Developing a Child and Youth Mental Health and Addictions Framework for Yukon as a Foundation for Policy Reform: Engaging Stakeholders Through a Policy and Research Partnership by Gillian Mulvale, Stanley K. Kutcher, Paddy (Patricia) Meade

“…Access, coordination and quality problems associated with existing services, growing public awareness of mental health issues, and a new national policy framework designed to assist provinces and territories, led Yukon policy makers to partner with researchers to capitalize on a Canadian Institutes of Health Research (CIHR) strategic grant initiative. …”
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Sustainability and impact of an intervention to improve initiation of tuberculosis preventive treatment: results from a follow-up study of the ACT4 randomized trialResearch in cont... by Dick Menzies, Joseph Obeng, Panji Hadisoemarto, Rovina Ruslami, Menonli Adjobimey, Dina Fisher, Leila Barss, Nancy Bedingfield, Richard Long, Catherine Paulsen, James Johnston, Kamila Romanowski, Victoria J. Cook, Greg J. Fox, Thu Anh Nguyen, Chantal Valiquette, Olivia Oxlade, Federica Fregonese, Andrea Benedetti

“…Funding: Funded by the Canadian Institutes of Health Research (Grant number 143350).…”
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Glycolytic lactate in diabetic kidney disease by Darshi, Manjula, Kugathasan, Luxcia, Maity, Soumya, Sridhar, Vikas S., Fernandez, Roman, Limonte, Christine P., Grajeda, Brian I., Saliba, Afaf, Zhang, Guanshi, Drel, Viktor R., Kim, Jiwan J., Montellano, Richard, Tumova, Jana, Montemayor, Daniel, Wang, Zhu, Liu, Jian-Jun, Wang, Jiexun, Perkins, Bruce A., Lytvyn, Yuliya, Natarajan, Loki, Lim, Su Chi, Feldman, Harold, Toto, Robert, Sedor, John R., Patel, Jiten, Waikar, Sushrut S., Brown, Julia, Osman, Yahya, He, Jiang, Chen, Jing, Reeves, W. Brian, de Boer, Ian H., Roy, Sourav, Vallon, Volker, Hallan, Stein, Gelfond, Jonathan A. L., Cherney, David Zi, Sharma, Kumar

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PROTOCOL: Barriers and facilitators to stakeholder engagement in health guideline development: A qualitative evidence synthesis by Olivia Magwood, Alison Riddle, Jennifer Petkovic, Lyubov Lytvyn, Joanne Khabsa, Pearl Atwere, Elie A. Akl, Pauline Campbell, Vivian Welch, Maureen Smith, Reem A. Mustafa, Heather Limburg, Leonila F. Dans, Nicole Skoetz, Sean Grant, Thomas W. Concannon, Peter Tugwell

“…To identify grey literature, we will search the websites of agencies who actively engage stakeholder groups such as the AHRQ, Canadian Institutes of Health Research (CIHR) Strategy for Patient‐Oriented Research (SPOR), INVOLVE, the National Institute for Health and Care Excellence (NICE) and the PCORI. …”
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Effect of the COVID-19 pandemic on mental health visits in primary care: an interrupted time series analysis from nine INTRePID countriesResearch in context by Javier Silva-Valencia, Carla Lapadula, John M. Westfall, Gabriela Gaona, Simon de Lusignan, Robert Sarkadi Kristiansson, Zheng Jye Ling, Lay Hoon Goh, Percy Soto-Becerra, Maria Sofia Cuba-Fuentes, Knut-Arne Wensaas, Signe Flottorp, Valborg Baste, William Chi-Wai Wong, Amy Pui Pui Ng, Angela Ortigoza, Jo-Anne Manski-Nankervis, Christine Mary Hallinan, Paula Zingoni, Luciano Scattini, Adrian Heald, Karen Tu, Karen Tu, Angela Ortigoza, Carla Lapadula, Paula Zingoni, Luciano Scattini, Jo-Anne Manski-Nankervis, Christine Mary Hallinan, Adrian Laughlin, William Chi-Wai Wong, Amy Pui Pui Ng, Zhou Li, Knut-Arne Wensaas, Signe Agnes Flottorp, Valborg Baste, Maria Sofia Cuba-Fuentes, Javier Silva-Valencia, Percy Soto-Becerra, Zheng Jye Ling, Lay Hoon Goh, Robert Kristiansson, Mats Martinell, Simon de Lusignan, Uy Hoang, Adrian Heald, Wilson Pace, John M. Westfall, Gabriela Gaona, Michael Kidd

