Vesicular Darier’s disease: a case report and review of the English literature of a rare disease variant by Ahmed Mourad, Habib A Kurwa, Richard M Haber

“…Darier’s disease is an autosomal dominant inherited skin disorder resulting from mutations in the ATP2A2 gene, which encodes SERCA2, an endoplasmic reticulum calcium ATPase. Darier’s disease classically manifests as confluent hyperkeratotic brown-to-red papules that manifest and follow a seborrheic distribution, which include the chest, neck, trunk, and face. …”
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Sub-chronic exposure to waterborne extracellular microcystin-LR impairs calcium homeostasis in rainbow trout by Diane A. Mielewczyk, Chris N. Glover, Chantelle E. Klaczek, Greg G. Goss, Gavin N. Saari

“…Microcystin-LR exposure resulted in a significant and persistent hypocalcaemia at the higher exposure concentration, but plasma sodium and branchial activities of the sodium/potassium ATPase, proton ATPase and calcium ATPase enzymes remained unaffected. An in vitro assessment failed to show any effect of microcystin-LR on branchial calcium ATPase activity even at exposure concentrations as high as 1000 µg L−1. …”
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A microplate technique to simultaneously assay calcium accumulation in endoplasmic reticulum and SERCA release of inorganic phosphate by McMullen David C, Kean William S, Verma Ajay, Cole Jeffrey T, Watson William D

“…Here we describe a technique that couples the simultaneous quantification of radio-labeled calcium accumulation in endoplasmic reticulum (ER) microsomes with the release of inorganic phosphate (Pi) by the hydrolytic activity of sarco-endoplasmic reticulum calcium ATPase (SERCA) all in the convenience of a 96-well format.…”
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Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies by Jian Li, Bing Zhou

“…Several hypotheses have been proposed to explain their actions, including alkylation of heme by carbon-centered free radicals, interference with proteins such as the sarcoplasmic/endoplasmic calcium ATPase (SERCA), as well as damaging of normal mitochondrial functions. …”
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Formalin evokes calcium transients from the endoplasmatic reticulum. by Michael J M Fischer, Kailey J Soller, Susanne K Sauer, Joanna Kalucka, Gianluigi Veglia, Peter W Reeh

“…The source of calcium is the endoplasmatic reticulum and inhibition of the sarco/endoplasmic reticulum calcium-ATPase has a major contribution. This TRPA1-independent mechanism may underlie formaldehyde-induced pan-neuronal excitation and subsequent inflammation.…”
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Two ENU-induced alleles of Atp2b2 cause deafness in mice. by Marina R Carpinelli, Michael G Manning, Benjamin T Kile, Rachel A Burt

“…Both contained causative mutations in Atp2b2, which encodes the plasma membrane calcium ATPase 2. The Atp2b2 (Deaf11) mutation leads to a p. …”
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Fast calcium transients in dendritic spines driven by extreme statistics. by Kanishka Basnayake, David Mazaud, Alexis Bemelmans, Nathalie Rouach, Eduard Korkotian, David Holcman

“…The mechanism relies on the asymmetric distributions of RyRs and sarco/ER calcium-ATPase (SERCA) pumps that we predict using a computational model and further confirm experimentally in culture and slice hippocampal neurons. …”
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Vascular nitric oxide: Beyond eNOS by Yingzi Zhao, Paul M. Vanhoutte, Susan W.S. Leung

“…NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC) to produce cyclic guanosine monophosphate (cGMP), although cGMP-independent signaling [S-nitrosylation of target proteins, activation of sarco/endoplasmic reticulum calcium ATPase (SERCA) or production of cyclic inosine monophosphate (cIMP)] also can be involved. …”
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Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism by Muthu Periasamy, Jose Luis Herrera, Felipe C. G. Reis

“…In this review we will describe the role of Sarcolipin-mediated uncoupling of Sarcoplasmic Reticulum Calcium ATPase (SERCA) as a potential mechanism for increased energy expenditure both during cold and diet-induced thermogenesis.…”
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Transcriptional levels of calcium handling genes in atrial cells of heart failure patients. by Wong, Ying Lei.

“…Extension studies could be conducted using other calcium regulating genes such as calcineurin and plasma membrane calcium ATPase etc.. Comprehension of calcium signalling pathways leading up to cardiac contraction and cardiomyocyte proliferation would aid in the better understanding of the mechanics of heart failure.…”
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Novel mutations in Darier disease and association to self-reported disease severity. by Ivone U S Leong, Alexander Stuckey, Tara Ahanian, Martin Cederlöf, Jakob D Wikstrom

“…Darier disease affects up to 1 in 30 000 people and is caused by mutations in the ATP2A2 gene, which encodes to the sarco/endoplasmic reticulum calcium-ATPase isoform 2 that pumps calcium into the endoplasmic reticulum. …”
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High oxygen-modified packaging (HiOx-MAP) mediates HIF-1α regulation of tenderness changes during postmortem aging of yak meat by Ke-qi Xin, Kai Tian, Qun-li Yu, Ling Han

