Epigenetic Input Dictates the Threshold of Targeting of the Integrin-Dependent Pathway in Non-small Cell Lung Cancer by Yang Zhang, Yang Zhang, Yang Zhang, Kai Cheng, Bingwei Xu, Bingwei Xu, Junfeng Shi, Jun Qiang, Jun Qiang, Shujin Shi, Yuanqin Yi, Yuanqin Yi, Yuanqin Yi, Hongxia Li, Hongxia Li, Hongxia Li, Hongxia Li, Tengchuan Jin, Ruihua Guo, Yadi Wu, Yadi Wu, Zeyi Liu, Xiaowei Wei, Jian-An Huang, Xiuwei H. Yang, Xiuwei H. Yang

“…Meanwhile, JQ1 alone or in combination with VS-6063 attenuated cell-cell adhesion and extracellular matrix (ECM)-dependent cell spreading, which is reminiscent of phenotype induced by malfunctional E-cadherin or integrins. Paradoxically, this phenotypic impact coincided with downregulation of epithelial-mesenchymal transition (EMT)-inducting transcription factor ZEB1 or Snail. …”
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Hepatocyte growth factor protects pulmonary endothelial barrier against oxidative stress and mitochondria-dependent apoptosis by Shanshan Meng, Feiping Xia, Jingyuan Xu, Xiwen Zhang, Ming Xue, Mingyuan Gu, Fengmei Guo, Yingzi Huang, Haibo Qiu, Yi Yang, Yanjie Yin, Xiuyuan Hao

“…Our study demonstrated that HGF protected the endothelium via the suppression of ROS production and intracellular calcium uptake, which lead to increased mitochondrial membrane potential (JC-1 and mitochondria tracker green detection) and specific proteins (complex I), raised anti-apoptosis Messenger Ribonucleic Acid level (B-cell lymphoma 2 and Bcl-xL), and increased endothelial junction proteins (VE-cadherin and occludin). Reversely, mTOR inhibitor rapamycin and STAT3 inhibitor S3I-201 could raise oxidative stress and mitochondria-dependent apoptosis even with HGF treatment in LPS-induced endothelial cells. …”
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Regulation of Activating Blood and Dredging Collate Method on Serum Bone Resorption/Angiogenesis/Osteogenic Protein in Patients with Steriod-induced Osteonecrosis of Femoral Head C... by HE Xianshun, WEI Yurou, HE Mincong, LIN Kun, TIAN Jiaqing, ZHAN Zhiwei, LIN Tianye, HE Xiaoming, HE wei, WEI Qiushi

“…Fasting serum was collected, and the expression levels of nuclear factor κB receptor activating factor ligand (RANKL), platelet-derived growth factor-BB (PDGF-BB), vascular endothelial growth factor A (VEGFA), osteoprotegerin (OPG) and cadherin-associated protein (CTNNB1) in serum were detected by enzyme-linked immunosorbent assay. …”
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Differential Gene Expression and Methylation Analysis of Melanoma in TCGA Database to Further Study the Expression Pattern of KYNU in Melanoma by Min Wang, Meng Liu, Yingjian Huang, Ziyang Wang, Yuqian Wang, Ke He, Ruimin Bai, Tingyi Ying, Yan Zheng

“…Overexpression of KYNU can promote changes in apoptotic BCL-2, metabolic KYN, 3-HAA, invasion and migration MMP9, E-cadherin, and other related proteins in melanoma. Fluorescence staining and flow analysis showed that a slower proliferation rate led to a stronger fluorescence intensity. …”
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YAP1/Piezo1 involve in the dynamic changes of lymphatic vessels in UVR-induced photoaging progress to squamous cell carcinoma by Yuling L. Yang, Chu Zhou, Qi Chen, Shuzhan Z. Shen, Jiandan D. Li, Xiuli L. Wang, Peiru R. Wang

