Impairment of aryl hydrocarbon receptor signalling promotes hepatic disorders in cancer cachexia by Adeline Dolly, Sarah A. Pötgens, Morgane M. Thibaut, Audrey M. Neyrinck, Gabriela S. deCastro, Chloé Galbert, Camille Lefevre, Elisabeth Wyart, Silvio P. Gomes, Daniela C. Gonçalves, Nicolas Lanthier, Pamela Baldin, Joshua R. Huot, Andrea Bonetto, Marília Seelaender, Nathalie M. Delzenne, Harry Sokol, Laure B. Bindels

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Drug–Drug Interactions Involving Intestinal and Hepatic CYP1A Enzymes by Florian Klomp, Christoph Wenzel, Marek Drozdzik, Stefan Oswald

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Evaluation of Drug–Drug Interactions of Rucaparib and CYP1A2, CYP2C9, CYP2C19, CYP3A, and P‐gp Substrates in Patients With an Advanced Solid Tumor by Jim J. Xiao, Dorota Nowak, Rodryg Ramlau, Monika Tomaszewska‐Kiecana, Piotr J. Wysocki, Jeff Isaacson, Jeri Beltman, Eileen Nash, Robert Kaczanowski, Gerhard Arold, Simon Watkins

“…At steady state, rucaparib 600 mg b.i.d. moderately inhibited CYP1A2, weakly inhibited CYP2C9, CYP2C19, and CYP3A, and marginally increased digoxin exposure.…”
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ANTIBODIES TO BENZO[A]PYRENE AND POLYMORPHISMS OF CYP1A1*2A, CYP1A2*1F, GSTT1, AND GSTM1 GENES IN HEALTHY MEN AND LUNG CANCER PATIENTS by A. N. Glushkov, E. G. Polenok, L. A. Gordeeva, S. A. Mun, V. A. Titov, M. V. Kostyanko, I. A. Vafin, S. E. Ragozhina

“…Among the lung cancer patients, the proportion of cases with a high level of IgG antibodies to benzo[a]pyrene in carriers of GSTT1+ and GSTM1+ in conjunction with the CYP1A2*1F C allele was significantly greater than in AA homozygotes CYP1A2*1F. …”
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Do asian patients require only half of the clozapine dose prescribed for caucasians? A critical overview by Jose de Leon, Anto P Rajkumar, Arun R Kaithi, Georgios Schoretsanitis, John M Kane, Chuan-Yue Wang, Yi-Lang Tang, Shih-Ku Lin, Kyung Sue Hong, Saeed Farooq, Chee H Ng, Can-Jun Ruan, Chittaranjan Andrade

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A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug–Drug–Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol, and Caffeine by Tobias Kanacher, Andreas Lindauer, Enrica Mezzalana, Ingrid Michon, Celine Veau, Jose David Gómez Mantilla, Valerie Nock, Angèle Fleury

“…Predicted concentration–time profiles accurately described a validation dataset, including data from patients with genetic polymorphisms, demonstrating that the models characterized the CYP2C19 and CYP1A2 network over the whole range of DDI studies investigated. …”
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Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System by Ryosuke Negoro, Mitsuki Tasaka, Sayaka Deguchi, Kazuo Takayama, Takuya Fujita

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The responses of the growth, cytochrome P450 isoenzymes activities and the metabolomics in earthworms to sublethal doses of dichlorvos in soil by Xiaoxia Yang, Jiuping Gong, Xuemei Zhang, Wei Zhang, Dianyan Li, Junjie Lin, Xiuying Li, Yong Chai, Jianfei Liu

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Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail†Approach by Chang-Xiao Liu, Mei-Yu Geng, Jie Shi

“…The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP1A2, while AOSC-971 induced the CYP 2E1 in male rats. …”
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ABCB11 accumulated in immature tertiary lymphoid structures participates in xenobiotic metabolic process and predicts resistance to PD-1/PD-L1 inhibitors in head and neck squamous... by Junya Ning, Jie Hao, Fengli Guo, Xiukun Hou, Lijuan Li, Jinmiao Wang, Shoujun Wang, Ying Gao, Xiangqian Zheng, Ming Gao

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Differential Susceptibility to Benzo[a]pyrene Exposure during Gestation and Lactation in Mice with Genetic Variations in the Aryl Hydrocarbon Receptor and <i>Cyp1</i> Genes by Mackenzie Feltner, Patrick M. Hare, Asia Good, Emma G. Foster, Katelyn Clough, Jade Perry, Amanda Honaker, Angela Kyntchev, Mickayla Kowalski, Christine Perdan Curran

