Metabolism studies in breast cancer by Sharma, A

“…<p>Metabolic reprogramming has emerged as a common phenotype of cancers. Otto Warburg in 1920s observed that cancer cells consume higher amounts of glucose for their metabolism producing high levels of lactate even in normal oxygen conditions, this has been termed as the Warburg effect. …”

Systems biology and cancer, [Editorial] by Soto, A, Sonnenschein, C, Maini, P

“…In the case of cancer the hope that by identifying what are called oncogenes we would not only understand cancer but be led naturally to its cure has not been fulfilled ([Sonnenschein and Soto, 1999] and [Sonnenschein and Soto, 2011]). …”

Translational relevance of AIPL1 and NUB1 in cancer by Tan, K

“…It suggested that low NUB1 nuclear localisation in hypoxia cause cancer cell cycle arrest. In MDA-MB-231 cell, upon hypoxia, neddylation inhibitor (MLN4924) treated and siNUB1 transfected cells showed decreased CUL1 and further accumulated p21 &amp; p27. …”

Cancer cell cycle modulation by metabolic gene expression and role of photoreceptor phosphodiesterase 6H in cancer cell growth by Yalaz, C

“…This project aimed to identify metabolic genes whose inhibition causes cell cycle arrest, which would allow further study of candidate genes in the context of cancer metabolism and cell proliferation. …”

Exploiting replication stress induced by IGF blockade in cancer therapy by Wu, X

“…<p>In recent work from our group, we found that genetic or pharmacological inhibition of type 1 insulin-like growth factor receptor (IGF-1R) promotes accumulation of cells in S phase and causes endogenous DNA damage by inducing replication stress. …”

Antitumor Effect of Zerumbone Isolated from Lempoyang (Zingiber Zerumbet) on Human Cervical Cancer Cells and Mouse Cervical Intraepithelial Neoplasia by Abdelwahab, Siddig Ibrahim

“…Malaysia as a tropical country is a rich source of biologically active phytochemicals, which could be useful as an alternative to the current unsafe regimens of cancer treatment. This includes the use of cisplatin (CIS), the current chemotherapeutic drug to treat cervical cancer, the second most lethal cancer affecting women in Malaysia. …”
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Nitric oxide induced S-nitrosation causes base excision repair imbalance by Engelward, Bevin P., Parrish, Marcus Curtis, Chaim, Isaac Alexander, Nagel, Zachary D., Tannenbaum, Steven R, Samson, Leona D, Engelward, Bevin P

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Active targeting of rhabdomyosarcoma cells using helenalin-loaded functionalised cubosomes by Mun, HM

Developing anti-p53/HLA-A*0201 T-cell receptor mimic antibodies for cancer immunotherapy by Trenevska, I

Familial isolated primary hyperparathyroidism caused by mutations of the MEN1 gene. by Hannan, F, Nesbit, M, Christie, P, Fratter, C, Dudley, N, Sadler, G, Thakker, R

“…BACKGROUND: Familial isolated primary hyperparathyroidism (FIHP) is an autosomal dominant disorder that can represent an early stage of either the multiple endocrine neoplasia type 1 (MEN1) or hyperparathyroidism-jaw tumor (HPT-JT) syndromes; alternatively, the condition can be caused by an allelic variant of MEN1 or HRPT2 (hyperparathyroidism 2 gene), or caused by a distinct entity involving another locus. …”

E2F1: Cause and consequence of DNA replication stress by Fouad, S, Hauton, D, D'Angiolella, V

The environmental stress response causes ribosome loss in aneuploid yeast cells by Terhorst, Allegra, Sandikci, Arzu, Keller, Abigail, Whittaker, Charles A, Dunham, Maitreya J, Amon, Angelika

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Causal relationships between obesity and the leading causes of death in women and men by Censin, JC, Peters, SAE, Bovijn, J, Ferreira, T, Pulit, SL, Mägi, R, Mahajan, A, Holmes, MV, Lindgren, CM

“…A Mendelian randomization analysis of 228,466 women and 195,041 men showed that obesity causes coronary artery disease, stroke (particularly ischemic), chronic obstructive pulmonary disease, lung cancer, type 2 and 1 diabetes mellitus, non-alcoholic fatty liver disease, chronic liver disease, and acute and chronic renal failure. …”

Association between diabetes and cause-specific mortality in rural and urban China by Bragg, F, Holmes, M, Iona, A, Guo, Y, Du, H, Chen, Y, Bian, Z, Yang, L, Herrington, W, Bennett, D, Turnbull, I, Liu, Y, Feng, S, Chen, J, Clarke, R, Collins, R, Peto, R, Li, L, Chen, Z

“…<br/><br/> Main Outcomes and Measures <br/> All-cause and cause-specific mortality, collected through established death registries. …”

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Diseas... by GBD 2017 Causes of Death Collaborators

“…GBD 2017 provides a comprehensive assessment of cause-specific mortality for 282 causes in 195 countries and territories from 1980 to 2017.…”

Heat fixation of cancer cells ablated with high-intensity-focused ultrasound in patients with breast cancer. by Wu, F, Wang, Z, Cao, Y, Xu, Z, Zhou, Q, Zhu, H, Chen, W

“…By using electronic microscopy and nicotinamide adenine dinucleotide-diaphorase stain, those who had normal-appearing cancer cells were not viable. CONCLUSIONS: HIFU can cause the heat fixation of ablated tumor through thermal effect.…”

The anti- cancer effect of clinacanthus nutans in 4T1 breast cancer in balb/c mice by Chua, Sik Juan

“…Breast cancer is one of the most common cancers that cause death in the world especially among women. …”
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Counselling cancer patients: a case study of perspectives of professional counsellors and cancer patients in Malaysia by Voon, Siok Ping, Chan, Siaw Leng

“…Globally, cancer is renowned as the top leading cause of death. …”

Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. by Duell, E, Travier, N, Lujan-Barroso, L, Clavel-Chapelon, F, Boutron-Ruault, M, Morois, S, Palli, D, Krogh, V, Panico, S, Tumino, R, Sacerdote, C, Quirós, JR, Sánchez-Cantalejo, E, Navarro, C, Gurrea, AB, Dorronsoro, M, Khaw, K, Allen, N, Key, T, Bueno-de-Mesquita, H, Ros, M, Numans, M, Peeters, P, Trichopoulou, A, Naska, A

“…BACKGROUND: Gastric cancer (GC) is the second leading cause of cancer death worldwide. …”

Radon exposure and cancers other than lung cancer among uranium miners in West Bohemia. by Tomásek, L, Darby, S, Swerdlow, A, Placek, V, Kunz, E

“…Recent observations have suggested that radon in the ambient air may cause cancers at sites other than the lung, but the evidence is indirect. …”