“…Funding: Canadian Institutes of Health Research grant #173094 and the Rathlyn Foundation Primary Care EMR Research and Discovery Fund.…”
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Colposcopy referral rates post-introduction of primary screening with human papillomavirus testing: evidence from a large British Columbia cohort studyResearch in context by Anna Gottschlich, Lovedeep Gondara, Laurie W. Smith, Jennifer Joy Anderson, Darrel Cook, Mel Krajden, Marette Lee, Ruth Elwood Martin, Joy Melnikow, Stuart Peacock, Lily Proctor, Gavin Stuart, Eduardo L. Franco, Dirk van Niekerk, Gina S. Ogilvie

“…Funding: This work was supported by the National Institutes of Health (R01 CA221918), Michael Smith Health Research BC (RT-2021-1595), and the Canadian Institutes of Health Research (MCT82072).…”
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Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimenResearch in cont... by Roux-Cil Ferreira, Steven J. Reynolds, Adam A. Capoferri, Owen R. Baker, Erin E. Brown, Ethan Klock, Jernelle Miller, Jun Lai, Sharada Saraf, Charles Kirby, Briana Lynch, Jada Hackman, Sarah N. Gowanlock, Stephen Tomusange, Samiri Jamiru, Aggrey Anok, Taddeo Kityamuweesi, Paul Buule, Daniel Bruno, Craig Martens, Rebecca Rose, Susanna L. Lamers, Ronald M. Galiwango, Art F.Y. Poon, Thomas C. Quinn, Jessica L. Prodger, Andrew D. Redd

“…Funding: Supported by the NIH (grant 1-UM1AI164565); Gilead HIV Cure Grants Program (90072171); Canadian Institutes of Health Research (PJT-155990); and Ontario Genomics-Canadian Statistical Sciences Institute.…”
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Intestinal barrier disruption with Plasmodium falciparum infection in pregnancy and risk of preterm birth: a cohort studyResearch in context by Julie K. Wright, Andrea M. Weckman, Michelle Ngai, Veselina Stefanova, Kathleen Zhong, Chloe R. McDonald, Robyn E. Elphinstone, Andrea L. Conroy, Bryan A. Coburn, Mwayi Madanitsa, Steve M. Taylor, Feiko O. ter Kuile, Kevin C. Kain

“…Funding: Open Philanthropy, Canadian Institutes of Health Research, Canada Research Chair program, European and Developing Countries Clinical Trials Partnership, Bill & Melinda Gates Foundation.…”
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Sex-related differences in functional capacity and its implications in risk stratification before major non-cardiac surgery: a post hoc analysis of the international METS studyRese... by Jonas Alfitian, Bernhard Riedel, Hilmy Ismail, Kwok M. Ho, Sophia Xie, Philipp Zimmer, Tobias Kammerer, Duminda N. Wijeysundera, Brian H. Cuthbertson, Robert Schier

“…The original METS study was funded by Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, Ontario Ministry of Health and Long-Term Care, Ontario Ministry of Research, Innovation and Science, UK National Institute of Academic Anaesthesia, UK Clinical Research Collaboration, Australian and New Zealand College of Anaesthetists, and Monash University.…”
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Seno-destructive smooth muscle cells in the ascending aorta of patients with bicuspid aortic valve diseaseResearch in context by Brittany Balint, Hao Yin, Zengxuan Nong, John-Michael Arpino, Caroline O'Neil, Stephanie R. Rogers, Varinder K. Randhawa, Stephanie A. Fox, Jacqueline Chevalier, Jason J. Lee, Michael W.A. Chu, J. Geoffrey Pickering