“…The expression of Piezo1 whose deletion in adult lymphatics led to substantial valve degeneration, VE-cadherin that maintained the permeability of LVs, and YAP1 were evaluated by immunohistochemistry staining as well. …”
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A study on mechanism of lncRNA-mediated SNHG5/miR-26a-5p/MTDH signal axis promoting metastasis of colorectal cancer by YE Junling, ZHENG Xiaoying, GUO Xinjian, CHEN Ruihui, YANG Liu, GOU Xiaodan, JIANG Hanmei

“…Overexpression of lncRNA SNHG5 could enhance the proliferation, clone formation, migration and invasion of CRC cells, promote the growth and lung metastasis of transplanted tumor, increase the relative expression level of Ki-67 proliferation index and vimentin (P<0.05), and decrease the relative expression level of E-cadherin (P<0.05). However, the development of CRC cells was inhibited after inhibition of lncRNA SNHG5 expression. …”
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Necroptosis-Related Prognostic Model for Pancreatic Carcinoma Reveals Its Invasion and Metastasis Potential through Hybrid EMT and Immune Escape by Haichuan Liu, Zhenghang Li, La Zhang, Mi Zhang, Shanshan Liu, Jianwei Wang, Changhong Yang, Qiling Peng, Chengyou Du, Ning Jiang

“…A GO analysis illustrated that model genes may participate in cell–cell junction, cadherin binding, cell adhesion molecule binding, and neutrophil migration and chemotaxis, while KEGG showed involvement in PI3K-Akt signaling pathway, ECMreceptor interaction, IL-17 signaling pathway, TNF signaling pathway, etc. …”
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Papillary renal neoplasm with reverse polarity: A clinicopathological and molecular genetic characterization of 16 cases with expanding the morphologic spectrum and further support... by Miaomiao Shen, Xiaona Yin, Yanfeng Bai, Huizhi Zhang, Guoqing Ru, Xianglei He, Xiaodong Teng, Guorong Chen, Ming Zhao

“…Fourteen out of 16 tumors showed a basolateral-membranous E-cadherin expression pattern, and 12/16 cases were positive for 34βE12.The expression of AMACR, CD10, and vimentin was either absent or only weak and focal. …”
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Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease by Gareth W. Price, Christos E. Chadjichristos, Panagiotis Kavvadas, Sydney C. W. Tang, Wai Han Yiu, Colin R. Green, Joe A. Potter, Eleftherios Siamantouras, Paul E. Squires, Claire E. Hills

“…Video Abstract Graphical abstract In proximal tubular epithelial cells (PTECs), tight junction proteins, including zona occuludens-1 (ZO-1), contribute to epithelial integrity, whilst the adherens junction protein epithelial (E)-cadherin (ECAD) maintains cell-cell coupling, facilitating connexin 43 (Cx43) gap junction-mediated intercellular communication (GJIC) and the direct transfer of small molecules and ions between cells. …”
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Mediastinal lymph node dissection effectiveness in patients with I stage of non-small cell lung cancer by A. P. Kolesnik

“…Immunohistochemical study was performed on paraffin sections of lung tumors using monoclonal antibodies to Ki-67, CD31, p53 , E-Cadherin, EGFR, c-erbB-2 , pantcytokeratin and visualization system EnVision FLEX. …”
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Cystathionine-γ-lyase overexpression modulates oxidized nicotinamide adenine dinucleotide biosynthesis and enhances neovascularization by Kevin Kiesworo, MS, Michael R. MacArthur, PhD, Peter Kip, MD, PhD, Thomas Agius, MS, Diane Macabrey, MS, Martine Lambelet, BS, Lauriane Hamard, PhD, C.-Keith Ozaki, MD, James R. Mitchell, PhD, Sébastien Déglise, MD, Sarah J. Mitchell, PhD, Florent Allagnat, PhD, Alban Longchamp, MD, PhD

