Transient Post-Natal Exposure to Xenoestrogens Induces Long-Term Alterations in Cardiac Calcium Signaling by Cassandra Tabasso, Marie-Pauline Frossard, Camille Ducret, Hassib Chehade, Claire Mauduit, Mohamed Benahmed, Umberto Simeoni, Benazir Siddeek

“…The evaluation of cardiac calcium signaling, through immunoblot approaches, highlighted decreased expression of the sarcoplasmic reticulum calcium ATPase 2 (SERCA2) and decreased Nuclear Factor of Activated T Cells (NFAT3) phosphorylation as a potential underlying mechanism of cardiac hypertrophy. …”
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Special issue in honour of Prof. Reto J. Strasser - Chlorophyll fluorescence, leaf gas exchange, and genomic analysis of chromosome segment substitution rice lines exposed to droug... by K. HUNGSAPRUG, T. KOJONNA, M. SAMLEEPAN, C. PUNCHKHON, W. UT-KHAO, B. KOSITSUP, W. KASETTRANUN, J.L. SIANGLIW, T. TOOJINDA, L. COMAI, K. PLAIMAS, S. CHADCHAWAN

“…The co-expression between calmodulin-stimulated calcium-ATPase and C2H2 zinc finger protein was detected. …”
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Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger Ca2+ER perturbation in hepatocellular carcinoma by Yanan Li, Keqin Li, Ting Pan, Qiaobo Xie, Yuyao Cheng, Xinfeng Wu, Rui Xu, Xiaohui Liu, Li Liu, Jiangming Gao, Wenmin Yuan, Xianjun Qu, Shuxiang Cui

“…Here, we report that IGF-1R signaling stimulates the growth of hepatocellular carcinoma (HCC) cells through the translocation of IGF-1R into the ER to enhance sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2) activity. In response to ligand binding, IGF-1Rβ is translocated into the ER by β-arrestin2 (β-arr2). …”
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Identification of Potential Muscle Biomarkers in McArdle Disease: Insights from Muscle Proteome Analysis by Inés García-Consuegra, Sara Asensio-Peña, Rocío Garrido-Moraga, Tomàs Pinós, Cristina Domínguez-González, Alfredo Santalla, Gisela Nogales-Gadea, Pablo Serrano-Lorenzo, Antoni L. Andreu, Joaquín Arenas, José L. Zugaza, Alejandro Lucia, Miguel A. Martín

“…Several proteins predominantly involved in the process of muscle contraction and/or calcium homeostasis, such as myosin, sarcoplasmic/endoplasmic reticulum calcium ATPase 1, tropomyosin alpha-1 chain, troponin isoforms, and alpha-actinin-3, showed significantly lower expression levels in the muscle of GSDV patients. …”
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Therapeutic Aspects of <i>Prunus cerasus</i> Extract in a Rabbit Model of Atherosclerosis-Associated Diastolic Dysfunction by Reka Szekeres, Daniel Priksz, Rita Kiss, Dana Diana Romanescu, Mariann Bombicz, Balazs Varga, Rudolf Gesztelyi, Anna Szilagyi, Barbara Takacs, Vera Tarjanyi, Beata Pelles-Tasko, Ildiko Forgacs, Judit Remenyik, Zoltan Szilvassy, Bela Juhasz

“…Dyslipidemia, impaired endothelial function, and signs of diastolic dysfunction were evident in hypercholesterolemic rabbits, accompanied by a reduced cardiac expression of eNOS (endothelial nitric oxide synthase), PKG, and SERCA2a (sarco/endoplasmic reticulum calcium ATPase 2a). Subsequent PCE treatment improved the lipid profile and the cardiac function. …”
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Diabetes mellitus exacerbates post‐myocardial infarction heart failure by reducing sarcolipin promoter methylation by Zhongwei Liu, Yong Zhang, Chuan Qiu, Haitao Zhu, Shuo Pan, Hao Jia, Hongyan Kang, Gongchang Guan, Rutai Hui, Ling Zhu, Junkui Wang