“…Fund: Canadian Institutes of Health Research, Lawson Health Research Institute, Heart and Stroke Foundation of Ontario/Barnett-Ivey Chair. …”
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Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk by Wilcox, Naomi, Dumont, Martine, González-Neira, Anna, Carvalho, Sara, Beauparlant, Charles Joly, Crotti, Marco, Luccarini, Craig, Soucy, Penny, Dubois, Stéphane, Nuñez-Torres, Rocio, Pita, Guillermo, Gardner, Eugene J., Dennis, Joe, Alonso, M. Rosario, Álvarez, Nuria, Baynes, Caroline, Collin-Deschesnes, Annie Claude, Desjardins, Sylvie, Becher, Heiko, Behrens, Sabine, Bolla, Manjeet K., Castelao, Jose E., Chang-Claude, Jenny, Cornelissen, Sten, Dörk, Thilo, Engel, Christoph, Gago-Dominguez, Manuela, Guénel, Pascal, Hadjisavvas, Andreas, Hahnen, Eric, Hartman, Mikael, Herráez, Belén, Jung, Audrey, Keeman, Renske, Kiechle, Marion, Li, Jingmei, Loizidou, Maria A., Lush, Michael, Michailidou, Kyriaki, Panayiotidis, Mihalis I., Sim, Xueling, Teo, Soo Hwang, Tyrer, Jonathan P., van der Kolk, Lizet E., Wahlström, Cecilia, Wang, Qin, Perry, John R. B., Benitez, Javier, Schmidt, Marjanka K., Schmutzler, Rita K., Pharoah, Paul D. P., Droit, Arnaud, Dunning, Alison M., Kvist, Anders, Devilee, Peter, Easton, Douglas F., Simard, Jacques, Tan, Benita Kiat-Tee, Tan,Veronique Kiak Mien, Tan, Su-Ming, Lim, Geok Hoon, Tan, Ern Yu, Ho, Peh Joo, Khng, Alexis Jiaying

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Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebol... by Henao-Restrepo, A, Camacho, A, Longini, I, Watson, C, Edmunds, W, Egger, M, Carroll, M, Dean, N, Diatta, I, Doumbia, M, Draguez, B, Duraffour, S, Enwere, G, Grais, R, Gunther, S, Gsell, P, Hossmann, S, Watle, S, Kondé, M, Kéïta, S, Kone, S, Kuisma, E, Levine, M, Mandal, S, Mauget, T, Norheim, G, Riveros, X, Soumah, A, Trelle, S, Vicari, A, Røttingen, J, Kieny, M

“…Headache (1832 [25·4%]), fatigue (1361 [18·9%]), and muscle pain (942 [13·1%]) were the most commonly reported adverse events in this period across all age groups. 80 serious adverse events were identified, of which two were judged to be related to vaccination (one febrile reaction and one anaphylaxis) and one possibly related (influenza-like illness); all three recovered without sequelae.The results add weight to the interim assessment that rVSV-ZEBOV offers substantial protection against Ebola virus disease, with no cases among vaccinated individuals from day 10 after vaccination in both randomised and non-randomised clusters.WHO, UK Wellcome Trust, the UK Government through the Department of International Development, Médecins Sans Frontières, Norwegian Ministry of Foreign Affairs (through the Research Council of Norway's GLOBVAC programme), and the Canadian Government (through the Public Health Agency of Canada, Canadian Institutes of Health Research, International Development Research Centre and Department of Foreign Affairs, Trade and Development).…”

Involving Patient Partners in the KRESCENT Peer Review: Intent, Process, Challenges, and Opportunities by Elisabeth A. Fowler, Karin Bell, Kevin Burns, Angela Chiazzese, Sacha A. DeSerres, Bethany J. Foster, Sunny Hartwig, Gwen Herrington, Matthew T. James, Victor Jensen, Nina Jones, Sandi Kidston, Serge Lemay, Adeera Levin, Anne MacPhee, Shanda McCutcheon, Pietro Ravani, Susan Samuel, James Scholey, Tomoko Takano, Navdeep Tangri, Nancy Verdin, R. Todd Alexander, Catherine M. Clase

