Inhibitory Effects of Eight Green Tea Catechins on Cytochrome P450 1A2, 2C9, 2D6, and 3A4 Activities by Takashi Satoh, Haruka Fujisawa, Ami Nakamura, Natsuko Takahashi, Kazuhiro Watanabe

“…That concentration of EGCG is equivalent to one-half to one-third of its Ki value for CYP1A2 and CYP3A4 in this study. The ingestion of beverages containing large amounts of green tea catechins together with drugs that are metabolized by CYP1A2, CYP2C9, and CYP3A4 should be avoided.   …”
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EROD and MROD as Markers of Cytochrome P450 1A Activities in Hepatic Microsomes from Entire and Castrated Male Pigs by Vladimir Zlabek, Galia Zamaratskaia

“…Further studies are needed to evaluate substrate specificities of porcine CYP1A1 and CYP1A2.…”
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Effects of salidroside on rat CYP enzymes by a cocktail of probe drugs by Yan-Li Wei, Hong-Jian Du, Yi-Ping Lin, Mei-Ling Wu, Ren-ai Xu

“…Objective(s): In this study, we aimed to evaluate the effect of salidroside on the activities of the different drug-metabolizing enzymes CYP1A2, CYP2B6, CYP2C9, CYP2D6 and CYP3A4 in rats, in which a specific probe drug was used for each enzyme. …”
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Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome by Krithika Lingappan, Suman Maity, Weiwu Jiang, Lihua Wang, Xanthi Couroucli, Alex Veith, Guodong Zhou, Cristian Coarfa, Bhagavatula Moorthy

“…Wild type (WT), Cyp1a1−/− and Cyp1a2−/− (8–10 wk, C57BL/6J background) mice were exposed to hyperoxia (FiO2 > 0.95) for 48 hours. …”
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Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity by Jin Zhou, Xian Qian, Yanqing Zhou, Shili Xiong, Shuxia Ji, Ying Wang, Ping Zhao

“…Conclusions Weak inhibitory effects of plantainoside D on the activity of CYP1A2, 2D6, and 3A were revealed in vitro, implying its potential of inducing interactions with CYP1A2-, 2D6-, and 3A-metabolized drugs. …”
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Spectroscopic and Molecular Docking Studies of the in Vitro Interaction between Puerarin and Cytochrome P450 by Jiangjuan Shao, Jianwei Chen, Tingting Li, Xiaoli Zhao

“…At the same temperature, puerarin bound to CYP1A2 more weakly than it did to CYP2D6. UV-Vis and circular dichroism spectroscopies confirmed the micro-environmental and conformational changes of CYP1A2 and CYP2D6. …”
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Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity by Kine Eide Kvitne, Anders Åsberg, Line K. Johnson, Christine Wegler, Jens K. Hertel, Per Artursson, Cecilia Karlsson, Shalini Andersson, Rune Sandbu, Eva Skovlund, Hege Christensen, Rasmus Jansson‐Löfmark, Jøran Hjelmesæth, Ida Robertsen

“…By contrast, there were no differences in the in vivo activities and protein concentrations of CYP3A, CYP1A2, and CYP2C9. Multivariable regression analyses also indicated that T2DM was associated with interindividual variability in CYP2C19 activity, but not CYP3A, CYP1A2, and CYP2C9 activities. …”
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Genetic Polymorphisms In The Phase I And Phase II Xenobiotic Metabolizing Enzymes In Malaysian Population And Their Influence On Colorectal Cancer Susceptibility by Shahpudin, Siti Nurfatimah Mohd

“…Ten polymorphisms from 6 genes encoding enzymes involved in xenobiotic metabolism (GSTT1, GSTM1, GSTP1 Ile105Val, CYP1A2 G3860A, CYP1A2 T739G, CYP1A2 C729T, NAT1 C1095A, NAT2 G191A, NAT2 A803G, NAT2 G857A) were selected as candidate SNPs to determine their influence, either singly or as combination genotypes, in CRC susceptibility risk and with the ultimate aim of identifying putatively protective and/or at risk genotypes.…”
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Polymorphisms of Cytochrome P450 Genes in Three Ethnic Groups from Russia by Elena Viktorova, Leysan Akhmadishina, Olga Kochetova, Gülnaz Korytina, Tatyana Victorova

“…Distribution of allele and genotype frequencies of CYP1A2 (rs35694136), CYP1B1 (rs1056836), CYP2C9 (rs1799853, rs1057910), CYP2F1 (rs11399890), CYP2J2 (rs890293), CYP2S1 (rs34971233, rs338583) genes were similar in Russians, Tatars, and Bashkirs. …”
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A Physiologically Based Pharmacokinetic Model to Predict the Impact of Metabolic Changes Associated with Metabolic Associated Fatty Liver Disease on Drug Exposure by Elise M. Newman, Andrew Rowland