“…Abstract Aims Sarcolipin (SLN) is a key regulator of sarcoplasmic reticulum calcium‐ATPase (SERCA)2a, which handles intracellular calcium re‐uptake. …”
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Mechanisms Underpinning Adaptations in Placental Calcium Transport in Normal Mice and Those With Fetal Growth Restriction by Christina E. Hayward, Christina E. Hayward, Kirsty R. McIntyre, Kirsty R. McIntyre, Colin P. Sibley, Colin P. Sibley, Susan L. Greenwood, Susan L. Greenwood, Mark R. Dilworth, Mark R. Dilworth

“…Parathyroid hormone-related protein (PTHrP), elevated in cord blood in FGR and known to stimulate plasma membrane calcium ATPase, might be important. We hypothesized that PTHrP expression would be increased in LvH WT placentas, and in P0 vs. …”
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Impairment of adrenergically-regulated thermogenesis in brown fat of obesity-resistant mice is compensated by non-shivering thermogenesis in skeletal muscle by Petra Janovska, Petr Zouhar, Kristina Bardova, Jakub Otahal, Marek Vrbacky, Tomas Mracek, Katerina Adamcova, Lucie Lenkova, Jiri Funda, Tomas Cajka, Zdenek Drahota, Sara Stanic, Arild C. Rustan, Olga Horakova, Josef Houstek, Martin Rossmeisl, Jan Kopecky

“…These changes appear to be related to skeletal muscle NST, mediated by sarcolipin-induced uncoupling of sarco(endo)plasmic reticulum calcium ATPase pump activity and accentuated by changes in mitochondrial respiratory chain supercomplexes assembly. …”
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Transcriptome-based screening of intracellular pathways and angiogenesis related genes at different stages of thiram induced tibial lesions in broiler chickens by Ali Raza Jahejo, Ding Zhang, Sheng Niu, Raza Ali Mangi, Afrasyab Khan, Muhammad Farhan Qadir, Ajab Khan, Huan-chun Chen, Wen-xia Tian

“…However, commonly DEGs were sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3), ubiquitin-conjugating enzyme E2 R2 (UBE2R2), centriole cilia and spindle-associated protein (CCSAP), coagulation factor XIII A chain protein (F13A1), shroom 2 isoform X6 (SHROOM2), ras GTPase-activating protein 3 (RASA3) and CLU. …”
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cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis by Shamsideen A. Ojelade, Tom V. Lee, Nikolaos Giagtzoglou, Lei Yu, Berrak Ugur, Yarong Li, Lita Duraine, Zhongyuan Zuo, Vlad Petyuk, Philip L. De Jager, David A. Bennett, Benjamin R. Arenkiel, Hugo J. Bellen, Joshua M. Shulman

“…Cindr associates and genetically interacts with 14-3-3ζ, regulates the ubiquitin-proteasome system, and affects turnover of Synapsin and the plasma membrane calcium ATPase (PMCA). Loss of cindr elevates PMCA levels and reduces cytosolic calcium. …”
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Intestinal segment and vitamin D3 concentration affect gene expression levels of calcium and phosphorus transporters in broiler chickens by Jincheng Han, Lihua Wu, Xianliang Lv, Mengyuan Liu, Yan Zhang, Lei He, Junfang Hao, Li Xi, Hongxia Qu, Chuanxin Shi, Zhiqiang Li, Zhixiang Wang, Fei Tang, Yingying Qiao

“…Results in experiment 1 showed that the mRNA levels of calcium-binding protein 28-kDa (CaBP-D28k), sodium-calcium exchanger 1 (NCX1), plasma membrane calcium ATPase 1b (PMCA1b), and IIb sodium-phosphate cotransporter (NaPi-IIb) were the highest in the broiler duodenum. …”
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Echocardiographic evaluation of right heart failure which might be associated with DNA damage response in SU5416-hypoxia induced pulmonary hypertension rat model by Meidan Kuang, Yilin Chen, Yue Xing, Min Du, Huazhuo Feng, Qifeng Yang, Dongmei Wen, Xuanyi Li, Kai Yang, Ziying Lin, Ning Lai, Qian Jiang, Shiyun Liu, Dansha Zhou, Wei Hong, Xin Fu, Wenju Lu, Tengteng Zhao, Jian Wang, Yuqin Chen