“…Purpose of review: The Kidney Research Scientist Core Education and National Training (KRESCENT) is a national Canadian training program for kidney scientists, funded by the Kidney Foundation of Canada (KFOC), the Canadian Institutes of Health Research (CIHR), and the Canadian Society of Nephrology (CSN). …”
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Genetic variants for head size share genes and pathways with cancer by Knol, Maria J., Poot, Raymond A., Evans, Tavia E., Satizabal, Claudia L., Mishra, Aniket, Sargurupremraj, Muralidharan, van der Auwera, Sandra, Duperron, Marie-Gabrielle, Jian, Xueqiu, Hostettler, Isabel C., van Dam-Nolen, Dianne H. K., Lamballais, Sander, Pawlak, Mikolaj A., Lewis, Cora E., Carrion-Castillo, Amaia, van Erp, Theo G. M., Reinbold, Céline S., Shin, Jean, Scholz, Markus, Håberg, Asta K., Kämpe, Anders, Li, Gloria H. Y., Avinun, Reut, Atkins, Joshua R., Hsu, Fang-Chi, Amod, Alyssa R., Lam, Max, Tsuchida, Ami, Teunissen, Mariël W. A., Aygün, Patel, Yash, Liang, Dan, Beiser, Alexa S., Beyer, Frauke, Bis, Joshua C., Bos, Daniel, Bryan, R. Nick, Bülow, Robin, Caspers, Svenja, Catheline, Gwenaëlle, Cecil, Charlotte A. M., Dalvie, Shareefa, Dartigues, Jean-François, DeCarli, Charles, Enlund-Cerullo, Maria, Ford, Judith M., Franke, Barbara, Freedman, Barry I., Friedrich, Nele, Green, Melissa J., Haworth, Simon, Helmer, Catherine, Hoffmann, Per, Homuth, Georg, Ikram, M. Kamran, Jack, Clifford R., Jahanshad, Neda, Jockwitz, Christiane, Kamatani, Yoichiro, Knodt, Annchen R., Li, Shuo, Lim, Keane, Longstreth, W. T., Macciardi, Fabio, Mäkitie, Outi, Mazoyer, Bernard, Medland, Sarah E., Miyamoto, Susumu, Moebus, Susanne, Mosley, Thomas H., Muetzel, Ryan, Mühleisen, Thomas W., Nagata, Manabu, Nakahara, Soichiro, Palmer, Nicholette D., Pausova, Zdenka, Preda, Adrian, Quidé, Yann, Reay, William R., Roshchupkin, Gennady V., Schmidt, Reinhold, Schreiner, Pamela J., Setoh, Kazuya, Shapland, Chin Yang, Sidney, Stephen, St Pourcain, Beate, Stein, Jason L., Tabara, Yasuharu, Teumer, Alexander, Uhlmann, Anne, van der Lugt, Aad, Vernooij, Meike W., Werring, David J., Windham, B. Gwen, Witte, A. Veronica, Wittfeld, Katharina, Yang, Qiong, Yoshida, Kazumichi, Brunner, Han G., Le Grand, Quentin, Sim, Kang, Stein, Dan J., Bowden, Donald W, Cairns, Murray J., Hariri, Ahmad R., Cheung, Ching-Lung, Andersson, Sture, Villringer, Arno, Paus, Tomas, Cichon, Sven, Calhoun, Vince D., Crivello, Fabrice, Launer, Lenore J., White, Tonya, Koudstaal, Peter J., Houlden, Henry, Fornage, Myriam, Matsuda, Fumihiko, Grabe, Hans J., Ikram, M. Arfan, Debette, Stéphanie, Thompson, Paul M., Seshadri, Sudha, Adams, Hieab H. H.

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Global transmission of extended-spectrum cephalosporin resistance in Escherichia coli driven by epidemic plasmidsResearch in context by Roxana Zamudio, Patrick Boerlin, Michael R. Mulvey, Marisa Haenni, Racha Beyrouthy, Jean-Yves Madec, Stefan Schwarz, Ashley Cormier, Gabhan Chalmers, Richard Bonnet, George G. Zhanel, Heike Kaspar, Alison E. Mather

“…Funding: This project was supported by the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR), through the Medical Research Council (MRC, MR/R000948/1), the Canadian Institutes of Health Research (CFC-150770), and the Genomics Research and Development Initiative (Government of Canada), the German Federal Ministry of Education and Research (BMBF) grant no. 01KI1709, the French Agency for food environmental and occupational health & safety (Anses), and the French National Reference Center (CNR) for antimicrobial resistance. …”
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The relationship between the epigenetic aging biomarker “grimage” and lung function in both the airway and blood of people living with HIV: An observational cohort study by Ana I Hernández Cordero, Chen Xi Yang, Julia Yang, Xuan Li, Steve Horvath, Tawimas Shaipanich, Julia MacIsaac, David Lin, Lisa McEwen, Michael S. Kobor, Silvia Guillemi, Marianne Harris, Wan Lam, Stephen Lam, Ma'en Obeidat, Richard M. Novak, Fleur Hudson, Hartwig Klinker, Nila Dharan, Julio Montaner, S.F. Paul Man, Ken Kunisaki, Don D. Sin, Janice M. Leung, J.V. Baker, D. Duprez, A. Carr, J. Hoy, M. Dolan, A. Telenti, C. Grady, G. Matthews, J. Rockstroh, W.H. Belloso, J.M. Kagan, E. Wright, B. Brew, R.W. Price, K. Robertson, L. Cysique, K.M. Kunisaki, J.E. Connett, D.E. Niewoehner, Endpoint Review Committee, A. Lifson, W.H. Belloso, R.T. Davey, Jr., D. Duprez, J.M. Gatell, J. Hoy, C. Pedersen, R.W. Price, R. Prineas, J. Worley