“…Leg perfusion was measured by laser Doppler imaging and vascular endothelial-cadherin immunostaining. To examine the angiogenic potential, aortic ring sprouting assay and postnatal mouse retinal vasculature development studies were performed. …”
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Regulation of PGC1α on SiO2-induced lipid accumulation in macrophages and fibrosis in pulmonary fibroblasts by Hailan HE, Yuhui ZHOU, Jie CUI, Jiahui CAO, Mingming LIU, Bo GUAN, Yufan ZHOU, Hongli WANG, Heliang LIU

“…The expression of collagen Ι (COL Ι), E-cadherin (Eca), and fibronectin (FN) were detected by cell immunofluorescence and Western blot to further evaluate the effect of silencing PGC1α on fibrosis. …”
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Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patien... by Shayista Akbar, Afsheen Raza, Afsheen Raza, Reyad Mohsin, Aladdin Kanbour, Shahnaz Qadri, Aijaz Parray, Abdul Rehman Zar Gul, Anite Philip, Suma Vijayakumar, Maysaloun Merhi, Maysaloun Merhi, Shereena Hydrose, Shereena Hydrose, Varghese Philipose Inchakalody, Varghese Philipose Inchakalody, Rajaa Al-Abdulla, Wafa Abualainin, Shaza Abu Sirriya, Issam Al-Bozom, Shahab Uddin, Shahab Uddin, Omar Muhammad Khan, Mohamed Izham Mohamed Ibrahim, Ussama Al Homsi, Said Dermime, Said Dermime, Said Dermime

“…There was a significant downregulation of exosomal PD-L1 (p=0.0156), E-Cadherin (p=0.0312), ULBP1 (p=0.0156), ULBP3 (p=0.0391), MICA (p=0.0391), MICB (p=0.0469), Siglec7 (p=0.0078) and significant upregulation of exosomal PD-1 (p=0.0156) and IFN- γ (p=0.0156) in responding patients. …”
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The long noncoding RNA EMBP1 inhibits the tumor suppressor miR-9-5p and promotes renal cell carcinoma tumorigenesis by Yejing Hong, Zhongming Yuan, Rongzhong Huang, Zhiqin Wu, Yongyong Li

“…The EMBP1-miR-9-5p axis dysregulated the expression of the epithelial-to-mesenchymal transition (EMT) markers E-cadherin, claudin, and vimentin, the stemness markers KLF4 and Nanog, and the cell cycle checkpoint gene cyclin E2 (CCNE2) and its downstream mediator E2F1. miR-9-5p overexpression or EMBP1 suppression inhibited xenograft tumor growth in vivo, effects that were abrogated by CCNE2 overexpression. …”
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Development of vascular inspired electrospun hollow fibre membranes for use in 3D tissue culture by Martin, RJ

“…Irrespective of fluid flow conditions, by day 28 of the culture period, HUVECs were shown to have flattened, flow-aligned morphologies, reached confluency, and expressed VE-cadherin cell-cell interactions. In addition, 𝜇CT image analysis revealed that HUVEC density peaked within 5000 𝜇m of the fibre inlet, after which it declined to a plateau, and that HUVEC growth was restricted to the lumen wall of the EHFM, with no cell ingress into the membrane wall.…”

Potential differentiation of human amniotic epithelial stem and mesenchymal bone marrow cells into cardiomyocytes by Motamedi, Batool

“…The antibodies against alpha-actin, connexin43, N-cadherin, desmin, nestin and vimentin were used to identify differentiated cells. …”
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Carcinomas invasores triples negativosde la glándula mamaria: incidencia y características clínico-patológicas Triple-Negative Invasive Breast Carcinoma: Incidence and Clinical - P... by José L Quirós-Alpízar, Yendry Jiménez-Rodríguez, Ernesto Jiménez-Montero, Melissa Monge-Víquez, Lizbeth Salazar-Sánchez

“…In addition, in this study a high proportion of tumors were of lobular type, other tests might be indicated such as e-cadherin to verify the cases of lobular carcinomas to increase in this way the reliability of results.…”
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