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The Role of Vitamin E in Protecting against Oxidative Stress, Inflammation, and the Neurotoxic Effects of Acute Paracetamol in Pregnant Female Rats by Alaa M. Hammad, Baraa Shawaqfeh, Suhair Hikmat, Tariq Al-Qirim, Lama Hamadneh, Sameer Al-Kouz, Mariam M. Awad, Frank S. Hall

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Modulation of mRNA expression and activities of xenobiotic metabolizing enzymes, CYP1A1, CYP1A2, CYP2E1, GPx and GSTP1 by the Salicornia freitagii extract in HT-29 human colon cancer cells by Altay Ahmet, İrtem Kartal Deniz, Sadi Gökhan, Güray Tülin, Yaprak Ahmet Emre

“…The mRNA expression levels of CYP1A2 and CYP2E1 were decreased, while those of GSTP1 and GPx in HT-29 cells were increased after application of either the SF extract or vanillic acid. …”
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Placental cytochrome P450 methylomes in infants exposed to prenatal opioids: exploring the effects of neonatal opioid withdrawal syndrome on health horizons by Uppala Radhakrishna, Uppala Radhakrishna, Senthilkumar Sadhasivam, Rupa Radhakrishnan, Ariadna Forray, Srinivas B. Muvvala, Raghu P. Metpally, Saumya Patel, Rakesh M. Rawal, Sangeetha Vishweswaraiah, Ray O. Bahado-Singh, Swapan K. Nath

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Maternal protein restriction during lactation modulated the expression and activity of rat offspring hepatic CYP1A1, CYP1A2, CYP2B1, CYP2B2, and CYP2E1 during development by N. Meireles Da Costa, S.B.C. Visoni, I.L. Dos Santos, T.C. Barja-Fidalgo, L.F. Ribeiro-Pinto

“…The inductions detected in MPR60 and MPR90 were of 5.0- and 2.0-fold (CYP1A2), 3.7- and 2.0-fold (CYP2B2) and 9.8- and 5.8– fold (CYP2E1), respectively, and a 3.8-fold increase of CYP2B1 in MPR90. …”
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Maternal protein restriction during lactation modulated the expression and activity of rat offspring hepatic CYP1A1, CYP1A2, CYP2B1, CYP2B2, and CYP2E1 during development by N. Meireles Da Costa, S.B.C. Visoni, I.L. Dos Santos, T.C. Barja-Fidalgo, L.F. Ribeiro-Pinto

“…The inductions detected in MPR60 and MPR90 were of 5.0- and 2.0-fold (CYP1A2), 3.7- and 2.0-fold (CYP2B2) and 9.8- and 5.8– fold (CYP2E1), respectively, and a 3.8-fold increase of CYP2B1 in MPR90. …”
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Stability investigations of cytochrome P450 (CYP) enzymes immediately after death in a pig model support the applicability of postmortem hepatic CYP quantification by Kata W. Pedersen, Jakob Hansen, Jørgen B. Hasselstrøm, Jakob R. Jornil

Subjects: “…CYP1A2…”
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Descriptors of Cytochrome Inhibitors and Useful Machine Learning Based Methods for the Design of Safer Drugs by Tyler C. Beck, Kyle R. Beck, Jordan Morningstar, Menny M. Benjamin, Russell A. Norris

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Genetic variation in the 3&#39;-UTR of CYP1A2, CYP2B6, CYP2D6, CYP3A4, NR1I2 and UGT2B7: potential effect on regulation by microRNA and pharmacogenomics relevance by Marelize eSwart, Collet eDandara

“…This project set out to investigate potential microRNA target sites in 11 genes and the extent of variation in the 3'-UTR of six selected genes; CYP1A2, CYP2B6, CYP2D6, CYP3A4, NR1I2 and UGT2B7. …”
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Polymorphisms in the cytochrome <it>P</it>450 genes <it>CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1</it>, <it>CYP19A1 </it>and colorectal cancer risk by Withey Laura, Penegar Stephen, Rudd Matthew, Sellick Gabrielle, Webb Emily, Bethke Lara, Qureshi Mobshra, Houlston Richard

“…</p> <p>Conclusion</p> <p>This study provides some support for polymorphic variation in <it>CYP1A2 </it>and <it>CYP1B1 </it>playing a role in CRC susceptibility.…”
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