Delineating and Operationalizing the Definition of Patient-Oriented Research: A Modified e-Delphi Study by Navdeep Kaur, Pierre Pluye

“…The current Canadian Institutes of Health Research (CIHR) definition of POR is overly broad and hinders the reliable selection of POR-related publications from bibliographic databases. …”
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ParticipACTION: Overview and introduction of baseline research on the "new" ParticipACTION by Craig Cora L, Tremblay Mark S

“…</p> <p>Results</p> <p>The research team was successful in obtaining funding through the new Canadian Institutes of Health Research Intervention Research (Healthy Living and Chronic Disease Prevention) Funding Program. …”
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A qualitative study of Canadian resident experiences with Competency-Based Medical Education by Leora Branfield Day, Terry Colbourne, Alex Ng, Franco Rizzuti, Linda Zhou, Rani Mungroo, Allan McDougall

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Reflections on patient engagement by patient partners: how it can go wrong by Dawn P. Richards, Sabrina Poirier, Vina Mohabir, Laurie Proulx, Sue Robins, Jeffery Smith

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mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis by Laplante, Mathieu, Sabatini, David

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Functional Clustering Drives Encoding Improvement in a Developing Brain Network during Awake Visual Learning by Dunfield, Derek, Podgorski, Kaspar, Haas, Kurt

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Barcoding bias in high-throughput multiplex sequencing of miRNA by Alon, Shahar, Vigneault, Francois, Eminaga, Seda, Christodoulou, Danos C., Seidman, Jonathan G., Church, George M., Eisenberg, Eli

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Metronidazole treatment rapidly reduces genital inflammation through effects on bacterial vaginosis–associated bacteria rather than lactobacilli by Eric Armstrong, Anke Hemmerling, Steve Miller, Kerianne E. Burke, Sara J. Newmann, Sheldon R. Morris, Hilary Reno, Sanja Huibner, Maria Kulikova, Rachel Liu, Emily D. Crawford, Gloria R. Castañeda, Nico Nagelkerke, Bryan Coburn, Craig R. Cohen, Rupert Kaul

“…BV treatment induced no change in the absolute abundance of L. crispatus or L. iners and only minor (&lt;1 log10–fold) increases in L. gasseri and L. jensenii that were not independently associated with reduced inflammation in multivariable models.CONCLUSION The genital immune benefits that are associated with Lactobacillus dominance after BV treatment were not directly attributable to an absolute increase in lactobacilli, but rather to the loss of BV-associated bacteria.Trial REGISTRATION Participants were recruited as part of a randomized controlled trial (ClinicalTrials.gov NCT02766023) from 2016 to 2019.FUNDING Canadian Institutes of Health Research (PJT-156123) and the National Institute of Allergy and Infectious Diseases (HHSN2722013000141 and HHSN27200007).…”
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Building a Pan-Canadian Real World Health Data Network by Mark Smith, Michael Schull, Kimberlyn McGrail, Alan Katz, Brent Diverty, Ted McDonald, Charles Victor, Lisa Lix, Alison Paprica

“…Background In December 2017 the Canadian Institutes of Health Research (CIHR) issued a request for proposals to develop a pan-Canadian health data platform. …”
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Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses by Annika Gompers, Madeline T. Olivier, Donna L. Maney

“…Methods Here, we evaluated three sets of publicly available online training materials on this topic: (1) Integrating Sex & Gender in Health Research from the Canadian Institutes of Health Research (CIHR); (2) Sex as a Biological Variable: A Primer from the United States National Institutes of Health (NIH); and (3) The Sex and Gender Dimension in Biomedical Research, developed as part of “Leading Innovative measures to reach gender Balance in Research Activities” (LIBRA) from the European Commission. …”
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Aerobic exercise elicits clinical adaptations in myotonic dystrophy type 1 patients independently of pathophysiological changes by Andrew I. Mikhail, Peter L. Nagy, Katherine Manta, Nicholas Rouse, Alexander Manta, Sean Y. Ng, Michael F. Nagy, Paul Smith, Jian-Qiang Lu, Joshua P. Nederveen, Vladimir Ljubicic, Mark A. Tarnopolsky

“…Additionally, we provide evidence for the involvement of snoRNAs and other noncoding RNAs in DM1 pathophysiology.Trial registration This trial was approved by the HiREB committee (no. 7901) and registered under ClinicalTrials.gov (NCT04187482).Funding Neil and Leanne Petroff. Canadian Institutes of Health Research Foundation (no. 143325).…”
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The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors by Davidson, Dominique, Zhong, Ming-Chao, Pandolfi, Pier Paolo, Bolland, Silvia, Seed, Brian, Li, Xin, Gu, Hua, Veillette, André, Xavier, Ramnik Joseph

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ACID: annotation of cassette and integron data by Boucher, Yan, Labbate, Maurizio, Polz, Martin F., Doolittle, W. Ford, Stokes, Harold W., Gillings, Michael R., Polz, Martin F., Koenig, Jeremy E., Joss, Michael J.

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Mediator and cohesin connect gene expression and chromatin architecture by Kagey, Michael H., Newman, Jamie Jennifer, Bilodeau, Steve, Zhan, Ye, Orlando, David A., van Berkum, Nynke L., Ebmeier, Christopher C., Goossens, Jesse, Rahl, Peter B., Levine, Stuart S., Taatjes, Dylan J., Dekker, Job, Young, Richard A.

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MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes by Rissland, Olivia S., Hong, Sue-Jean, Bartel, David, Rissland, Olivia S.

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Fast gene transfer into the adult zebrafish brain by herpes simplex virus 1 (HSV-1) and electroporation: methods and optogenetic applications by Zou, Ming, De Koninck, Paul, Neve, Rachael L., Friedrich, Rainer W.

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Direct experimental visualization of waves and band structure in 2D photonic crystal slabs by Ofori-Okai, Benjamin Kwasi, Sivarajah, Prasahnt, Werley, Christopher A., Teo, Stephanie M., Nelson, Keith Adam

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Multiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elements by Dowen, Jill M., Bilodeau, Steve, Orlando, David A., Hübner, Michael R., Abraham, Brian J., Spector, David L., Young, Richard A., Young, Richard A.

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Nanoparticles with photoinduced precipitation for the extraction of pollutants from water and soil by Brandl, Ferdinand, Bertrand, Nicolas, Lima, Eliana Martins, Langer, Robert S

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Proteomics for comprehensive characterization of extracellular vesicles in neurodegenerative disease by Vinaiphat, Arada, Sze, Siu Kwan

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