“…Funding: Canadian Institutes of Health Research and the British Columbia Lung Association. …”
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GAA-FGF14 disease: defining its frequency, molecular basis, and 4-aminopyridine response in a large downbeat nystagmus cohortResearch in context by David Pellerin, Felix Heindl, Carlo Wilke, Matt C. Danzi, Andreas Traschütz, Catherine Ashton, Marie-Josée Dicaire, Alexanne Cuillerier, Giulia Del Gobbo, Kym M. Boycott, Jens Claassen, Dan Rujescu, Annette M. Hartmann, Stephan Zuchner, Bernard Brais, Michael Strupp, Matthis Synofzik

“…The Care4Rare Canada Consortium is funded in part by Genome Canada and the Ontario Genomics Institute (OGI-147 to KMB), the Canadian Institutes of Health Research (CIHR GP1-155867 to KMB), Ontario Research Foundation, Genome Quebec, and the Children's Hospital of Eastern Ontario Foundation. …”
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Variations in the financial impact of the COVID-19 pandemic across 5 continents: A cross-sectional, individual level analysis by Aditya K Khetan, Salim Yusuf, Patricio Lopez-Jaramillo, Andrzej Szuba, Andres Orlandini, Nafiza Mat-Nasir, Aytekin Oguz, Rajeev Gupta, Álvaro Avezum, Ismail Rosnah, Paul Poirier, Koon K Teo, Andreas Wielgosz, Scott A. Lear, Lia M. Palileo-Villanueva, Pamela Serón, Jephat Chifamba, Sumathy Rangarajan, Maha Mushtaha, Deepa Mohan, Karen Yeates, Martin McKee, Prem K Mony, Marjan Walli-Attaei, Hamda Khansaheb, Annika Rosengren, Khalid F Alhabib, Iolanthé M Kruger, María-José Paucar, Erkin Mirrakhimov, Batyrbek Assembekov, Darryl P Leong

“…Funding: Funding for this study was provided by the Canadian Institutes of Health Research and the International Development Research Centre.…”
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Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity by Yu, Vanessa, Yong, Fiona, Marta, Angellica, Khadayate, Sanjay, Osakwe, Adrien, Bhattacharya, Supriyo, Varghese, Sneha S., Chabosseau, Pauline, Tabibi, Sayed M., Chen, Keran, Georgiadou, Eleni, Parveen, Nazia, Suleiman, Mara, Stamoulis, Zoe, Marselli, Lorella, De Luca, Carmela, Tesi, Marta, Ostinelli, Giada, Delgadillo-Silva, Luis, Wu, Xiwei, Hatanaka, Yuki, Montoya, Alex, Elliott, James, Patel, Bhavik, Demchenko, Nikita, Whilding, Chad, Hajkova, Petra, Shliaha, Pavel, Kramer, Holger, Ali, Yusuf, Marchetti, Piero, Sladek, Robert, Dhawan, Sangeeta, Withers, Dominic J., Rutter, Guy A., Millership, Steven J.

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Rebalancing of mitochondrial homeostasis through an NAD+-SIRT1 pathway preserves intestinal barrier function in severe malnutritionResearch in context by Catriona Ling, Christian J. Versloot, Matilda E. Arvidsson Kvissberg, Guanlan Hu, Nathan Swain, José M. Horcas-Nieto, Emily Miraglia, Mehakpreet K. Thind, Amber Farooqui, Albert Gerding, Karen van Eunen, Mirjam H. Koster, Niels J. Kloosterhuis, Lijun Chi, YueYing ChenMi, Miriam Langelaar-Makkinje, Celine Bourdon, Jonathan Swann, Marieke Smit, Alain de Bruin, Sameh A. Youssef, Marjon Feenstra, Theo H. van Dijk, Kathrin Thedieck, Johan W. Jonker, Peter K. Kim, Barbara M. Bakker, Robert H.J. Bandsma

“…Funding: This work was supported by the Bill and Melinda Gates Foundation, the Sickkids Research Institute, the Canadian Institutes of Health Research, and the University Medical Center Groningen.…”
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