibroblasts into hepatocyte-like cells by Mariane Fráguas-Eggenschwiler, Reto Eggenschwiler, Jenny-Helena Söllner, Leon Cortnumme, Florian W. R. Vondran, Tobias Cantz, Michael Ott, Heiner Niemann

“…Reprogrammed 3TF-piHeps display a hepatocyte-like morphology and show functional characteristics of hepatic cells, including albumin secretion, Dil-AcLDL uptake, storage of lipids and glycogen and activity of cytochrome P450 enzymes CYP1A2 and CYP2C33 (CYP2C9 in humans). Moreover, we show that markers of mature hepatocytes are highly expressed in 3TF-piHeps, while fibroblastic markers are reduced. …”
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Gut microbiome affects the metabolism of metronidazole in mice through regulation of hepatic cytochromes P450 expression by Nina Zemanová, Kateřina Lněničková, Markéta Vavrečková, Eva Anzenbacherová, Pavel Anzenbacher, Iveta Zapletalová, Petra Hermanová, Tomáš Hudcovic, Hana Kozáková, Lenka Jourová

“…Administration of metronidazole itself influenced significantly mRNA expression of Cyp1a2, Cyp2b10, Cyp2c38 and Cyp2d22. Finally, GF mice have shown lower level of enzyme activity of CYP2A and CYP3A than their SPF counterparts. …”
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Neonatal androgenization exacerbates alcohol-induced liver injury in adult rats, an effect abrogated by estrogen. by Whitney M Ellefson, Ashley M Lakner, Alicia Hamilton, Iain H McKillop, Herbert L Bonkovsky, Nury M Steuerwald, Yvette M Huet, Laura W Schrum

“…No change was observed in CYP1A2 protein expression. Further, continuous exogenous administration of E2 to Andro in adulthood attenuated these effects, suggesting that E2 has protective effects in the androgenized animal. …”
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Relationship between schizophrenia and tobacco smoking - literature analysis by Magdalena Kozyra, Krystian Cholewa, Justyna Kaczerska, Natalia Śmiech, Joanna Milanowska

“…In post mortem studies in schizophrenic patients a decrease in the number of M1 and M2 receptors in the brain was found, mainly in the dorsal lateral part of the prefrontal cortex, hippocampus, striatum and cingulate cortex, and decreased number of nicotinic receptors in the hippocampus, thalamus, cingulate cortex and prefrontal cortex The key process of undergoing of nicotine is the induction of the cytochrome P450 1A2 enzyme (CYP 1A2), thus increasing the metabolism of antipsychotic therapeutics, e.g. olanzapine, clozapine what explain why usage of nicotine is told to be self-treatment in schizophrenic people. …”
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Yeast polysaccharide mitigated oxidative injury in broilers induced by mixed mycotoxins via regulating intestinal mucosal oxidative stress and hepatic metabolic enzymes by Jing Zhang, Yong Fang, Yutong Fu, Sangita Jalukar, Jinglin Ma, Yanrong Liu, Yongpeng Guo, Qiugang Ma, Cheng Ji, Lihong Zhao

“…Dietary YPS supplementation reduced the concentrations of serum MDA and 8-OHdG, jejunal CD, mRNA expression of jejunal TLR2, and 4EBP1, hepatic CYP1A2, and p53, and the AFB1 residues in the liver (P < 0.05), and elevated the serum T-AOC and SOD, jejunal VH, and VH/CD, and mRNA expression of jejunal XDH, hepatic GST of broilers (P < 0.05). …”
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In- silico evaluation of bioactive compounds from selected medicinal plants from Southern Nigeria against hepatitis C virus genotype 1 RNA-directed RNA polymerase by Clement I. Mboto, Uwem O. Edet, Elizabeth N. Mbim, Wilfred O. Ndifon, Eno E. Ebenso, Henry O. Egharevba, Uwem E. George, Francisca O. Nwaokorie, Samuel.I. Udo

“…All the ligands were not inhibitors of CYP1A2, CYP2C19, CYPCC9, CYPAD6, and CYP3A4, except for 1,3-dihydrobenzo-[c]thiophen, docosahexaenoic acid, and benzonitrile N-oxide, which were inhibitors of CYP1A2. …”
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Uso de la farmacogenética como herramienta de precisión en psiquiatría: hacia una medicina personalizada by N. Ana María Wielandt, C. Mauricio Moreno, L. Lina Ortiz

