CYP1A2 mRNA Expression Rather than Genetic Variants Indicate Hepatic CYP1A2 Activity by Ferenc Fekete, Katalin Mangó, Annamária Minus, Katalin Tóth, Katalin Monostory

Subjects: “…CYP1A2…”
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The involvement of CYP1A2 in biodegradation of dioxins in pigs. by Sylwia Swigonska, Tomasz Molcan, Anna Nynca, Renata E Ciereszko

“…The goal of the study was to explore the potential role of CYP1A2 in the metabolism of TCDD. We investigated a molecular structure of CYP1A2 and the binding selectivity and affinity between the pig CYP1A2 and: 1/ DiCDD or TCDD (dioxins differing in toxicity and biodegradability) or 2/ their selected metabolites. pCYP1A2 demonstrated higher affinity towards DiCDD and TCDD than other pCYP1 enzymes. …”
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CYP1A2 Gene Polymorphism and Theophylline Level in Asthma by Amelia Lorensia, Zullies Ikawati, Tri Murti Andayani, Daniel Maranatha, Mariana Wahyudi

“…Most homozygote alleles exist in CYP1A2*1D and CYP1A2*1F. There was significant difference between CYP1A2*1D (p<0.005), CYP1A2*1E (p<0.023) and CYP1A2*1F (p<0.000) polymorphisms and theophylline level. …”
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Pathway-targeted pharmacogenomics of CYP1A2 in human liver by Kathrin eKlein, Stefan eWinter, Miia eTurpeinen, Matthias eSchwab, Matthias eSchwab, Ulrich M Zanger

“…In conclusion, we identified novel trans-associations between regulatory genes and hepatic CYP1A2 function and expression, but additional genetic factors must be assumed to explain the full extent of CYP1A2 heritability.…”
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The influence of trans-resveratrol and quercetin on the activity of CYP1A2 in rat by Ondřej ZENDULKA, Lucia ZAHRADNÍKOVÁ, Jan JUŘICA, Jiří TOTUŠEK

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The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine by Womack Christopher J, Saunders Michael J, Bechtel Marta K, Bolton David J, Martin Michael, Luden Nicholas D, Dunham Wade, Hancock Melyssa

“…A (C/A) single nucleotide polymorphism at intron 1 of the cytochrome P450 (CYP1A2) gene influences caffeine metabolism and clinical outcomes from caffeine ingestion. …”
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Pharmacokinetics of dacarbazine and unesbulin and CYP1A2‐mediated drug interactions in patients with leiomyosarcoma by Lan Gao, Diksha Kaushik, Brian A. Van Tine, Matthew A. Ingham, Steven Attia, Christian F. Meyer, Gary K. Schwartz, Pius Maliakal, John D. Baird, Jiyuan Ma, Rosemary Barrett, Dhiren D'Silva, Kylie O'Keefe, Ronald Kong

“…Co‐administration of unesbulin orally at 200 mg or above with DTIC inhibited cytochrome P450 (CYP)1A2‐mediated DTIC metabolism, resulting in 66.7% reduction of AIC exposures. …”
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ROLE OF THE CYP1A2 GENE POLYMORPHISM ON EARLY AGEING FROM OCCUPATIONAL EXPOSURE by Eshkoor Sa., Ismail P., Rahman Sa., Moin S., Adon My.

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Breast density and polymorphisms in genes coding for CYP1A2 and COMT: the Multiethnic Cohort by Maskarinec Gertraud, Takata Yumie, Le Marchand Loïc

“…</p> <p>Results</p> <p>A positive association between the C allele in the <it>CYP1A2*1F </it>gene and percent density, but not the dense area, was suggested (<it>p </it>= 0.11). …”
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Potent and Selective Inhibition of CYP1A2 Enzyme by Obtusifolin and Its Chemopreventive Effects by Eun-Ji Park, Keunwan Park, Prasannavenkatesh Durai, Ki-Young Kim, So-Young Park, Jaeyoung Kwon, Hee Ju Lee, Cheol-Ho Pan, Kwang-Hyeon Liu