“…These findings indicate that MAFLD patients are likely to be experience meaningfully higher exposure to drugs that are primarily metabolized by CYP 1A2, 2C19, 2D6 and 3A4, but not CYP2C9. Closer monitoring of MAFLD patients using drugs primarily cleared by CYP 1A2, 2C19 and 3A4 is warranted as reduced metabolic activity and increased drug exposure are likely to result in an increased incidence of toxicity in this population.…”
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Effects of mulberry leaf extracts on activity and mRNA expression of five cytochrome P450 enzymes in rat by Chenming Sheng, Xiaoyan Shi, Zexian Ding, Yunna Chen, Xiaoqian Shi, Yifan Wu, Wenjing Zhang, Weidong Chen

“…In addition, EML exhibited inhibitory effects on CYP1A2, CYP2D6, and CYP2C19, while no significant change in CYP2C8 activity was observed. …”
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Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami by Mohd Noor Azami, Nur Amirah

“…The purpose of this study is to evaluate the interactions of Malaysian traditional herbs with CYP1A2 enzymes. CYP1A2 is one of the major member of CYP and it constitute about 12-20% of the total CYP content and it mostly a hepatic enzymes. …”
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Inhibitory effects of Triphala on CYP isoforms in vitro and its pharmacokinetic interactions with phenacetin and midazolam in rats by Jannarin Nontakham, Pongpun Siripong, Hitoshi Sato, Savita Chewchinda, Kuntarat Arunrungvichian, Jantana Yahuafai, Arman Syah Goli, Vilasinee Hirunpanich Sato

“…The inhibitory effects of Triphala on CYP1A2 and 3A4 were not time-dependent. Moreover, Triphala did not affect the P-gp activity in Caco-2 cells. …”
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Evaluación de la actividad de la enzima citocromo P-450 1A2 en una población colombiana by Fanny Cuesta González, Ignacio Rodríguez, Damaris Díaz

“…</span></p> <p class="MsoNormal"><span style="font-size: 8.5pt; font-family: Arial">Debido a la baja incidencia de efectos secundarios y la facilidad en la medición de los metabolitos en orina, la Cafeína es utilizada como fármaco prueba para la determinación de la actividad enzimática CYP1A2, calculando la relación entre las concentraciones molares de sus metabolitos (Actividad CYP1A2 = AFMU+MU+MX/17DMU).…”
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Metabolism of sumatriptan revisited by Timo Pöstges, Matthias Lehr

“…Using recombinant human enzymes and HPLC‐MS analysis, we found that CYP enzymes may also be involved in the metabolism of sumatriptan. The CYP1A2, CYP2C19, and CYP2D6 isoforms converted this drug into N‐desmethyl sumatriptan, which was further demethylated to N,N‐didesmethyl sumatriptan by CYP1A2 and CYP2D6. …”
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Influence of genetic polymorphisms and habitual caffeine intake on the changes in blood pressure, pulse rate, and calculation speed after caffeine intake: A prospective, double bli... by Tatsuya Yoshihara, Masayoshi Zaitsu, Fumie Shiraishi, Hisatomi Arima, Fumi Takahashi-Yanaga, Masaki Arioka, Shunichi Kajioka, Toshiyuki Sasaguri

“…Keywords: Caffeine, ADORA2A, CYP1A2, Polymorphism, Blood pressure…”
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The Aggravation of Clozapine-Induced Hepatotoxicity by Glycyrrhetinic Acid in Rats by Ling-ling Jia, Ze-yu Zhong, Feng Li, Zhao-li Ling, Yang Chen, Wei-man Zhao, Ying Li, Shu-wen Jiang, Ping Xu, Yang Yang, Meng-yue Hu, Li Liu, Xiao-dong Liu

“…All these results support the conclusion that GA aggravated CLZ-induced hepatotoxicity, which was partly via inhibiting CYP2C11 and CYP2C13 or inducing CYP1A2. Keywords:: glycyrrhetinic acid, clozapine, hepatotoxicity, CYP2C11, CYP1A2…”
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Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population by Laith N. AL-Eitan, Doaa M. Rababa’h, Mansour A. Alghamdi, Rame H. Khasawneh

“…Results The CYP19A1 SNP rs7176005 (p < 0.0045) and the CYP1A2 SNP rs762551 (p = 0.004) were significantly associated with BC risk. …”
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A Negative Feedback Loop and Transcription Factor Cooperation Regulate Zonal Gene Induction by 2, 3, 7, 8‐Tetrachlorodibenzo‐p‐Dioxin in the Mouse Liver by Yongliang Yang, David Filipovic, Sudin Bhattacharya

“…The cytochrome P450 (Cyp) proteins Cyp1A1 and Cyp1A2 are strongly induced in the mouse liver by the potent environmental toxicant 2, 3, 7, 8‐tetrachlorodibenzo‐p‐dioxin (TCDD), acting through the aryl hydrocarbon receptor (AHR). …”
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Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method by Yiping Lin, Yanli Wei, Xiaoxia Hu, Mei-Ling Wu, Jingchan Yao, Xiaoqian Ying, Xiaoyan Fu, Mingxing Ding, Liman Qiao

“…Results: We found that various concentrations of lentinan increased the activity of rat CYP1A2, CYP3A4, CYP2D6, and CYP2C19 but not CYP2C9. …”
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