“…Dicho estudio incluyó las variantes genómicas de un grupo de 6 genes pertenecientes a la familia del Citocromo P450 (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 y CYP3A5), responsables en gran medida del metabolismo de la mayoría de las drogas usadas en psiquiatría. …”
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Selective Serotonin Reuptake Inhibitors and Clozapine: Clinically Relevant Interactions and Considerations by Amber N. Edinoff, Juliana M. Fort, Joshua J. Woo, Christopher D. Causey, Caroline R. Burroughs, Elyse M. Cornett, Adam M. Kaye, Alan D. Kaye

“…Fluvoxamine is one of the most potent inhibitors of CYP1A2 and can lead to an increase in clozapine levels. …”
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Effect of P450 Oxidoreductase Polymorphisms on the Metabolic Activities of Ten Cytochrome P450s Varied by Polymorphic CYP Genotypes in Human Liver Microsomes by Yan Fang, Na Gao, Xin Tian, Jun Zhou, Hai-Feng Zhang, Jie Gao, Xiao-Pei He, Qiang Wen, Lin-Jing Jia, Han Jin, Hai-Ling Qiao

“…The POR mutations were significantly associated with decreased overall Km for CYP2B6 and 2E1, and specific genotypes within CYP1A2, 2A6, 2B6, 2C8, 2D6 and 2E1 were identified as being affected by these POR SNPs. …”
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Modulation of expression and activity of cytochrome P450s and alteration of praziquantel kinetics during murine schistosomiasis by Mara A Gotardo, Juliana T Hyssa, Renato S Carvalho, Rosangela R De-Carvalho, Luciana S Gueiros, Carolina M Siqueira, Marcia Sarpa, Ana Cecilia AX De-Oliveira, Francisco JR Paumgartten

“…On PID 30, when egg-laying was initiated by the worms, no change of CYP expression and activity was found, except for a depression of CYP1A2 and 3A11 mRNAs in female mice.…”
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Pharmacokinetic, metabolic stability, plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-... by Haijun Qu, Xiaoxiao Hu, Xiaoli Shi, Chuan Wang, Longyuan Wang, Guoping Wang

“…NHPPC showed no significant inhibitory effects on major CYP450 enzymes, and had no significant induction potential on CYP1A2 and CYP3A4. Following oral administration in rats and dogs, tmax was 6 and 0.5 h, respectively. …”
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Pharmacogenomic profile of a central European urban random population-Czech population. by Riccardo Proietti, Geraldo A Maranho Neto, Sarka Kunzova, Oriana Lo Re, Ari Ahola-Olli, Juho Heliste, Juan Pablo Gonzalez-Rivas, Manlio Vinciguerra

“…Blood DNA was extracted and 59 single nucleotide polymorphisms within 13 genes (BCHE, CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A5, F2, F5, IFNL3, SLCO1B1, TPMT, UGT1A1, VKORC1), associated to different drug metabolizing rates, were characterized by genotyping using a genome wide commercial array. …”
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Hydroxylated Tetramethoxyflavone Affects Intestinal Cell Permeability and Inhibits Cytochrome P450 Enzymes by Kuo-Ching Jan, Mohsen Gavahian

“…IC₅₀ values of TMFs (78-TMF, 57-TMF, 3H7-TMF, 3H6-TMF) against CYP enzymes (CYP1A2, CYP2D6, CYP2C9, CYP2C19, CYP3A4) range from 0.15 to 108 μM, indicating potent inhibition. …”
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DNMT1/PKR double knockdowned HepG2 (HepG2-DP) cells have high hepatic function and differentiation ability by Rieko Tanaka-yachi, Kazuko Aizawa, Kie Shimizu, Hidenori Akutsu, Kazuaki Nakamura

“…Albumin production, expression of CYP1A2 genes, and accumulation of lipid droplets were increased in HepG2-DP cells compared with the original HepG2 cells. …”
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Pharmacogenetic Testing of Cytochrome P450 Drug Metabolizing Enzymes in a Case Series of Patients with Prader-Willi Syndrome by Janice Forster, Jessica Duis, Merlin G. Butler

“…Among the total PWS cohort, extensive metabolizer (EM) activity prevailed across all cytochromes except CYP1A2, which showed greater ultra-rapid metabolizer (UM) status (<i>p</i> < 0.05), especially among UPD. …”
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