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lncRNA NEAT1 regulates CYP1A2 and influences steroid-induced necrosis by Zhou Yongfang, Zhang Fei, Xu Fengyang, Wang Qiang, Wu Jianhua, Peng Wuxun, Dong Wentao

“…The expression of lncRNA NEAT1, miR-23b-3p and CYP1A2 in hBMSCs were intervened. Compared to the control group, the lncRNA NEAT1 and CYP1A2 expression in the SNFH group was increased, while miR-23b-3p expression was decreased. …”
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The Impact of CYP1A2 and CYP2E1 Genes Polymorphism on Theophylline Response by Em Sutrisna

“…Theophylline is metabolized by CYP1A2 and CYP2E1. The aim of this review is to know the impact of CYP1A2 and CYP2E1 genes polymorphism on theophylline response. …”
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Frequencies of CYP1A2 Single Nucleotide Polymorphism in Indonesian and Its Effect on Blood Pressure by Erizal Sugiono, Andi Wijaya, Anwar Santoso, Ferry Sandra, Ilham Jaya Patellongi, Irawan Yusuf

“…Caffeine is mainly metabolized by cytochrome-P450 (CYP)1A2 enzyme. Polymorphism of CYP1A2 is known to cause interindividual variation on enzymatic activity, thus affects caffeine metabolism and its effect on cardiovascular (CV) system. …”
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Serum Phosphorus, Serum Bicarbonate, and Renal Function in Relation to Liver CYP1A2 Activity by Joy Ito, Hector Lemus, Tianying Wu

Subjects: “…CYP1A2…”
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CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance by Jozo Grgic, Craig Pickering, David J. Bishop, Brad J. Schoenfeld, Pavle Mikulic, Zeljko Pedisic

“…Background It has been suggested that polymorphisms within CYP1A2 impact inter-individual variation in the response to caffeine. …”
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CYP1A2 expression rather than genotype is associated with olanzapine concentration in psychiatric patients by Ferenc Fekete, Ádám Menus, Katalin Tóth, Ádám Ferenc Kiss, Annamária Minus, Dávid Sirok, Aleš Belič, Ádám Póti, Gábor Csukly, Katalin Monostory

“…CYP2D6 genotype-based phenotype appeared to have negligible contribution to olanzapine metabolism, whereas a dominant role of CYP1A2 in olanzapine exposure was confirmed. However, CYP1A2 expression rather than CYP1A2 genetic variability was demonstrated to be associated with olanzapine concentration in patients. …”
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Genetic polymorphisms of cytochrome P450-1A2 (CYP1A2) among Emiratis. by Mohammad M Al-Ahmad, Naheed Amir, Subramanian Dhanasekaran, Anne John, Yousef M Abdulrazzaq, Bassam R Ali, Salim M A Bastaki

“…However, there are limited studies on CYP1A2 phenotypes and CYP1A2 genotypes among Emiratis and thus this study was carried out to fill this gap. …”
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Does celecoxib inhibit agomelatine metabolism via CYP2C9 or CYP1A2? by Yasar U

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Association of CYP1A2 and GST gene variants with asthma in cases presenting with allergic chronic rhinosinusitis by Madhavi Jangala, Santoshi Kumari Manche, Madhu Mohan Katika, Raja Meghanadh Koralla, Jyothy Akka

“…Conclusion The present study reports the significantly increased association of CYP1A2, GSTM, and GSTP gene variants with asthma in allergic CRS.…”
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Dissecting CYP1A2 Activation by Arylalkanoic Acid Prodrugs toward the Development of Anti-Inflammatory Agents by Maria Antonietta Occhiuzzi, Giuseppina Ioele, Michele De Luca, Bruno Rizzuti, Domenica Scordamaglia, Rosamaria Lappano, Marcello Maggiolini, Antonio Garofalo, Fedora Grande

“…Therefore, representative arylalkane derivatives were investigated through molecular docking techniques to verify the possible hepatic activation mode toward active metabolites by CYP1A2. In this regard, arylalkanoic acid prodrugs were docked with a crystallographic structure of human CYP1A2, in which the enzyme is co-crystallized with the selective competitive inhibitor α-naphthoflavone BHF. …”
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