“…HiOx-MAP increased the activity of sarcoplasmic reticulum calcium-ATPase (SERCA). The energy disperse spectroscopy (EDS) mapping showed gradually reduced calcium distribution in the treated endoplasmic reticulum. …”
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Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson’s Disease and Synucleinopathies by Cristine Betzer, Cristine Betzer, Poul Henning Jensen, Poul Henning Jensen

“…Surprisingly, we observed a yet unrecognized phase characterized by a reduced cytosolic calcium in cellular and neuronal models of Parkinson’s disease, caused by α-synuclein aggregates activating the endoplasmic calcium ATPase, SERCA. Counteracting the initial phase with low calcium rescues the subsequent degenerative phase with increased calcium and cell death – and demonstrates this early phase initiates decisive degenerative signals. …”
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Interplay of channels, pumps and organelle location in calcium microdomain formation by Martin Peglow, Barbara A Niemeyer, Markus Hoth, Heiko Rieger

“…With the help of theoretical models we predict that, after the formation of a local Ca ^2+ influx pathway via STIM1 and Orai1, mitochondria relocation toward and accumulation of plasma membrane Ca ^2+ ATPase and sarcoplasmic/ endoplasmic reticulum calcium ATPase pumps at the immunological synapse are sufficient to achieve a long-lasting increased global Ca ^2+ concentration. …”
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Endoplasmic Reticulum Calcium Pumps and Cancer Cell Differentiation by Nadine Varin-Blank, Jocelyne Enouf, Régis Bobe, Tünde Kovács, Pascal Gélébart, Atousa Arbabian, Jean-Philippe Brouland, Béla Papp, Ágota Apáti

“…Calcium is accumulated in the ER by Sarco/Endoplasmic Reticulum Calcium ATPase (SERCA)-type calcium pumps. SERCA activity can determine ER calcium content available for intra-ER functions and for calcium release into the cytosol, and can shape the spatiotemporal characteristics of calcium signals. …”
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Blockade of oncogenic NOTCH1 with the SERCA inhibitor CAD204520 in T cell acute lymphoblastic leukemia by Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Heit, S, Olesen, CE, Møller, JV, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacono, C, La Starza, R, Mecucci, C, Stegmaier, K, Aversa, F, Stilli, D, Lund Winther, A-M, Sportoletti, P, Bublitz, M, Dalby-Brown, W, Roti, G

“…The identification of SERCA (sarco/endoplasmic reticulum calcium ATPase) as a target for modulating gain-of-function NOTCH1 mutations in Notch-dependent cancers has spurred the development of this compound class for cancer therapeutics. …”

PMCA4 (ATP2B4) mutation in familial spastic paraplegia. by Miaoxin Li, Philip Wing-Lok Ho, Shirley Yin-Yu Pang, Zero Ho-Man Tse, Michelle Hiu-Wai Kung, Pak-Chung Sham, Shu-Leong Ho

“…In this study, we identified a novel missense mutation (c.803G>A, p.R268Q) in the plasma membrane calcium ATPase (PMCA4, or ATP2B4) gene in a Chinese family with autosomal dominant FSP using whole-exome sequencing and confirmed with Sanger sequencing. …”
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Pharmacological therapy of acute heart failure: what is available now and what is expected in future by A. A. Eremenko

“…In the nearest future, data will be obtained that will allow evaluating the possibility of wide clinical use of new groups of drugs: cardiac myosin activators, natriuretic peptides, vasopressin receptor inhibitors, drugs that affect the expression of calcium ATPase in the cardiac sarcoplasmic network (SERCA2a), including those developed using genetically engineered technologies.…”
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SERCA Activity Controls the Systolic Calcium Increase in the Nucleus of Cardiac Myocytes by Tobias-Oliver Kiess, Jens Kockskämper

“…We focused on the roles of (1) the cytoplasmic calcium transient (CaT), (2) the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), and (3) intracellular calcium stores for nuclear calcium handling. …”
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NR1D1 controls skeletal muscle calcium homeostasis through myoregulin repression by Alexis Boulinguiez, Christian Duhem, Alicia Mayeuf-Louchart, Benoit Pourcet, Yasmine Sebti, Kateryna Kondratska, Valérie Montel, Stéphane Delhaye, Quentin Thorel, Justine Beauchamp, Aurore Hebras, Marion Gimenez, Marie Couvelaere, Mathilde Zecchin, Lise Ferri, Natalia Prevarskaya, Anne Forand, Christel Gentil, Jessica Ohana, France Piétri-Rouxel, Bruno Bastide, Bart Staels, Helene Duez, Steve Lancel

“…Our data demonstrate that NR1D1 deficiency in mice impaired sarco/endoplasmic reticulum calcium ATPase–dependent (SERCA-dependent) SR calcium uptake. …”
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