“…Furthermore, sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2), a marker of myocardial damage, was highly expressed in week 2 of SuHx-induced PH and had higher levels of expression of γ-H2AX at all timepoints, as well as higher levels of DDR-related proteins p-ATM and p53/p-p53 and p21 in week 4 and week 6. …”
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Investigation of dose-dependent effects of berberine against renal ischemia/reperfusion injury in experimental diabetic rats by Meltem Kumaş, Mukaddes Eşrefoğlu, Ersin Karataş, Nurcihan Duymaç, Songül Kanbay, Ilyas Samet Ergün, Mehmet Üyüklü, Abdurrahim Koçyiğit

“…Tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), Na+/K+-ATPase (sodium pump), and Ca2+-ATPase (calcium ATPase) enzyme levels were measured in tissues using the ELISA method. …”
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Investigation of dose-dependent effects of berberine against renal ischemia/reperfusion injury in experimental diabetic rats by Meltem Kumaş, Mukaddes Eşrefoğlu, Ersin Karataş, Nurcihan Duymaç, Songül Kanbay, Ilyas Samet Ergün, Mehmet Üyüklü, Abdurrahim Koçyiğit

“…Tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), Na+/K+-ATPase (sodium pump), and Ca2+-ATPase (calcium ATPase) enzyme levels were measured in tissues using the ELISA method. …”
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P-type transport ATPases in Leishmania and Trypanosoma by Meade John C.

“…The P-type ATPase complement in these trypanosomatids includes the P1B (metal pumps), P2A (SERCA, sarcoplasmic-endoplasmic reticulum calcium ATPases), P2B (PMCA, plasma membrane calcium ATPases), P2D (Na+ pumps), P3A (H+ pumps), P4 (aminophospholipid translocators), and P5B (no assigned specificity) subfamilies. …”
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Altered Organelle Calcium Transport in Ovarian Physiology and Cancer by Laura Caravia, Cristina Elena Staicu, Beatrice Mihaela Radu, Carmen Elena Condrat, Dragoș Crețoiu, Nicolae Bacalbașa, Nicolae Suciu, Sanda Maria Crețoiu, Silviu Cristian Voinea

“…The most important proteins described as contributing to ovarian cancer progression are inositol trisphosphate receptors, ryanodine receptors, transient receptor potential channels, calcium ATPases, hormone receptors, G-protein-coupled receptors, and/or mitochondrial calcium uniporters. …”
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Neuroplastin in human cognition: review of literature and future perspectives by Katarina Ilic, Kristina Mlinac-Jerkovic, Goran Sedmak, Ivana Rosenzweig, Svjetlana Kalanj-Bognar

“…Recently, it was found that some of the effects of neuroplastin are related to regulation of calcium homeostasis through interactions with plasma membrane calcium ATPases. Neuroplastin is increasingly seen as a key factor in complex brain functions, but studies in humans remain scarce. …”
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Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis by Béla Papp, Jean-Philippe Brouland

“…Calcium uptake into the endoplasmic reticulum is performed by Sarco/Endoplasmic Reticulum Calcium ATPases (SERCA enzymes). In order to study endoplasmic reticulum calcium homeostasis in situ in mammary tissue, in this work SERCA3 expression was investigated in normal breast and in its benign and malignant lesions in function of the cell type, degree of malignancy, and histological and molecular parameters of the tumors. …”
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Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation by Bela Papp, Sophie Launay, Pascal Gélébart, Atousa Arbabian, Agnes Enyedi, Jean-Philippe Brouland, Edgardo D. Carosella, Homa Adle-Biassette

“…Calcium is accumulated in the ER by sarco/endoplasmic reticulum calcium ATPases (SERCA enzymes) that generate by active, ATP-dependent transport, a several thousand-fold calcium ion concentration gradient between the cytosol (low nanomolar) and the ER lumen (high micromolar). …”
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Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus Latent Membrane Protein-1 by Joab Irène, Chomienne Christine, Kovàcs Tünde, Rowe Martin, Brouland Jean-Philippe, Arbabian Atousa, Dellis Olivier, Papp Béla

“…Calcium is accumulated in the ER by Sarco/Endoplasmic Reticulum Calcium ATPases (SERCA enzymes), and therefore these enzymes play an important role in ER calcium homeostasis and in the control of B of cell activation. …”
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